This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry Shows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discovery Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods
Yen Jaffe's Reproductive Endocrinology helps you successfully diagnose and manage the spectrum of female and male reproductive system diseases, from impaired fertility, infertility, and recurrent pregnancy loss through problems of sexual development, puberty, menstrual disturbances, fibroids, endometriosis, and reproductive aging. This trusted endocrinology reference book is ideal for fellows, endocrinologists, or as a quick reference when making daily diagnostic and therapeutic decisions. It is just the resource you need to offer your patients the best possible reproductive care. "This new edition helps the reader to stay on top of recent developments. It is a must for subspecialists in reproductive medicine and a valuable source of information in the library of any department and clinical unit involved in reproductive medicine." Reviewed by Acta Obstetricia et Gynecologica Scandinavica February 2015 "It is a must for subspecialists in reproductive medicine and a valuable source of information in the library of any department and clinical unit involved in reproductive medicine." Reviewed by Acta Obstetricia et Gynecologica Scandinavica , March 2015 Get unmatched guidance you can trust, such as fresh insights into today's field and future advances, through the knowledge gleaned from worldwide fertility experts in reproductive medicine. Further your study of Reproductive Endocrinology with a list of suggested readings at the end of each chapter. Conveniently access the fully searchable text and view all of the images online at Expert Consult. Apply the latest reproductive endocrinology advances in basic and clinical science, including molecular, cellular, and genetic concepts, and grasp their relevance to pathophysiology, diagnosis, and therapy. Maximize fertility in women and men undergoing chemotherapy and other cancer treatments, and counsel patients on environmental factors affecting reproduction. Stay on top of recent developments including the impact of obesity on fertility; ovarian tissue banking; cryopreservation; pre-implantation genetic diagnosis; ovulation induction; and risks and treatments for steroid hormone-responsive cancers. View basic anatomic structures, endocrine processes, and cell function and dysfunction with absolute clarity through full-color illustrations and new images throughout. Confidently perform procedures through expanded coverage of reproductive and infertility surgery and online videos demonstrating key techniques.
Integrated Optics explains the subject of optoelectronic devices and their use in integrated optics and fiber optic systems. The approach taken is to emphasize the physics of how devices work and how they can be (and have been) used in various applications as the field of optoelectronics has progressed from microphotonics to nanophotonics. Illustrations and references from technical journals have been used to demonstrate the relevance of the theory to currently important topics in industry. By reading this book, scientists, engineers, students and engineering managers can obtain an overall view of the theory and the most recent technology in Integrated Optics.
This is the first full history of voting in Wisconsin from statehood in 1848 to the present. Fowler both tells the story of voting in key elections across the years and investigates electoral trends and patterns over the course of Wisconsin's history. He explores the ways that ethnic and religious groups in the state have voted historically and how they vote today, and he looks at the successes and failures of the two major parties over the years. Highlighting important historical movements, Fowler discusses the great struggle for women's suffrage and the rich tales of many Wisconsin third parties--the Socialists, Progressives, the Prohibition Party, and others. Here, too, are the famous politicians in Wisconsin history, such as the La Follettes, William Proxmire, and Tommy Thompson. Winner, Award of Merit for Leadership in History, American Association for State and Local History
George Benjamin Luks (1867-1933) is renowned for the oil paintings, watercolours, and pastel drawings he created as an acclaimed member of the artists' collective known as the Ashcan School. His professional development came, however, from his apprenticeship as a newspaper and magazine artist. Luks spent his early career drawing cartoons, spot illustrations, political caricatures, and comic strips. This study brings Luks's early work to light and reveals the funny, often edgy, and sometimes prejudicial creations that formed the base upon which Luks built his later career.
