Iron is of fundamental importance to the growth, development and well-being of almost all living organisms. Multiple biological systems have evolved for the uptake, utilisation, storage, and homeostasis of iron in microbes, plants and mammals. Both iron deficiency and iron overload are found extensively in humans; the intimate links between iron and oxidative stress are associated with a wide range of pathologies. Iron has a well established role in infections by a range of microorganisms and parasites. Other metals such as copper and zinc are also closely linked with iron metabolism. Iron overloads and deficiencies are important factors in the health of humans and are therefore a key target in drug development. Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, 3rd Edition presents a comprehensive overview of this important field.Topics covered include: Solution chemistry of iron in biological media The importance of iron for biological systems Microbial iron transport and metabolism Iron uptake by plants and fungi Cellular iron uptake and export in mammals Intracellular iron storage and biomineralization Intracellular iron metabolism and cellular iron homeostasis Iron absorption in mammals, with particular reference to man, and regulation of systemic iron balance Pathophysiology of iron deficiency and iron overload in man Iron and oxidative stress Brain iron homeostasis and its perturbation in various neurodegenerative diseases Interactions between iron and other metals Written in a lively style by one of the leaders in the field and presented in full colour, this third, expanded edition of Iron Metabolism has been fully updated with the latest discoveries. Major additions include recent information on mitochondrial iron metabolism and the role of frataxin; transcriptional control of iron homeostasis; orally active iron chelators; the roles of hepcidin and erythropoietin; the increasing number of types of iron overload; and the importance of iron in Alzheimer’s disease. Iron Metabolism is essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and the medical sciences. It will also find space on the bookshelves of bioinorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, and pharmacologists in the pharmaceutical industry interested in developing novel iron-binding drugs.
Written by well-known experts in a reader-friendly style, this is the only book to focus specifically on post-surgical guidelines for successful rehabilitation of the knee and shoulder for sports patients. Content covers basic concepts related to soft tissue healing, as well as core concepts in sports medicine rehabilitation, all of which lay the groundwork for discussions of specific protocols. Detailed descriptions of the latest post-surgical procedures for various knee and shoulder pathologies equip readers with essential knowledge needed to recommend the most effective treatment plans. Includes a separate section on multiple ligament knee injuries. Numerous photos and radiographs of topics discussed in the text serve as excellent visual references in the clinical setting. Detailed descriptions of the most current surgical protocols for various knee and shoulder pathologies help readers recommend the best treatment based on proven rehabilitation plans. The inflammatory response is described, with regard to its role in soft tissue healing following surgical procedures of the knee and shoulder. Protocols based on the most recent research available promotes evidence-based practice. A chapter on rotator cuff injuries includes authoritative, up-to-date information on this topic. A chapter on cartilage replacement focuses on the "nuts and bolts" of rehabilitation for this common injury, offering current, hands-on information about one of the fastest changing treatment protocols. Contributors are expert therapists and physicians - respected leaders in their field. Each chapter highlights post-op guidelines and protocols in a consistent format that's immediately accessible and easy to reference. Comprehensive information on soft tissue healing is presented. A separate section on multiple ligament knee injuries presents hard-to-find information that's rarely covered in other resources or literature.
A reprint of the 1973 biography of the American inventor. Divided into pre-telephone, telephone, and post-telephone sections, also covers his work with the Smithsonian, the deaf, the National Geographic Society, and Science magazine. Paper edition ($12.95) not seen. Annotation copyrighted by Book News, Inc., Portland, OR
Refined in detail through three editions, the manuals outstanding features include: an explanation of keys and how to use them; the inclusion of keys designed to identify by order or family extant mammals of the world; special sections containing comments and suggestions on identification; information on working with map coordinates and global positioning receivers; coverage of the use of computer programs to get estimates of home-range size and characteristics; and ideas for locating reliable, authoritative literature on mammals. A section on techniques for studying mammals in the field and in the laboratory rounds out this student-friendly learning tool. Beautifully wrought illustrations and diagrams accurately portray visual details of mammal groups or characteristics that are unavailable to study in person. Moreover, well-designed laboratory exercises provide opportunities to apply knowledge and master understanding.
