Twists, Tilings, and Tessellation describes the underlying principles and mathematics of the broad and exciting field of abstract and mathematical origami, most notably the field of origami tessellations. It contains folding instructions, underlying principles, mathematical concepts, and many beautiful photos of the latest work in this fast-expanding field.
The magnum opus of one of the world's leading origami artists, the second edition of Origami Design Secrets reveals the underlying concepts of origami and how to create original origami designs. Containing step-by-step instructions for 26 models, this book is not just an origami cookbook or list of instructions-it introduces the fundamental buildin
The connections between origami, mathematics, science, technology, and education have been a topic of considerable interest now for several decades. While many individuals have happened upon discrete connections among these fields during the twentieth century, the field really took off when previously isolated individuals began to make stronger con
In Origami Zoo, two of the world's finest paper folders present an exciting collection of original origami animals. Their creatures, ranging from the exotic to the familiar, the elegant to the whimsical, will both inspire the beginner and challenge the most accomplished folder. Choose among the dolphin, penguin, swan, owl, goose, kangaroo, praying mantis, or even the mythical Pegasus or extinct wooly mammoth. Each of these thirty-seven new projects is true origami-folded from a single piece of paper with no cutting or gluing-and is complete with clear step-by-step diagrams, instructions, and a photograph of the finished model. Origami Zoo will challenge and delight anyone with a penchant for creating something wonderful out of (almost) nothing.
Robert J. Lang, one of the worlds foremost origami artists and scientists, presents the never-before-described mathematical and geometric principles that allow anyone to design original origami, something once restricted to an elite few. From the theoretical underpinnings to detailed step-by-step folding sequences, this book takes a modern look at the centuries-old art of origami.
This beautiful origami art book is a collection of the best contemporary pieces from some of the worlds most renowned papercraft artists. Thanks to pioneering masters such as Dr. Robert J. Lang, origami has transcended its humble roots as a traditional Japanese papercraft to take its place among the global fine arts. In Folding Paper: The Infinite Possibilities of Origami, Dr. Lang and Asian art curator Meher McArthur chronicle origami's remarkable evolution and showcases the widespread applications of paper folding solutions in the fields of contemporary mathematics, engineering, design, and the international peace movement. Based around a groundbreaking museum show by the same name, Folding Paper features the work of more than forty leading origami artists from around the world. It traces the development of paper folding in both the East and the West, recognizing the global influences on this international art form. Now in the early twenty-first century, origami is a sophisticated fine art form consisting of many different styles, from representational to geometric, abstract, and even conceptual. It has become a symbol of peace, an inspiration for engineers, and a conduit for scientific advancement. Featured origami artists include: Brian Chan Erik Joisel Erik and Martin Demaine Tomoko Fuse Daniel Kwan Michael LaFosse Jeannine Moseley Akira Yoshizawa Combining Dr. Lang's and McArthur's illuminating narrative history with lavish color photographs of more than sixty breathtaking works—from Joel Cooper's haunting Cyrus mask to Linda Tomoko Mihara's delicate Crane Cube to Eric Joisel's lifelike Pangolin model—Folding Paper is an enthralling introduction to the contemporary art of paper folding.
Every project in the book can really move! Origami in Action presents 39 actions origami models that are as animated as they are exquisite. Each project is complete with clear step-by-step diagrams, instructions, and a photograph of the finished model. Included are such traditional favorites as the cootie catcher and the waterbomb, as well as some modern novelties--a strumming guitar player and a toothy Tyrannosaurus Rex. Other projects include: --Flapping Butterfly --Blow-up Bunny --Barking Wolf --Talking Dragon --Wagging-Tail Doggie --Boardsailor --Swimming Manatee --Indian Paddling a Canoe
The gold standard reference for all those who work with people with mental illness, Kaplan & Sadock's Comprehensive Textbook of Psychiatry, edited by Drs. Robert Boland and Marcia L. Verduin, has consistently kept pace with the rapid growth of research and knowledge in neural science, as well as biological and psychological science. This two-volume eleventh edition offers the expertise of more than 600 renowned contributors who cover the full range of psychiatry and mental health, including neural science, genetics, neuropsychiatry, psychopharmacology, and other key areas.