Many universities now offer a course in biomedical optics, but lack a textbook specifically addressing the topic. Intended to fill this gap, An Introduction to Biomedical Optics is the first comprehensive, introductory text describing both diagnostic and therapeutic optical methods in medicine. It provides the fundamental background needed for grad
Make the most effective diagnostic and therapeutic decisions quickly and efficiently! A best seller for over 25 years, The 5-Minute Clinical Consult 2019 is a practical, highly organized resource for clinicians in primary care, family medicine, emergency medicine, nursing, and pediatrics. It provides rapid access to guidance on diagnosis, treatment, medications, follow-up, and associated factors for more than 540 diseases and conditions. The 5-Minute Clinical Consult 2019 is designed to deliver maximum clinical confidence as efficiently as possible...allowing you to focus your valuable time on giving your patients the best possible care. Get quick access to all-new topics, including Advance Care Planning, Geriatric Care, and Medical Marijuana. Find the answers you need quickly thanks to an intuitive, at-a-glance format, with concise, bulleted text; hundreds of diagnostic and therapeutic algorithms; ICD-10 codes, DSM-5 criteria; and much more. Make confident decisions aided by current evidence-based designations in each topic.
Students will write more effective term papers with this guide to 500 term paper ideas—as well as a listing of appropriate print and nonprint sources— on twentieth-century U.S. history. This guide presents entries on 100 of the most important events and developments in twentieth-century U.S. history organized in chronological order. Each entry consists of a short description of the event, followed by five specific suggestions for term papers about the event, and a wide-ranging annotated bibliography of 15-35 books, articles, videos, and a web site appropriate for student research. In every case the emphasis is on recent and up-to-date material, as well as landmark works and primary sources. Every entry contains a video and concludes with a recommended web site, producing a multimedia approach designed to appeal to the current information-gathering habits and preferences of young people. From the Spanish-American War to the creation of NAFTA, the 100 events and developments cover political, social, economic, and cultural issues. The work has been designed to meet the needs of the U.S. history curriculum. Term paper topic ideas offer students thought-provoking suggestions that are challenging and develop critical thinking skills. The annotated bibliography is organized into reference sources, general sources, specialized sources, biographical sources, periodical articles, recommended videos and World Wide Web sites. All items are readily available in school, public, and academic library collections. This unique guide is valuable not only to students, but to teachers and librarians who guide students in research, and is an excellent purchasing guide for librarians who serve student needs.
This book offers an exercise in theoretical planetology, presenting five different scenarios to assess the evolution of habitable conditions on Mars to assess planetary terraforming potential and to give insight into the ongoing search for habitable exoplanets. Four of the scenarios involve Martian satellite capture models, in which gravitational capture via tidal deformation and energy dissipation processes are measured to predict a pathway of biological evolution, while the fifth scenario analyzes the possible model that led to the Mars that we have today (i.e. with no life forms). In ten chapters, readers will learn how a Mars-like terrestrial planet can be transformed into a habitable planet, and what conditions must be assessed when searching for exoplanets in a star-centered orbit to support life. The book is intended for planetologists, and general enthusiasts of planetary evolution and our solar system.
With 1 in 4 people experiencing a mental health problem in any given year, mental health is a more important part of social work training than ever before, and all successful social workers need to understand the core values, skills and knowledge that underpin excellent practice in a modern mental health system. Written as an accessible introduction to the complex issues around mental health, this book has become a classic in its field. Law and policy are clearly outlined while the authors give space to important ethical considerations when working with the most vulnerable in society. There are clear links between policy, legislation and real life practice as well as a wealth of learning features.
