The ability to image brain processes non-invasively has created a flood of experiments that fall into two categories—aiming to localize brain performance of abstractions like love, memory or intention—or to identify neuronal activities in response to observable behavior.
This volume is the first to describe all clinically and experimental relevant aspects of primary and secondary brain stem lesions important to clinicians. It contains a detailed description of the computer-tomographical and morphological changes of the cerebral cisterns in acutely and chronically increased intracranial pressure. The prognostic value of clinical parameters of primary and secondary brain stem lesions is demonstrated. The possibilities of assessing the clinical course by computer-aided evaluation are presented. In addition to that, comprehensive view of morphological, radiological and clinical findings, extensive investigation concerning blink reflex (BR) and auditory evoked brain stem potentials (BAEP) supply highly relevant functional aspects of those lesions. The effects of raised intracranial pressure upon BR, BAEP as well as upon cerebral blood flow and focal flow in different brain areas were studied in animal experiments and reveal new and fascinating conclusions. Based on these investigations, a mathematical model following modern concepts of system analysis was developed. The model includes the intracranial system, autoregulation of cerebral flow (cardiovascular components) and the short-time behaviour of arterial blood pressure regulation.
Complex and unexplained phenomena tend to foster unorthodox perspectives. This publication is an example, as is a prior publication that emphasized the concept that intermediary metabolism might play a significant and determining role in hepatocyte proliferation and 1 tumorigenesis. Formulation of this hypothesis was based on an attempt to clarify several poorly understood phenomena; including the observations: 1) that xenobiotic peroxisome proliferators such as the fibrate hypolipidemic agents induce hepatocyte proliferation and carcinogenesis in rodents; 2) that benign and malignant liver tumors complicate the human syndrome of glycogen storage disease type I (glucose-6-phosphatase deficiency); and 3) that in this same syndrome, administration of glucose exerts an anti-tumor effect. Fatty acid and glucose metabolism are tightly linked in a we- established and profoundly inportant interplay. This connection, together with the fact that peroxisome proliferator-induced hepatocyte proliferation and carcinogenesis reflects inhibition of mitochondrial carnitine palmitoyltransferase-I and fatty acid oxidation, suggested the possibility that regulation of fatty acid metabolism could prove to be a pivotal determinant in the control of cell growth. In 1993, the year in which the paper cited above was published, insight into the importance of growth factors and signal transduction pathways in cell cycle regulation was increasing rapidly, but metabolic and energetic aspects of cell proliferation had attracted relatively little attention. Despite this, the concept seemed inescapable that the two seemingly distinct and unrelated determinants — signal transduction and metabolism — were integrally linked.
Succinct, authoritative, and affordable, Kaplan & Sadock’s Concise Textbook of Psychiatry, 5th Edition, provides must-know information in clinical psychiatry from the names you trust. From cover to cover, it contains the most relevant clinical material from the bestselling Kaplan and Sadock’s Synopsis of Psychiatry, 12th Edition, including the foundational chapters on assessment, the disorder specific chapters, and all of the treatment-specific chapters among other essential topics such as emergency psychiatry, ethics, and palliative/end-of-life care. New editors Robert Boland and Marcia L. Verduin, along with consulting editor Pedro Ruiz, have updated all content with a focus on reformatting and summarizing for faster access to key information.
Free radicals and related reactive species, including reactive oxygen and nitrogen species (ROS/RNS) play a critical role in the pathophysiological processes of various human diseases, including cardiovascular diseases, diabetes and metabolic syndrome, neurological disorders, and cancer among many others. This peer-reviewed E-book covers both the fundamental principles and the recent advances in free radical biomedicine along with in-depth discussions of the clinical correlations. It also provides a thorough coverage of the commonly used methods in free radical and antioxidant research with detailed schematic illustrations as well as succinct descriptions of the procedures. This volume should also be a valuable source of information for readers who wish to gain a sound understanding of the research methodologies in this rapidly evolving field.
The ability to image brain processes non-invasively has created a flood of experiments that fall into two categories—aiming to localize brain performance of abstractions like love, memory or intention—or to identify neuronal activities in response to observable behavior.
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