Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.
This book examines the history of a military expedition the Japanese government sent to southern Taiwan in 1874, in the context of Japan’s subordination to Western powers in the unequal treaty system in East Asia. It argues that events on the ground in Taiwan show the Japanese government intended to establish colonies in southern and eastern Taiwan, and justified its colonial intent based on the argument that a state must spread civilization and political authority to territories where it claimed sovereignty, thereby challenging Chinese authority in East Asia and consolidating its power domestically. The book considers the history of the Taiwan Expedition in the light of how Japanese imperialism began: it emerged as part of the process of consolidating government power after the Meiji Restoration, it derived from Western imperialism, it developed in a dynamic relationship with Western imperialism and it increased Japan’s leverage in its competition for influence in East Asia.
Based on the travels of Griffis, Morse, and Hearn in the late 1800s, these stories evoke the immediacy of daily experience in Meiji, Japan, a nation still feudal in many of its habits yet captivating to Westerners for its gentleness, beauty, and pure charm. Illustrated.
It may be tempting to view political development and democratization in East Asia from a global view and conclude that the contours of democracy will converge throughout the world. However, a close examination of the cultural and economic development of Asian societies suggests a contrary picture. The story of Asia is one of political and economic survival, in which political elites sought to legitimate their authority through the use of both traditional and modern symbols. Traditional communitarian values and the modern symbols of economic growth and materialism coexist in Asian political systems. The stability and legitimacy of Asian governments depend on the ability of political elites to balance these symbols. As globalization proceeds, the standard traditional and modern symbols have waned in their effectiveness. Therefore, democracy as a symbol and practice can provide new sources of legitimacy to these political systems. Compton's Asian political development model is tested with quantitative indicators and through a series of case studies. The three case studies—Japan, South Korea, and Thailand—build on each other through a rigorous historical comparison. While the case studies themselves are interesting, he makes connections to the model and tests the congruence of these cases to the model, and concludes that the model's validity is predicated on the internal environment, including culture and economy. Of particular interest to scholars, students, and researchers involved with comparative and Asian politics, political development, and political culture.
The B-29 Superfortress was for many years a cornerstone of American military aviation. Best known as a bomber, it also served in reconnaissance, as a tanker, and as a rescue plane. It was a crucial tool for American and Allied forces during World War II, Korea and beyond. This operational history of the B-29 gives in-depth information on the career of each plane. A list of the names and serial numbers of the planes, each plane's history from delivery date to removal from service, a description of the B-29's physical characteristics and performance parameters, and a description of the five B-29 variants are provided. Sections of the book give complete mission data for the B-29's World War II service in the China-Burma-India theater of operations, operations over Japan, aerial mining missions and test atomic bombing runs.
AN EXHILARATING SAGA OF A JAPANESE AMERICAN FAMILY DURING WWII. Three brothers find their lives turned upside down when they are caught in the cataclysm of war. Eldest brother, Akira Omura, is stranded in Japan and forced to fight against the country of his birth. Complicating matters is a love triangle with Akira, his beautiful fiancée, and two other men. In America, wartime hysteria sends younger brothers Tad and Danny to internment camps. They traverse oceans and even wider chasms of prejudice, hatred, and separation from loved ones, risking their lives to seek freedom and hope for the future. Check out the book trailer at: majesty.org/cb World War II, Japanese American, Internment, 442 Regiment, Nisei, Okinawa
This study examines the development and characteristics of various historical and contemporary genres of Korean literature. It presents explanations on the development of Korean literacy and offers a history of literary criticism, traditional and modern, giving the discussion an historical context.
Presenting fresh insights on the internal dynamics and global contexts that shaped foreign relations in early modern Japan, Robert I. Hellyer challenges the still largely accepted wisdom that the Tokugawa shogunate, guided by an ideology of seclusion, stifled intercourse with the outside world, especially in the eighteenth and nineteenth centuries. Examining diplomacy, coastal defense, and foreign trade, this study demonstrates that while the shogunate created the broader framework, foreign relations were actually implemented through cooperative but sometimes competitive relationships with the Satsuma and Tsushima domains, which themselves held largely independent ties with neighboring states. Successive Tokugawa leaders also proactively revised foreign trade, especially with China, taking steps that mirrored the commercial stances of other Asian and Western states. In the nineteenth century, the system of foreign relations continued to evolve, with Satsuma gaining a greater share of foreign trade and Tsushima assuming more responsibility in coastal defense. The two domains subsequently played key roles in Japan’s transition from using early modern East Asian practices of foreign relations to the national adoption of international relations, especially the recasting of foreign trade and the centralization of foreign relations authority, in the years surrounding the Meiji Restoration of 1868.