The oil crisis during the 1970s turned interest towards the utilization of renewable resources and towards lignocellulosics in particular. The 1970s were also the cradle period of biotechnology, and the years when biotechnical utilization of lignocellulosic waste from agriculture and forestry gained priori ty. This was a logical conclusion since one of nature's most important biologi cal reactions is the conversion of wood and other lignocellulosic materials to carbon dioxide, water and humic substances. However, while biotechnology in other areas like medicine and pharmacology concerned production of expen sive products on a small scale, biotechnical utilization and conversion of ligno cellulosics meant production of inexpensive products on a large scale. Biotechnical utilization of lignocellulosic materials is therefore a very difficult task, and the commercial utilization of this technology has not progressed as rapidly as one would have desired. One reason for this was the lack of basic knowledge of enzyme mechanisms involved in the degradation and conversion of wood, other lignocellulosics and their individual components. There are also risks associated with initiating a technical development before a stable platform of knowledge is available. Several of the projects started with en thusiasm have therefore suffered some loss of interest. Also contributing to this failing interest is the fact that the oil crisis at the time was not a real one. At present, nobody predicts a rapid exhaustion of the oil resources and fuel production from lignocellulosics is no longer a high priority.
Harwood-Nuss' Clinical Practice of Emergency Medicine presents a clinically focused and evidence-based summary of emergency medicine. Chapters are templated to include the clinical presentation, differential diagnosis, evaluation, management and disposition, with highlighted critical interventions and common pitfalls. Management and disposition are especially critical in the emergency department, and their emphasis is unique to Harwood-Nuss. Often, a diagnosis can not be made, given the constraints of an ED evaluation; thus, effecive management of the patient, with or without a confirmed diagnosis, is key. Also distinct to Harwood-Nuss is the High-Risk Chief Complaints section, which covers the key presentations in the ED: chest pain, abdominal pain, shortness of breath, altered mental status. When patients present in the ED, they don't present with a known diagnosis; this chapter walks the physician through possible differential diagnoses and the evaluation and management of these patients so that they can be stabilized and treated quickly and effectively.
From Pharmacoeconomics in Perspective: A Primer on Research, Techniques, and Information you will discover comprehensive explanations of principles in this sophisticated field through up-to-date research overviews, analysis types, research techniques, information evaluations. This unique book is primarily nonmathematical and highlights the qualitative details underpinning pharmacoeconomics for pharmacists and other medical professionals. This information is also a must for graduate students who need guidance through today's complicated pharmacy environment. Pharmacoeconomics in Perspective addresses a diverse yet increasingly growing slice of the healthcare environment where noneconomists are challenged to prepare, interpret, and use pharmacoeconomic information. This book provides you with the means to defend yourself against unscrupulous promotion of new drugs, unfounded conclusions in scientific literature, and research studies conducted with inaccurate methods. Pharmacoeconomics in Perspective provides charts, graphs, and figures to help you put all of its useful information into perspective. This invaluable book covers a broad range of topics within this subject area, including: pharmacoeconomics as outcomes research healthcare expenditures and pharmacoeconomics pharmacoeconomics within drug development types of pharmacoeconomic analysis, including cost of illness analysis, cost benefit analysis, cost effectiveness analysis, cost utility analysis, and cost minimization analysis techniques of pharmacoeconomics, including perspectives for research analysis, determination of outcomes measures, and categorization of pharmacoeconomic costs review of recent pharmacoeconomic research From this book, you will find that all medical treatments come with a cost and that once resources are used on one item, those same resources cannot be reused on another item; your choice has an opportunity cost. The new tools presented in Pharmacoeconomics in Perspective will assist you in making judgements and comparisons among treatment alternatives and help you make educated decisions about such important issues as what drugs to prescribe or from what company to buy prescription drugs.
A sports cardiologist evaluates affected athletes and suggests the most appropriate treatment options that may allow them to stay active in sports. This issue will discuss the following topics: Cardiovascular Adaptation and Remodeling to Rigorous Athletic Training, The Historical Perspective of Athletic Sudden Death, The ECG in Elite Athletes, The Management of Athletes with Congenital Heart Disease, Genetic testing in athletesThe Impact of Sports Cardiology on the Practice of Sports Medicine and many more!
