The LIBOR Market Model (LMM) is the first model of interest rates dynamics consistent with the market practice of pricing interest rate derivatives and therefore it is widely used by financial institution for valuation of interest rate derivatives. This book provides a full practitioner's approach to the LIBOR Market Model. It adopts the specific language of a quantitative analyst to the largest possible level and is one of first books on the subject written entirely by quants. The book is divided into three parts - theory, calibration and simulation. New and important issues are covered, such as various drift approximations, various parametric and nonparametric calibrations, and the uncertain volatility approach to smile modelling; a version of the HJM model based on market observables and the duality between BGM and HJM models. Co-authored by Dariusz Gatarek, the 'G' in the BGM model who is internationally known for his work on LIBOR market models, this book offers an essential perspective on the global benchmark for short-term interest rates.
The revolution of 1905 in the Russian-ruled Kingdom of Poland marked the consolidation of major new influences on the political scene. As he examines the emergence of a mass political culture in Poland, Robert E. Blobaum offers the first history in any Western language of this watershed period. Drawing on extensive archival research to explore the history of Poland's revolutionary upheavals, Blobaum departs from traditional interpretations of these events as peripheral to an essentially Russian movement that reached a climax in the Russian Revolution of 1917. He demonstrates that, although Polish independence was not formally recognized until after World War I, the social and political conditions necessary for nationhood were established in the years around 1905.
Defying predictions that the Internet would eventually create a world where nations disappeared in favor of a unified 'global village, ' the new millennium has instead seen a proliferation of nationalism on the Web. Cyberspace, a vast digital terrain built upon interwoven congeries of data and sustained through countless public/private communication networks, has even begun to alter the very fabric of national identity. This is particularly true among stateless nations, diasporic groups, and national minorities, which have fashioned the Internet into a shield again the assimilating efforts of their countries of residence. As a deterritorialized medium that allows both selective consumption and inexpensive production of news and information, the Internet has endowed a new generation of technology-savvy elites with a level of influence that would have been impossible to obtain a decade ago. Challenged nations-from Assyrians to Zapotecs-have used the Web to rewrite history, engage in political activism, and reinvigorate moribund languages. This book explores the role of the Internet in shaping ethnopolitics and sustaining national identity among four different national groups: Albanians outside of Albania, Russians in the 'near abroad, ' Roma (Gypsies), and European Muslims. Accompanying these case studies are briefer discussions of dozens of other online national movements, as well as the ramifications of Internet nationalism for offline domestic and global politics. The author discusses how the Internet provides new tools for maintaining national identity and improves older techniques of nationalist resistance for minorities. Bringing together research and methodologies from a range of fields, Saunders fills a gap in the social science literature on the Internet's central role in influencing nationalism in the twenty-first century. By creating new spaces for political discourse, alternative avenues for cultural production, and novel means of social organization, the Web is remaking what it means to be part of nation. This insightful study provides a glimpse of this exciting and sometimes disturbing new landscap
This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry Shows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discovery Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods
The Encyclopedia of Medieval Literature in Britain vereint erstmals wissenschaftliche Erkenntnisse zu Multilingualität und Interkulturalität im mittelalterlichen Britannien und bietet mehr als 600 fundierte Einträge zu Schlüsselpersonen, Zusammenhängen und Einflüssen in der Literatur vom fünften bis sechzehnten Jahrhundert. - Einzigartiger multilingualer, interkultureller Ansatz und die neuesten wissenschaftlichen Erkenntnisse. Das gesamte Mittelalter und die Bandbreite literarischer Sprachen werden abgedeckt. - Über 600 fundierte, verständliche Einträge zu Schlüsselpersonen, Texten, kritischen Debatten, Methoden, kulturellen Zusammenhängen sowie verwandte Terminologie. - Repräsentiert die gesamte Literatur der Britischen Inseln, einschließlich Alt- und Mittelenglisch, das frühe Schottland, die Anglonormannen, Nordisch, Latein und Französisch in Britannien, die keltische Literatur in Wales, Irland, Schottland und Cornwall. - Beeindruckende chronologische Darstellung, von der Invasion der Sachsen bis zum 5. Jahrhundert und weiter bis zum Übergang zur frühen Moderne im 16. Jahrhundert. - Beleuchtet die Überbleibsel mittelalterlicher britischer Literatur, darunter auch Manuskripte und frühe Drucke, literarische Stätten und Zusammenhänge in puncto Herstellung, Leistung und Rezeption sowie erzählerische Transformation und intertextuelle Verbindungen in dieser Zeit.
INDEPENDENT BOOKS OF THE YEAR This completely new edition of the Penguin Guide reviews the 1000 best classical albums issued and reissued over the past five decades, many of which dominate the catalogue because of their sheer excellence, irrespective of recording dates. More comprehensive than ever before, it indicates key recordings on CD, DVD and enhanced SACD, including those in surround sound. If you want the finest available version of any major classical album you will find it listed and assessed in these pages. Ranging from long-established albums to the newest releases, the latest edition represents the cream of the international repertoire and has all the information you need to select the finest classical music available.
