This book represents a method by which students are assisted to make wise decisions about the use of alcohol and other drugs. Situations which are essential to effective daily living are employed to reach effective decisions. The role of parents in assisting the children toward a better understanding of the nature of drug use is also explored. Specifically, the use of alcohol and other drugs in the workplace places the drug situation directly in the light of the job market. The current problem of HIV and drugs is also discussed, along with drugs and pregnancy.
A capsule history of American architecture since 1960.”—Wall Street Journal Architect, historian, and educator Robert A. M. Stern presents a personal and candid assessment of contemporary architecture and his fifty years of practice. For more than fifty years, Robert A. M. Stern has designed extraordinary buildings around the world. Founding partner of Robert A. M. Stern Architects (RAMSA), Stern was once described as “the brightest young man I have ever met in my entire teaching career” by Philip Johnson and recently called “New York City’s most valuable architect” by Bloomberg. Encompassing autobiography, institutional history, and lively, behind-the-scenes anecdotes, Between Memory and Invention: My Journey in Architecture surveys the world of architecture from the 1960s to the present and Robert A. M. Stern’s critical role in it. The book chronicles Stern’s formative years, architectural education, and half-century of architectural practice, touching on all the influences that shaped him. He details his Brooklyn upbringing, family excursions to look at key twentieth-century buildings, and relationships with prominent teachers—Paul Rudolph and the legendary Vincent Scully among them. Stern also recounts the origins of RAMSA and major projects in its history, including the new town of Celebration, Florida, the restoration of Times Square and 42nd Street, 15 Central Park West, Benjamin Franklin and Pauli Murray Colleges at Yale, and the George W. Bush Presidential Center, as well as references the many clients, fellow architects, and professional partners who have peopled his extraordinary career. By turns thoughtful, critical, and irreverent, this accessible, informative account of a life in architecture is replete with personal insights and humor. Stern’s voice comes through clearly in the text—he details his youthful efforts to redraw house plans in real estate ads, his relationship to Philip Johnson, which began at Yale and was sustained through countless lunches at the Four Seasons, his love of Cole Porter and movies from the 1930s and 1940s, his struggle to launch an architecture practice in the 1970s in the midst of a recession, and his complex association with Disney and Michael Eisner. Unsurprisingly, New York City plays a big role in Between Memory and Invention. Stern has a deep commitment to the city and recording its past—he is the lead author of the monumental New York book series, the definitive history of architecture and urbanism from the late nineteenth century to the present—and shaping its future. Though now a global practice, RAMSA residential towers rise throughout Manhattan to enrich the skyline in the tradition of the luxurious apartment buildings of the 1920s and 1930s. Supported by a lively mix of images drawn from Stern's personal archive and other resources, this much-anticipated memoir is interspersed with personal travel slides, images of architectural precedents and the colleagues that have shaped his thinking, and photographs of the many projects he discusses. With a thoughtful afterword by architectural historian Leopoldo Villardi that delves into Stern’s process of putting together this extraordinary autobiographical work, Between Memory and Invention is a personal candid assessment of a foremost practitioner, historian, instructor, and advocate of architecture today.
This book presents the stream-tube method (STM), a method offering computational means of dealing with the two- and three-dimensional properties of numerous incompressible materials in static and dynamic conditions. The authors show that the kinematics and stresses associated with the flow and deformation in such materials can be treated by breaking the system down into simple computational sub-domains in which streamlines are straight and parallel and using one or two mapping functions in steady-state and non-steady-state conditions. The STM is considered for various problems in non-Newtonian fluid mechanics with different geometries. The book makes use of examples and applications to illustrate the use of the STM. It explores the possibilities of computation on simple mapped rectangular domains and three-dimensional parallel-piped domains under different conditions. Complex materials with memory are considered simply without particle tracking problems. Readers, including researchers, engineers and graduate students, with a foundational knowledge of calculus, linear algebra, differential equations and fluid mechanics will benefit most greatly from this book.
