The interaction of neurotransmitters, neuromodulators and neuroactive drugs with receptors localized at the cell surface initiates a chain of molecular events leading to integrated neuronal responses to the triggering stimuli. Major advancements in the characterization and isolation of recep tor molecules have answered many quest ions regarding the nature of the ele ments that determine the specificity in these interactions. At the same time, recent studies have provided evidence that delicate regulation by intracellular enzymatic systems determines the efficiency of the stimulus response coupling process, mediates the interaction between receptors, operates in feedback control mechanisms and transduces signals from the receptors to various effector sites in a highly coordinated fashion. These studies are at the focus of the present volume, which is an outcome of a symposium held at the University of Vermont College of Medicine on March 21-23, 1986, in conjunction with the seventeenth annual meeting of the Amer ican Society for Neurochemistry. The symposium has demonstrated clearly that the concerted efforts of investigators in neurophysiology, biochemis try, pharmacology, cell-biology, molecular genetics, neurology, and psy chiatry are required to achieve better understanding of the processes under lying neuronal responsiveness. This volume includes contributions provided by prominent investigators in all these research areas. We hope that the readers will find here a useful source of information and ideas for stimu lating further studies which may serve to narrow the gap between basic neuroscience research and its clinical implications.
The book presents a unified and self-sufficient and reader-friendly introduction to the anisotropic elasticity theory necessary to model a wide range of point, line, planar and volume type crystal defects (e.g., vacancies, dislocations, interfaces, inhomogeneities and inclusions).The necessary elasticity theory is first developed along with basic methods for obtaining solutions. This is followed by a detailed treatment of each defect type. Included are analyses of their elastic fields and energies, their interactions with imposed stresses and image stresses, and the interactions that occur between them, all employing the basic methods introduced earlier.All results are derived in full with intermediate steps shown, and 'it can be shown' is avoided. A particular effort is made to describe and compare different methods of solving important problems. Numerous exercises (with solutions) are provided to strengthen the reader's understanding and extend the immediate text.In the 2nd edition an additional chapter has been added which treats the important topic of the self-forces that are experienced by defects that are extended in more than one dimension. A considerable number of exercises have been added which expand the scope of the book and furnish further insights. Numerous sections of the book have been rewritten to provide additional clarity and scope.The major aim of the book is to provide, in one place, a unique and complete introduction to the anisotropic theory of elasticity for defects written in a manner suitable for both students and professionals.
This text, now in its second edition, offers an up-to-date, expanded treatment of the behaviour of polymers with regard to material variables and test and use conditions. It highlights general principles, useful empirical rules and practical equations.;Detailing the specific behaviour of many common polymers, the text: places emphasis on time and frequency dependence over temperature dependence; uses contemporary molecular mechanisms to explain creep, stress relaxation, constant strain rate responses and crazing; provides explicit equations to predict responses; supplies a discussion of large deformation multiaxial responses; compares statistical and continuum theories on the same data set; and updates stress-strain behaviour and particulate filled systems.
As pediatric cardiology becomes more and more neonatal cardiology and even fetal cardiology, Neonatal Heart Disease by Robert M. Freedom, MO, Leland N. Benson, MD, and Jeffrey F. Smallhorn, MB is extraordinarily timely. Neonatal Heart Disease consists of 50 chapters by 25 distinguished contributors and is a worthy successor to The Neonate With Congenital Heart Disease by Richard D. Rowe, MD and his colleagues (1968 and 1981). The first ~dition of this book in 1968 established Richard D. Rowe, MD as the father of neonatal cardiology. As most pediatric cardiologists now know, Dick Rowe died on January 18, 1988 after a brief illness. It will therefore come as no surprise that the present volume is dedicated to this great and gentle man. Nor will it come as a surprise that I have been asked to devote this Foreword to Richard D. Rowe, MD, pioneering neonatal cardiologist and incomparable personal friend. What can one say about Dick Rowe? Well, there are at least two very different tales. There is Dick Rowe the public man -the factual account of Dick Rowe's achievements as a physician, educator, and research man - the Dick Rowe that virtually "everyone" knows. And then there is Dick Rowe the private man -the extraordinary human being who only his personal friends were privileged to know. I shall try to tell something of both stories. First, the public man - the factual account - is really quite amazing.
