The rollicking memoir from the cardiologist turned legendary scientist and winner of the Nobel Prize that revels in the joy of science and discovery. Like Richard Feynman in the field of physics, Dr. Robert Lefkowitz is also known for being a larger-than-life character: a not-immodest, often self-deprecating, always entertaining raconteur. Indeed, when he received the Nobel Prize, the press corps in Sweden covered him intensively, describing him as “the happiest Laureate.” In addition to his time as a physician, from being a "yellow beret" in the public health corps with Dr. Anthony Fauci to his time as a cardiologist, and his extraordinary transition to biochemistry, which would lead to his Nobel Prize win, Dr. Lefkowitz has ignited passion and curiosity as a fabled mentor and teacher. But it's all in a days work, as Lefkowitz reveals in A Funny Thing Happened on the Way to Stockholm, which is filled to the brim with anecdotes and energy, and gives us a glimpse into the life of one of today's leading scientists.
This year we honor Leap Year, that phenomenon that comes around every four years allowing us to regain lost time. We dedicate this year's LocoThology to the Leap. Join a hitch-hiking vampire, space traveling religious alien, and a brain jumping philosopher on this rollercoaster ride through fantasy, space, and time. Whether jumping from the mouth of a dragon or leaping across dimensions to an alternate earth, this year's anthology has something for everyone. Now put down the cards and quit gambling with the card shark wildlife, climb on board, and settle in for a great read.
The rollicking memoir from the cardiologist turned legendary scientist and winner of the Nobel Prize that revels in the joy of science and discovery. Like Richard Feynman in the field of physics, Dr. Robert Lefkowitz is also known for being a larger-than-life character: a not-immodest, often self-deprecating, always entertaining raconteur. Indeed, when he received the Nobel Prize, the press corps in Sweden covered him intensively, describing him as “the happiest Laureate.” In addition to his time as a physician, from being a "yellow beret" in the public health corps with Dr. Anthony Fauci to his time as a cardiologist, and his extraordinary transition to biochemistry, which would lead to his Nobel Prize win, Dr. Lefkowitz has ignited passion and curiosity as a fabled mentor and teacher. But it's all in a days work, as Lefkowitz reveals in A Funny Thing Happened on the Way to Stockholm, which is filled to the brim with anecdotes and energy, and gives us a glimpse into the life of one of today's leading scientists.
Authorial Ethics is a normative study that deals with the many ways in which writers abuse their commitment to truth and integrity. It is divided by academic discipline and includes chapters on journalism, history, literature, art, psychology, and science, among others. Robert Hauptman offers generalizations and theoretical remarks exemplified by specific cases. Two major abrogations are inadvertent error and purposeful misconduct, which is subdivided into falsification, fabrication, and plagiarism. All of these problems appear in most disciplines, although their negative impact is felt most potently in biomedical research and publication. Professor Mary Lefkowitz, the classicist, provides an incisive foreword.
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). It regulates normal CNS function, is a major participant in pathology, and serves learning, memory, and higher cognitive functions. The 12 chapters of this book provide the first comprehensive coverage of all the major features of glutamate as excitatory neurotransmitter. The book begins with a valuable historical backdrop. Building from a chapter on the common structure of glutamate receptors, several others cover the major ionotropic receptors, their structure, function, and pharmacology. A follow-up chapter discusses the metabotropic receptors that are directly coupled to second messenger metabolism. A central theme of the book is the capacity of the excitatory amino acid system to contribute to the diverse array of signaling systems in the CNS as a direct result of the large assortment of receptors (including, for the ionotropic receptors, various subunits) the combination of which determine distinct functional properties. A recent development in the field discussed in several chapters is the biochemical characterization of a supermolecular protein complex, the post-synaptic density, that makes the unique structure of excitatory synapses. This complex subserves the experience-dependent modulation of synaptic strength and synaptic plasticity, and gives the synapse the capacity to change dynamically in both structure and receptor composition. Drawing on the individual properties of the receptors, transporters, and functional architecture of the synapse, the concluding chapters describe the functional integration of these components in the more complex physiological processes of plasticity and pathology. Recognition that the regulation of excitatory amino acid receptor activity underlies the pathology of many neurological diseases, including stroke, Alzheimer's disease and schizophrenia, has opened up an exciting frontier that will allow the translation of our understanding of these basic mechanisms into new concepts of pathology and new therapeutic strategies. This book will be invaluable for neuroscientists, pharmacologists, neurologists, and psychiatrists, and for their students and trainees.
