CYBER JACK chronicles Robert Clardy's adventures throughout his self-made career as a computer programmer. He shares business advice, humorous stories, and insightful experiences of creating and expanding Synergistic Software - a company best-known for popular computer games for the Apple II, Atari, IBM PC, Commodore 64, Commodore Amiga, and Mac. Clardy had fun along the way.... Robert Clardy says, "In these days where people are living longer and perhaps finding alternate work after they have officially retired, I have come to believe that the only essential difference between employment and retirement is whether you are being paid to do what others tell you to do, or you are following your own personal passion whether it pays the bills or not. By this measure, I first retired when I was 26. I'd like to share how that can be done if you are lucky enough to live at the right time and are able to take the leap when the moment appears. I have been very fortunate.
Synergistic Software, founded by Robert C. Clardy, established itself as a computer game company in 1978 and produced more than 160 titles over the next 20 years, encompassing games, business, educational, and utility software. This book focuses on Synergistic's early games for the Apple II computer, and includes 17 enhanced retro game manuals. As a bonus, Clardy shares detailed insights into what makes a good computer game and the programming challenges he experienced. Apple II game manuals included are: Apventure to Atlantis, Bolo, Crisis Mountain, Death Run, Doom Cavern, Dungeon Campaign, Escape From Arcturus, Microbe, Nightmare Gallery, Odyssey, Procyon Warrior, Sorcerer's Challenge, Tank Attack, U-Boat Command, and Wilderness Campaign. Additionally, two manuals for the Atari 800 are included: Probe One and Warlock's Revenge.
In a dramatic change of role, the noted television and film star has written a vivid and incisive account of the House Committee on Un-American Activities' probe of the entertainment industry from 1938 to 1958. Formed to investigate alleged subversives, by the late fifties the committee had succeeded in ruining the careers and sometimes the lives of many of Hollywood and Broadway's top writers and performers. Quoting generously from transcripts of its hearings, Vaughn shows how the committee's primary purpose was punitive rather than legislative, and concludes that its most serious damage to American theatre and film is not easily documented: the loss of all the words never written or spoken because of the impact - and the fear - of the committee's misdeeds.
Organizations matter. Most people spend a third to a half of their lives working in organizations. Given the high rates of unemployment people also spend more time looking for work. In addition, globalization and technological innovation continues to profoundly shape organizational culture, leadership, demography, and structure. For these and many other reasons, it is important for individuals to understand the nature of contemporary organizations. "Psychology and Systems at Work" provides know-how for retaining commitment to collective goals while taping the knowledge of a diverse workforce for riding the waves of change, utilizing mistakes to perfect systems, and insuring quality production. 21st Century theory, empirical findings, systemic intervention processes, and tool sets are thoroughly treated. Organizational life goes through times of relative harmony disrupted by periods of stress and uncertainty. However, in our own many decades of experience, we’ve been pleasantly surprised at how well people face challenges, defy the odds, and triumph. Success is the result of many factors—including good luck. But we have noticed, as Louis Pasteur observed long ago, that chance favors the prepared mind and resilient work habits. Learning Goals Upon completing this book, readers should be able to: Design systems that are flexible in a fast-changing environment Understand the basic foundations that shape organizational behavior Apply material they learn to real-life scenarios
The grass-roots Populist movement that swept rural America a century ago millions of farmers and clusters of non-farmers into a powerful crusade to reshape the nation's political economy by ushering in a "cooperative commonwealth" to reverse the growth of America's monopoly capitalism. McMath crisply interprets the development of the Populist crusade from its early beginnings in the turbulent 1870s to its ultimate demise, and places it in a larger context as he compares it to later, parallel movements in the Great Plains and Canada.