United for Truth: The ACFEI story recounts the founding and the growth of the American College of Forensic Examiners Institute, the world's leading forensic science association. It includes fascinating forensic science case stories as well as profiles of leading forensic science professionals.
Radiation Pathology is an up-to-date compendium of the effects of ionizing radiation on human tissues. It will be of great value to radiation oncologists, pathologists, and other professionals. The early chapters deal with basic science: physics, radiobiology, genetics, etc. The circumstances of human exposures (therapeutic, accidental, warfare) are then considered in the light of extensive epidemiological data. Acute radiation syndromes and radiation cardiogenesis are described in detail, including recent information on mechanisms of oncogenesis. For the benefit of readers who are not radiation oncologists, two chapters outline the current uses of radiation in therapy and in diagnosis, including the various applications of radionuclides. The bulk of the text deals with radiopathology and its morphologic expression. An overview orients the reader and classifies the main types of lesions. The chapters on specific organs or organ systems are consistently divided into sections to facilitate rapid retrieval of information on: normal structure, tolerance doses, experimental studies, morphology and pathogenesis, and clinical manifestations. The authors' lucid, well-organized descriptions will inform radiation oncologists about the types of injury to be expected, and will guide pathologists in making differential diagnoses.
The Junipers of the World contains a synthesis of data on evolution by examining: Geographic Variation: Pan-Arctic variation in Juniperus communis, etc. Speciation in sections of the genus: Species concepts, Speciation in Juniperus section Juniperus, etc. In addition, Keys to Juniperus are provided by region: Eastern Hemisphere, Europe (including Azores, Canary Islands, Asia Minor and Africa), Central Asia (Turkmenistan to western Himalayas), China, Far East (Japan, Korea, Sakhalin Island, Taiwan), Western Hemisphere, Continental North America, United States and Canada, Mexico and Guatemala, and the Caribbean. Also included are Species' Descriptions, Distribution Maps and Plant Photos, and chapters on Hybridization, Ecology, Cultivated Junipers, Commercial uses of leaf and wood oils of Juniperus, a Cross Indexed Synonymy of Juniperus, and Tables on the Leaf essential oils by species in sections. This book supplements the web site www.juniperus.org and the reader will find literature citations and a detailed discussion of data that is not present on the web site. "The Junipers of the World is now the authoritative reference for Juniperus" "Prof. Adams has presented arguments for the recognition of species and varieties by showing the data analyses that led to taxonomic decisions. This is one of the few treatments that really integrates data and the reasoning behind taxonomic decisions. In addition, Prof. Adams is candid in admitting that the recognition of some taxa are not well supported and deserve additional study." "An essential reference book that will be useful for herbaria, museums, wildlife biologists, Range scientist, foresters, ecologists and all who are involved in identification and study of Juniperus species.
The complete guide to the business of running a successful legal practice Many attorneys in small and mid-size practices are experts on the law, but may not have considered their practice as much from a business perspective. Michael Gerber’s The E-Myth Attorney fills this void, giving you powerful advice on everything you need to run your practice as a successful business, allowing you to achieve your goals and grow your practice. Featuring Gerber's signature easy-to-understand, easy-to-implement style, The E-Myth Attorney features: A complete start-up guide you can use to get your practice off the ground quickly, as well as comprehensive action steps for maximizing the performance of an existing practice Industry specific advice from two recognized legal experts that have developed a highly successful legal practice using Gerber’s principles Gerber’s universal appeal as a recognized expert on small businesses who has coached, taught, and trained over 60,000 small businesses The E-Myth Attorney is the last guide you'll ever need to make the difference in building or developing your successful legal practice.
This new edition successfully combines elements of radiographic technique with interpretation information for readers. Five sections cover the concepts of radiologic imaging, radiographic techniques and procedures, special imaging techniques, radiation health, and assessment and interpretation. Based on the Oral and Maxillofacial Radiology guidelines published by the American Association of Dental Schools, this unique book features numerous high-quality photographs, radiographs, and line drawings. New information on digital radiography, radiation health, periodontal disease, and image assessment is included, as well as chapter review questions, case-based questions, and workshop and laboratory exercises. To help readers prepare for certification, sample multiple-choice and case-based questions for the National and State Board Certification Examinations are also included.
