A reprint of the 1973 biography of the American inventor. Divided into pre-telephone, telephone, and post-telephone sections, also covers his work with the Smithsonian, the deaf, the National Geographic Society, and Science magazine. Paper edition ($12.95) not seen. Annotation copyrighted by Book News, Inc., Portland, OR
This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development. Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.
This book offers a comprehensive study on the subject of ocean disposal of treated and untreated sewage waste. The early chapters cover the philosophy of outfall design, properties of sewage from developed towns and an overview of water quality regulations in New Zealand, Great Britain and the U.S. Alternative ways of satisfying these regulations are discussed. The book also provides information required to design outfall pipelines and diffusers.
Polymers are substances containing a large number of structural units joined by the same type of linkage. These substances often form into a chain-like structure. Starch, cellulose, and rubber all possess polymeric properties. Today, the polymer industry has grown to be larger than the aluminium, copper and steel industries combined. Polymers already have a range of applications that far exceeds that of any other class of material available to man. Current applications extend from adhesives, coatings, foams, and packaging materials to textile and industrial fibres, elastomers, and structural plastics. Polymers are also used for most composites, electronic devices, biomedical devices, optical devices, and precursors for many newly developed high-tech ceramics. This new book presents leading-edge research in this rapidly-changing and evolving field.
In your practice, you require advanced knowledge of the obstetrical, medical, genetic and surgical complications of pregnancy and their effects on the mother and fetus. With both basic science and clinical information, six new chapters, and an updated color design, you need look no further than the 6th edition of this long-time best seller. Includes both basic science and clinical information to give you comprehensive knowledge of the biology of pregnancy. Acts as an excellent resource for OB/GYNs studying for their Maternal-Fetal Medicine boards — and for practitioners who need quick access to practical information. Provides an updated and focused reference list to keep you up to date on the standards of care in maternal-fetal medicine today. Keeps you current with a new section: Disorders at the Maternal-Fetal Interface...and 6 new chapters: Biology of Parturition, Developmental Origins of Health and Disease, Intrapartum Assessment of Fetal Health, Pathogenesis of Pre-term Birth, Maternal and Fetal Infectious Disorders, and Benign Gynecological Conditions of Pregnancy. Features over 50% new authorship with increased focus on international perspectives. Includes the following hot topics in Maternal-Fetal Medicine: o Biology of Parturition o Fetal Growth o Prenatal Genetic Screening and Diagnosis o Fetal Cardiac Malformations and Arrhythmias o Thyroid Disease and Pregnancy o Management of Depression and Psychoses during Pregnancy and the Puerperium Focuses on evidence based medicine, the current best practice in MFM for diagnosing and treating high risk pregnancies. Includes new illustrations and an updated, color design.
Island biogeography is the study of the distribution and dynamics of species in island environments. Due to their isolation from more widespread continental species, islands are ideal places for unique species to evolve, but they are also places of concentrated extinction. Consequently, they are widely studied by ecologists, evolutionary biologists, and conservationists. This accessible textbook builds on the success and reputation of its predecessors, documenting the recent advances in this exciting field and explaining how islands have contributed to both theory development and testing. In addition, the book describes the main processes of island formation, subsequent dynamics, and eventual demise, explaining the relevance of island environmental history to island biogeography. The authors demonstrate the significance of islands as hotspots of biodiversity and of prehistoric and historic anthropogenic extinction. Since island species continue to feature disproportionally in the lists of threatened species today, the book examines both the chief threats to their persistence and some of the mitigation measures that can be put in play, with conservation strategies specifically tailored to islands.
This book traces Swift's fluctuating reception in Ireland through the centuries, finding in Swift's ambivalence about his homeland - which he could not love even as he defended its cause - echoes and anticipations of the ambiguities that have marked the development of Irish identity at large. Mahony looks at Swift's posthumous reputation in literary culture and examines his unusual place in Irish political rhetoric. He shows that Swift's patriotic reputation suffered in the later eighteenth century through its seeming irrelevance to shifting political circumstances.
Quantum theory is one of the great achievements of twentieth century physics. Born at the very beginning of the century, it attained a definitive form by 1932, yet continued to evolve throughout the century. Its applications remain fully a part of modern life. It should thus come as no surprise that literature on the history of quantum theory is vast, but author Robert D. Purrington approaches the story from a new angle, by examining the original physics papers and scientific studies from before the creation of quantum mechanics to how scientists think about and discuss the subject today. The Heroic Age presents for the first time a detailed but compact and manageable history of the creation of quantum theory, and shows precisely where each important idea originated. Purrington provides the history of the crucial developmental years of quantum theory with an emphasis on the literature rather than an overview of this period focusing on personalities or personal stories of the scientists involved. This book instead focuses on how the theoretical discoveries came about, when and where they were published, and how they became accepted as part of the scientific canon.
As models of the Earth/atmosphere system and observations become ever more sophisticated, and concerns about climate change and societal impacts of extreme weather and its forecasting grow, understanding the role of clouds in the atmosphere is increasingly vital. Cloud Dynamics, Second Edition provides the essential information needed to understand how clouds affect climate and weather. This comprehensive book examines the underlying physics and dynamics of every specific type of cloud that occurs in the Earth's atmosphere, showing how clouds differ dynamically depending on whether they occur over oceans or mountains, or as parts of atmospheric storms, such as thunderstorms, tropical cyclones, or warm and cold fronts. Covering both the microphysical and macrophysical aspects of clouds, the book treats all of the physical scales involved in cloud processes, from the microscale of the individual drops and ice particles up to scales of storms in which the clouds occur. As observational technology advances with increasingly sophisticated remote sensing capabilities, detailed understanding of how the dynamics and physics of clouds affect the quantities being measured is of paramount importance. This book underpins the work necessary for proper interpretation of these observations, now and in the future. Provides the holistic understanding of clouds needed to pursue research on topics vital to life on Earth Provides in-depth understanding of all types of clouds over all regions of Earth, from the poles to the equator Includes detailed physical and dynamical insight into the entire spectrum of clouds populating Earth's atmosphere
This latest edition improves and builds upon the features of previous editions. With impressive pedagogy, learning objectives and summaries, this clearly written book will be another winner with students of international economics and business.
Bristol is a major city and port in the south-west of England. In medieval times, it became the third largest city in the kingdom, behind London and York. Bristol was founded in the late Saxon period and grew rapidly in the 12th and 13th centuries. Initially, seaborne trading links with Ireland and France were particularly significant; later, from the 16th century onwards, the city became a focus for trade with Iberia, Africa, and the New World. This led to the growth of new industries such as brass manufacture, glass production and sugar refining, producing items for export, and processing imported raw materials. Bristol also derived wealth from the slave trade between Africa and the New World. The city has a long history of antiquarian and archaeological investigation. This volume provides, for the first time, a comprehensive overview of the historical development of Bristol, based on archaeological and architectural evidence. Part 1 describes the geological and topographical context of Bristol and discusses evidence for the environment prior to the foundation of the city. The history of archaeological work in Bristol is discussed in detail, as is the pictorial record and the cartographic evidence for the city. In Part 2, a series of period-based chapters considers the historical background and archaeological evidence for Bristol’s development from the prehistoric, Roman, and post-Roman eras through the establishment and growth of Bristol between about 950 and 1200 AD; the medieval city; early modern period; and the period from 1700 to 1900 AD, when Bristol was particularly important for its role in transatlantic trade. Each chapter discusses the major civic, military, and religious monuments of the time and the complex topographical evolution of the city. Part 3 assesses the significance of Bristol’s archaeology and presents a range of themes for future research.
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