Three important literary questions in early Greek lyrics are addressed in this study. First, Fowler attempts to determine the extent that Homer and epic poetry generally influenced the lyric poets, with respect to both the style of compositions and their content. Identifying the certain examples of influence – which are far fewer than often thought – he analyses the technique of imitation, tracing a development from simpler to more complex as the archaic period proceeds. Throughout this and the following chapter, he often finds occasion to take issue with the famous and influential view of the early Greek mind championed by Bruno Snell and Hermann Fränkel. In the second chapter Fowler studies the organization of individual poems, identifying compositional principles that may be used to solve literary and textual problems. Some of these principles, like ring-composition, are old familiars; others are not. All are found to be more pervasive than is often realized, and reflect an attitude to composition rather different from the disorderly and associative techniques traditionally ascribed to the lyrics poets. The last chapter explores the nature of genres in the archaic period, starting from the vexed question of the definition of elegy. In all the genres associated with particular occasions, the author finds that the poets' professional skills and self-consciousness became more important than the purely occasional aspects of their composition. Observations of interest are made on, among others, citharodic songs, epigrams and epinician odes; and elegy in the end turns out, paradoxically, not to be a true genre at all.
A Field in Flux chronicles the extraordinary journey of industrial and labor relations expert Robert McKersie. One of the most important industrial relations scholars and leaders of our time, McKersie pioneered the study of labor negotiations, helping to formulate the concepts of distributive and integrative bargaining that have served as analytical tools for understanding the bargaining process more generally. The book provides a window into McKersie's life and work and its impact on the evolution of labor and industrial relations. Spanning six decades, the reader learns about the intersection of labor and the Civil Rights movement, the watershed moment of the Air Traffic Controller's Strike, his relationship with George Schultz, the shift from labor relations to human resource management, and McKersie's role in the seminal cases (Motorola, GM, Toyota) of the labor movement. A Field in Flux serves two important functions: it demonstrates how people have influenced past employment policies and practices when called to action in critical situations, and it seeks to instill confidence in those who will be called on to address the big challenges facing the future of work today and in the years to come. During a time when the basic values of industrial relations are being challenged and violated, McKersie argues that the profession must adapt to the changing world of work and not forget about the value placed on efficiency, equity, and inclusive employment policies and practices.
This book sets the standard in delivering a comprehensive, state-of-the-art approach for understanding, treating, and preventing classroom behavior difficulties. It should be on the bookshelves of all professionals who work in school settings. I will certainly recommend this text to my colleagues and students." —George J. DuPaul, PhD, Professor of School Psychology, Associate Chair, Education and Human Services, Lehigh University A classic guide to creating a positive classroom environment Covering the most recent and relevant findings regarding behavior management in the classroom, this new edition of Understanding and Managing Children's Classroom Behavior has been completely updated to reflect the current functional approach to assessing, understanding, and positively managing behavior in a classroom setting. With its renewed focus on the concept of temperament and its impact on children's behavior and personality, Understanding and Managing Children's Classroom Behavior emphasizes changing behavior rather than labeling it. Numerous contributions from renowned experts on each topic explore: How to identify strengths and assets and build on them Complete functional behavioral assessments The relationship between thinking, learning, and behavior in the classroom Practical strategies for teachers to improve students' self-regulation How to facilitate social skills Problem-solving approaches to bullies and their victims Medications and their relationship to behavior The classic guide to helping psychologists, counselors, and educators improve their ability to serve all students, Understanding and Managing Children's Classroom Behavior, Second Edition will help educators create citizens connected to each other, to their teachers, to their families, and to their communities.