R in Action' presents both the R system and the use cases that make it such a compelling package for business developers. The book begins by introducing the R language, and then moves on to various examples illustrating R's features.
IgG antibodies are highly potent molecules, with the unique ability to link foreign particles to innate immune cells. IgG antibodies recognize antigens with high affinity and bind cellular Fc receptors with low affinity individually. These interactions occur in the form of immune complexes, resulting in high-avidity interactions. In fact, the effector functions triggered by IgG antibodies are highly dependent on the type of Fc receptor that is bound; however, many aspects can influence Fc receptor binding by IgG antibodies, including the IgG isotype and the composition of the glycan on the IgG antibody. Further, FcγR expression is not stagnant but instead is affected by the inflammatory milieu. These considerations, and others that affect targeting of IgG Fcs to specific FcγRs to elicit desired effector functions, are discussed herein.
Sergei Rachmaninoff was a renowned composer, pianist, and conductor. Because he was a member of the Russian aristocracy, he fled the country after the tsar's abdication, and eventually relocated in the United States. Many of his compositions are for piano, yet he also composed orchestral and symphony works, three operas, choral and liturgical works, some chamber works, and numerous songs. This guide catalogues his numerous works and performances, provides a detailed bibliography, and includes a discography of recordings released within the last half-century. Cross-referenced throughout, this volume should appeal to music and Rachmaninoff scholars who are looking for a comprehensive guide to further research.
Salivary Gland Pathology: Diagnosis and Management, SecondEdition, updates the landmark text in this important disciplinewithin oral and maxillofacial surgery, otolaryngology/head and necksurgery, and general surgery. Written by well-establishedclinicians, educators, and researchers in oral and maxillofacialsurgery, this book brings together information on the etiology,diagnosis, and treatment of all types of salivary gland pathology.Clear and comprehensive, Salivary Gland Pathology: Diagnosis andManagement offers complete explanation of all points, supportedby a wealth of clinical and surgical illustrations to allow thereader to gain insight into every facet of each pathologic entityand its diagnosis and treatment. Salivary Gland Pathology: Diagnosis and Management offerscomprehensive coverage of all aspects of this topic. Beginning withthe embryology, anatomy and physiology of the salivary glands, thefirst section of the book discusses radiographic imaging,infections, cystic conditions, sialoadenitis and sialolithiasis,and systemic diseases. The second section of the book is devoted tothe classification of salivary gland tumors and devotes individualchapters to the discussion of each type. Additions for this sectionof the second edition include molecular biology of salivary glandneoplasia, radiation therapy, and chemotherapy and targeted therapyfor salivary gland malignancies. The book closes with adiscussion of pediatric salivary gland pathology, traumaticinjuries of the salivary glands and miscellaneous pathologicprocesses of the salivary glands and ducts, including a section onsaliva as a diagnostic fluid. The book is intended for a very diverse audience, includingacademic oral and maxillofacial surgeons, otolaryngologists / headand neck surgeons, general surgeons, as well as residents in thesedisciplines. Private practitioners will want to place thispublication on the bookshelves of their offices so as to consultthe textbook when evaluating a patient with salivary glandpathology.
More than an essential companion to the complete "Penguin Guide to Compact Discs" (1999), the "Yearbook 2000/1" reviews hundreds of brand new CDs and takes a closer look at some of the more unusual areas of the classical-music repertoire.
The authors of the acclaimed Penguin Guide to Compact Discs and Cassettes are back with the best bargains in classical music recordings. The authors evaluate interpretations as well as performances and consider both the quality of the recorded sound and the value for money in terms of playing time.
Authoritative, hands-on desk reference for the practicing oncologist—from the leader in the field of cancer management and treatment A Doody's Core Title for 2019! The MD Anderson Manual of Medical Oncology details the personalized multidisciplinary approach to cancer management and treatment of common and rare cancers pioneered by The University of Texas MD Anderson Cancer Center. Its pragmatic presentation can provide valuable insights at any stage of your career. This completely updated third edition reflects the most recent advancements, including expanded coverage of the rapidly evolving area of biological and immune therapies of cancer, many developed at MD Anderson. It emphasizes and discusses continuing developments in diagnostic procedures, which include the incorporation of new molecular markers and revised staging systems. It also reinforces how imaging and molecular profiling can prevent administration of overly aggressive, toxic treatment regimens or invasive surgery to treat superficial or indolent tumors. To help you quickly assess cancer management options, every chapter includes numerous tables, diagrams, imaging photographs, and prescriptive advice. Evidence-based treatment algorithms in the form of flowcharts and diagrams shaped by the clinical experience of MD Anderson’s world-class faculty enhance the text. The third edition features important new chapters on key topics such as: · Pediatric Cancers · Molecular Biomarkers and Cancer · Immuno-Oncology · Targeted Therapies in Cancer · Onco-Cardiology · Pulmonary Complications of Cancer Therapy · Applied Biostatistics Offering the perfect balance of narrative text, summary tables, and clinical photographs (many in full color), there is truly not a more accessible, up-to-date, or authoritative clinician’s guide to the medical management of patients with cancer and its complications than The MD Anderson Manual of Medical Oncology.
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