Many national parks and monuments tell unique stories of the struggle between the rights of native peoples and the wants of the dominant society. These stories involve our greatest parks—Yosemite, Yellowstone, Mesa Verde, Glacier, the Grand Canyon, Olympic, Everglades—as well as less celebrated parks elsewhere. In American Indians and National Parks, authors Robert Keller and Michael Turek relate these untold tales of conflict and collaboration. American Indians and National Parks details specific relationships between native peoples and national parks, including land claims, hunting rights, craft sales, cultural interpretation, sacred sites, disposition of cultural artifacts, entrance fees, dams, tourism promotion, water rights, and assistance to tribal parks. Beginning with a historical account of Yosemite and Yellowstone, American Indians and National Parks reveals how the creation of the two oldest parks affected native peoples and set a pattern for the century to follow. Keller and Turek examine the evolution of federal policies toward land preservation and explore provocative issues surrounding park/Indian relations. When has the National Park Service changed its policies and attitudes toward Indian tribes, and why? How have environmental organizations reacted when native demands, such as those of the Havasupai over land claims in the Grand Canyon, seem to threaten a national park? How has the Park Service dealt with native claims to hunting and fishing rights in Glacier, Olympic, and the Everglades? While investigating such questions, the authors traveled extensively in national parks and conducted over 200 interviews with Native Americans, environmentalists, park rangers, and politicians. They meticulously researched materials in archives and libraries, assembling a rich collection of case studies ranging from the 19th century to the present. In American Indians and National Parks, Keller and Turek tackle a significant and complicated subject for the first time, presenting a balanced and detailed account of the Native-American/national-park drama. This book will prove to be an invaluable resource for policymakers, conservationists, historians, park visitors, and others who are concerned about preserving both cultural and natural resources.
Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. The 4th edition of Iron Metabolism is written in a lively style by one of the leaders in the field, presented in colour and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.
The purpose of NEURAL MECHANISM in TASTE is to emphasize physiological principles and reveal new insights of this most recent research. This book is aimed to reach scientists within the broad area of neurophysiology as well as those in other disciplines who have interests in sensory mechanisms. The focus is on two major themes--peripheral mechanisms and neural processing at the central level. Every chapter is written by an expert on the subject matter, including definitive updates on the status of each topic. This work is not only useful to researchers in taste, but also to basic and applied scientists in related fields (such as food technology), doctoral and postdoctoral students.
The Evolution of Metabolic Function presents comprehensive discussions on a variety of topics that will interest scientists and students studying the evolution of enzyme activities, the evolution of enzymatic pathways, and the evolution and development of metabolic functions. Laboratory experiments designed to develop new enzyme activities and new metabolic pathways are discussed. The most recent techniques comparing protein and gene structures are used to analyze and discuss the evolution and development of such metabolic functions as the bacterial phosphoenolpyruvate:sugar phosphotransferase system, the mandelate pathway of microorganisms, bacterial alcohol metabolism, and certain microbial amino acid biosynthetic pathways. The book also includes some unique speculations regarding the origin of early Archaean cells and the prebiotic evolution of complex molecules.
From 1980 to 2000, half the new housing in the United States was built in a development project governed by a neighborhood association. More than 50 million Americans now live in these associations. In Private Neighborhoods and the Transformation of Local Government, Robert Nelson reviews the history of neighborhood associations, explains their recent explosive growth, and speculates on their future role in American society. Unlike many previous studies, Nelson takes on the whole a positive view. Neighborhood associations are providing the neighborhood environment controls desired by the residents, high quality common services, and a stronger sense of neighborhood community. Identifying significant operating problems, Nelson proposes new options for improving the future governance of neighborhood associations.
An updated edition of the classic history of schizophrenia in America, which gives voice to generations of patients who suffered through "cures" that only deepened their suffering and impaired their hope of recovery Schizophrenics in the United States currently fare worse than patients in the world's poorest countries. In Mad in America, medical journalist Robert Whitaker argues that modern treatments for the severely mentally ill are just old medicine in new bottles, and that we as a society are deeply deluded about their efficacy. The widespread use of lobotomies in the 1920s and 1930s gave way in the 1950s to electroshock and a wave of new drugs. In what is perhaps Whitaker's most damning revelation, Mad in America examines how drug companies in the 1980s and 1990s skewed their studies to prove that new antipsychotic drugs were more effective than the old, while keeping patients in the dark about dangerous side effects. A haunting, deeply compassionate book -- updated with a new introduction and prologue bringing in the latest medical treatments and trends -- Mad in America raises important questions about our obligations to the mad, the meaning of "insanity," and what we value most about the human mind.