Every project in the book can really move! Origami in Action presents 39 actions origami models that are as animated as they are exquisite. Each project is complete with clear step-by-step diagrams, instructions, and a photograph of the finished model. Included are such traditional favorites as the cootie catcher and the waterbomb, as well as some modern novelties--a strumming guitar player and a toothy Tyrannosaurus Rex. Other projects include: --Flapping Butterfly --Blow-up Bunny --Barking Wolf --Talking Dragon --Wagging-Tail Doggie --Boardsailor --Swimming Manatee --Indian Paddling a Canoe
Welcome to the 21st Edition of Nelson Textbook of Pediatrics – the reference of choice among pediatricians, pediatric residents, and others involved in the care of young patients. This fully revised edition continues to provide the breadth and depth of knowledge you expect from Nelson, while also keeping you up to date with new advances in the science and art of pediatric practice. Authoritative and reader-friendly, it delivers the information you need in a concise, easy-to-use format for everyday reference and study. From rapidly changing diagnostic and treatment protocols to new technologies to the wide range of biologic, psychologic, and social problems faced by children today, this comprehensive reference keeps you on the cutting edge of the very best in pediatric care. Includes more than 70 new chapters, including Postural Orthostatic Tachycardia Syndrome (POTS), Rare and Undiagnosed Diseases, Approach to Mitochondrial Disorders, Electronic Nicotine Delivery Systems, Zika, update on Ebola, Epigenetics, Autoimmune Encephalitis, Global Health, Racism, Media Violence, Strategies for Health Behavior Change, Positive Parenting, and many more. Features hundreds of new figures and tables throughout for visual clarity and quick reference. Offers new and expanded information on CRISPR gene editing; LGBT health care; gun violence; vaccinations; immune treatment with CAR-T cells; new technology in imaging and genomics; new protocols in cancer, genetics, immunology, and pulmonary medicine; and much more. Provides fresh perspectives from four new associate editors: Nathan J. Blum of The Children’s Hospital of Philadelphia; Karen Wilson of Mt. Sinai School of Medicine in New York; Samir S. Shah of Cincinnati Children’s Hospital Medical Center; and Robert C. Tasker of Boston Children’s Hospital. Remains your indispensable source for definitive, evidence-based answers on every aspect of pediatric care.
The remarkable career of composer-orchestrator Robert Russell Bennett [1894-1981] encompassed a wide variety of both "legitimate" and popular music-making in Hollywood, on Broadway, and for television. Bennett is principally responsible for what is known worldwide as the "Broadway sound" and for greatly elevating the status of the theater orchestrator. He worked alongside Jerome Kern, Cole Porter, George Gershwin, Irving Berlin, Richard Rodgers, and Frederick Loewe on much of the Broadway canon, eventually providing orchestrations for all or part of more than 300 musicals between 1920 and 1975. This work is the first publication of Bennett's autobiography, which was written in the late 1970s. It also includes eight of his most important essays on the art of orchestration. George J. Ferencz is Professor of Music at the University of Wisconsin at Whitewater.
Laryngeal Manifestations of Systemic Diseases synthesizes current knowledge about voice dysfunctions associated with various disorders. The authors review pathophysiology of systemic diseases and their effects on phonation, with summaries of current literature. Clinicians will benefit from the unique case studies, with photos, to supplement various chapters. Difficulty with the voice is often the first manifestation of systemic disease. Because of this, familiarity with laryngeal manifestation of systemic disease is important not only for otolaryngologists and phoniatrists, but also for family practitioners, internists, medical students, physician assistants, nurse practitioners, nurse clinicians, speech-language pathologists, singing voice specialists, acting voice specialists, voice teachers, and others entrusted with the care, education, and health of the human voice. This book is intended for all such professionals, and for patients, particularly professional voice users, who want to know as much as possible about their instrument and conditions that might affect it adversely.
Twists, Tilings, and Tessellation describes the underlying principles and mathematics of the broad and exciting field of abstract and mathematical origami, most notably the field of origami tessellations. It contains folding instructions, underlying principles, mathematical concepts, and many beautiful photos of the latest work in this fast-expanding field.
