This Festschrift volume in honor of Professor Alexander Karczmar is the outcome of a three-day symposium entitled "Neurobiology of Acetylcholine" held at Loyola University Medical Center from June 3 to 5, 1985. This volume serves two purposes. It expresses the respect and admiration of the contributors to Alex Karczmar, and it provides a forum for detailing recent advances in the cholinergic field which has attracted the undivided and untiring attention of Dr. Karczmar over some 40 years. During this period, the cholinergic system has grown from its infancy to become one of the most studied and understood transmitter systems today. Dr. Karczmar's interest in cholinergic system is appropriately reflected by the range of topics, molecular, cellular, developmental, behavioral and toxicological, that were discussed here. A detailed synopsis of Dr. Karczmar's research and his contributions to the field of cholinergic systems can be found in the following chapter by his close friend and colleague, Dr. George Koelle. We would like to take this opportunity to thank the enthusiastic responses of the participants making this Festschrift a memorable event.
Evolution and Medicine provides an accessible introduction to the new field of evolutionary medicine. Evolutionary concepts help explain why we remain vulnerable to disease, how pathogens and cancer cells evolve, and how the diseases that affected our evolutionary ancestors have shaped our biology.
This book offers a comprehensive overview of fundamental concepts of animal behavior as they relate to insects. Considerably updated and expanded, this new edition includes 26 case studies, as well as 45 new color plates and 173 figures (over 40% of them new) with detailed legends that add richness to the well-written, accessible text.
The most common demyelinating disease of the central nervous system (CNS) in the young adult population is multiple sclerosis (MS). MS is characterized by the focal loss of myelin sheaths in the brain and in the spinal cord of patients that is correlated with elevated activity of the immune system directed toward CNS antigens including myelin. The progression of MS is highly variable, but in many cases, it is characterized by a series of relapsing and remitting attacks that slowly increase residual functional deficit. Often, after several years, the disease transitions to a more progressive phenotype. Much of what is known about the pathology of MS is derived from a number of animal models. The most common animal model for the study of MS is experimental allergic encephalitis (EAE), which depending upon the host animal can present as relapsing/remitting or progressive disease. Although EAE has provided mechanistic insights implicating T-cell activation in the onset and progression of disease, understanding the mechanisms of pathology onset and myelin repair in the CNS require alternative models. One emerging hypothesis is that activation of T cells is secondary to pathogenesis of oligodendrocytes and animals models in which targeted loss of oligodendrocytes are beginning to reveal an understanding of the initiation of CNS demyelination. Myelin repair is difficult to study in the setting of EAE or oligodendrocyte pathogenesis; however, toxin models that result in localized demyelination as a consequence of direct injection or oral delivery have provided critical insights into cells of origin, timing, and molecular mechanisms guiding remyelination. Taken together, these three distinct model systems provide a strong basis for dissecting cell and molecular mechanism of demyelination as well as characterizing the efficacy of targeted therapeutics.
Extensively revised and expanded, this third edition of Neuropsychology for Psychologists, Health Care Professionals, and Attorneys provides a clear, concise, and comprehensive discussion of neuropsychology, outlining its purpose, use, and historical development. It covers the anatomy of the brain, a wide variety of neurobehavioral disorders, compr
Regardless of your specialty - physician, psychologist, nurse, rehabilitation specialist, or attorney -post-traumatic stress disorder cases and brain injury cases are arguably the most difficult to understand, treat, and evaluate. All of the tools you need are in the new Neuropsychology for Health Care Professionals and Attorneys, Second Edition. It contains An easy-to-understand description of the neuroanatomy of the brain Four chapters devoted to neurobehavioral disorders such as amnesia, attentional deficits, delirium, dementia, disorders of executive functions of the brain, electrical injury, hypoxic encephalopathy, neurotoxic encephalopathy, learning disorders, post-traumatic stress disorders, mild traumatic brain injury (MTBI), post-concussive syndrome, seizure disorders, and others A detailed description of neuropsychological assessment, including a critique of approximately 80 neuropsychological tests: their intended use, purpose, administration, sensitivity to brain damage, reliability, validity, strengths, and limitations How factors such as medical illness, medication, psychiatric disorders, stress, anxiety, culture, language, suboptimal motivation, and pre-existing neurological disorders can alter test performance Ways to determine whether the neuropsychological test results are consistent with brain damage or due to non-neurological factors A discussion of how the use of test norms can result in the misdiagnosis of brain damage A critical review of actual neuropsychological reports A glossary of neuropsychological and neurological terms
With each chapter written by a distinguished expert in the biochemistry field, this comprehensive volume describes the preparation and use of a variety of radioactive and non-radioactive probes in situations ranging from research laboratories to routine diagnosis laboratories. The enzymatic and chemical techniques for labeling nucleic acid probes with radioisotopes and with non-radioactive ligands and haptens are discussed. Additionally, the associated methods for their detection, the use of these probes in the diagnosis of human and microbial pathogens, of plant viruses and viroids, and of human genetic disorders, as well as in the detection of nucleic acids in tissues and cells by in situ hybridization are presented.
Distilling a set of practical principles from his forty years of experience as a pioneer in the computer industry, the author shows that innovation can be learned and practiced by everyone, that it can offer solutions to everyday problems as well as high-profile ones, and that it provides opportunities to solve business problems while meeting a variety of human needs.