Why doesn’t everyone see sustainability as a huge issue? Why don’t people think more carefully before making choices? What will it take for people to change? Examining the many psychological factors that lead to human behavioral effects on the environment, this book answers these questions definitively and provides practical guidance for approaches that have been used to successfully stimulate change. The Applied Psychology of Sustainability provides an extensive, integrated definition of the processes that lead to climatic, ecological, and socio-economic results: It defines a Psychology of Sustainability. Each chapter applies elements from the core research areas of cognitive, social, and developmental psychology into the context of criteria specific to sustainability. Comprehensively updated to embrace great change in the field, this new edition expands on critical issues yet maintains its strong foundation that the psychology of decisions is the essential precursor to sustainability and that these decisions should be treated as the primary target of change. Throughout the book, readers will find new ways of framing questions related to human adaptability and evolutionary psychology. The Applied Psychology of Sustainability is essential reading for students and professionals in a range of disciplines who wish to contribute to this crucial conversation.
The motivation for us to conceive this series of volumes on regulation was mainly our belief that it would be fun, and at the same time productive, to approach the subject in a way that differs from that of other treatises. We thought it might be interesting and instructive for both author and reader-to examine a particular area of investigation in a framework of many different problems. Cutting across the traditional boundaries that have separated the subjects in past volumes on regulation is not an easy thing to do-not because it is difficult to think of what interesting topics should replace the old ones, but because it is difficult to find authors who are willing to write about areas outside those pursued in their own laboratories. Anyone who takes on the task of reviewing a broad area of interest must weave together its various parts by picking up the threads from many different laboratories, and attempt to produce a fabric with a meaningful design. Finding persons who are likely to succeed in such a task was the most difficult part of our job. In the first volume of this treatise, most of the chapters dealt with the mechanisms of The second volume involved a somewhat regulation of gene expression in microorganisms. broader area, spanning the prokaryotic-eukaryotic border. Topics ranged from phage mor phogenesis to the role of gradients in development. The last volume-Volume 3A-con cerned hormones, as does this volume-Volume 3B.
Introduction to Neuropsychopharmacology expands on the molecular and cellular foundations of the classic Biochemical Basis of Neuropharmacology, Eighth Edition (Cooper, Bloom, and Roth) by now including the behavioral methods used to study psychoactive drugs in experimental animals and in humans. Authored by four founders of modern neuroscience, this concise and comprehensive text covers the current series of medications used to treat diseases of the brain and nervous system--both psychiatric and neurologic--as well as legal and illegal recreational drugs and the neuroscientific information that explains how these medications act on the brain from the molecular to the clinical level. The text ranges from drugs that affect the mood and behavior to hypnotics, narcotics, anticonvulsants, and analgesics.
The Presidency of George W. Bush is the first balanced academic study to analyze the entirety of his presidency—domestic, social, economic, and national security policies—as well as the administration’s response to 9/11 and the subsequent War on Terror. In so doing, John Robert Greene argues persuasively that the judgment of most scholars—that the Bush administration was a complete failure—has been made in haste and without the benefit of primary sources. This book is the first scholarly work to make wide use of the documents at the George W. Bush Presidential Library, many of which have only recently been made available to researchers through the Freedom of Information Act. John Robert Greene offers a balanced assessment and nuanced conclusions supported by documentary evidence. Yet in doing so he does not absolve the Bush administration of its shortcomings. The Presidency of George W. Bush shows that the administration could be vindictive, as demonstrated by the Plame Wilson affair and the firing of the US attorneys. It all too often moved too slowly, as shown by the National Security Council’s lethargic handling of terrorism pre-9/11, the failed attempt to revise Social Security, and the sluggish reaction to Hurricane Katrina. It was an administration that accepted, and acted on, the highly suspect theory of the unitary presidency as advocated by Dick Cheney and accepted by the president. On the other side of the balance sheet, however, the evidence also makes it eminently clear that the Bush administration was responsible for many positive achievements: No Child Left Behind set the nation on the road toward affecting serious educational reform. In healthcare reform, the Bush administration both strengthened the Medicare system and extended its benefits for millions of Americans. And Bush did more to combat the worldwide scourge of AIDS, particularly in Africa, than any other president. In sum, the actions of this presidency continue to affect the presidencies of each of his successors as well as the trajectory of world history to the present day.
