London’s suspense thriller focuses on the fine distinction between state- justified murder and criminal violence in the Assassination Bureau—an organization whose mandate is to rid the state of all its enemies. For more than seventy years, Penguin has been the leading publisher of classic literature in the English-speaking world. With more than 1,700 titles, Penguin Classics represents a global bookshelf of the best works throughout history and across genres and disciplines. Readers trust the series to provide authoritative texts enhanced by introductions and notes by distinguished scholars and contemporary authors, as well as up-to-date translations by award-winning translators.
Traditional Native recipes featuring products from the land, sea and sky, symbols of an enduring cuisine that illustrate respect for the nurturing land, and acknowledgment of the spiritual power food can have in our lives. This publication meets the EPUB Accessibility requirements and it also meets the Web Content Accessibility Guidelines (WCAG-AA). It is screen-reader friendly and is accessible to persons with disabilities. A book with many images, which is defined with accessible structural markup. This book contains various accessibility features such as alternative text for images, table of contents, page-list, landmark, reading order and semantic structure.
While kicking a ball through the dusty streets of his Brazilian hometown, young Edson Arantes do Nascimento was given the nickname Pelé so casually that no one remembers its meaning. Today, the name is famous worldwide as belonging to history's greatest soccer player. Here, in Pelé's own words, is his incredible life story: his five goals in the last two games of the 1958 World Cup at the tender age of 17, his glory years with his Brazilian club FC Santos, his role in four World Cup tournaments, his comeback as a member of the storied New York Cosmos, and his lifelong role as goodwill ambassador for the world's favorite sport. Skyhorse Publishing, along with our Arcade, Good Books, Sports Publishing, and Yucca imprints, is proud to publish a broad range of biographies, autobiographies, and memoirs. Our list includes biographies on well-known historical figures like Benjamin Franklin, Nelson Mandela, and Alexander Graham Bell, as well as villains from history, such as Heinrich Himmler, John Wayne Gacy, and O. J. Simpson. We have also published survivor stories of World War II, memoirs about overcoming adversity, first-hand tales of adventure, and much more. While not every title we publish becomes a New York Times bestseller or a national bestseller, we are committed to books on subjects that are sometimes overlooked and to authors whose work might not otherwise find a home.
A quartet of killings threaten to derail Lieutenant James Reardon’s relationship—and end his life Jan has been dating James Reardon long enough to know that she wants to be with him forever, but she will not marry him as long as he’s a cop. She has spent too many nights lying awake, afraid that this will be the case that gets him killed, and she cannot make that her whole life. But she and Reardon both know that death is the only thing that could make him take off his badge—and for this hard-boiled San Francisco detective, death may come sooner than he thinks. It starts with a stabbing in the Embarcadero. A particularly sleazy bartender has gotten knifed in the gut, and he is dead before the cops arrive. Three more killings follow, and each time the victim is one of the city’s worst criminals. Is it a vendetta, or a vigilante? Reardon will risk his life to find out. The Gremlin’s Grampa is the 2nd book in the Lieutenant Reardon Mysteries, but you may enjoy reading the series in any order.
A comprehensive and entertaining historical and botanical review, providing an enjoyable and cognitive read.”—Nature The foods we eat have a deep and often surprising past. From almonds and apples to tea and rice, many foods that we consume today have histories that can be traced out of prehistoric Central Asia along the tracks of the Silk Road to kitchens in Europe, America, China, and elsewhere in East Asia. The exchange of goods, ideas, cultural practices, and genes along these ancient routes extends back five thousand years, and organized trade along the Silk Road dates to at least Han Dynasty China in the second century BC. Balancing a broad array of archaeological, botanical, and historical evidence, Fruit from the Sands presents the fascinating story of the origins and spread of agriculture across Inner Asia and into Europe and East Asia. Through the preserved remains of plants found in archaeological sites, Robert N. Spengler III identifies the regions where our most familiar crops were domesticated and follows their routes as people carried them around the world. With vivid examples, Fruit from the Sands explores how the foods we eat have shaped the course of human history and transformed cuisines all over the globe.
A global view of responsible forestry management Sustainable Forestry Management and Wood Production in a Global Economy examines emerging issues and key strategies for sustaining wood production while maintaining other forest resources. Internationally recognized forestry experts explore a broad range of topics on sustainable forestry at t
This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development. Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.