This book is an insider’s account of the problems facing the Self-Defense Forces (SDF), Japan’s postwar military, authored by the country’s leading submariner, Hideki Nakamura. Specializing in the submarine fleet, he became an ace commander, in addition to serving as an analyst and professor in security studies. During his career, he became increasingly troubled by the SDF’s ability to fight due to legal, political, and operational restrictions placed upon it. This book, a translation of his 2017 bestseller, is a must-read for those interested in Japan’s military and its ability to partner with other countries.
I am Soldier brings together the profiles of sixty soldiers who have fought over the past 2,500 years. These vivid accounts graphically depict the role of the soldier in battle often using the soldiers' own words to reveal what they felt during the chaos of war and its aftermath. From the Spartans at Thermopylae to the war in the Persian Gulf, this book shows the lives of the individual men and woman who made up the great armies that changed the world.
Wally Yonamine was both the first Japanese American to play for an NFL franchise and the first American to play professional baseball in Japan after World War II. This is the unlikely story of how a shy young man from the sugar plantations of Maui overcame prejudice to integrate two professional sports in two countries. ø In 1951 the Tokyo Yomiuri Giants chose Yonamine as the first American to play in Japan during the Allied occupation. He entered Japanese baseball when mistrust of Americans was high?and higher still for Japanese Americans whose parents had left the country a generation earlier. Without speaking the language, he helped introduce a hustling style of base running, shaking up the game for both Japanese players and fans. Along the way, Yonamine endured insults, dodged rocks thrown by fans, initiated riots, and was threatened by yakuza (the Japanese mafia). He also won batting titles, was named the 1957 MVP, coached and managed for twenty-five years, and was honored by the emperor of Japan. Overcoming bigotry and hardship on and off the field, Yonamine became a true national hero and a member of Japan?s Baseball Hall of Fame.
Singapore Houses features top architects and designers with ideas that are stylish, contemporary, and show twenty-first century savvy. The houses in this book epitomize cutting-edge residential architecture in Singapore. they demonstrate a remarkable surge of design exploration in the city-state. Architects in Singapore are producing work with a level of refinement and sophistication that is comparable with the best in the world and one would be hard pressed to find a nation of similar size with such an abundance of accomplished young designers who have built independently. The houses include recent designs by doyens of the profession such as Sonny Chan Sau Yan, Kerry Hill and Ernesto Bedmar in addition to the firmly established "next" generation including Mok Wei Wei, Chan Soo Khian, Siew Man Kok and Richard Hassell. For those looking for new architecture or interior design ideas, Singapore Houses will surely add a unique, fresh element to their homes and projects.
This Festschrift volume in honor of Professor Alexander Karczmar is the outcome of a three-day symposium entitled "Neurobiology of Acetylcholine" held at Loyola University Medical Center from June 3 to 5, 1985. This volume serves two purposes. It expresses the respect and admiration of the contributors to Alex Karczmar, and it provides a forum for detailing recent advances in the cholinergic field which has attracted the undivided and untiring attention of Dr. Karczmar over some 40 years. During this period, the cholinergic system has grown from its infancy to become one of the most studied and understood transmitter systems today. Dr. Karczmar's interest in cholinergic system is appropriately reflected by the range of topics, molecular, cellular, developmental, behavioral and toxicological, that were discussed here. A detailed synopsis of Dr. Karczmar's research and his contributions to the field of cholinergic systems can be found in the following chapter by his close friend and colleague, Dr. George Koelle. We would like to take this opportunity to thank the enthusiastic responses of the participants making this Festschrift a memorable event.
Explains how the persistence of party institutions (factions, PARC, koenkai) and the transformed role of party leadership in Japan contributed both to the LDP's success at remaining in power for 15 years and its downfall.