Head and neck cancer is a very common cancer worldwide with an estimated 500,000 individuals diagnosed each year. In the United States an average of 39,000 new cases are reported each year representing between 3 to 5% of all new cancer cases diagnosed annually. Head and neck cancers are more common in men and in individuals over the age of 50. The treatment of head and neck cancer is extremely challenging and involves insight and expertise from multiple disciplines. Multidisciplinary Management of Head and Neck Cancer is a comprehensive textbook looking at different aspects of head and neck cancer, including the diagnosis, treatment and outcomes for patients with this disease. The chapters written by world-renowned experts cover the entire discipline of head and neck oncology and include discussion of the role of HPV infections, advances in radiotherapy, new surgical techniques, novel agents in thyroid therapy and more. The book is designed to be both practical and comprehensive for the physicians treating this complex disease. Features of Multidisciplinary Management of Head and Neck Cancer include: A chapter on the role of HPV infections in head and neck cancer A chapter on new advances in radiotherapy for head and neck cancer, including review IMRT, new standards and potential pitfalls Detailed discussion of the role of chemotherapy in head and neck cancer, including commonly used drugs and how to combine them with radiotherapy to improve patient outcomes Detailed discussion on incorporating novel agents with radiotherapy Detailed discussion of novel therapeutics in head and neck cancer, including new drugs and biologics
For almost a millennium, a modest wooden ship lay underwater off the coast of Serçe Limani, Turkey, filled with evidence of trade and objects of daily life. The ship, now excavated by the Institute of Nautical Archaeology at Texas A&M University, trafficked in both the Byzantine and Islamic worlds of its time. Known as "the Glass Wreck," it bore cargo that included three metric tons of glass cullet, including broken Islamic vessels and eighty pieces of intact glassware, along with various artifacts of ship life. This second volume of the discovery’s investigation focuses on the excavation, conservation, and study of the glass found in the wreckage. The extensive catalog will be a valuable tool for archaeologists and scholars of Islamic glass and Islamic trade. Further, the systematic methodology and presentation of such a large undertaking will serve as a model for future study across many disciplines.
This book provides a thorough, well-balanced analysis of common research practices with banked tissues, DNA, and genetic data. Describing many examples of beneficial tissue research, the authors focus on problematic research practices, controversial cases, and federal and institutional policies that limit the informed choices of patients and research participants. They offer a series of recommendations to help overcome these problems.
Psaiku takes haiku to the next level. Rather than celebrating nature, Psaiku reflects on the nature of man - on his psyche. Robert Meyers-Lussier uses this new form of poetry on his journey of self-discovery. In three lines, and 30 words or less, join him as he encapsulates his observations and experiences with is own style and flair. Within our mind's eye The pristine soul of nature Sees with clarity ---12 July 1996---
Vital information for discovering and optimizing new drugs "Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discovery. This book helps medicinal chemists and pharmacologists to do exactly that in the realm of enzyme inhibitors." -Paul S. Anderson, PhD This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications. Targeted to medicinal chemists and pharmacologists, Evaluation of Enzyme Inhibitors in Drug Discovery focuses on the questions that they need to address: * What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism? * How are inhibitors evaluated for potency, selectivity, and mode of action? * What are the advantages and disadvantages of specific inhibition modalities with respect to efficacy in vivo? * What information do medicinal chemists and pharmacologists need from their biochemistry and enzymology colleagues to effectively pursue lead optimization? Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules that lend themselves to therapeutic use. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, the publication delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted. This publication is designed to provide students with a solid foundation in enzymology and its role in drug discovery. Medicinal chemists and pharmacologists can refer to individual chapters as specific issues arise during the course of their ongoing drug discovery efforts.
The disciplines of school effectiveness research and school improvement practice and research have been apart for too long. This book is the first major attempt, by leading writers and practitioners in these fields, to bring the areas together in a coherent way. Existing knowledge about the characteristics of `good' schools is outlined, together with the knowledge base about how to `make schools good schools'. The book also makes an entirely original contribution to re-thinking practice in school improvement that can revolutionise our thinking in the late 1990s, and which can be of use to academics, to policymakers and to the practitioners which much existing work has neglected.