Knowledge has been described as being like an expanding sphere with the volume of knowledge contacting a surface on the unknown. This new comprehensive review of the many fields of basic and clinical research that impact our understanding of multiple sclerosis has its basis in this premise. In doing research on MS, it is not enough to know clinical neurology or neurochemistry or neuroanatomy or pathology; it is important to understand the many other areas that relate to them. This volume provides an overview of MS-related research and will benefit many investigators in the field and help to advance our efforts to cure this, thus far intractable, disease. It is now more than 160 years since the first clinical-pathological descriptions of cases of multiple sclerosis and more than 130 years since the classic clinical description and development of diagnostic criteria by Charcot, yet MS remains an enigma. After decades of intense effort to find the cause, no cause has been clearly identified and the disease remains poorly understood. Despite the introduction of immunomodulatory therapies and immunosuppressive regimens, MS remains a devastating disease. While a great deal of progress has been made, much remains to be done. Our understanding of the disease remains limited, treatments remain inadequate, and comprehensive management all too rare. This volume is an overview of the basic sciences as they relate to MS and will provide clinicians and investigators a better understanding of the basic aspects of the disease. While it is possible to find excellent reviews of almost any aspect of MS, few attempts have been made to bring these very different aspects together in a single source. This volume is a companion to Multiple Sclerosis: Diagnosis, Medical Management, and Rehabilitation, edited by Drs. Jack S. Burks and Kenneth P. Johnson. Together, they represent an attempt to comprehensively cover the field of MS from basic research to comprehensive management and to provide a broad overview for those interested in understanding the disease better or in pursuing MS research.
The standard-setting reference in medical toxicology—trusted as the leading evidencebased resource for poison emergencies A Doody's Core Title for 2017! For decades, one name has been synonymous with the most respected, rigorous perspectives on medical toxicology and the treatment of poisoned and overdosed patients: Goldfrank's Toxicologic Emergencies. Presented in full color, Goldfrank’s delivers essential, patientcenteredcoverage of every aspect of poison management. The editors and authors are recognized as preeminent scholars in their specialties and provide unmatched coverage of all aspects of toxicologic emergencies, from pharmacology and clinical presentation to cutting-edge treatment strategies. Goldfrank's Toxicologic Emergencies, Tenth Edition begins with an examination of medical toxicology principles and techniques. It then reviews the biochemical, molecular, and pathophysiologic basis of toxicology, followed by an intense focus on toxicologic principles related to special patient populations. Features Case studies enhance your understanding of the clinical application of the text material Practical focus on the pathophysiologic basis of medical toxicology The Antidotes in Depth sections delivers the expertise of toxicologists across the world as they present treatments for critically ill poisoned and overdosed patients and allow you to easily identify key issues relating to the use of complex and often unfamiliar therapies The principles of risk management, medicolegal decision making, patient safety, post mortem toxicology and the assessment of ethanol induced impairment described in chapters and Special Considerations emphasize the interface between medical toxicology, the law, and quality care
Today educational activities take place not only in school but also in after-school programs, community centers, museums, and online communities and forums. The success and expansion of these out-of-school initiatives depends on our ability to document and assess what works and what doesn't in informal learning, but learning outcomes in these settings are often unpredictable. Goals are open-ended; participation is voluntary; and relationships, means, and ends are complex. This report charts the state of the art for learning assessment in informal settings, offering an extensive review of the literature, expert discussion on key topics, a suggested model for comprehensive assessment, and recommendations for good assessment practices.
The most trusted, rigorous, and up-to-date toxicology resource and educational companion available – now in full color Goldfrank’s Toxicologic Emergencies continues to be the source you can turn to first for any poisoning or overdose. The text provides clear information on every aspect of toxicologic emergencies, from pharmacology to clinical presentation to management. Fully referenced and featuring a consistent organization, Goldfrank’s begins with an in-depth examination of general principles of medical toxicology. It then progresses to the biochemical principles and molecular basis of toxicology, and provides detailed insight into how xenobiotics affect vital signs, organs, and systems throughout the body. Next, a wide spectrum of clinically important exposures -- including drugs, plants, metals, household products, occupational and environmental xenobiotics are covered within logical categories for easy access to information. Finally, the book concludes with sections on principles of practicing clinical toxicology in today’s challenging healthcare environment. NEW TO THIS EDITION Full-color design and uniformly drawn figures clarify key concepts Special Considerations focus on decision-making in unique toxicologic circumstances, that influence clinical practice and have the potential to improve patient care Antidotes in Depth, following pertinent chapters, place each antidote in its proper context to ensure immediate availability of essential information relevant for clinical use More clinically-relevant figures and quick-reference tables Online learning center, available at www.goldfrankstoxicology.com, includes case studies, and a database of multiple choice questions that allow you to create a custom test for review and study. Every chapter is thoroughly rewritten and new chapters are added to reflect the very latest thinking in the field Here's why Goldfrank's is known worldwide as the field's leading text: General Approach to Medical Toxicology; The Biochemical and Molecular Basis of Medical Toxicology; The Pathophysiologic Basis of Medical; Toxicology: The Organ System Approach; The Clinical Basis of Medical Toxicology: Analgesics and Nonprescription Medications; Prescription Medications Psychopharmacologic Medications; Alcohols and Drugs of Abuse; Food Poisoning; Botanicals; Heavy Metals; Household Toxins; Pesticides; Occupational and Environmental Toxins; Toxic Envenomations; V. Special Populations; Preventive, Psychosocial, Nursing, Epidemiologic, Research & Legal Perspectives.
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