Five years of research carried out by the U.S. Department of Agriculture Forest Services' Northern Global Change Program, contributing to our understanding of the effects of multiples stresses on forest ecosystems over multiple spatial and temporal scales. At the physiological level, reports explore changes in growth and biomass, species composition, and wildlife habitat; at the landscape scale, the abundance distribution, and dynamics of species, populations, and communities are addressed. Chapters include studies of nutrient depletion, climate and atmospheric deposition, carbon and nitrogen cycling, insect and disease outbreaks, biotic feedbacks with the atmosphere, interacting effects of multiple stresses, and modeling the regional effects of global change. The book provides sound ecological information for policymakers and land-use planners as well as for researchers in ecology, forestry, atmospheric science, soil science and biogeochemistry.
Robert Pasnau traces the developments of metaphysical thinking through four rich but for the most part neglected centuries of philosophy, running from the thirteenth century through to the seventeenth. At no period in the history of philosophy, other than perhaps our own, have metaphysical problems received the sort of sustained attention they received during the later Middle Ages, and never has a whole philosophical tradition come crashing down as quickly and completely as did scholastic philosophy in the seventeenth century. The thirty chapters work through various fundamental metaphysical issues, sometimes focusing more on scholastic thought, sometimes on the seventeenth century. Pasnau begins with the first challenges to the classical scholasticism of Bonaventure and Thomas Aquinas, runs through prominent figures like John Duns Scotus and William Ockham, and ends in the seventeenth century, with the end of the first stage of developments in post-scholastic philosophy: on the continent, with Descartes and Gassendi, and in England, with Boyle and Locke.
Cheney and Seyfarth enter the minds of vervet monkeys and other primates to explore the nature of primate intelligence and the evolution of cognition. "This reviewer had to be restrained from stopping people in the street to urge them to read it: They would learn something of the way science is done, something about how monkeys see their world, and something about themselves, the mental models they inhabit."—Roger Lewin, Washington Post Book World "A fascinating intellectual odyssey and a superb summary of where science stands."—Geoffrey Cowley, Newsweek "A once-in-the-history-of-science enterprise."—Duane M. Rumbaugh, Quarterly Review of Biology
A tool for students, educators, and clinicians, Foundations of Orthopedic Physical Therapy contains the latest literature in orthopedic physical therapy and guides readers through all elements of orthopedic assessment and treatment. Drs. Harvey Wallmann and Robert Donatelli offer a contemporary, evidence-based approach, working to address the topics that influence clinical decisions when developing rehabilitation and exercise programs. The text is consistent with the concepts and terminology presented in the APTA Guide to Physical Therapist Practice 3.0 and reviews the clinical practice guidelines for different conditions and body regions with an explanation of different levels of evidence. Foundations of Orthopedic Physical Therapy emphasizes a comprehensive method to assessment that produces treatment guidelines instead of rigid protocols and incorporates basic principles of evaluation, examination, and clinical reasoning. Each chapter contains author comments focusing on their perception of an effective patient intervention, evidence-based support for their decisions, and illustrative client case studies featuring unique and diverse patients who require specific interventions related to their orthopedic issues. Five main areas are addressed: • Foundations of orthopedic rehabilitation • Upper extremity • Lower extremity • Spinal column • Special topics in orthopedic rehabilitation Foundations of Orthopedic Physical Therapy is the perfect guide for students intending to work with the orthopedic population in the treatment and intervention of injuries, pathologies, and disorders, or practicing physical therapists who want to expand their knowledge.
Offering state-of-the-art techniques for both attorneys and environmental scientists, Environmental Forensics: Principles and Applications discusses non-chemical methods such as corrosion modeling, inventory reconciliation, and aerial photography interpretation. The book also covers chemical fingerprinting used to identify the origin and age of a contaminant release- relevant techniques include the use of radioactive isotope analysis, degradation modeling based on half-lives, and fuel additives such as MTBE. Environmental Forensics provides case study examples of environmental trial exhibits. It covers misused techniques that can bias the scientific validity of a trial exhibit, such as scale exaggeration, use of statistical manipulation, data contouring, and selective presentation. Detailed information is provided for identifying and interpreting those portions of environmental reports that are "target rich" sources of scientific biases. These include the identification of false positive, false negative and the intentional manipulation of environmental data that occurs primarily in the sample collection process.