Robert J. Lang, one of the worlds foremost origami artists and scientists, presents the never-before-described mathematical and geometric principles that allow anyone to design original origami, something once restricted to an elite few. From the theoretical underpinnings to detailed step-by-step folding sequences, this book takes a modern look at
Traumatic Brain Injury: Methods for Clinical and Forensic Neuropsychiatric Assessment, Third Edition provides physicians and psychologists with a scientifically based schema for the clinical evaluation of traumatic brain injury (TBI). The book assists physicians and psychologists in developing treatment plans for patients who have sustained TBIs and also guides those providing forensic analysis to lawyers, insurance bodies, workers’ compensation systems, triers of fact, and other stakeholders in the adjudication of victims of TBI. The procedures and recommendations in this book are grounded in highly referenced evidence-based science but also come from more than 5000 cases wherein the author and contributors have personally examined individuals who have sustained a TBI, or who claim to have sustained a TBI. This edition has been entirely rewritten. The style now follows a more traditional neuropsychiatric format than previous editions. Since the last edition, there has been increased awareness and scientific study regarding the effects of blast brain injury as a consequence of US military experiences in Afghanistan and Iraq. There is also increased interest in the phenomenology of mild traumatic brain injury and, in particular, the forensic complications associated with evaluations of this disorder. Chronic traumatic encephalopathy has also received significant scrutiny in the last decade, possibly associated with sports injuries. This book is a comprehensive resource for clinicians treating patients as well as for forensic specialists. Its purpose remains the same as in prior editions—to provide physicians or psychologists with a practical method for an effective evaluation of TBI based upon known scientific principles of brain-behavior relationships and state-of-the-art clinical, neuroimaging, neuropsychological, and psychological techniques.
This widely acclaimed book is a complete, authoritative reference on nutrition and its role in contemporary medicine, dietetics, nursing, public health, and public policy. Distinguished international experts provide in-depth information on historical landmarks in nutrition, specific dietary components, nutrition in integrated biologic systems, nutritional assessment through the life cycle, nutrition in various clinical disorders, and public health and policy issues. Modern Nutrition in Health and Disease, Eleventh Edition, offers coverage of nutrition's role in disease prevention, international nutrition issues, public health concerns, the role of obesity in a variety of chronic illnesses, genetics as it applies to nutrition, and areas of major scientific progress relating nutrition to disease.
This handbook has been designed for practicing dental clinicians and students, which includes dental hygienists, general dentists, periodontists, and students of dental hygiene and dentistry who are responsible for treating patients with a broad spectrum of periodontal diseases. The book will enable practicing clinicians and students to successfully meet the challenge of excellent patient care, by providing , in a concise and simplified format, both classic and contemporary practical measures that address all aspects of non-surgical periodontal disease management. Readers are carefully guided through an extensive body of accumulated knowledge in eight broad chapters which includes: the patient’s involvement in disease control and prevention, the clinician’s instrumentation for the diagnosis and basic treatment of gingivitis/periodontitis along with pharmacotherapeutics and supportive maintenance therapy to ensure long-term success. Numerous illustrations help to bring the presented ideas and suggestions to life and the succinct nature of the text will allow readers to transfer useful information quickly to their own clinical settings.
Comprehensive, easy to read, and clinically relevant, Bradley’s Neurology in Clinical Practice provides the most up-to-date information presented by a veritable "Who's Who" of clinical neuroscience. Its unique organization allows users to access content both by presenting symptom/sign and by specific disease entities—mirroring the way neurologists practice. A practical, straightforward style; templated organization; evidence-based references; and robust interactive content combine to make this an ideal, dynamic resource for both practicing neurologists and trainees. Authoritative, up-to-date guidance from Drs. Daroff, Jankovic, Mazziotta, and Pomeroy along with more than 150 expert contributors equips you to effectively diagnose and manage the full range of neurological disorders. Easy searches through an intuitive organization by both symptom and grouping of diseases mirrors the way you practice. The latest advances in clinical neurogenetics, brain perfusion techniques for cerebrovascular disease, the relationship between neurotrauma and neurodegenerative disease, management strategies for levodopa-related complications in movement disorders, progressive neuropsychiatric disorders arising from autoimmune encephalitis, and more keep you at the forefront of your field. Reorganized table of contents which includes new chapters on: Brain Death, Vegetative, and Minimally Conscious States; Deep Brain Stimulation; Sexual Dysfunction in Degenerative and Spinal Cord Disorders; Sports and Performance Concussion; Effects of Drug Abuse on the Nervous System; and Mechanisms of Neurodegenerative Disorders. Regular online updates reflect the latest information on the diagnosis and treatment of neurologic diseases based on the latest recommendations and methodologies. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.
