The experiences and attitudes of a man who lived under Chinese Communism, rising to a position of importance before his decision to flee to the West, whose story describes much of life and society under Maoism. Robert Loh is the first educated Chinese to give a view from the inside of life in Red China. Son of a well-to-do family who was sent to study political science in the United States during the period when the authority of the Nationalist Government was disintegrating, Loh chose to return to Shanghai to contribute what he could toward reshaping China into a major world power. Robert Loh is at pains to make clear that he could not have survived, and indeed lived a relatively privileged life in communist China without giving in to much that he hated and despised.
During the tumultuous 1970s, competing warlords are killing each other to gain control of the opium grown in the Golden Triangle, the mountainous region in Southeast Asia where the borders of Thailand, Laos, and Burma join. The winner in the latest opium war, Tai Los, which means "dope boss," is now the "King of the Golden Triangle." Tai Los is the leader of a militia he calls the Shan Liberation Army-a group fighting for independence from the Burmese government and the creation of a separate Shan state. To raise money for guns and to gain respectability, he has offered to sell the opium crop now under his control to the United States. When President Carter's administration decides to turn down Tia Los's offer, the CIA brings in Mike Shannon, a young drug enforcement agent from South Boston, to broker a new deal. Shannon faces two major threats as he heads into the perilous assignment: knowing that he is expendable, and the Triads. An ancient Chinese gang operating out of Hong Kong, the Triads are dependent on the Golden Triangle for their supply of heroin. Once they learn that their supply is threatened, they will not hesitate to hunt Shannon down for the sole purpose of eliminating him.
When private investigator Andrew Schlakier receives a phone call out of the blue from State Corporate Affairs Mister Fix-it, Peter Michael, to investigate a case, he knows he’s going to be in for a harrowing time. A mother and daughter have been tragically found dead in their car in a quiet Melbourne street. The finger of blame points to the husband, but with an iron-clad alibi there is simply no way he could have done it. Or is there? It's an increasingly dangerous game of cat and mouse, but as Schlakier delves more deeply into the case and endeavours to deconstruct the suspect’s story, it becomes less and less clear if he is the hunter or the quarry.
Since its discovery, a substantial body of information has been amassed concerning the functions of parathyroid hormone-related protein (PTHrP) in normal and malignant states. This book provides a state-of-the-art discussion of the major aspects of PTHrP biology and pathophysiology, in addition to presenting a historical perspective and discussions on the molecular biology of PTHrP, its mechanism of action, bioassays and radioimmunoassays, and its role in normal physiology. The book will be a primary resource for physicians interested in the clinical aspects of paraneoplastic hypercalcemia and mineral metabolic disorders. It will also serve as a primary resource for basic scientists in skeletal and renal physiology, tumor biology, and hormone action. PROPOSED CONTENTS: INTRODUCTION (A. BROADUS). HISTORY. Identification of Clinical Syndrome of MAH. Evidence for Unique PTH-Like Factor. ISOLATION AND PURIFICATION OF PTHrP. CHEMICAL DESCRIPTION OF PTHrP. MOLECULAR BIOLOGY OF PTHrP (D. GOLTZMAN). GENE STRUCTURE. Intron and Exon Boundaries. Identification of Promoter and Putative Regulatory Elements. Alternative Splicing. EVOLUTIONARY RELATIONSHIP TO PTH GENE. EXPRESSION OF PTHrP (M. THIEDE). EXPRESSION IN TUMOR TISSUES. EXPRESSION IN NORMAL TISSUES. EXPRESSION IN CELL CULTURE. SECRETED FORMS. ASSAY OF PTHrP AND ITS ROLE IN MAH (A. STEWART, W. BURTIS). BIO- AND RADIOIMMUNOASSAYS. SERUM CONCENTRATIONS IN NORMAL SUBJECTS AND CANCER PATIENTS. RELATIONSHIP BETWEEN EXPRESSION OF PTHRP AND HYPERCALCEMIA. EFFECTS ON TARGET TISSUES. Bone. Kidney. ROLE OF FACTORS OTHER THAN PTHrP IN MAH. MOLECULAR MECHANISM OF ACTION OF PTHrP (R. NISSENSON, G. STREWLER). RECEPTOR BINDING AND CELL SIGNALING. IMPLICATIONS FOR STRUCTURE-FUNCTION FOR PTHrP FAMILY. PTHrP IN NORMAL PHYSIOLOGY (J. MARTIN). EMBRYONIC AND NEONATAL DEVELOPMENT. LACTATION. RELATIONSHIP TO PTH.