Although local neighborhood associations are found in many countries, Japan’s are distinguished by their ubiquity, scope of activities, and very high participation rates, making them important for the study of society and politics. Most Japanese belong to one local neighborhood association or another, making them Japan’s most numerous civil society organization, and one that powerfully shapes governance outcomes in the country. And, they also often blur the state-society boundary, making them theoretically intriguing. Neighborhood Associations and Local Governance in Japan draws on a unique and novel body of empirical data derived from the first national survey of neighborhood associations carried out in 2007 and provides a multifaceted empirical portrait of Japan’s neighborhood associations. It examines how local associational structures affect the quality of local governance, and thus the quality of life for Japan’s citizens and residents, and illuminates the way in which these ambiguous associations can help us refine civil society theory and show how they contribute to governance. As well as outlining the key features of neighbourhood associations, the book goes on to examine in detail the way in which neighbourhood associations contribute to governance, in terms of social capital, networks with other community organizations, social service provision, cooperation with local governments and political participation. This book will be welcomed by students and scholars of Japanese politics, Japanese society, anthropology, urban studies as well as those interested in social capital and civil society.
Complete with maps and extensive advice, this guide to Japan's hot springs is an invaluable resource for anyone travelling to Japan. Easier to get to than many might imagine, Japan's hidden hot springs are among the few remaining repositories of ancient Japanese ambiance and sensibility. Bucolic and charming, they bear little resemblance to the sterile, clinic-like spas of the West or to the concrete jungles of Japan's best-known onsen towns. The hot springs introduced here belong to another time but they are disappearing fast. Discover them before it's too late through this selective, personalized, and authoritative guide. In this spa guide are unbelievable gems that you would otherwise never, ever, find by yourself. Japanese people are often shocked that you found such a place. It's a very concise collection of the "true and traditional" Japanese onsen ryokan. It is for anyone who seeks a traditional experience of what onsen used to be before modernization set in.
Part of the practical, highly illustrated Operative Techniques series, this fully revised title by Drs. Donald H. Lee and Robert J. Neviaser brings you up to speed with must-know surgical techniques in today's technically demanding shoulder and elbow surgery. Step-by-step, evidence-based guidance walks you through both common and unique cases you're likely to see in your practice, while tips, pearls, and pitfalls help you optimize outcomes. - Features full-color intraoperative photos and detailed illustrations alongside expert technical guidance on instrumentation, placement, step-by-step instructions and more. A bulleted, highly templated format allows for quick understanding of surgical techniques. - Retains the clear organization of the first edition with each chapter covering case history/indications, physical exam, imaging, surgical technique, tips, pearls and pitfalls, post-operative management and references for further reading. - Includes new and comprehensive coverage of nerve transfers for shoulder and elbow restoration after upper trunk brachial plexus injuries, thoracic outlet syndrome, suprascapular nerve neuropathy, closed treatment of shoulder dislocations, and more. - Provides access to nearly 70 videos online, including new videos on the surgical treatment of scapular fractures, arthroscopic distal clavicle resection, radiocapitellar replacement, endoscopic cubital tunnel release, and much more. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Over the last century mankind has irrevocably damaged the environment through the unscrupulous greed of big business and our own willful ignorance. Here are the strikingly poignant accounts of disasters whose names live in infamy: Chernobyl, Bhopal, Exxon Valdez, Three Mile Island, Love Canal, Minamata and others. And with these, the extraordinary and inspirational stories of the countless men and women who fought bravely to protect the communities and environments at risk.
Ownership of the Senkaku Islands in the East China Sea is disputed between China and Japan, though historically the islands have been part of Okinawa, the southernmost islands of the Japanese archipelago. The dispute, which also involves Taiwan, has the potential to be a flashpoint between the two countries if relations become more strained, especially as the exploitation of gas reserves in the adjoining seabed is becoming an increasingly important issue. A key aspect of the dispute is the attitude of the United States, which, surprisingly, has so far refrained from committing itself to supporting the claims of one side or the other, despite its long-standing, strong alliance with Japan. This book charts the development of the Senkaku Islands dispute, and focuses in particular on the negotiations between the United States and Japan prior to the handing back to Japan in 1972 of Okinawa. The book shows how the detailed progress of these negotiations was critical in defining the United States' neutral attitude to the dispute and the problems this position presents.