In this thesis, we identify and develop simple combinatorial models for four natural team management tasks and identify tractable and intractable cases with respect to their computational complexity. To this end, we perform a multivariate complexity analysis of the underlying problems and test some of our algorithms on synthetic and empirical data. Our first task is to find a team that is accepted by competing groups and also satisfies the agenda of some principal. Extending an approval balloting procedure by an agenda model, we formalize this task as a simple combinatorial model where potential team members are represented by a set of proposals and the competing groups are represented by voters with favorite ballots, that is, subsets of proposals. We show that the underlying problems UNANIMOUSLY ACCEPTED BALLOT and MAJORITYWISE ACCEPTED BALLOT are NP-hard even without an agenda for the principal. Herein, UNANIMOUSLY ACCEPTED BALLOT asks for a set of proposals that is accepted by all voters and MAJORITYWISE ACCEPTED BALLOT asks for a set of proposals that is accepted by a strict majority of the voters where acceptance means that each voter supports the majority of the proposals. On the positive side, we show fixed-parameter tractability with respect to the parameters "number of proposals" and "number of voters". With respect to the parameter "maximum size of the favorite ballots" we show fixed-parameter tractability for UNANIMOUSLY ACCEPTED BALLOT and W[1]-completeness for MAJORITYWISE ACCEPTED BALLOT. On the negative side, we show W[2]-hardness for the parameter "size of the solution" and NP-hardness for various special cases. Our second task is to partition a set of individuals into homogeneous groups. Using concepts from the combinatorial data anonymization model k-ANONYMITY, we develop a new model which formalizes this task. The information about the individuals is stored in a matrix where rows represent individuals and columns represent attributes of the individuals. The homogeneity requirement of each potential group is specified by a "pattern vector". We show that some special cases of the underlying problem HOMOGENEOUS TEAM FORMATION are NP-hard while others allow for (fixed-parameter) tractability results. We transfer our "pattern vector" concept back to combinatorial data anonymization and show that it may help to improve the usability of the anonymized data. We show that the underlying problem PATTERN-GUIDED k-ANONYMITY is NP-hard and complement this by a fixed-parameter tractability result based on a "homogeneity parameterization". Building on this, we develop an exact ILP-based solution method as well as a simple but very effective greedy heuristic. Experiments on several real-world datasets show that our heuristic easily matches up to the established "Mondrian" algorithm for k-ANONYMITY in terms of quality of the anonymization and outperforms it in terms of running time. Our third task is to effectively train team members in order to ensure that from a set of important skills each skill is covered by a majority of the team. We formalize this task by a natural binary matrix modification problem where team members are represented by rows and skills are represented by columns. The underlying problem is known as LOBBYING in the context of bribery in voting. We study how natural parameters such as "number of rows", "number of columns", "number of rows to modify", or the "maximum number of ones missing for any column to have a majority of ones" (referred to as "gap value") govern the computational complexity. On the negative side, we show NP-hardness even if each row contains at most three ones. On the positive side, for example, we prove fixed-parameter tractability for the parameter "number of columns" and provide a greedy logarithmic-factor approximation algorithm. We also show empirically that this greedy algorithm performs well on general instances. As a further key result, we prove LOGSNP-completeness for constant gap values. Our fourth task is to redistribute teams of equal size. More precisely, one asks to reduce the number of equal-size teams by dissolving some teams, distributing their team members to non-conflicting non-dissolved teams, and ensuring that all new teams are again of equal size. We formalize this task by a new combinatorial graph model. We show relations to known graph models such as perfect matchings, flow networks, and star partitions. On the negative side, we show that the underlying problem is NP-hard even if the old team size and the team size increase are distinct constants. On the positive side, we show that even our two-party variant of the problem is polynomial-time solvable when there are no conflicts or when the districts to dissolve and the districts to win are known. Furthermore, we show fixed-parameter tractability with respect to treewidth when the old team size and the team