The Junipers of the World contains a synthesis of data on evolution by examining: Geographic Variation: Pan-Arctic variation in Juniperus communis, etc. Speciation in sections of the genus: Species concepts, Speciation in Juniperus section Juniperus, etc. In addition, Keys to Juniperus are provided by region: Eastern Hemisphere, Europe (including Azores, Canary Islands, Asia Minor and Africa), Central Asia (Turkmenistan to western Himalayas), China, Far East (Japan, Korea, Sakhalin Island, Taiwan), Western Hemisphere, Continental North America, United States and Canada, Mexico and Guatemala, and the Caribbean. Also included are Species' Descriptions, Distribution Maps and Plant Photos, and chapters on Hybridization, Ecology, Cultivated Junipers, Commercial uses of leaf and wood oils of Juniperus, a Cross Indexed Synonymy of Juniperus, and Tables on the Leaf essential oils by species in sections. This book supplements the web site www.juniperus.org and the reader will find literature citations and a detailed discussion of data that is not present on the web site. The Junipers of the World is now the authoritative reference for Juniperus Prof.Adams has presented arguments for the recognition of species and varieties by showing the data analyses that led to taxonomic decisions. This is one of the few treatments that really integrates data and the reasoning behind taxonomic decisions. In addition, Prof. Adams is candid in admitting that the recognition of some taxa are not well supported and deserve additional study. An essential reference book that will be useful for herbaria, museums, wildlife biologists, Range scientist, foresters, ecologists and all who are involved in identification and study of Juniperus species.
2014 BMA Medical Book Awards Highly Commended in Radiology category! Image-Guided Interventions, a title in the Expert Radiology Series, brings you in-depth and advanced guidance on all of today?s imaging and procedural techniques. Whether you are a seasoned interventionalist or trainee, this single-volume medical reference book offers the up-to-the-minute therapeutic methods necessary to help you formulate the best treatment strategies for your patients. The combined knowledge of radiology experts from around the globe provides a broad range of treatment options and perspectives, equipping you to avoid complications and put today's best approaches to work in your practice. "... the authors and editors have succeeded in providing a book that is both useful, instructive and practical" Reviewed by RAD Magazine, March 2015 Formulate the best treatment plans for your patients with step-by-step instructions on important therapeutic radiology techniques, as well as discussions on equipment, contrast agents, pharmacologic agents, antiplatelet agents, and protocols. Make effective clinical decisions with the help of detailed protocols, classic signs, algorithms, and SIR guidelines. Make optimal use of the latest interventional radiology techniques with new chapters covering ablation involving microwave and irreversible electroporation; aortic endografts with fenestrated grafts and branch fenestrations; thoracic endografting (TEVAR); catheter-based cancer therapies involving drug-eluting beads; sacroiliac joint injections; bipedal lymphangiography; pediatric gastrostomy and gastrojejunostomy; and peripartum hemorrhage. Know what to look for and how to proceed with the aid of over 2,650 state-of-the-art images demonstrating interventional procedures, in addition to full-color illustrations emphasizing key anatomical structures and landmarks. Quickly reference the information you need through a functional organization highlighting indications and contraindications for interventional procedures, as well as tables listing the materials and instruments required for each. Access the fully searchable contents, online-only material, and all of the images online at Expert Consult.
In the current age of information technology, the issues of distributing and utilizing images efficiently and effectively are of substantial concern. Solutions to many of the problems arising from these issues are provided by techniques of image processing, among which segmentation and compression are topics of this book. Image segmentation is a process for dividing an image into its constituent parts. For block-based segmentation using statistical classification, an image is divided into blocks and a feature vector is formed for each block by grouping statistics of its pixel intensities. Conventional block-based segmentation algorithms classify each block separately, assuming independence of feature vectors. Image Segmentation and Compression Using Hidden Markov Models presents a new algorithm that models the statistical dependence among image blocks by two dimensional hidden Markov models (HMMs). Formulas for estimating the model according to the maximum likelihood criterion are derived from the EM algorithm. To segment an image, optimal classes are searched jointly for all the blocks by the maximum a posteriori (MAP) rule. The 2-D HMM is extended to multiresolution so that more context information is exploited in classification and fast progressive segmentation schemes can be formed naturally. The second issue addressed in the book is the design of joint compression and classification systems using the 2-D HMM and vector quantization. A classifier designed with the side goal of good compression often outperforms one aimed solely at classification because overfitting to training data is suppressed by vector quantization. Image Segmentation and Compression Using Hidden Markov Models is an essential reference source for researchers and engineers working in statistical signal processing or image processing, especially those who are interested in hidden Markov models. It is also of value to those working on statistical modeling.
