Robert D. Duval's Books

Bootstrapping

A Nonparametric Approach to Statistical Inference

By: Christopher Z. Mooney,Robert D. Duval,Robert Duvall

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Bootstrapping

A Nonparametric Approach to Statistical Inference

By: Christopher Z. Mooney,Robert D. Duval,Robert Duvall

This book is. . . clear and well-written. . . anyone with any interest in the basis of quantitative analysis simply must read this book. . . . well-written, with a wealth of explanation. . ." --Dougal Hutchison in Educational Research Using real data examples, this volume shows how to apply bootstrapping when the underlying sampling distribution of a statistic cannot be assumed normal, as well as when the sampling distribution has no analytic solution. In addition, it discusses the advantages and limitations of four bootstrap confidence interval methods--normal approximation, percentile, bias-corrected percentile, and percentile-t. The book concludes with a convenient summary of how to apply this computer-intensive methodology using various available software packages.

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SAGE

Published Date

ISBN 10

080395381X

ISBN 13

9780803953819

Integration of Metabolism, Energetics, and Signal Transduction

Unifying Foundations in Cell Growth and Death, Cancer, Atherosclerosis, and Alzheimer Disease

By: Robert K. Ockner

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Integration of Metabolism, Energetics, and Signal Transduction

Unifying Foundations in Cell Growth and Death, Cancer, Atherosclerosis, and Alzheimer Disease

By: Robert K. Ockner

Complex and unexplained phenomena tend to foster unorthodox perspectives. This publication is an example, as is a prior publication that emphasized the concept that intermediary metabolism might play a significant and determining role in hepatocyte proliferation and 1 tumorigenesis. Formulation of this hypothesis was based on an attempt to clarify several poorly understood phenomena; including the observations: 1) that xenobiotic peroxisome proliferators such as the fibrate hypolipidemic agents induce hepatocyte proliferation and carcinogenesis in rodents; 2) that benign and malignant liver tumors complicate the human syndrome of glycogen storage disease type I (glucose-6-phosphatase deficiency); and 3) that in this same syndrome, administration of glucose exerts an anti-tumor effect. Fatty acid and glucose metabolism are tightly linked in a we- established and profoundly inportant interplay. This connection, together with the fact that peroxisome proliferator-induced hepatocyte proliferation and carcinogenesis reflects inhibition of mitochondrial carnitine palmitoyltransferase-I and fatty acid oxidation, suggested the possibility that regulation of fatty acid metabolism could prove to be a pivotal determinant in the control of cell growth. In 1993, the year in which the paper cited above was published, insight into the importance of growth factors and signal transduction pathways in cell cycle regulation was increasing rapidly, but metabolic and energetic aspects of cell proliferation had attracted relatively little attention. Despite this, the concept seemed inescapable that the two seemingly distinct and unrelated determinants — signal transduction and metabolism — were integrally linked.

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393

Publisher

Springer Science & Business Media

Published Date

ISBN 10

030648529X

ISBN 13

9780306485299

Local Electrode Atom Probe Tomography

A User's Guide

By: David J. Larson,Ty J. Prosa,Robert M. Ulfig,Brian P. Geiser,Thomas F. Kelly

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Local Electrode Atom Probe Tomography

A User's Guide

By: David J. Larson,Ty J. Prosa,Robert M. Ulfig,Brian P. Geiser,Thomas F. Kelly

This book is the first, single-source guide to successful experiments using the local electrode atom probe (LEAP®) microscope. Coverage is both comprehensive and user friendly, including the fundamentals of preparing specimens for the microscope from a variety of materials, the details of the instrumentation used in data collection, the parameters under which optimal data are collected, the current methods of data reconstruction, and selected methods of data analysis. Tricks of the trade are described that are often learned only through trial and error, allowing users to succeed much more quickly in the challenging areas of specimen preparation and data collection. A closing chapter on applications presents selected, state-of-the-art results using the LEAP microscope.

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328

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Springer Science & Business Media

Published Date

ISBN 10

1461487218

ISBN 13

9781461487210

Book's by Robert D. Duval

Bootstrapping

Bootstrapping

Integration of Metabolism, Energetics, and Signal Transduction

Integration of Metabolism, Energetics, and Signal Transduction

Local Electrode Atom Probe Tomography

Local Electrode Atom Probe Tomography

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