Praise for the previous edition: "Editors' Choice Reference Source"—Booklist "Best Reference Source"—Library Journal "Runner-up, General Nonfiction category"—Green Book Festival "Top 40 Reference Titles"—Pennsylvania School Librarians Association "A worthwhile reference for high school students and the general public."—Library Journal "...interesting and helpful...will help readers gain an understanding of major concepts, terms, and events in modern pollution studies. Recommended."—Choice "Definitive yet accessible...notable for reliable information on a topic of interest to both undergraduate and lay audiences, merits high recommendation for high-school, public, and academic libraries."—Booklist, starred review "...fascinating..."—Library Journal "...an excellent addition for all academic libraries and large public libraries."—American Reference Books Annual "This accessible and attractive encyclopedia provides depth, variety and currency and would be valuable for most high school collections."—Pennsylvania School Librarians Association "...recommended...an excellent source of background reading."—Reference Reviews Newly updated, the Encyclopedia of Pollution, Revised Edition is a comprehensive reference designed to address all aspects of pollution and the global impact on the environment in a single source. Containing more than 300 entries and essays interspersed throughout, it uses the most current scientific data to explain the different types of pollutants including properties, production, uses, environmental release and fate, adverse health response to exposure, and environmental regulations on human exposure. It provides the scientific background on the water, soil, and air of environments where the pollutants are released. Coverage also includes pollution regulation, the function of federal regulatory agencies and environmental advocacy groups, and the technology and methods to reduce pollution and to remediate existing pollution problems. Numerous case studies explore the most infamous of pollution events such as the Exxon Valdez oil spill, the Gulf War oil well fires, the Chernobyl disaster, Hurricane Katrina, the World Trade Center disaster, and the Love Canal in New York, among many others—including those that had great impact on legislation or that were used in popular media such as the films Erin Brockovich and A Civil Action. Biographies are provided of some of the leaders and pioneers of pollution study and activism. Other useful features include a detailed glossary, a timeline, and tables.
Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields— from pharmacology to medicinal chemistry to biophysics to clinical medicine.
Evidence of ancient moundbuilding civilizations proves that this region along the banks of the Ohio River has been considered prime real estate for a long time. Celeron de Bienville led a military voyage down the Ohio River-known in New France as La Belle Riviere-in 1749, burying lead plates along the way and claiming the land for the king of France. In 1750, the Ohio Company employed frontiersman Christopher Gist to explore the area. But even before Celeron and Gist, hunters and fur trappers penetrated the region. Tensions arose between the Europeans and the native inhabitants, developing into a rash of Indian wars and border rivalries, and producing such legendary figures as Lewis Wetzel, the Indian fighter. The Ohio River was an early highway to the frontier, bringing settlers from Pennsylvania, New York and the other colonies. Some immigrants came from the tidewater areas of Virginia and Maryland, traveling first up the Potomac River and then over the Alleghenies to the Ohio Valley. French, English, Germans, Moravians and others poured into the area. This book encompasses all aspects of the settlement of the area now known as Pleasants County, including: geographical description, rival discoveries and claims between England and France, first settlers, the Revolution, the Civil War, early industries, schools, newspapers, railroads, the oil boom, religious activities and more. The book is brimming with names of Pleasants County citizens, and includes 20 pages of biographical information about the oldest families in the area. It also contains a few portraits and photographs of local scenery.
This book gives a comparative treatment of topics accross lake, reservoir, and rive ecosystems. These analysis do indeed indicate differences among the properties of lakes, land-water interface regions, reservoirs, and rivers. Importantly, these analysis also indicate marked commonality in function.
Rely on Rosen's Emergency Medicine for the latest answers on every facet of emergency medicine practice. For decades, this medical reference book has set the standard in emergency medicine, offering unparalleled comprehensiveness, clarity, and authority - to help you put the latest and best knowledge to work for your patients in the ER. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Practice confidently with easily actionable, dependable guidance on the entire breadth of emergency medicine topics. Get expert guidance on how to approach specific clinical presentations in the ER. The "Cardinal Presentations Section" provides quick and easy reference to differential diagnosis and directed testing for fever in the adult patient; dizziness and vertigo; chest pain; and over 20 other frequently seen presentations in the emergency department. Effectively apply the newest emergency medicine techniques and approaches, including evidence-based therapies for shock; high-cost imaging; evaluation and resuscitation of the trauma patient; cardiovascular emergencies; evaluation and risk stratification for transient ischemic attack (TIA) patients; and much more. Locate the answers you need quickly thanks to a user-friendly, full-color design, complete with more illustrations than ever before. Access the complete contents on the go from your laptop or mobile device at Expert Consult, fully searchable, with links to PubMed.
Practical Guide to Managing Acidic Surface Waters and Their Fisheries explains how to manage acidic surface waters to preserve or restore fisheries. The work gives readers the basic tools to carry out a variety of surface water management activities. Topics include biological productivity and recovery, costs of liming, fish stocking, lake liming techniques, nutrients, regulations and permits, sampling, stream liming techniques, water quality analysis, and watershed liming techniques. The book will be a useful reference for fishing club managers, state and local government personnel, lake association managers, and others responsible for maintaining lakes and streams that may be affected by acidity from any source.
Historically viewed as a sub-discipline of biology or ecology, environmental science has quickly grown into its own interdisciplinary field; grounded in natural sciences with branches in technology and the social science, today’s environmental science seeks to understand the human impacts on the Earth and develop solutions that incorporate economic, ethical, planning, and policy thinking. This lab manual incorporates the field’s broad variety of perspectives and disciplines to provide a comprehensive introduction to the everyday practice of environmental science. Hands-on laboratory activities incorporate practical techniques, analysis, and written communication in order to mimic the real-world workflow of an environmental scientist. This updated edition includes a renewed focus on problem solving, and offers more balanced coverage of the field’s diverse topics of interest including air pollution, urban ecology, solid waste, energy consumption, soil identification, water quality assessment, and more, with a clear emphasis on the scientific method. While labs focus on the individual, readers are encouraged to extrapolate to assess effects on their campus, community, state, country, and the world.
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