Transfer RNA in Protein Synthesis is a comprehensive volume focusing on important aspects of codon usage, selection, and discrimination in the genetic code. The many different functions of tRNA and the specialized roles of the corresponding codewords in protein synthesis from initiation through termination are thoroughly discussed. Variations that occur in the initiation process, in reading the genetic code, and in the selection of codons are discussed in detail. The book also examines the role of modified nucleosides in tRNA interactions, tRNA discrimination in aminoacylation, codon discrimination in translation, and selective use of termination codons. Other topics covered include the adaptation of the tRNA population to codon usage in cells and cellular organelles, the occurence of UGA as a codon for selenocysteine in the universal genetic code, new insights into translational context effects and in codon bias, and the molecular biology of tRNA in retroviruses. The contributions of outstanding molecular biologists engaged in tRNA research and prominent investigators from other scientific disciplines, specifically retroviral research, make Transfer RNA in Protein Synthesis an essential reference work for microbiologists, biochemists, molecular biologists, geneticists, and other researchers involved in protein synthesis research.
Together with the Paramedic Association of Canada and the American Academy of Orthopaedic Surgeons, Jones and Bartlett Publishers is proud to publish Emergency Care in the Streets, originally authored by Dr. Nancy Caroline. In the United States, this textbook has been central to paramedic training since the 1970s. Much loved and greatly respected, this textbook is still unrivalled in its ability to speak directly to the paramedic through humor and wisdom. Now, for the first time, Dr. Caroline's textbook has been adapted by a team of Canadian paramedics! Dedicated to the late Dr. Caroline, this textbook honors her work with: Progressive case studies that lead you through an emergency call from beginning to end Practical at-the-scene advice Notes from Nancy: Words of wisdom from Dr. Caroline A mixture of text, colour photographs, diagrams, and cartoons to suit all learning styles Skill Drills with written step-by-step explanations and visual summaries of important skills and procedures C.
Drawing on both economics and ecology, this book offers telling insights into the confusing "jobs versus environment" debates as well as charts a recommended path towards a more co-habitable relationship. Avoiding the extreme views that economic growth will either destroy or save our natural environment, this book takes a more discriminating stance and illuminates why our nation’s natural environment is both better and worse than forty years ago.
This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development. Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.
How do bacteria help to make milk into cheese? What is genetically modified food? What are extremophiles and where are they found? The books in the 'Microlife' series explore the fascinating, unseen kingdoms of the microscopic world. Each title looks at the ways in which bacteria, viruses, and other microorganisms affect your body and the world around you.
Chief among its contents we find abstracts of land grants, court records, conveyances, births, deaths, marriages, wills, petitions, military records (including a list of North Carolina Officers and Soldiers of the Continental Line, 1775-1782), licenses, and oaths. The abstracts derive from records now located in the state archives and from the public records of the following present-day counties of the Old Albemarle region: Beaufort, Bertie, Camden, Chowan, Currituck, Dare, Gates, Halifax, Hyde, Martin, Northampton, Pasquotank, Perquimans, Tyrrell, and Washington, and the Virginia counties of Surry and Isle of Wight.
First published in 1953, The Miners: Years of Struggle is the official history of the British miners, which draws on original sources, moving into the stormy period when the economic bargaining of the million colliery employees with the mine owners became the concern of Parliament and people. The great strike of 1921; the stoppages of 1921 and 1926 (the latter opening with the General Strike); and how successive administrations met those crises – these form an historical matrix from which the present public ownership inevitably emerged. The conflict of ideas and personalities is shown as part of the struggles of these stormy times. This book will be of interest to students of history, sociology, economics and political science.
The English Pig is an account of pigs and pig-keeping from the sixteenth century to modern times, concentrating on the domestic, cottage pig, rather than commercial farming. In Victorian England the pig was an integral part of village life: both visible and essential. Living in close proximity to its owners, fed on scraps and the subject of perennial interest, the pig when dead provided the means to repay social and monetary debts as well as excellent meat. While the words associated with the pig, such as 'hoggish', 'swine' and 'pigsty', and phrases like 'greedy as a pig', associate the pig with greed and dirt, this book shows the pig's virtues, intelligence and distinctive character. It is a portrait of one of the most recognisable but least known of farm animals, seen here also in many photographs and other representations. The pig has a modest place in literature from Fielding's pig-keeping Parson Trulliber to Hardy's Jude the Obscure and to Flora Thompson's Lark Rise to Candleford. In modern times, while vanishing from the sight of most people, it has been sentimentalised in children's stories and commercialised in advertisements.