Using a proven, practical, algorithmic approach, Surgical Decision Making summarizes evidence-based guidelines and practice protocols in an easy-to-follow format. Designed to sharpen the decision-making skills of both trainees and practicing surgeons, the 6th Edition directs your focus to the critical decision points in a wide range of clinical scenarios, helping you determine optimal evaluation and management to secure the best possible patient outcomes. Algorithms are accompanied by annotations that explain all critical factors affecting decisions in a concise, readable manner. - Reflects the scope of practice of today's general surgeon, with fresh, expert perspectives from new editor Dr. Richard Schulick and numerous new contributors. - Contains 58 new chapters and thoroughly revised content throughout. - Includes new coverage of Preoperative Evaluation of the Geriatric Patient, Pancreatic Cystic Neoplasm, Familial Breast Cancer, Resuscitative Endovascular Balloon Occlusion of the Aorta, Blunt Cerebrovascular Injury, and much more. - Uses an easy-to-follow, consistent format, with an algorithm on one page and short descriptions explaining the various steps in the decision-making process on the opposite page. - Includes explanatory notes that summarize presenting signs and symptoms, laboratory investigation, diagnostic modalities, surgical therapies, and adjuvant therapies for each condition. - Encompasses both general surgery and surgical subspecialties―helping you directly manage a broad range of problems. - Emphasizes information that frequently appears on board exams.
The skin, uniquely positioned at the interface between the human body and the external world, plays a multifaceted role in the expression of cancer. Primary skin cancer is the most common cancer afflicting mankind and is rising in inci dence, despite the fact that it is often preventable. Besides primary cancer, the skin may show direct and indirect evidence of internal cancer, thus serving as a window to the body for both laymen and physicians alike. In addition, the acces sibility of the skin is useful for the study of carcinogenesis as well as cancer treat ment options. lowe much of my interest in skin cancer to Dr. Leon Goldman, the father of dermatologic laser surgery, and to Dr. Edmund Klein, the father of modern immunotherapy. We, at the Roswell Park Memorial Institute, were indeed for tunate to have a wealth of patients available for study. Many of the illustrations used in this book were of my patients at the Institute, and I kindly thank the fol lowing publications and their respective publishers for allowing me to reuse some of my photographs, most notably: Cancer Medicine (2nd edition), Journal of Surgical Oncology, Journal of the American Academy of Dermatology, Archives of Dermatology, Cancer, and Journal of Dermatologic Surgery and Oncology. We are very fortunate in this work to have some of the world's foremost authorities in their areas as contributors, such as Drs. Zackheim, Lambert, J.W. Trimble, J.R. Trimble, Jackson, Crutcher, Mashberg, Wick, Sidell, F. Helm, G.
Two of the savviest Flash experts in the industry show you how to add impact to your Web content. Robert Reinhardt and Snow Dowd know all the techniques and tricks, and they take you under the hood in this one-stop total reference guide to Flash CS3 Professional. Follow their tutorials, learn from cool examples, and discover insider secrets you won't find in any other book. Don't miss the special 16-page color insert loaded with spectacular examples. Also includes a CD-ROM. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.
Lee Marvin did not receive his first starring film role until he was 40, but in three short years--following the successes of Cat Ballou (for which he won the Academy Award as Best Actor), The Professionals and especially The Dirty Dozen--he was the most popular film actor in America. Marvin was a fascinating man, a loving husband and father, and one of the most natural, effective actors of his time. This is a comprehensive reference of the Oscar-winning actor's work. It includes biographical information on Marvin, an analysis of each of his 64 movies, chapters on his two television shows (M Squad and Lawbreaker), a listing of his television appearances, and a complete filmography (which includes video availability). The work is supplemented with dozens of photographs and film stills.
Written by Johns Hopkins University School of Medicine faculty and surgical residents, the second edition of The Johns Hopkins ABSITE Review Manual delivers comprehensive coverage of the American Board of Surgery In-Training Examination through two full-length practice tests. Both tests are based on actual key words from recent ABSITEs, and are accompanied by test review sections, which go over every practice test question and answer, providing rationales behind surgical decision-making. ABSITE-style question format familiarizes readers with the test’s presentation and content. This edition features twice the number of questions as in the previous edition, offering even more opportunities for self-paced review. Rationales for correct and incorrect responses help to identify the test-taker’s strengths and weaknesses. This book is ideal not only for those preparing for the ABSITE, but also for surgeons and residents studying for the general surgery qualifying exam and for all surgical residents seeking to review key topics during rotations.