As Mississippi's attorney general from 1956 to 1969, Joe T. Patterson led the legal defense for Jim Crow in the state. He was inaugurated for his first term two months before the launch of the Sovereignty Commission—charged “to protect the sovereignty of Mississippi from encroachment thereon by the federal government”—which made manifest a century-old states' rights ideology couched in the rhetoric of massive resistance. Despite the dubious legal foundations of that agenda, Patterson supported the organization's mission from the start and served as an ex-officio leader on its board for the rest of his life. Patterson was also a card-carrying member of the segregationist Citizens' Council and, in his own words, had “spent many hours and driven many miles advocating the basic principles for which the Citizens' Councils were originally organized.” Few ever doubted his Jim Crow credentials. That is until September 1962 and the integration of the University of Mississippi by James Meredith. That fall Patterson stepped out of his entrenchment by defying a circle of white power brokers, but only to a point. His seeming acquiescence came at the height of the biggest crisis for Mississippi's racist order. Yet even after the Supreme Court decreed that Meredith must enter the university, Patterson opposed any further desegregation and despised the federal intervention at Ole Miss. Still he faced a dilemma that confronted all white southerners: how to maintain an artificially elevated position for whites in southern society without resorting to violence or intimidation. Once the Supreme Court handed down its decision in Meredith v. Fair, the state attorney general walked a strategic tightrope, looking to temper the ruling's impact without inciting the mob and without retreating any further. Patterson and others sought pragmatic answers to the dilemma of white southerners, not in the name of civil rights but to offer a more durable version of white power. His finesse paved the way for future tactics employing duplicity and barely yielding social change while deferring many dreams.
Through six editions, Thompson & Thompson's Genetics in Medicine has been a well-established favorite textbook on this fascinating and rapidly evolving field, integrating the classic principles of human genetics with modern molecular genetics to help you understand a wide range of genetic disorders. The 7th edition incorporates the latest advances in molecular diagnostics, the Human Genome Project, and much more. More than 240 dynamic illustrations and high-quality photos help you grasp complex concepts more easily. This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included. Acquire the state-of-the-art knowledge you need on the latest advances in molecular diagnostics, the Human Genome Project, pharmacogenetics, and bio-informatics. Better understand the relationship between basic genetics and clinical medicine with a variety of clinical case studies. Recognize a wide range of genetic disorders with visual guidance from more than 240 dynamic illustrations and high-quality photos. This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included.
How Los Angeles, Hong Kong, and China deal with such urban environmental issues as ports, goods movement, air pollution, water quality, transportation, and public space. Over the past four decades, Los Angeles, Hong Kong, and key urban regions of China have emerged as global cities—in financial, political, cultural, environmental, and demographic terms. In this book, Robert Gottlieb and Simon Ng trace the global emergence of these urban areas and compare their responses to a set of six urban environmental issues. These cities have different patterns of development: Los Angeles has been the quintessential horizontal city, the capital of sprawl; Hong Kong is dense and vertical; China's new megacities in the Pearl River Delta, created by an explosion in industrial development and a vast migration from rural to urban areas, combine the vertical and the horizontal. All three have experienced major environmental changes in a relatively short period of time. Gottlieb and Ng document how each has dealt with challenges posed by ports and the movement of goods, air pollution (Los Angeles, Hong Kong, and urban China are all notorious for their hazardous air quality), water supply (all three places are dependent on massive transfers of water) and water quality, the food system (from seed to table), transportation, and public and private space. Finally they discuss the possibility of change brought about by policy initiatives and social movements.
Costa Rica by Bus is the only Costa Rica tourism guide that gives complete, detailed, up-to-date information about this nation's extensive, inexpensive, public bus system, a system that will take you almost anywhere in this beautiful country border to border and coast to coast at minimal cost. The eBook is densely linked to help you navigate within the document and externally when you are online, enabling you to visit CR Tourism websites. The guide gives you information on schedules, fares, international bus connections, domestic air schedules, and most importantly where to find your bus. It also includes an English-Spanish Traveler's Glossary.
Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world.The Biology of Cancer is a textbook for students studying the molecular and cellula
Over the last decade the world has experienced a growing interest in problems associated with the nonmedical use of drugs. This interest has corresponded to a real growth in the extent, diversity, and social impact of the use of alcohol and drugs in many societies. As a result, the amount of research and writing on the subject of drug problems has greatly increased, and it has become very difficult for one individual to keep up with all the relevant literature. There is thus an acute need in the field for critical reviews that assess current developments, and the present series is intended to fill this need. The series is not to be an "annual review" in the usual sense. The aim is not to cover all the work reported during the preceding year in relation to a fixed selection of topics. Rather, it is to present each year evaluative papers on topics in which enough recent progress has been made to alter the general scope in a particular area. Owing to the multidisciplinary nature of problems of drug use and dependence, the papers published in each volume will be drawn from several disciplines. However, some volumes may be devoted to one partic ular problem, with individual reviews and papers examining various aspects of it. The composition of the editorial board and the international advisory board reflects these objectives. The editors are members of the senior scientific staff of the Addiction Research Foundation of Ontario.
Long recognized as the standard general reference work providing a complete overview of contemporary gynaecological practice, this new edition of Shaw, Gynaecology provides all the information that trainees need to master in order to successfully take their professional certification exams as well as providingthe practicing gynaecologist with an accessible overview of the "state of play" of diagnostic and therapeutic procedures. Totally rewritten, it gives a succinct but comprehensive account of all currently available resources in the management of gynaecological disorders. Comprehensive overview of contemporary gynaecological practice with a clinically focused approach. It covers all of the areas that a gynaecologist covers on a day-to-day basis and helps in the formulation and implementation of the most effective treatment. Details the use of various imaging modalities and investigative techniques as they relate to specific diseases in order to provide a solid foundation for clinical practice. User-friendly features such as chapter outlines, summary tables, key point boxes incorporated throughout.Provides quick access to the most necessary information for practitioners needing a quick consult or trainees preparing for exams. Copiously illustrations clarify and enhance the text whenever appropriate. Highly selective and current list of references quickly directs the reader to further investigations. New full colour illustrations incorporated throughout to accurately depict the full range of both common and rare disorders. Details up-to-date investigative and minimally invasive therapeutic techniques to keep the user abreast of the latest diagnostic and management options. Enhanced emphasis on surgical outcomes to help the user select the most appropriate procedure for any given patient. Two brand new editors and many brand new contributors provide a fresh perspectives on gynaecological oncology, reproductive and urogynaecological conditions.
Many leading figures in the field of Athabaskan languages contributed to this volume, and their range of topics matches Robert Young's interests. Four papers deal with northern Athabaskan languages, which Young studied in the 1930s. The remaining essays focus on aspects of Navajo language and culture; Young has specialized in this area for over fifty years in collaboration with his mentor, William Morgan, Sr. Several essays present detailed analysis of verb and sentence structure in Navajo, two are studies of Navajo literacy, another examines Navajo philosophy, and one offers the first study of how children learn the complexities of the Navajo verb. Anyone interested in Navajo studies or Athabaskan languages will find these essays invaluable.
Featuring more than 300 illustrations, the text covers pathology, biology, epidemiology, genetics, and screening through surgical management, the latest in chemotherapeutic regimens, and finally, palliative care"--P. [4] of cover.
Herbert Henri Jasper is a scientist whose research activities have initiated and encompassed many of the major themes of neuroscience. He has pioneered in single unit recording, chronic neuronal studies, neurochemistry, electroencephalography, and many other disciplines. His students now hold important positions in universities and hospitals around the world. From July 21 to 23, 1986, a symposium entitled Neurotransmitters and Cortical Function: From Molecules to Mind was held in Montreal to honor Professor Jasper and to continue his pioneering efforts. The following chapters originated in that meeting. They summarize the current v vi PREFACE status of our knowledge in some of the fields influenced by Professor Jasper. They share a focus on neurotransmitters in cortical function, where we presume higher mental events originate. Professor Jasper has made contributions to the understanding of three different classes of neuro transmitters: GABA, acetylcholine, and catecholamines. It is an interest in trying to link neu rochemical events to some aspects of complex brain function and behavior that has characterized his work, and it is this philosophy that led to the present symposium to honor him. We dedicate this volume to Professor Jasper and the integrative approach that he has fostered. The Editors Montreal Contents 1. H. H. Jasper, Neuroscientist of Our Century .......................... .