Endosonography—by Drs. Robert H. Hawes, Paul Fockens, and Shyam Varadarjulu—is a rich visual guide that covers everything you need to effectively perform EUS, interpret your findings, diagnose accurately, and choose the best treatment course. World-renowned endosonographers help beginners apply endosonography in the staging of cancers, evaluating chronic pancreatitis, and studying bile duct abnormalities and submucosal lesions. Practicing endosonographers can learn cutting-edge techniques for performing therapeutic interventions such as drainage of pancreatic pseudocysts and EUS-guided anti-tumor therapy. This updated 2nd edition features online access to the fully searchable text, videos detailing various methods and procedures, and more at www.expertconsult.com. You’ll have a complete overview of all aspects of EUS, from instrumentation to therapeutic procedures. Gain a detailed visual understanding on how to perform EUS using illustrations and high-quality images. Understand the role of EUS with the aid of algorithms that define its place in specific disease states. Locate information quickly and easily through a consistent chapter structure, with procedures organized by body system. Access the fully searchable text online at www.expertconsult.com, along with 60 procedural video clips, 300 downloadable PowerPoint slides, and 400 downloadable images, and regular updates reflecting the latest findings. Stay abreast of the most recent studies thanks to downloadable tables that summarize new information, updated on a quarterly basis. Master the technique of systematically performing EUS, then download the hundreds of slides and videos available online to teach and train the newer generation of endoscopists. Find coverage relevant to your needs with detailed chapters, illustrations, and videos on how to perform EUS for the beginner; a new section on international EUS and technical tips on how to handle difficult FNAs for the advanced user; a totally revised chapter on cytopathology for the pathologist; and a chapter on EBUS and EUS dedicated to the mediastinum for the pulmonologist. Get a clear overview of everything you need to know to establish an endoscopic practice, from what equipment to buy to providing effective cytopathology service. Tap into the expertise of world-renowned leaders in endosonography, Drs. Robert H. Hawes, Paul Fockens, and Shyam Varadarajulu.
The mythological, folkloric, and religious beliefs of Western culture have resulted in a long and ongoing history of esoteric themes in theatre from the Middle Ages to the present in Spain and the America. Now Robert Lima, a noted comparatist, brings to bear on this material his wide knowledge of the world of the occult. Lima defines the terms "occult" and "occultism" broadly to embrace the many ways in which humans have sought to fathom a secret knowledge held to be accessible only through such supernatural agencies as alchemy, angelology, asceticism, astrology, demonolatry, divination, ecstasy, magic, necromancy, possession, Santeria, séances, voudoun, and witchcraft. The dramatic works covered range from medieval materializations of Hell to the Golden Age plays of Lope de vega, Tirso de Molina, and Calderón de la Barca, to modern stage works by Valle-Inclán, García Lorca, Casona, Miras, and a number of significant Afro-Brazilian and Caribbean dramatists. The concluding comprehensive bibliography of the drama of the occult is invaluable.
Since its revolutionary first edition in 1983, Rosen's Emergency Medicine set the standard for reliable, accessible, and comprehensive information to guide the clinical practice of emergency medicine. Generations of emergency medicine residents and practitioners have relied on Rosen’s as the source for current information across the spectrum of emergency medicine practice. The 9th Edition continues this tradition of excellence, offering the unparalleled clarity and authority you’ve come to expect from the award-winning leader in the field. Throughout the text, content is now more concise, clinically relevant, and accessible than ever before – meeting the needs of today’s increasingly busy emergency medicine practitioner. Delivers clear, precise information, focused writing and references; relevant, concise information; and generous use of illustrations provide definitive guidance for every emergency situation. Offers the most immediately relevant content of any emergency medicine reference, providing diagnostic and treatment recommendations with clear indications and preferred actions. Presents the expertise and knowledge of a new generation of editors, who bring fresh insights and new perspectives to the table. Includes more than 550 new figures, including new anatomy drawings, new graphs and algorithms, and new photos. Provides diligently updated content throughout, based on only the most recent and relevant medical literature. Provides improved organization in sections to enhance navigation and six new chapters: Airway Management for the Pediatric Patient; Procedural Sedation and Analgesia for the Pediatric Patient; Drug Therapy for the Pediatric Patient; Co-Morbid Medical Emergencies During Pregnancy; Drug Therapy in the Geriatric Patient; and Global and Humanitarian Emergency Medicine. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
Stress and Immunity introduces and updates the status of research on stress and immunity. Clinical aspects of stress and immunity are presented in the first 17 chapters and include discussions regarding the influence of depression disorders on immune functions and stress interrelationships with cancer, AIDS, Chronic Fatigue Syndrome, and Herpes Simplex infections. There is also a review of physical exercise and immunity. The second half of the book is devoted to discussions regarding basic research being conducted in the field of stress and immunity. This includes discussions on the interrelationships of the central nervous system and the immune system and research on stress hormones (e.g., enkephalins, endorphins) as they interrelate with the immune system. In addition, animal models for the study of stress and immunity are discussed. Psychiatrists, neurologists, psychologists, clinical psychologists, internists, immunologists, and researchers in psychosomatic disorders should consider this an essential reference volume.
Merrill, who urged a unique vision of reality that shaped a Mormon eschatology. He shows how authorities eventually retreated from the perception of reality as "true" and adopted a scientifically less secure position in order to protect their theology, an eventuality which ultimately resulted in a reactionary response to science within Mormonism.
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