A daring look into the art and technique of one of history’s most celebrated literary scholars, Shakespeare, Religion and Beyond is a detailed documentation on that attempt to shed light on a missing piece in a cryptic puzzle. As described by Robin L. Inboden, Ph.D. (Wittenberg University), “Fleissners’s book summarized, interrogates, and extends both long-held assumptions about Shakespeare’s work and newer claims alike. His speculative web of connections among plays, the life, the religion, and the literary inspirations of Shakespeare links the unexpected and thus suggests potentially fruitful avenues for further study.”
This book is a guide to numerical methods for solving fluid dynamics problems. The most widely used discretization and solution methods, which are also found in most commercial CFD-programs, are described in detail. Some advanced topics, like moving grids, simulation of turbulence, computation of free-surface flows, multigrid methods and parallel computing, are also covered. Since CFD is a very broad field, we provide fundamental methods and ideas, with some illustrative examples, upon which more advanced techniques are built. Numerical accuracy and estimation of errors are important aspects and are discussed in many examples. Computer codes that include many of the methods described in the book can be obtained online. This 4th edition includes major revision of all chapters; some new methods are described and references to more recent publications with new approaches are included. Former Chapter 7 on solution of the Navier-Stokes equations has been split into two Chapters to allow for a more detailed description of several variants of the Fractional Step Method and a comparison with SIMPLE-like approaches. In Chapters 7 to 13, most examples have been replaced or recomputed, and hints regarding practical applications are made. Several new sections have been added, to cover, e.g., immersed-boundary methods, overset grids methods, fluid-structure interaction and conjugate heat transfer.
This classic text has been extensively updated and restructured to use the "problems" approach which analyzes underlying, conflicting public policies and the legal solutions for those problems. It continues to be the helpful one-volume overview of healthcare law that it and its predecessor, Problems in Hospital Law, have been since 1968. Topics covered include: organizational, physical, and staffing resources; relationships with patients including both medical decision-making issues and the handling of medical information; financing of health care services; and liability issues.
The second edition of the Handbook of Organizational Consultation includes more than 35 additional chapters and an expanded list of international contributors. It addresses all aspects of organizational consulting, including normative, empirical and political topics - and offers a broad view of consultation diagnoses, problem centers, and interventions. Perspectives on Political Science said this book is a reference guide, training handbook, and practitioner's tool [that] .stand[s] alone as a comprehensive source of information and guidance on the consultancy enterprise. . ..a careful reading of this book will be a profitable endeavor for both consulting practitioners and their clients.
#1 NATIONAL BESTSELLER. The definitive insider's account of American policy making in Vietnam. "Can anyone remember a public official with the courage to confess error and explain where he and his country went wrong? This is what Robert McNamara does in this brave, honest, honorable, and altogether compelling book."—Arthur Schlesinger, Jr. Written twenty years after the end of the Vietnam War, former Secretary of Defense Robert McNamara's controversial memoir answers the lingering questions that surround this disastrous episode in American history. With unprecedented candor and drawing on a wealth of newly declassified documents, McNamara reveals the fatal misassumptions behind our involvement in Vietnam. Keenly observed and dramatically written, In Retrospect possesses the urgency and poignancy that mark the very best histories—and the unsparing candor that is the trademark of the greatest personal memoirs. Includes a preface written by McNamara for the paperback edition.