Sataloff's Comprehensive Textbook of Otolaryngology: Head & Neck Surgery - Head & Neck Surgery is part of a multi-volume textbook covering basic and clinical science across the entire field of otolaryngology. Volumes in the set include; otology, neurotology and skull-based surgery; rhinology, allergy and immunology; facial plastic and reconstructive surgery; laryngology and paediatric otolaryngology. The full set is enhanced by over 5000 full colour images and illustrations, spanning nearly 6000 pages, complete with a comprehensive index on DVD. Edited by Robert T Sataloff from Drexel University College of Medicine, Philadelphia, this volume includes contributions from internationally recognised experts in otolaryngology, ensuring authoritative content throughout. Sataloff's Comprehensive Textbook of Otolaryngology: Head & Neck Surgery - Head & Neck Surgery is an indispensable, in-depth guide to the field for all otolaryngology practitioners. Key Points Textbook of head and neck surgery, part of six-volume set covering the entire field of otolaryngology Volumes include otology/neurotology, rhinology, plastic surgery, laryngology, and paediatric otolaryngology Over 5000 full colour images and illustrations across six volumes Edited by Robert T Sataloff, with contributions from internationally recognised otolaryngology experts
It was 1968 and Robert Hartley was on his first combat mission in Vietnam as copilot of a helicopter gunship. As he and his platoon leader flew over the A Shau Valley, a Chinook helicopter engulfed in flames suddenly came into view. Hartley noticed tiny black smoking objects exiting the tail ramp of the aircraft. Seconds later, he realized those objects were men escaping the flames and plunging to their deaths. It was in that moment that he silently wondered, How the hell did I get here? Mr. Hartley was still wet behind the ears when he was tossed into the cauldron of Americas most unpopular war as an attack helicopter gunship pilot. As he shares a gripping, birds-eye view of battles that took him from the Demilitarized Zone in the north to the Mekong Delta in the south, Mr. Hartley compellingly details how he learned to rely on his superior training and equipment to follow through with his mission to kill the enemy and save the lives of his fellow soldiers below. Gunship Pilot provides an unforgettable glimpse into two combat tours of duty in Vietnam as a helicopter pilot soaring high above rice paddies and jungles attempts to fulfill his duty of protecting Americas warriors on the ground.
Lurps is the revised edition of the memoir of a juvenile delinquent who drops out of ninth grade to chase his dream of military service. After volunteering for Vietnam, he joins the elite U.S. Army LRRP/Rangers—small, heavily armed long-range reconnaissance teams that patrol deep in enemy-held territory. It is 1968, and the Lurps find themselves in some of the war's hairiest campaigns and battles, including Tet, Khe Sanh, and A Shau. Readers witness all the horrors, humor, adrenaline, and unexpected beauty through the eyes of a green young warrior. Gone are the heroic clichZs and bravado as compelling narrative and realistic dialogue sweep the reader along with a powerful sense that this is actually happening. This poignant coming-of-age story explores the social background that shaped the protagonist's thinking, his uncertain quest for redemption through increased responsibility, the brotherhood of comrades in arms, women and sexual awakening, and the baffling randomness of who lives and who dies.