The U.S. Marine Corps’ four-year campaign against al Qaeda in Anbar is a fight certain to take its place next to such legendary clashes as Belleau Wood, Guadalcanal, Peleliu, Iwo Jima, Okinawa, Chosin, and Khe Sanh. Its success, the author contends, constituted a major turning point in the Iraq War and helped alter the course of events and set the stage for the Surge in Baghdad a year later. This book brings to light all the decisive details of how the Marines, between 2004 and 2008, adapted and improvised as they applied the hard lessons of past mistakes. In March 2004, when part of the 1st Marine Expeditionary Force (I MEF) was deployed to Anbar Province in the heart of the Sunni triangle, the Marines quickly found themselves locked in a bloody test of wills with al Qaeda, and a burgeoning violent insurgency. By the spring of 2006, according to all accounts, enemy violence was skyrocketing, while predictions for any U.S. success were plummeting. But at that same time new counterinsurgency initiatives were put in place when I MEF returned for its second tour in Anbar, and the Marines began to gain control. By September 2008 the fight was over. Richard Shultz, a well-known author and international security studies expert, has thoroughly researched this subject. His book effectively argues the case for the Marines changing the course of the war at Anbar, which is contrary to the conventional wisdom that the Surge was the turning point.
This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials – the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of "steroid-like" natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.
Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields— from pharmacology to medicinal chemistry to biophysics to clinical medicine.
ENZYMES A complete and approachable introduction to the study of enzymes, from theory to practice Enzymes catalyze the bulk of important biological processes, both metabolic and biochemical. They are specialized proteins whose function is determined by their structure, understanding which is therefore a key focus of biological, pharmacological, and agrarian research, among many others. A thorough knowledge of enzyme structure, pathways, and mechanisms is a fundamental building block of the life sciences and all others connected to them. Enzymes offers a detailed introduction to this critical subject. It analyzes enzyme proteins at the structural level and details the mechanisms by which they perform their catalyzing functions. The book’s in-depth engagement with primary literature and up-to-date research allows it to continuously deploy illustrative examples and connect readers with further research on key subjects. Fully updated after decades as the standard text, this book unlocks a thriving field of biological and biochemical research. Readers of the third edition of Enzymes will also find: Expanded chapters on steady-state and transient-state enzyme kinetics, structural components of enzymes, and more New chapters on enzyme regulation, enzyme-macromolecule interactions, enzyme evolution, and enzymes in human health Key Learning Points at the beginning of each chapter to assist students and instructors Enzymes promises to continue as the standard reference on this subject for practitioners of the life sciences and related fields in both academia and industry.
The second edition of Fleisher & Ludwig’s 5-Minute Pediatric Emergency Medicine Consult helps anyone working in a busy emergency or urgent care setting diagnose, treat and manage over 500 diseases and common pediatric conditions. You’ll instantly find clear answers—summarized succinctly—on clinical orientation, differential diagnosis, medications, management, discharge criteria and more. Practice guidelines are evidence-based, and the book is formatted for quick reference, double-checking or a 5-minute refresher.
Environmental forensics is the application of scientific techniques for the purpose of identifying the source and age of a contaminant. Over the past several years, this study has been expanding as a course of study in academia, government and commercial markets. The US Environmental Protection Agency (EPA), Federal Bureau of Investigation (FBI), and Federal Emergency Management Agency (FEMA) are among the governmental agencies that utilize the study of environmental forensics to ensure national security and to ensure that companies are complying with standards. Even the International Network for Environmental Compliance and Enforcement (INECE), a group supported by the European Commission and the World Bank, utilizes the study of environmental forensics as it applies to terror threats.This title is a hands-on guide for environmental scientists, engineers, consultants and industrial scientists to identify the origin and age of a contaminant in the environment and the issues involved in the process. An expansion of the authors’ first title with Academic Press, Introduction to Environmental Forensics, this is a state-of-the-art reference for those exploring the scientific techniques available. Up-to-date compendium for referencing forensic techniques unique to particular contaminants. International scientific unit system Contributors from around the world providing international examples and case studies.