More than three dozen of the best and most popular stories by the acknowledged master of the short science fiction story. The thirty-nine works contained in this volume—twenty-six from the author’s ten other Open Road collections, plus thirteen additional pieces unique to this volume—include these vintage Sheckley stories: “The Eye of Reality,” “The Language of Love,” “The Accountant,” “A Wind Is Rising,” “The Robot Who Looked Like Me,” “The Mnemone,” “Warm,” “The Native Problem,” “Fishing Season,” “Shape,” “Beside Still Waters,” “Silversmith Wishes,” “Meanwhile, Back at the Bromide,” “Fool’s Mate,” “Pilgrimage to Earth,” “All the Things You Are,” “The Store of the Worlds,” “Seventh Victim,” “Cordle to Onion to Carrot,” “Is That What People Do?”, “The Prize of Peril,” “Fear in the Night,” “Can You Feel Anything When I Do This?”, “The Battle,” “The Monsters,” and “The Petrified World.” This volume also includes the following uncollected Sheckley tales: “Five Minutes Early,” “Miss Mouse and the Fourth Dimension,” “The Skag Castle,” “The Helping Hand,” “The Last Days of (Parallel?) Earth,” “The Future Lost,” “Wild Talents, Inc.,” “The Swamp,” “The Future of Sex: Speculative Journalism,” “The Life of Anybody,” “Goodbye Forever to Mr. Pain,” “The Shaggy Average American Man Story,” “Shootout in the Toy Shop,” and “How Pro Writers Really Write—or Try To.” From the very beginning of his career, Robert Sheckley was recognized by fans, reviewers, and fellow authors as a master storyteller and the wittiest satirist working in the science fiction field. Open Road is proud to republish his acclaimed body of work, with nearly thirty volumes of full-length fiction and short story collections. Rediscover, or discover for the first time, a master of science fiction who, according to the New York Times, was “a precursor to Douglas Adams.”
Iron is of fundamental importance to the growth, development and well-being of almost all living organisms. Multiple biological systems have evolved for the uptake, utilisation, storage, and homeostasis of iron in microbes, plants and mammals. Both iron deficiency and iron overload are found extensively in humans; the intimate links between iron and oxidative stress are associated with a wide range of pathologies. Iron has a well established role in infections by a range of microorganisms and parasites. Other metals such as copper and zinc are also closely linked with iron metabolism. Iron overloads and deficiencies are important factors in the health of humans and are therefore a key target in drug development. Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, 3rd Edition presents a comprehensive overview of this important field.Topics covered include: Solution chemistry of iron in biological media The importance of iron for biological systems Microbial iron transport and metabolism Iron uptake by plants and fungi Cellular iron uptake and export in mammals Intracellular iron storage and biomineralization Intracellular iron metabolism and cellular iron homeostasis Iron absorption in mammals, with particular reference to man, and regulation of systemic iron balance Pathophysiology of iron deficiency and iron overload in man Iron and oxidative stress Brain iron homeostasis and its perturbation in various neurodegenerative diseases Interactions between iron and other metals Written in a lively style by one of the leaders in the field and presented in full colour, this third, expanded edition of Iron Metabolism has been fully updated with the latest discoveries. Major additions include recent information on mitochondrial iron metabolism and the role of frataxin; transcriptional control of iron homeostasis; orally active iron chelators; the roles of hepcidin and erythropoietin; the increasing number of types of iron overload; and the importance of iron in Alzheimer’s disease. Iron Metabolism is essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and the medical sciences. It will also find space on the bookshelves of bioinorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, and pharmacologists in the pharmaceutical industry interested in developing novel iron-binding drugs.
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