Both the interpretation of atomic spectra and the application of atomic spectroscopy to current problems in astrophysics, laser physics, and thermonuclear plasmas require a thorough knowledge of the Slater-Condon theory of atomic structure and spectra. This book gathers together aspects of the theory that are widely scattered in the literature and augments them to produce a coherent set of closed-form equations suitable both for computer calculations on cases of arbitrary complexity and for hand calculations for very simple cases.
This Fourth Edition introduces the latest theory and applications in optimization. It emphasizes constrained optimization, beginning with a substantial treatment of linear programming and then proceeding to convex analysis, network flows, integer programming, quadratic programming, and convex optimization. Readers will discover a host of practical business applications as well as non-business applications. Topics are clearly developed with many numerical examples worked out in detail. Specific examples and concrete algorithms precede more abstract topics. With its focus on solving practical problems, the book features free C programs to implement the major algorithms covered, including the two-phase simplex method, primal-dual simplex method, path-following interior-point method, and homogeneous self-dual methods. In addition, the author provides online JAVA applets that illustrate various pivot rules and variants of the simplex method, both for linear programming and for network flows. These C programs and JAVA tools can be found on the book's website. The website also includes new online instructional tools and exercises.
The authors begin with discrete time and discrete state spaces. From there, they proceed to cover continuous time, and progress from linear models to nonlinear models, and from completely known models to only partially known models.
Computational Mathematics: Models, Methods, and Analysis with MATLAB and MPI is a unique book covering the concepts and techniques at the core of computational science. The author delivers a hands-on introduction to nonlinear, 2D, and 3D models; nonrectangular domains; systems of partial differential equations; and large algebraic problems requirin
Every financial professional wants and needs an advantage. A firm foundation in advanced mathematics can translate into dramatic advantages to professionals willing to obtain it. Many are not—and that is the advantage these books offer the astute reader. Published under the collective title of Foundations of Quantitative Finance, this set of ten books presents the advanced mathematics finance professionals need to advantage their careers, these books present the theory most do not learn in graduate finance programs, or in most financial mathematics undergraduate and graduate courses. As a high-level industry executive and authoritative instructor, Robert R. Reitano presents the mathematical theories he encountered in nearly three decades working in the financial industry and two decades teaching in highly respected graduate programs. Readers should be quantitatively literate and familiar with the developments in the first book in the set, Foundations of Quantitative Finance Book I: Measure Spaces and Measurable Functions.
More than 30 new contributors participated in this new edition, allowing you to learn from experts in each field. Unique! Rheumatic Disorders chapter covers disorders such as arthritis, gout, fibromyalgia, and systemic lupus erythematosus, including pathophysiology, a description of the inflammation, and pharmacological and non-pharmacological interventions. Unique! Pain and Pain Syndromes chapter covers types of pain, pain mechanisms, its measurement, and its management. Unique! Bracing, Orthotics, and Prosthetics chapter outlines the types of materials used to construct braces, orthotics, and prosthetics; the use of each unit by anatomic area; their biomechanics; the indications and contraindications for each; as well as an introduction to amputation.
These six volumes--the result of a ten year collaboration between two distinguished international figures--compile the mathematical knowledge required by researchers in mechanics, physics, engineering, chemistry and other branches of application of mathematics for the theoretical and numerical resolution of physical models on computers. It is a comprehensive and up-to-date publication that presents the mathematical tools needed in applications of mathematics.
This book provides a thorough introduction to the theory of complex semisimple quantum groups, that is, Drinfeld doubles of q-deformations of compact semisimple Lie groups. The presentation is comprehensive, beginning with background information on Hopf algebras, and ending with the classification of admissible representations of the q-deformation of a complex semisimple Lie group. The main components are: - a thorough introduction to quantized universal enveloping algebras over general base fields and generic deformation parameters, including finite dimensional representation theory, the Poincaré-Birkhoff-Witt Theorem, the locally finite part, and the Harish-Chandra homomorphism, - the analytic theory of quantized complex semisimple Lie groups in terms of quantized algebras of functions and their duals, - algebraic representation theory in terms of category O, and - analytic representation theory of quantized complex semisimple groups. Given its scope, the book will be a valuable resource for both graduate students and researchers in the area of quantum groups.