Significant as a political, economic, and social organization, the southern Farmers' Alliance was the largest and most influential farmers' organization in the history of the United States until the rise of the American Farm Bureau Federation. McMath suggests that the ideas advanced by the People's party in the 1890s had been incubated within the alliance and that the shared experience of 1.5 million rural Americans helped give those ideas power in the Populist crusade. Originally published 1976. A UNC Press Enduring Edition -- UNC Press Enduring Editions use the latest in digital technology to make available again books from our distinguished backlist that were previously out of print. These editions are published unaltered from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value.
In compiling the third and entirely revised edition of Construction Disputes: Representing the Contractor, the editors have sought out as specialists in their field: contributing authors who are not only experienced in resolving construction disputes but also known and respected for their expertise in specific critical areas commonly encountered in construction litigation. Although intended primarily to assist attorneys, this book also provides a useful desk reference for anyone whose activities touch on long-term contract matters and gives individual contractors a better understanding of how their actions may affect this increasingly important part of operations.
The updated edition of Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas is designed to act as a one-stop medical reference book for the entire gastrointestinal system, providing exhaustive coverage and equipping you with all of the necessary tools to make a comprehensive diagnostic workup. You'll access thousands of high-quality illustrations and eight brand-new chapters, so you can recognize and diagnose any pathological slide you encounter. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Make a comprehensive diagnostic workup with data from ancillary techniques and molecular findings whenever appropriate. Effectively grasp complex topics and streamline decision-making by using extensive tables, graphs, and flowcharts. Avoid diagnostic errors thanks to practical advice on pitfalls in differential diagnosis. Navigate the book quickly with a "road map" featured at the beginning of each chapter. Provide the clinician with the most accurate and up-to-date diagnostic and prognostic indicators, including key molecular aspects of tumor pathology, with access to the latest classification and staging systems available. Evaluate diagnostically challenging cases using diagnostic algorithms. Stay abreast of the latest advances with eight new chapters: Autoimmune Disorders of the GI Tract; Drug Induced Disorders of the GI Tract; Molecular Diagnostics of Tubal Gut Neoplasms; Molecular Diagnostics of the Gallbladder, Extrahepatic Biliary Tree, and Pancreatic Tumors; Tumors of the Ampulla; Molecular Diagnostics of Hepatocellular Neoplasms; Approach to the Liver Biopsy, and Approach to Gastrointestinal Tract Biopsies. Remain at the forefront of your field with coverage of new molecular and genetic markers in GI neoplasms; updated knowledge on liver and biliary tree pathology; and expanded information on tumors of the ampulla. Recognize and diagnose any tissue sample under the microscope with help from over 3000 high-quality color illustrations.
The Mature Market provides the guidance needed to tap the lucrative senior market and attract the formidable spending power of mature customers. It contains ideas and information to help fine tune marketing strategy and improve advertising results on products and services targeted to seniors. The book segments the over-50 population into target markets defined by usage and lifestyle — the young-old in their 50's, the active seniors in their 60's and early 70's, and the elderly 75 and over.In addition, The Mature Market is a single-volume sourcebook with charts, tables, lists of senior publications and mailing list sources, and other practical and timely information to help win the 62 million senior consumers.
This book provides the "nuts and bolts" background for a successful study of carbohydrates - the essential molecules that not only give you energy, but are an integral part of many biological processes.A question often asked is 'Why do carbohydrate chemistry?' The answer is simple: It is fundamental to a study of biology. Carbohydrates are the building blocks of life and enable biological processes to take place.Therefore the book will provide a taste for the subject of glycobiology.Covering the basics of carbohydrates and then the chemistry and reactions of carbohydrates this book will enable a chemist to gain essential knowledge that will enable them to move smoothly into the worlds of biochemistry, molecular biology and cell biology. Includes perspective from new co-author Spencer Williams, who enhances coverage of the connection between carbohydrates and life Describes the basic chemistry and biology of carbohydrates Reviews the concepts, synthesis, reactions, and biology of carbohydrates
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