Comprehensive, easy to read, and clinically relevant, Bradley’s Neurology in Clinical Practice provides the most up-to-date information presented by a veritable "Who's Who" of clinical neuroscience. Its unique organization allows users to access content both by presenting symptom/sign and by specific disease entities—mirroring the way neurologists practice. A practical, straightforward style; templated organization; evidence-based references; and robust interactive content combine to make this an ideal, dynamic resource for both practicing neurologists and trainees. Authoritative, up-to-date guidance from Drs. Daroff, Jankovic, Mazziotta, and Pomeroy along with more than 150 expert contributors equips you to effectively diagnose and manage the full range of neurological disorders. Easy searches through an intuitive organization by both symptom and grouping of diseases mirrors the way you practice. The latest advances in clinical neurogenetics, brain perfusion techniques for cerebrovascular disease, the relationship between neurotrauma and neurodegenerative disease, management strategies for levodopa-related complications in movement disorders, progressive neuropsychiatric disorders arising from autoimmune encephalitis, and more keep you at the forefront of your field. Reorganized table of contents which includes new chapters on: Brain Death, Vegetative, and Minimally Conscious States; Deep Brain Stimulation; Sexual Dysfunction in Degenerative and Spinal Cord Disorders; Sports and Performance Concussion; Effects of Drug Abuse on the Nervous System; and Mechanisms of Neurodegenerative Disorders. Regular online updates reflect the latest information on the diagnosis and treatment of neurologic diseases based on the latest recommendations and methodologies. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.
Authored by three prominent specialists in the field, this text provides comprehensive coverage of diagnostic and treatment modalities for optimal glaucoma management. Revised throughout, this new edition presents the latest guidance in clinical examination, randomized trials, medical treatment, laser therapy, and surgical procedures. Hundreds of illustrations-with many classic black and white figures from the previous editions supplemented with new color images-depict the features of glaucomas and step-by-step procedures for their management, while expanded use of highlighted boxes, lists, and summary tables make the material easy to access. Evidence-based and updated information on all aspects of the glaucomas-including physiology, genetics, interventional trials, and new surgical techniques-offer a well-rounded foundation of knowledge for making the most informed diagnoses and choosing the most effective course of treatment. Combines the cumulative experience of three prominent glaucoma specialists-addressing a full range of clinical needs for practitioners of all levels-for a uniquely written coherent perspective.Includes extensive references to current and historically important sources to provide comprehensive interpretation of the latest medical literature. Synthesizes a classical approach to the glaucomas-based on seven earlier editions spanning over 40 years-with the most up-to-date evidence-based and epidemiologically-derived classifications and outcomes.Coherently correlates with authoritative consensus documents on key areas of glaucoma, drawn up by the world-wide specialists of the World Glaucoma Association, and reprinted in the text.Revamps traditional teachings on the angle closure glaucomas, in concert with the newest international literature and technologies, to keep you up to date on the latest advances.Illustrates detailed surgical interventions applicable to the complete spectrum of clinical settings-from the developing world through contemporary operating rooms.Examines the newest and most promising developments in pharmacology, laser and surgical advances for glaucoma management, to enable you to choose the most effective patient approach.Illustrates invaluable but little-known instruments for clinical and research diagnoses, including optic nerve cupping scales, bleb assessment instruments, and more.