size increase are constants. In dieser Dissertation identifizieren und entwickeln wir einfache kombinatorische Modelle für vier natürliche Teamverwaltungsaufgaben und untersuchen bezüglich Berechnungskomplexität handhabbare und nicht handhabbare Fälle. Hierzu analysieren wir die multivariate Komplexität der zu Grunde liegenden Probleme und testen manche unserer Algorithmen auf synthetischen und empirischen Daten. Unsere erste Aufgabe ist es ein Team zu finden, welches von einer Gemeinschaft akzeptiert wird und den Vorstellungen (im Folgenden „Agenda“) eines Chefs entspricht. Wir formalisieren diese Aufgabe mit einem einfachen kombinatorischen Modell, indem wir ein bekanntes Verfahren aus dem Wahlkontext durch ein Agendamodell erweitern. In diesem Modell wird die Gemeinschaft durch Wähler mit je einer „Favoritenmenge“ repräsentiert. Wir zeigen, dass die resultierenden Probleme UNANIMOUSLY ACCEPTED BALLOT und MAJORITYWISE ACCEPTED BALLOT NP-schwer sind, sogar wenn es keine Agenda des Chefs gibt. Hierbei fragt UNANIMOUSLY ACCEPTED BALLOT, ob es ein Team gibt, welches von allen Wählern akzeptiert wird. MAJORITYWISE ACCEPTED BALLOT fragt, ob es ein Team gibt, welches von einer strikten Mehrheit der Wähler akzeptiert wird. Akzeptanz bedeutet in diesem Zusammenhang, dass jeder Wähler die Mehrheit der Teammitglieder unterstützt. Auf der positiven Seite zeigen wir „fixed-parameter tractability“ (FPT) für die Parameter „Anzahl an potentiellen Teammitgliedern“ und „Anzahl an Wählern“. Für den Parameter „maximale Größe der Favoritenmengen“ zeigen wir ein FPT-Ergebnis für UNANIMOUSLY ACCEPTED BALLOT und W[1]-Vollständigkeit für MAJORITYWISE ACCEPTED BALLOT. Unsere zweite Aufgabe ist es eine Menge von Individuen in homogene Gruppen zu partitionieren. Unter Ausnutzung von Konzepten des kombinatorischen Datenanonymisierungsmodells k-ANONYMITY entwickeln wir ein neues Modell, welches diese Aufgabe formalisiert. Dabei werden die Homogenitätsanforderungen jeder potentiellen Gruppe durch einen „Mustervektor“ spezifiziert. Die Informationen über die Individuen sind in einer Matrix gespeichert, wo Individuen durch Zeilen und ihre Attribute durch Spalten repräsentiert werden. Wir zeigen, dass einige Spezialfälle des sich ergebenden Problems HOMOGENEOUS TEAM FORMATION NP-schwer sind während andere FPT-Ergebnisse ermöglichen. Wir übertragen unser „Mustervektorkonzept“ zurück in die Welt der kombinatorischen Datenanonymisierung und zeigen, dass es helfen kann die Nutzbarkeit der anonymisierten Daten zu verbessern. Wir zeigen, dass das zu Grunde liegende Problem NP-schwer ist und ergänzen dies durch ein FPT-Ergebnis bezüglich eines „Homogenitätsparameters“. Aufbauend darauf entwickeln wir sowohl eine ILP-basierte exakte Lösungsmethode als auch eine Heuristik und testen diese in Experimenten mit empirischen Daten. Unsere dritte Aufgabe ist es ein Team effektiv auszubilden, um sicherzustellen, dass aus einer Menge von wichtigen Fähigkeiten jede jeweils von der Mehrheit der Teammitglieder beherrscht wird. Wir formalisieren diese Aufgabe durch ein natürliches Matrixmodifikationsproblem auf binären Matrizen, wobei Teammitglieder durch Zeilen und deren Fähigkeiten durch Spalten repräsentiert werden. Das resultierende Problem ist bekannt als LOBBYING im Kontext von Bestechung in Wahlen. Wir untersuchen wie natürliche Parameter wie „Anzahl an Zeilen“, „Anzahl an Spalten“ oder die „maximale Anzahl an fehlenden Einsen pro Spalte um eine Mehrheit an Einsen zu erhalten“ (im Folgenden „Gap-Wert“) die Berechnungskomplexität unseres Problems beeinflussen. Auf der negativen Seite zeigen wir NP-Schwere, sogar wenn jede Zeile höchstens drei Einsen enthält. Auf der positiven Seite zeigen wir zum Beipiel ein FPT-Ergebnis für den Parameter „Anzahl an Spalten“ und entwickeln eine Heuristik mit logarithmischen Approximationsfaktort und testen diese auf empirischen Daten. Als weiteres Schlüsselergebnis zeigen wir, dass unser Problem LOGSNP-vollständig ist für konstante Gap-Werte. Unsere vierte Aufgabe ist es Teams gleicher Größe neu aufzuteilen. Genauer versucht man die Anzahl gleichgroßer Teams zu reduzieren indem man einige Teams auflöst, deren Mitglieder an nicht in Konflikt stehenden verbleibende Teams verteilt und dabei sicherstellt, dass alle neuen Teams wiederum gleich groß sind. Wir formalisieren diese Aufgabe durch ein neues kombinatorisches Graphmodell. Wir zeigen dessen Beziehungen zu bekannten Graphkonzepten wie Perfekten Matchings, Flussnetzwerken, und Sternpartitionen von Graphen. Auf der negativen Seite zeigen wir, dass das zu Grunde liegende Problem NP-schwer ist, sogar wenn die alte Teamgröße und der Teamgrößenanstieg voneinander verschiedene Konstanten sind. Auf der positiven Seite zeigen wir unter anderem, dass unser Problem in Polynomzeit lösbar ist, wenn es keine Konflikte gibt oder wenn die aufzulösenden und zu gewinnenden Teams bereits bekannt sind.
