Robert M. Winokur's Books

Drug Toxicity in Embryonic Development I

Advances in Understanding Mechanisms of Birth Defects: Morphogenesis and Processes at Risk

By: Robert J. Kavlock,George P. Daston

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Drug Toxicity in Embryonic Development I

Advances in Understanding Mechanisms of Birth Defects: Morphogenesis and Processes at Risk

By: Robert J. Kavlock,George P. Daston

Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that the experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.

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Page Count

650

Publisher

Springer

Published Date

ISBN 10

3540612599

ISBN 13

9783540612599

Understanding and Evaluating Research in Applied and Clinical Settings

By: George A. Morgan,Jeffrey A. Gliner,Robert J. Harmon

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Understanding and Evaluating Research in Applied and Clinical Settings

By: George A. Morgan,Jeffrey A. Gliner,Robert J. Harmon

Clinically oriented professionals and students need to understand and evaluate the research and statistics in professional articles, especially given today's emphasis on evidence-based practice. This book demonstrates how the research approach and design help determine the appropriate statistical analysis. Understanding and Evaluating Research in Applied and Clinical Settings features: *short, independent, chapters that do not have to be read in order; *a guide to understanding why a particular statistic was selected; *an emphasis on effects sizes including measures of risk potency; *numerous cross-disciplinary examples to illustrate the material; and *methods to help determine practical and clinical significance and their relation to meta-analysis and evidence-based practice. This book is intended for practitioners and students in psychology, education, counseling, mental and allied health, nursing, and medicine, and as a text for courses on understanding research methods and statistics.

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Page Count

377

Publisher

Psychology Press

Published Date

ISBN 10

1135604533

ISBN 13

9781135604530

Hypercarbon Chemistry

By: George A. Olah,G. K. Surya Prakash,Robert E. Williams,Kenneth Wade,Árpád Molnár

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Hypercarbon Chemistry

By: George A. Olah,G. K. Surya Prakash,Robert E. Williams,Kenneth Wade,Árpád Molnár

The essential new edition of the book that put hypercarbon chemistry on the map A comprehensive and contemporary treatment of the chemistry of hydrocarbons (alkanes, alkenes, alkynes, and aromatics) towards electrophiles, Hypercarbon Chemistry, Second Edition deals with all major aspects of such chemistry involved in hydrocarbon transformations, and of the structural and reaction chemistry of carboranes, mixed hydrides in which both carbon and boron atoms participate in the polyhedral molecular frameworks. Despite the firmly established tetravalency, carbon can bond simultaneously to five or more other atoms. "Hypercarbon" bonding permeates much organic, inorganic and organometallic chemistry, and the book serves as the compendium for this phenomenon. Copious diagrams illustrate the rich variety of hypercarbon structures now known, and patterns therein. Individual chapters deal with specific categories of compound (e.g. organometallics, carboranes, carbocations) or transformations that proceed through transient hypercarbon species, detailing fundamental chemistry, including reactivity, selectivity, stereochemistry, mechanistic factors and more.

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Page Count

477

Publisher

John Wiley & Sons

Published Date

ISBN 10

1118016459

ISBN 13

9781118016459

Book's by Robert M. Winokur

Drug Toxicity in Embryonic Development I

Drug Toxicity in Embryonic Development I

Understanding and Evaluating Research in Applied and Clinical Settings

Understanding and Evaluating Research in Applied and Clinical Settings

Hypercarbon Chemistry

Hypercarbon Chemistry

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