Final report of the 1970-1974 research conducted in the Salama Valley, Baja Verapaz, and adjacent areas of the highlands of Guatemala. The volume presents the results of the first comprehensive study of northern highland preclassic occupation and cultural development in light of the question of highland-lowland interaction and its role in the growth of Maya civilization.
A Single Cohesive Framework of Tools and Procedures for Psychometrics and Assessment Bayesian Psychometric Modeling presents a unified Bayesian approach across traditionally separate families of psychometric models. It shows that Bayesian techniques, as alternatives to conventional approaches, offer distinct and profound advantages in achieving many goals of psychometrics. Adopting a Bayesian approach can aid in unifying seemingly disparate—and sometimes conflicting—ideas and activities in psychometrics. This book explains both how to perform psychometrics using Bayesian methods and why many of the activities in psychometrics align with Bayesian thinking. The first part of the book introduces foundational principles and statistical models, including conceptual issues, normal distribution models, Markov chain Monte Carlo estimation, and regression. Focusing more directly on psychometrics, the second part covers popular psychometric models, including classical test theory, factor analysis, item response theory, latent class analysis, and Bayesian networks. Throughout the book, procedures are illustrated using examples primarily from educational assessments. A supplementary website provides the datasets, WinBUGS code, R code, and Netica files used in the examples.
Beginning with the development of finite difference equations, and leading to the complete FDTD algorithm, this is a coherent introduction to the FDTD method (the method of choice for modeling Maxwell's equations). It provides students and professional engineers with everything they need to know to begin writing FDTD simulations from scratch and to develop a thorough understanding of the inner workings of commercial FDTD software. Stability, numerical dispersion, sources and boundary conditions are all discussed in detail, as are dispersive and anisotropic materials. A comparative introduction of the finite volume and finite element methods is also provided. All concepts are introduced from first principles, so no prior modeling experience is required, and they are made easier to understand through numerous illustrative examples and the inclusion of both intuitive explanations and mathematical derivations.
Designed specifically for the securities regulation course, this statutory supplement contains all the relevant statutes, rules, and forms needed—in a remarkably concise and uncluttered format. A highly effective teaching tool, it is the ideal complement to any casebook for securities regulation, including but not exclusive to the authors’ own Securities Regulation: Cases and Materials. New to the 2022 Edition: Securities Exchange Act of 1934, Section 21: Investigations; Injunctions and Prosecution of Offenses, updated to authorize the Securities Exchange Commission (SEC) to seek disgorgement of unjust enrichment received as the result of certain violations of the Act, rules and regulations thereunder, and SEC cease-and-desist orders. Schedule 14A, Information Required in Proxy Statement pursuant to Section 14(a) of the Securities Exchange Act of 1934, updated to require the use of universal proxy cards in contested elections that include all director nominees up for election at shareholder meetings, as well as to modernize filing fee disclosures and payment methods. Latest updates to statutes, rules, regulations, and forms.
Diatomic Molecules: Results of Ab Initio Calculations provides the results obtained from quantum-mechanical calculations on the electronic structure of diatomic molecules. This six-chapter text also discusses the related concepts of ab initio calculation methods. This book considers first the primary methods used in the computation of molecular wave functions and of related properties. This topic is followed by discussions on the linear combination of atomic orbital and linear combination of mixed atomic orbital approximations and basis sets; electronic population analysis; spectroscopic transition probabilities; and the nature of chemical bonding. The remaining chapters examine the features of various theories that become prominent when two or more electrons are present, or are important in hydrides or homopolar and heteropolar molecules. This text will be of great value to organic and inorganic chemists and physicists.
This textbook is a complete, self-sufficient, self-study/tutorial-type source of mathematical problems. It serves as a primary source for practicing and developing mathematical skills and techniques that will be essential in future studies and engineering practice. Rigor and mathematical formalism is drastically reduced, while the main focus is on developing practical skills and techniques for solving mathematical problems, given in forms typically found in engineering and science. These practical techniques cover the subjects of algebra, complex algebra, linear algebra, and calculus of single and multiple argument functions. In addition, the second part of the book covers problems on Convolution and Fourier integrals/sums of typical functions used in signal processing. Offers a large collection of progressively more sophisticated mathematical problems on main mathematical topics required for engineers/scientists; Provides, at the beginning of each topic, a brief review of definitions and formulas that are about to be used and practiced in the following problems; Includes tutorial-style, complete solutions, to all problems.
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