Over recent years research into suicidal behaviour has burgeoned, and the third edition of this successful pocketbook reflects major developments in the evidence base and clinical practice. New chapters cover risk assessment and system-wide approaches to suicide prevention, and the role of clinical guidelines and national policies is also considered. This edition features extensive updates to the epidemiology of suicidal behaviour across the world, and also considers the individual and societal causes of suicide, particularly the effect of recent economic downturns in many countries. The chapter on biological factors includes the current research on the genetics and neuroscience of suicide. The chapters on interventions discuss the latest evidence from systematic reviews and new randomized controlled trials and highlight implications for clinical practice. The positive and negative impacts of the web and social media on suicidal behaviour are a major focus of research activity and new sections have been included to reflect this. The 'Frequently Asked Questions' section was well received in the previous edition and this has been revised further to include new/updated FAQs on euthanasia, assisted suicide, and suicide martyrdom. Part of the Oxford Psychiatry Library series, this useful handbook is an invaluable resource and quick-reference guide.
Inorganic Geochemistry of Coal explains how to determine the concentrations and modes of occurrence of elements in coal, how to diminish adverse effects of toxic elements on the environment and human health, which elements in coal could be industrially utilized, and which elements can be successfully used as indications for deciphering depositional environments and tectonic evolution. As coal use will remain at an all-time high for the next several decades, there is a critical need for understanding the properties of this fuel to ensure efficient use, encourage its economic by-product potential, and to help minimize its negative technological, environmental and health impacts. - Features dozens of never-before published illustrations of critical features of the inorganic geochemistry of coal - Covers both the theory and applications of the topic, including case studies to serve as real-world examples - Includes a chapter on the health and environmental impacts of the mining, development and use of coal
Robert Arking's Biology of Aging, 3rd edition, is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging. As a result, six important conceptual changes are included here: · Clarified distinctions between the biological mechanisms involved in longevity determination and those involved in senescent processes. · A new conceptual framework around which we can organize all the new facts about aging. This will assist readers to make sense of the information and use the data to form their own ideas. · Increased knowledge of aging cells has lead to new ideas on how a cell transits from a healthy state to a senescent state, while still allowing for high levels of intra- and inter-specific variability. · Discussion of senescent mechanisms assists the reader to understand that aging is a non-programmatic loss of function, likely arising from the loss of regulatory signals, and so is modifiable in the laboratory. · Because the standard evolutionary story does not fully explain the evolution of social organisms, this edition also includes recent work dealing with intergenerational resource transfers. · Lastly, if aging mechanisms are plastic, then the demand to move these anti-aging interventions into the human arena will inevitably grow. A discussion of the biological and ethical arguments on both sides of the question frames the question in an appropriate manner. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. The last two chapters integrate all this material into a coherent view of how the relevant biological processes change over the life span. This view is expressed in two non-technical figures (you might say that the whole book exists to fully support Figs 9-4 & 14-9), whose meanings are elucidated as the reader progresses through the book.
Inorganic Aspects of Biological and Organic Chemistry investigates the inorganic aspects of biological and organic chemistry. Topics include the inorganic chemistry of group Ia and IIa metals; complexes of Ia and IIa cations in organic and biological chemistry; atomic structure and structure-activity correlations; and bonding in ligands and metal complexes. Ligand exchange reactions and factors in complex stability are also discussed. Comprised of 12 chapters, this book begins with an overview of some of the important roles of metals in biological and organic chemistry, followed by an analysis of the inorganic chemistry of group Ia and IIa metals. Complexes of Ia and IIa cations in organic and biological chemistry are then described, together with atomic structure and structure-activity correlations. Subsequent chapters deal with bonding in ligands and metal complexes; ligand exchange reactions and factors in complex stability; redox potentials and processes; and the influence of metal ions on equilibria. The book also considers catalysis by metal ions, metal complexes, and metalloenzymes before concluding with a chapter that examines the reactions of ligands in organometallic complexes. This monograph is written for teachers, students, and practitioners of organic, biological, and inorganic chemistry.
The volume is concerned exclusively with all the binary species formed between the elements silicon and fluorine such as SiF, SiF2, SiF3, SiF4, and Sif62-. Most of the volume, i.e. 144 pages, is devoted to the description of the well known physical and chemical properties of the SiF4 as well as to its preparation. This is followed in length by the report on SiF2 with its interesting chemistry, along with a section on the diatomic radical SiF. Species with fivefold and sixfold coordination of silicon are exemplified by SiF5- and by the well known SiF62-. Interestingly, the detailed models for describing the bonding situation in both ions are still a matter of discussion. While for Si2F6 most of the basic data are known, information on the chemical and physical properties of the higher members of the acylic perfluorosilanes, SinF2n+2, is scarce. All available information on the unstable cyclic perfluorosilanes of composition (SiF2)n and some even more exotic species is also included.
This book is about faithful witnesses -- from the Reformation to South African apartheid to Bonhoeffer -- to the promise of Jesus Christ. Even in the midst of trials, these faithful followers have testified that the gospel is authority enough for the church's life and unity. Significantly, this is the first book in print by the late Robert Bertram, described by Edward Schroeder as “perhaps the most unpublished major Lutheran theologian of the twentieth century.”
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