QUANTITATIVE ENVIRONMENTAL RISK ANALYSIS FOR HUMAN HEALTH An updated edition of the foundational guide to environmental risk analysis Environmental risk analysis is a systematic process essential for the evaluation, management, and communication of the human health risk posed by the release of contaminants to the environment. Performed correctly, risk analysis is an essential tool in the protection of the public from the health hazards posed by chemical and radioactive contaminants. Cultivating the quantitative skills required to perform risk analysis competently is a critical need. Quantitative Environmental Risk Analysis for Human Health meets this need with a thorough, comprehensive coverage of the fundamental knowledge necessary to assess environmental impacts on human health. It introduces readers to a robust methodology for analyzing environmental risk, as well as to the fundamental principles of uncertainty analysis and the pertinent environmental regulations. Now updated to reflect the latest research and new cutting-edge methodologies, this is an essential contribution to the practice of environmental risk analysis. Readers of the second edition of Quantitative Environmental Risk Analysis for Human Health will also find: Detailed treatment of source and release characterization, contaminant migration, exposure assessment, and more New coverage of computer-based analytical methods A new chapter of case studies providing actual, real-world examples of environmental risk assessments Quantitative Environmental Risk Analysis for Human Health is must-have for graduate and advanced undergraduate students in civil engineering, environmental engineering, and environmental science, as well as for risk analysis practitioners in industry, environmental consultants, and regulators.
This book provides the practical basis for the use of remote sensing to accomplish landscape ecological projects, through the merging of theory and practice, with examples. This is a specialized application and both these topics have evolved rapidly in the past decade. This evolution is not in the previous edition, and indeed this update provides much new information and valuable ideas for the professional and assist in directing the training of new personnel. The new edition will feature a combination of landscape ecology metrics, quantitative field measurements, and geospatial analyses.
This book provides a far-sighted perspective on the role of wearable and wireless systems for movement disorder evaluation, such as Parkinson’s disease and Essential tremor. These observations are brought together in the application of quantified feedback for deep brain stimulation systems using the wireless accelerometer and gyroscope of a smartphone to determine tuning efficacy. The perspective of the book ranges from the pioneering application of these devices, such as the smartphone, for quantifying Parkinson’s disease and Essential tremor characteristics, to the current state of the art. Dr. LeMoyne has published multiple first-of-their-kind applications using smartphones to quantify movement disorder, with associated extrapolation to portable media devices.
What America does - or fails to do - in the next few years to solve the problem of climate change will largely determine the fate of the earth and humanity for centuries to come. Despite the efforts by some states, local governments and individual citizens to respond, controversy still embroils national efforts to come up with a solution. This book by Robert Repetto, a leading environmental economist, lets the reader cut through the confusion and political rhetoric and understand the way to resolve the climate problem. It explains in clear, accessible language how a sensible national policy to reduce greenhouse gas emissions can bring about a transition to clean energy sources while preserving healthy economic growth and high standards of living. It shows where the pitfalls are in developing a climate solution, how they can be avoided, and how to bring resistant interest groups on board. America cannot act alone but other nations will not take action if the United States does not lead, and this book explains how America can successfully promote international cooperation on climate solutions. Never has there been an environmental problem of such importance. Every citizen will benefit from the insight this book provides in solving it successfully.
Since the publication of the first edition of Police and Policing in 1989, the amount of research being conducted on the police as well as public interest in the issues concerning the role of law enforcement has grown considerably. This second, complementary edition examines new issues and changes in law enforcement since 1989, drawing from the most recent and creative research projects in the field. Some of the country's leading experts discuss their findings on topics such as officer fatigue, collaborative problem-solving, tactical patrol, suicide, the role of religion in law enforcement, affirmative action, and psychological testing. This edited collection will prove to be an invaluable resource for students, scholars, and practitioners alike.
This book is about the impact of the COVID-19 pandemic on human society. The current global pandemic has thrown a diverse set of entwined social, psychological, and economic disruptive impacts of human suffering on societies, groups, and individuals due to the flow on effects of not only the disease itself but massive dislocations of the everyday routines of life driven by mandated restrictions imposed by national governments. This intersecting set of experiences has evoked considerable human distress particularly in the fields of employment, education, healthcare work, and bereavement rituals. This text reviews, from existing knowledge and the research emanating in the last two years from around the world, the issues and problems faced by people and their governments.