This book comprehensively discusses the basic principles and working mechanism of all kind of batteries towards clean energy storage devices. In addition, it focuses on the synthesis of various electrode materials with 1D architecture via electrospinning technique. This book will give a clear idea about recent synthetic strategy towards nanofibers and nanocomposites for alkali-ion storage applications. The reader could understand the formation mechanism of nanofibers and their potential application in the future energy storage system.
Create nearly 40 striking paper figures with clear, step-by-step instructions and helpful diagrams. Features simple to advanced objects: cube, parrot, rabbit, seagull, cuckoo clock, rocket, mouse, elephant, violinist, Viking ship, and many more.
The premier single-volume reference in the field of anesthesia, Clinical Anesthesia is now in its Sixth Edition, with thoroughly updated coverage, a new full-color design, and a revamped art program featuring 880 full-color illustrations. More than 80 leading experts cover every aspect of contemporary perioperative medicine in one comprehensive, clinically focused, clear, concise, and accessible volume. Two new editors, Michael Cahalan, MD and M. Christine Stock, MD, join Drs. Barash, Cullen, and Stoelting for this edition. A companion Website will offer the fully searchable text, plus access to enhanced podcasts that can be viewed on your desktop or downloaded to most Apple and BlackBerry devices. This is the tablet version which does not include access to the supplemental content mentioned in the text.
Expand your skills in the rapidly growing field of laser dentistry! Principles and Practice of Laser Dentistry uses a concise, evidence-based approach in describing protocols and procedures. Dr. Robert A. Convissar, a renowned lecturer on this subject, has assembled a diverse panel of international contributors; he’s also one of the first general dentists to use lasers in his practice. The book covers the history of lasers in dentistry and laser research, plus the use of lasers in periodontics, periodontal surgery, oral pathology, implantology, fixed and removable prosthetics, cosmetic procedures, endodontics, operative dentistry, pediatrics, orthodontics, and oral and maxillofacial surgery. Full-color images show the latest laser technology, surgical techniques, and key steps in patient treatment. Full-color photos and illustrations demonstrate surgical techniques and key teaching points. A Laser Fundamentals chapter describes the physics of lasers and the wavelengths that can produce better outcomes. Introducing Lasers into the Dental Practice chapter provides guidelines on investing in laser technology and in marketing this new procedure. Clinical Tip and Caution boxes include advice and alerts that can only be offered by a seasoned practitioner of 27 years.
This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development. Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.
This book is about adaptive mesh generation and moving mesh methods for the numerical solution of time-dependent partial differential equations. It presents a general framework and theory for adaptive mesh generation and gives a comprehensive treatment of moving mesh methods and their basic components, along with their application for a number of nontrivial physical problems. Many explicit examples with computed figures illustrate the various methods and the effects of parameter choices for those methods. Graduate students, researchers and practitioners working in this area will benefit from this book.
Global environmental change is one of the most pressing international issues of the next century. There is a need to monitor the Earth's vital signs, from atmospheric ozone to tropical deforestation to sea level change. Models used to predict global changes have not yet fully used global observational data sets. Satellite data sets will be vital in addressing global change issues, in determining natural variability and monitoring global and regional changes. This timely volume provides an illustration of the variety of satellite-derived global data sets now available, their uses, advantages and limitations, and the range of variation that has already been observed with these data. A team of distinguished contributors provide a highly illustrated and accessible account suitable for the general scientific reader.