highly acclaimed comprehensive and practical text covering the principles and practice of the management of cancer Why Buy This Book? Includes up-to-date information on the most recent techniques and therapies available Comprehensive and practical reference source of both common and rarer forms of cancer Highlights frequent dilemmas and difficulties encountered during cancer management Covers controversial topics including screening, genetic testing, prevention and AIDS-related cancers Provides the reader with fundamental knowledge about oncogenes, epidemiology and staging, through to basic actions of different treatment modalities Cancer and its management is ideal for all those concerned with he management of cancer: Surgical, clinical and medical oncologists – both consultants and trainees Nursing staff with an interest in cancer General practitioners, and medical, nursing and pharmacy students "This book is exactly what was needed. All in all, this book is destined to become a classic." The Lancet "......should be compulsory reading for all would-be cancer specialists. The authors' discussion of controversial topics...is excellent." British Medical Journal “This is, without exaggeration, the book when it comes to Cancer. ... All in all, the Cancer Bible.” Microscope (NottinghamUniversityMedicalSchool Gazette)
A Celebration of Representation Theory and Harmonic Analysis : an AMS Special Session Honoring the Memory of Harish-Chandra, January 9-10, 1998, Baltimore, Maryland
A Celebration of Representation Theory and Harmonic Analysis : an AMS Special Session Honoring the Memory of Harish-Chandra, January 9-10, 1998, Baltimore, Maryland
Harish-Chandra was a mathematician of great power, vision, and remarkable ingenuity. His profound contributions to the representation theory of Lie groups, harmonic analysis, and related areas left researchers a rich legacy that continues today. This book presents the proceedings of an AMS Special Session entitled, "Representation Theory and Noncommutative Harmonic Analysis: A Special Session Honoring the Memory of Harish-Chandra", which marked 75 years since his birth and 15 years since his untimely death at age 60. Contributions to the volume were written by an outstanding group of internationally known mathematicians. Included are expository and historical surveys and original research papers. The book also includes talks given at the IAS Memorial Service in 1983 by colleagues who knew Harish-Chandra well. Also reprinted are two articles entitled, "Some Recollections of Harish-Chandra", by A. Borel, and "Harish-Chandra's c-Function: A Mathematical Jewel", by S. Helgason. In addition, an expository paper, "An Elementary Introduction to Harish-Chandra's Work", gives an overview of some of his most basic mathematical ideas with references for further study. This volume offers a comprehensive retrospective of Harish-Chandra's professional life and work. Personal recollections give the book particular significance. Readers should have an advanced-level background in the representation theory of Lie groups and harmonic analysis.
Updated to reflect the newest changes in genetics, Thompson & Thompson's Genetics in Medicine returns as one of the most favored texts in this fascinating and rapidly evolving field. By integrating the classic principles of human genetics with modern molecular genetics, this medical reference book utilizes a variety of learning tools to help you understand a wide range of genetic disorders. Acquire the state-of-the-art knowledge you need on the latest advances in molecular diagnostics, the Human Genome Project, pharmacogenetics, and bio-informatics. Better understand the relationship between basic genetics and clinical medicine with a variety of clinical case studies. Recognize a wide range of genetic disorders with visual guidance from more than 240 dynamic illustrations and high-quality photos. Immerse yourself in updated graphics, full-color text, illustrations, line diagrams, and clinical photos of genetic diseases. Explore the latest genetic content available in order to remain up to date on the most current trends in the field. Take advantage of a double-page clinical case study section that demonstrates and reinforces general principles of disease inheritance, pathogenesis, diagnosis, management, and counseling. Enhance your critical thinking skills and better retain information. Each chapter ends with up to 5 quick genetic "problems" related to what has just been reviewed, with answers provided in the back of the book. Student Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. You'll also access USMLE-style and multiple choice questions.
This military history chronicles a time during the Vietnam War when fighting stopped and the 101st Airborne helped those in need during a natural disaster. For three days during the Vietnam War, it wasn’t rockets or artillery that came through the skies, but a horrific force of nature that suddenly put both sides in awe. When Super Typhoon Joan arrived in October 1970, an unofficial truce began. Air crewman faced masses of Vietnamese civilians outside their base perimeters for the first time. Could we trust them not to shoot? Could they trust us not to drop them off in a detention camp? Truces never last, but while they do, life changes for everyone involved. The “typhoon truce” stopped the war for three days in northern I Corps—that area bordering the demilitarized zone separating South Vietnam from North. Then, less than a week later, Super Typhoon Kate hit the same area with renewed fury. As the entire countryside was flooded, the people faced war and natural disaster at the same time. No one but the Americans had the resources to help the people who lived in the lowlands, and so they did. The everyday dangers they faced were only magnified by low clouds and poor visibility. But the aircrews of the 101st Airborne went out to help anyway. In this book, we see how, for a brief period during an otherwise vicious war, saving life took precedence over bloody conflict.