Since the publication of the original edition in 1982, pesticide-related poisonings, both single cases and epidemic-scale situations, have continued to occur unabated. This new edition of Pesticides and Neurological Diseases reviews current literature describing the effects of insecticides (chlorinated hydrocarbons, organophosphorus and carbamate e
This volume offers both an introduction to and an insight into key contemporary architects as well as giving a snapshot of the varied nature of architecture today. For each architect there are details of their life and work and illustrations of their most representative and iconic buildings.
Biological Inorganic Chemistry: A New Introduction to Molecular Structure and Function, Third Edition, provides a comprehensive discussion of the biochemical aspects of metals in living systems. The fascinating world of the role of metals in biology, medicine and the environment has progressed significantly since the very successful Second Edition of the book published in 2012. Beginning with an overview of metals and selected nonmetals in biology, the book supports the interdisciplinary nature of this vibrant area of research by providing an introduction to basic coordination chemistry for biologists and structural and molecular biology for chemists. Having built this accessible foundation, the book progresses to discuss biological ligands for metal ions, intermediary metabolism and bioenergetics, and methods to study metals in biological systems. The book also covers metal assimilation pathways; transport, storage, and homeostasis of metal ions; sodium and potassium channels and pumps; magnesium phosphate metabolism and photoreceptors; calcium and cellular signaling; the catalytic role of several classes of mononuclear zinc enzymes; the biological chemistry of iron; and copper chemistry and biochemistry. In addition, the book discusses nickel and cobalt enzymes; manganese chemistry and biochemistry; molybdenum, tungsten, vanadium, and chromium; non-metals in biology; biomineralization; metals in the brain; metals and neurodegeneration; metals in medicine and metals as drugs; and metals in the environment. Now in its Third Edition, this popular and award-winning resource highlights recent exciting advances and provides a thorough introduction for both researchers approaching the field from a variety of backgrounds, as well as advanced students. - Winner of a 2019 Textbook Excellence Award (Texty) from the Textbook and Academic Authors Association - Includes a thorough survey of metals in biological systems: in the human body, in medicine and in the environment - Previous winner (Second Edition) of the 2013 Textbook Excellence Award (Texty) from the Text and Academic Authors Association - Features new sections: an overview of the different functions of essential metal ions; toxic metals in diagnosis and therapeutics; crystal and ligand field theory and their limitations; molecular orbital theory; genetic and molecular biological approaches to study metals; more complex cofactors and their biosynthesis; photosynthetic oxidation of water; man-made environmental pollution; and metals as poisons
Presents a detailed account of the attempt to reconcile the United States and Japan through the 1934 All American baseball tour which included Babe Ruth, Lou Gehrig, Jimmie Foxx, future secret agent Moe Berg, and Connie Mack.
In the nineteenth century the predominant focus of American anthropology centered on the native peoples of North America, and most anthropologists would argue that Korea during this period was hardly a cultural area of great anthropological interest. However, this perspective underestimates Korea as a significant object of concern for American anthropology during the period from 1882 to 1945—otherwise a turbulent, transitional period in Korea’s history. An Asian Frontier focuses on the dialogue between the American anthropological tradition and Korea, from Korea’s first treaty with the United States to the end of World War II, with the goal of rereading anthropology’s history and theoretical development through its Pacific frontier. Drawing on notebooks and personal correspondence as well as the publications of anthropologists of the day, Robert Oppenheim shows how and why Korea became an important object of study—with, for instance, more published about Korea in the pages of American Anthropologist before 1900 than would be seen for decades after. Oppenheim chronicles the actions of American collectors, Korean mediators, and metropolitan curators who first created Korean anthropological exhibitions for the public. He moves on to examine anthropologists—such as Aleš Hrdlicka, Walter Hough, Stewart Culin, Frederick Starr, and Frank Hamilton Cushing—who fit Korea into frameworks of evolution, culture, and race even as they engaged questions of imperialism that were raised by Japan’s colonization of the country. In tracing the development of American anthropology’s understanding of Korea, Oppenheim discloses the legacy present in our ongoing understanding of Korea and of anthropology’s past.
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