This pre-eminent work has developed over six editions in response to man's attempts to climb higher and higher unaided, and to spend more time at altitude for both work and recreation. Building on this established reputation, the new and highly experienced authors provide a fully revised and updated text that will help doctors continue to improve the health and safety of all people who visit, live or work in the cold, thin air of high mountains. The sixth edition remains invaluable for any doctor accompanying an expedition or advising patients on a visit to altitude, those specialising in illness and accidents in high places, and for physicians and physiologists who study our dependence on oxygen and the adaptation of the body to altitude.
Robert Wuthnow has been praised as one of "the country's best social scientists" by columnist David Brooks, who hails his writing as "tremendously valuable." The New York Times calls him "temperate, balanced, compassionate," adding, "one can't but admire Mr. Wuthnow's views." A leading authority on religion, he now addresses one of the most profound subjects: the end of the world. In Be Very Afraid, Wuthnow examines the human response to existential threats--once a matter for theology, but now looming before us in multiple forms. Nuclear weapons, pandemics, global warming: each threatens to destroy the planet, or at least to annihilate our species. Freud, he notes, famously taught that the standard psychological response to an overwhelming danger is denial. In fact, Wuthnow writes, the opposite is true: we seek ways of positively meeting the threat, of doing something--anything--even if it's wasteful and time-consuming. The atomic era that began with the bombing of Hiroshima sparked a flurry of activity, ranging from duck-and-cover drills, basement bomb shelters, and marches for a nuclear freeze. All were arguably ineffectual, yet each sprang from an innate desire to take action. It would be one thing if our responses were merely pointless, Wuthnow observes, but they can actually be harmful. Both the public and policymakers tend to model reactions to grave threats on how we met previous ones. The response to the terrorist attacks of 9/11, for example, echoed the Cold War--citizens went out to buy duct tape, mimicking 1950s-era civil defense measures, and the administration launched two costly conflicts overseas. Offering insight into our responses to everything from An Inconvenient Truth to the bird and swine flu epidemics, Robert Wuthnow provides a profound new understanding of the human reaction to existential vulnerability.
First book to achieve an integrated medical and surgical approach to tumors of the pediatric nervous system, giving you a broad array of treatment options. You will find full coverage of the newest diagnostic and management techniques, state-of-the-art technologies, molecular biology advances, and the latest trends in the operating theatre. And you will benefit from in-depth discussions of the most commonly seen tumors as well as the rarer and more esoteric ones.Special benefits of Tumors of the Pediatric Nervous System:- Full discussions of medical and surgical treatment protocols, with advantages, disadvantages, complications, and outcomes of each - Coverage of dramatic advances in genetics, molecular biology and surgery (e.g. endoscopic, frameless, stereotaxy) as well as chemotherapy, radiotherapy, and immunotherapy- Dozens of case studies by leaders in the field offering important clinical insights- Numerous algorithms, charts, tables, and management guidelines for at-a-glance summaries of key points- Nearly 130 full-color pathologic slides- Cost/benefit analysis integrated throughoutTake advantage of this comprehensive approach to diagnosis and treatment that is so critical in today's health care environment. Whether you are a surgeon, oncologist, pediatrician or ancillary specialist, you will find a wealth of broad-based information that enhances patient care and leads to improved outcomes. Stay informed and up-to-date.
Carboxylic Ortho Acid Derivatives: Preparation and Synthetic Applications discusses the principal classes of ortho acid derivatives and their preparation, properties, and reactions. The book is a critical survey and attempts to collate literature regarding the wide array of information on ortho acid derivatives to be of use to chemists studying different sorts of problems. The text is divided into seven chapters, where Chapter 1 begins with a discussion of the general concepts of carboxylic ortho esters, their synthesis, and properties. Chapters 2 to 4 tackle reactions of ortho esters that result to different bonds and bond formations such as (a) carbon-oxygen and carbon-halogen bond, (b) carbon-nitrogen or carbon-phosphorus, and (c) carbon-carbon or carbon-hydrogen bond formation. Chapter 5 discusses the synthesis, properties, and applications of carbohydrate ortho esters. Related compounds and their properties, preparation, and chemical transformations are the topic of Chapters 6 and 7. Some of these compounds are trithioorthocarboxylates, tetrathioorthocarbonates, and amide acetals. The book is a valuable reference to students or anyone else interested in chemistry.