The Pulitzer Prize–winning author “shares his insights into—and passion for—the creation and experience of fiction with total openness” (Publishers Weekly, starred review). Robert Olen Butler, author of Perfume River, A Good Scent from a Strange Mountain, and A Small Hotel, teaches graduate fiction at Florida State University—his version of literary boot camp. In From Where You Dream, Butler reimagines the process of writing as emotional rather than intellectual, and tells writers how to achieve the dreamspace necessary for composing honest, inspired fiction. Proposing that fiction is the exploration of the human condition with yearning as its compass, Butler reinterprets the traditional tools of the craft using the dynamics of desire. Offering a direct view into the mind and craft of a literary master, From Where You Dream is an invaluable tool for the novice and experienced writer alike. “Incisive and provocative, Butler’s tutorials are a must for anyone even thinking about writing fiction, and readers, too, will benefit from his passionate exhortations.” —Booklist
Editors Robert Sawyer and Tracy Hedrick and authors review the latest in Surgical Infections. Articles will include Bloodstream Infections and Central Line-Associated Bloodstream Infections; Surgical Intervention for Thoracic Infections; Intra-abdominal Infections; Clostridium difficile infection; Urinary Tract Infections; Surgical Site Infections; Prosthetic Joint Infections; Resistant Pathogens, Fungi, and Viruses; Infection Control in the Intensive Care Unit; Pneumonia; Differences Between Murine and Human sepsis; of the intestinal Microbiome and the emerging pathobiome; Advancing Technologies for the Diagnosis and Management of Infections; Upcoming Rules and Benchmarks Affecting the Monitoring and Payment for Surgical Infections; and more!
2014 BMA Medical Book Awards Highly Commended in Radiology category! Image-Guided Interventions, a title in the Expert Radiology Series, brings you in-depth and advanced guidance on all of today?s imaging and procedural techniques. Whether you are a seasoned interventionalist or trainee, this single-volume medical reference book offers the up-to-the-minute therapeutic methods necessary to help you formulate the best treatment strategies for your patients. The combined knowledge of radiology experts from around the globe provides a broad range of treatment options and perspectives, equipping you to avoid complications and put today's best approaches to work in your practice. "... the authors and editors have succeeded in providing a book that is both useful, instructive and practical" Reviewed by RAD Magazine, March 2015 Formulate the best treatment plans for your patients with step-by-step instructions on important therapeutic radiology techniques, as well as discussions on equipment, contrast agents, pharmacologic agents, antiplatelet agents, and protocols. Make effective clinical decisions with the help of detailed protocols, classic signs, algorithms, and SIR guidelines. Make optimal use of the latest interventional radiology techniques with new chapters covering ablation involving microwave and irreversible electroporation; aortic endografts with fenestrated grafts and branch fenestrations; thoracic endografting (TEVAR); catheter-based cancer therapies involving drug-eluting beads; sacroiliac joint injections; bipedal lymphangiography; pediatric gastrostomy and gastrojejunostomy; and peripartum hemorrhage. Know what to look for and how to proceed with the aid of over 2,650 state-of-the-art images demonstrating interventional procedures, in addition to full-color illustrations emphasizing key anatomical structures and landmarks. Quickly reference the information you need through a functional organization highlighting indications and contraindications for interventional procedures, as well as tables listing the materials and instruments required for each. Access the fully searchable contents, online-only material, and all of the images online at Expert Consult.
This book is about adaptive mesh generation and moving mesh methods for the numerical solution of time-dependent partial differential equations. It presents a general framework and theory for adaptive mesh generation and gives a comprehensive treatment of moving mesh methods and their basic components, along with their application for a number of nontrivial physical problems. Many explicit examples with computed figures illustrate the various methods and the effects of parameter choices for those methods. Graduate students, researchers and practitioners working in this area will benefit from this book.
Shook and Farber invite eager entrepreneurs to join 33 of today’s business and sales best as they share the details behind their greatest sales moves and ultimately, impart valuable lessons on how to sell your way to success. Crafted to cover a variety of industries, products, and services, this entertaining playbook urges entrepreneurs to reinvent their sales approach, illustrating proven techniques, tips, and tricks in each story and summarizing the unique take-away offered by its teller. Entrepreneurs uncover such pearls as how to ignite creativity to overcome sale barriers, how to create long-term customers, and how to sell what the customer wants (hint: it’s not always a product or service). Entrepreneurs also gain invaluable insight and encouragement as they turn from story to story, leaving the pages with lessons learned and the excitement of being privy to an exchange among the elite in their industry.
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