Widely recognized as the definitive text in pediatric cardiology, Moss and Adams' Heart Disease in Infants, Children, and Adolescents provides the authoritative, state-of-the-art information you need when caring for young patients with heart disease. The editorial team, led by Dr. Robert Shaddy, from Children's Hospital Los Angeles and the University of Southern California, ensures that you are kept fully up to date with recent advances in this complex and fast-changing field. This award-winning title, now in its Tenth Edition, continues to be the reference of choice for today’s cardiology fellows, pediatric cardiologists, and cardiology practitioners worldwide.
In Origami Sea Life, John Montroll and Robert J. Lang have collaborated to produce a truly elegant work. The pages of this book contain some of the most creative origami published to date. Each project is accompanied by a biological sketch of the animal to enhance the visual description. There are 38 models in all ranging from the lowly barnacle to the mighty whale. in between are to be found a cuttlefish, angelfish, lionfish, and fiddler crab, to name but a few of the unusual origami projects presented. Each project is illustrated with step-by-step instructions, utilizing the unique folds which make each of these animals so lifelike. Beginner and expert alike will find hours of creative fun in these pages. Origami Sea Life also includes a summary of the history of origami sea life. Information on types of paper and the technique of wet folding make this book indispensible for all those with an interest in papercraft.
This book reviews the interface between the traits of civilization and voice. It addresses concepts such as where the human voice stands in society and what the impact of civilization is on voice as a means of communication across diverse cultures, social hierarchies, and religious practices. Understanding voice disorders in the context of civilization traits and changes, and analyzing the impact of those traits is invaluable for otolaryngologists, speech language pathologists, voice teachers and others engaged in the diagnosis, treatment and/or training of patients with dysphonia. The book highlights cross-cultural variations in voice acoustics and self-perceived dysphonia, and the impact of religious observance on voice. This information is crucial in differentiating the normal voice from the abnormal, given differences associated with various civilizations and cultures. Traits of Civilization and Voice Disorders provides a far-reaching perspective on the interface between the human voice and its surroundings; as a result, this book is situated as an invaluable resource for otolaryngologists, speech language pathologists, and voice teachers in the diagnosis, treatment and training of patients with voice disorders.
Succinct, authoritative, and affordable, Kaplan & Sadock’s Concise Textbook of Psychiatry, 5th Edition, provides must-know information in clinical psychiatry from the names you trust. From cover to cover, it contains the most relevant clinical material from the bestselling Kaplan and Sadock’s Synopsis of Psychiatry, 12th Edition, including the foundational chapters on assessment, the disorder specific chapters, and all of the treatment-specific chapters among other essential topics such as emergency psychiatry, ethics, and palliative/end-of-life care. New editors Robert Boland and Marcia L. Verduin, along with consulting editor Pedro Ruiz, have updated all content with a focus on reformatting and summarizing for faster access to key information.
`This is a highly readable and accurate translation. The very useful annotations help to orient the modern reader with respect to medieval concepts, reflecting a profound understanding of thirteenth-century institutional history and the social and legal context of medieval Christianity. An extraordinary piece of scholarship.' James Ginther, Department of Theological Studies, St Louis University Robert Grosseteste (c.1170-1253) was an English statesman, philosopher, theologian, and bishop of Lincoln, and also one of the most controversial figures in his country's episcopate. His long life coincided with the central period of institutional, intellectual, and religious consolidation in medieval Europe and his letters provide important insights into the practices and preoccupations of the English clergy and laity in the first half of the thirteenth century. This volume contains the first complete translation of Grosseteste's collected Latin letters and shows that these were most likely chosen and arranged by Grosseteste himself. Shedding light on some of the period's crucial debates on issues of theology, law, pastoral care, and episcopal authority, F.A.C. Mantello and Joseph Goering's richly annotated English translation makes his letters more accessible than ever for scholars and students, and for those interested in medieval history, religion, and culture.
This book provides a practical guide to flow-aware networking (FAN), one of the most promising new quality-of-service architectures for the Future Internet. The latest concepts are examined in detail, including coverage of approximate flow-aware networking. The scope and evolution of the debate on network neutrality is also discussed. Topics and features: provides a broad survey of flow-oriented approaches and solutions based on the concept of flows; presents a range of mechanisms for improving transmission performance of streaming flows under congestion; illustrates how problems caused by congestion may be solved in a multilayer environment, proposing new methods for enhancing transmission in wired-wireless FAN; analyzes aspects of fair transmission in FAN, reviewing algorithms that improve transmission of streaming flows during network failures; describes the implementation aspects of the cross-protect router; concludes each chapter with review questions, with answers provided at the end of the book.