Lewin’s Gastrointestinal Pathology and Its Clinical Implications, Second Edition This comprehensive, two-volume resource highlights the practical aspects the pathology of biopsies and gross specimens, the clinical/pathological correlation, and differential diagnoses, and the ways in which these affect the management of patients with gastrointestinal disorders. The authors provide valuable insights on many important areas of gastrointestinal pathology, and openly address controversies within the specialty. This all-inclusive work stands alone in its illustrative quality and in its emphasis on the clinical implications of patient management as related to pathologic findings. The Second Edition has been completely revised to reflect two decades of advances in the field. The book’s focus on clinical/pathological correlations and differential diagnoses emphasizes their affect on patient management. Major revisions of the chapters on colitis and gastritis feature new approaches to treatment. Over 2100 full-color illustrations highlight pathologic features to sharpen diagnostic skills and guide treatment choices. NEW to the Second Edition... Completely revised content reflects two decades of advances in the field. Focus on clinical/pathological correlations and differential diagnoses emphasizes their affect on patient management Major revisions of the chapters on colitis and gastritis feature new approaches to treatment. Over 2100 full-color illustrations highlight pathologic features to sharpen diagnostic skills and guide treatment choices.
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. This extensive title, which combines scientific principles with up-to-date clinical procedures, has been thoroughly updated for the fourteenth edition. You’ll find in-depth material on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them.
The Revolution of ’28 explores the career of New York governor and 1928 Democratic presidential nominee Alfred E. Smith. Robert Chiles peers into Smith’s work and uncovers a distinctive strain of American progressivism that resonated among urban, ethnic, working-class Americans in the early twentieth century. The book charts the rise of that idiomatic progressivism during Smith’s early years as a state legislator through his time as governor of the Empire State in the 1920s, before proceeding to a revisionist narrative of the 1928 presidential campaign, exploring the ways in which Smith’s gubernatorial progressivism was presented to a national audience. As Chiles points out, new-stock voters responded enthusiastically to Smith's candidacy on both economic and cultural levels. Chiles offers a historical argument that describes the impact of this coalition on the new liberal formation that was to come with Franklin Delano Roosevelt’s New Deal, demonstrating the broad practical consequences of Smith’s political career. In particular, Chiles notes how Smith’s progressive agenda became Democratic partisan dogma and a rallying point for policy formation and electoral success at the state and national levels. Chiles sets the record straight in The Revolution of ’28 by paying close attention to how Smith identified and activated his emergent coalition and put it to use in his campaign of 1928, before quickly losing control over it after his failed presidential bid.
A practical and up-to-date tutorial on everything necessary to understand how to apply fiber in a communications application. covers components, system design, cable installation, and systems and fiber measurement. For technicians, associates, trainers, supervisors, or engineers that have to either design, install and/or maintain a practical fiber system in today's environment.
On first consideration, acute myeloid leukemia (AML) represents a nearly insurmountable challenge in terms of understanding it at the molecular level in large part because of its immense heterogeneity as well as its variability across different age groups. In addition, while significant progress has been made in the overall survival of subsets of patients with AML, many continue to show little progress in terms of positive treatment outcomes. Cytogenetic and initial molecular studies have resulted in the ability to stratify patients into specific risk categories that predict favorable-, intermediate- and poor-risk outcomes. However, these categories are limited in their ability to predict accurately how individual patients will respond to therapy and have not resulted in the ability to treat effectively patients with specific treatments. They have, however, resulted in excluding hematopoietic stem cell transplantation for patients with favorable-risk disease. Genome-wide analysis promises to improve both treatment and outcomes. The initial studies using whole-exon or whole-genome sequencing identified mutations in several novel genes that surprisingly were involved in regulating DNA methylation and chromatin structure. Subsequently, mutations were found in genes encoding transcription factors, signaling pathway modulators and genes involved in RNA splicing. Further analyses have identified mutations in key elements of miRNAs. Genome-wide methylation studies have highlighted key patterns that track with specific cytogenetic and gene mutations. Such epigenetic studies have led to the use of treatments directed to altering chromatin structure and DNA methylation. These treatments remain targeted specifically at specific enzymatic components of chromatin structure and function, but their key molecular consequences remain unclear and clinical responses unpredictable. RNA sequencing has led to the identification of both novel pathways of leukemia cell survival and unexpected fusion transcripts, which may ultimately be therapeutically targeted.
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