Ideal for cardiologists who need to keep abreast of rapidly changing scientific foundations, clinical research results, and evidence-based medicine, Braunwald’s Heart Disease is your indispensable source for definitive, state-of-the-art answers on every aspect of contemporary cardiology, helping you apply the most recent knowledge in personalized medicine, imaging techniques, pharmacology, interventional cardiology, electrophysiology, and much more! Practice with confidence and overcome your toughest challenges with advice from the top minds in cardiology today, who synthesize the entire state of current knowledge and summarize all of the most recent ACC/AHA practice guidelines. Locate the answers you need fast thanks to a user-friendly, full-color design with more than 1,200 color illustrations. Learn from leading international experts, including 53 new authors. Explore brand-new chapters, such as Principles of Cardiovascular Genetics and Biomarkers, Proteomics, Metabolomics, and Personalized Medicine. Access new and updated guidelines covering Diseases of the Aorta, Peripheral Artery Diseases, Diabetes and the Cardiovascular System, Heart Failure, and Valvular Heart Disease. Stay abreast of the latest diagnostic and imaging techniques and modalities, such as three-dimensional echocardiography, speckle tracking, tissue Doppler, computed tomography, and cardiac magnetic resonance imaging. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.
This volume presents articles from several lectures presented at the school on ``Quantum Symmetries in Theoretical Physics and Mathematics'' held in Bariloche, Argentina. The various lecturers provided significantly different points of view on several aspects of Hopf algebras, quantum group theory, and noncommutative differential geometry, ranging from analysis, geometry, and algebra to physical models, especially in connection with integrable systems and conformal field theories.Primary topics discussed in the text include subgroups of quantum $SU(N)$, quantum ADE classifications and generalized Coxeter systems, modular invariance, defects and boundaries in conformal field theory, finite dimensional Hopf algebras, Lie bialgebras and Belavin-Drinfeld triples, real forms ofquantum spaces, perturbative and non-perturbative Yang-Baxter operators, braided subfactors in operator algebras and conformal field theory, and generalized ($d$) cohomologies.
This book has been produced as a tribute to the work of Martin Lee on the role of sport in the socio-moral education of young people. After conducting the first UK conference on Children in Sport, founded the Institute for the Study of Children in Sport at Bedford College of Higher Education in 1986 and created level 1, 2 and 3 courses on coaching children for the National Coaching Foundation. He also edited a book on Coaching Children in Sport. His course book on Coaching Children in Mini-basketball was produced for international distribution. The study of values has been central in Martin’s research which also embraced such topics as self-concept, leadership, coaching behaviour, and parental influence. In a series of research commissions examined the literature, clarified measurement requirements, identified values activated in sport, and led an international project on fair play. He then ran a survey to show how values influence attitudes directly and through the mediation of achievement goals. Two new instruments arose from this research: the Attitudes to Moral Decision-making in Youth Sport Questionnaire and the Youth Sport Values Questionnaire-2. These will open up research into gamesmanship, by which competitors seek an unfair advantage without breaking the rules, and into the mechanisms by which moral, competence and status values guide behaviour and create value conflicts. I am also grateful to colleagues at the University of Coimbra for their initiative in gathering the distinguished international scholars who have contributed to this book. Their collective insights will enhance the understanding of socio-moral education through sport and lead to informed and sensitive policy development in both sport and education.
Imprensa da Universidade de Coimbra / Coimbra University Press
Published Date
ISBN 10
9898074167
ISBN 13
9789898074164
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