Accurate, reliable, objective, and comprehensive, Kaplan & Sadock’s Synopsis of Psychiatry has long been the leading clinical psychiatric resource for clinicians, residents, students, and other health care professionals both in the US and worldwide. Now led by a new editorial team of Drs. Robert Boland and Marcia L. Verduin, it continues to offer a trusted overview of the entire field of psychiatry while bringing you up to date with current information on key topics and developments in this complex specialty. The twelfth edition has been completely reorganized to make it more useful and easier to navigate in today’s busy clinical settings.
Dr. Kliegman and Dr. Bordini have written a primer on Undiagnosed and Rare Diseases in Children. Leading experts have presented the current knowledge in the following areas: How Doctor’s Think: Common Diagnostic Errors in Clinical Judgment; Team-Based Approach to Undiagnosed and Rare Diseases; Ending a Diagnostic Odyssey: Family Education Counselling and Their Response to Eventual Diagnosis; Eczema and Urticaria as Manifestations of Undiagnosed and Rare Diseases; Usual and Unusual Manifestations of Familial Hemophagocytic and Langerhans Cell Histiocytosis Syndromes; When Autistic Behavior Suggests a Disease Other than Classic Autism; Non-classic Inflammatory Bowel Disease in Young Infants; IPEX and Other Disorders; Usual and Unusual Presentation of Mitochondrial Disorders; When to Suspect Auto-inflammatory/Recurrent Fever Syndromes; Primary and Secondary Causes of Autonomic Dysfunction; Usual and Unusual Manifestations of Systemic and CNS Vasculitis; Fever of Unknown Origin; Differentiating Familial Neuropathies from Guillain-Barre Syndrome; and Munchausen by Proxy: A Factitious Undiagnosed Disease. Readers will come away with cutting-edge information to use immediately in their clinical management of patients.
Nelson Pediatric Symptom-Based Diagnosis uses a unique, step-by-step, symptom-based approach to differential diagnosis of diseases and disorders in children and adolescents. Conveniently linked to the world’s best-selling pediatric reference, Nelson Textbook of Pediatrics, 20th Edition, it focuses on the symptoms you’re likely to see in general practice, as well as uncommon disorders. You’ll find clear guidance on exactly what to consider and how to proceed when faced with a host of common symptoms such as cough, fever, headache, chest pain, gait disturbances, and many more. Features a practical, symptom-based approach that enables you to form an accurate diagnosis. Uses the same consistent, step-by-step presentation in every chapter: History, Physical Examination, Diagnosis (including laboratory tests), Imaging, Diagnosis, and Treatment. Covers new approaches to diagnostic imaging and genetic testing, new diagnostic guidelines, BRUE (brief resolved unexplained event), stroke in children, behavior disorders, syncope, recurrent fever syndromes, and much more. Includes full-color illustrations, algorithms, tables, and "red flags" to aid differential diagnosis. Serves as an ideal companion to Nelson Textbook of Pediatrics, 20th Edition.
This book provides a far-sighted perspective on the role of wearable and wireless systems for movement disorder evaluation, such as Parkinson’s disease and Essential tremor. These observations are brought together in the application of quantified feedback for deep brain stimulation systems using the wireless accelerometer and gyroscope of a smartphone to determine tuning efficacy. The perspective of the book ranges from the pioneering application of these devices, such as the smartphone, for quantifying Parkinson’s disease and Essential tremor characteristics, to the current state of the art. Dr. LeMoyne has published multiple first-of-their-kind applications using smartphones to quantify movement disorder, with associated extrapolation to portable media devices.
The 5-Minute Clinical Consult Standard 2016, 24th Edition, provides rapid-access in a quick-reference print format. It delivers diagnosis, treatment, medications, follow-up, and associated factors for a broad range of diseases and conditions. Organized alphabetically by diagnosis, this best-selling clinical reference continues to present brief, bulleted information on disease topics in a consistent and reader-friendly three-column format. The 5-Minute Clinical Consult Standard 2016, 24th Edition provides: 650+ commonly encountered diseases and disorders 150+ Treatment and diagnostic algorithms ICD10 Codes Current evidence-based designations highlighted in each topic A revised and updated Health Maintenance section The Health Maintenance 1-page summaries, based on the US Preventive Services Task Force recommendations
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