Some people you live with for years and go on to have thought you had known them all your life, yet you never knew who they really were. Yes, they were your mom and dad. Dad was like that, a very quiet but an intelligent man. He was a great provider for his family. Mom was more open in her puzzle pieces of life. I am still trying to put together those pieces to understand and see the big picture of two people whom I called my parents. With the plethora of information and documentation I found after my dad’s death in his war cedar chest, I now know who he was and maybe why he was such a quiet man. Knowing this information before his death might have brought us closer together. As the saying goes, you often find out more about a person after they have died. Why is that?
One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100 percent effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common.The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anti-cancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance. Studies on mechanisms of cancer drug resistance have yielded important information on how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs.
Even as the media environment has changed dramatically in recent years, one thing at least remains true: photographs are everywhere. From professional news photos to smartphone selfies, images have become part of the fabric of modern life. And that may be the problem. Even as photography bears witness, it provokes anxieties about fraudulent representation; even as it evokes compassion, it prompts anxieties about excessive exposure. Parents and pundits alike worry about the unprecedented media saturation that transforms society into an image world. And yet a great news photo can still stop us in our tracks, and the ever-expanding photographic archive documents an era of continuous change. By confronting these conflicted reactions to photography, Robert Hariman and John Louis Lucaites make the case for a fundamental shift in understanding photography and public culture. In place of suspicions about the medium’s capacity for distraction, deception, and manipulation, they suggest how it can provide resources for democratic communication and thoughtful reflection about contemporary social problems. The key to living well in the image world is to unlock photography from viewing habits that inhibit robust civic spectatorship. Through insightful interpretations of dozens of news images, The Public Image reveals how the artistry of the still image can inform, challenge, and guide reflection regarding endemic violence, environmental degradation, income inequity, and other chronic problems that will define the twenty-first century. By shifting from conventional suspicions to a renewed encounter with the image, we are challenged to see more deeply on behalf of a richer life for all, and to acknowledge our obligations as spectators who are, crucially, also citizens.
Molecular Biology, 4/e by Robert Weaver, is designed for an introductory course in molecular biology. Molecular Biology 5/e focuses on the fundamental concepts of molecular biology emphasizing experimentation. In particular author, Rob Weaver, focuses on the study of genes and their activities at the molecular level. Through the combination of excellent illustrations and clear, succinct writing students are presented fundamental molecular biology concepts.
The Bidwell-Bartleson party may have been generally forgotten, but the group was the first true emigrant train to cross South Pass. If the memories of these men has dimmed, the road they followed has not, for the route is one of the most famous in the history of human migration-the Oregon Trail. Saleratus & Sagebrush chronicles the journeys of these and many other emigrants on the trails west. Robert Munkres relates the stories about the famous and indispensable Fort Bridger and Fort Laramie, the fork in the road at Soda Springs, women's lives on the trail, the family dog, and tales of Indians, friendly and not-so-friendly are richly enhanced by photographs and several reproductions of works by William Henry Jackson.
Modern Labor Economics: Theory and Public Policy, now in its thirteenth edition, continues to be the leading text for one-semester courses in labor economics at the undergraduate and graduate levels. It offers a thorough overview of the modern theory of labor market behavior, and reveals how this theory is used to analyze public policy. Designed for students who may not have extensive backgrounds in economics, the text balances theoretical coverage with examples of practical applications that allow students to see concepts in action. Experienced educators for nearly four decades, co-authors Ehrenberg and Smith believe that showing students the social implications of the concepts discussed in the course will enhance their motivation to learn. As such, this text presents numerous examples of policy decisions that have been affected by the ever-shifting labor market. This new edition continues to offer: a balance of relevant, contemporary examples; coverage of the current economic climate; introduction to basic methodological techniques and problems; tools for review and further study. In addition to providing updated data and examples throughout, the thirteenth edition offers greater coverage of inequality, healthcare policy, and labor-replacing technologies. The text is also supported by a full range of companion online materials.
The first history of the dramatic civil rights battles fought by the National Association for the Advancement of Colored People (NAACP) in the 1920s, struggles that paved the way for advances made in the 1950s and 1960s.
During the 1920s a new generation of American sociologists tried to make their discipline more objective by adopting the methodology of the natural sciences. Robert Bannister provides the first comprehensive account of the emergence of this "objectivism" within the matrix of the evolutionism of Lester Ward and other founders of American sociology. Objectivism meant confining inquiry to the observable externals of social behavior and quantifying the results. Although objectivism was a marked departure from the theoretical and reformist sociology of the prewar years, and caused often-fierce intergenerational struggle, sociological objectivism had roots deep in prewar sociology. Objectivism first surfaced in the work of sociology's "second generation," the most prominent members of which completed their graduate work prior to World War I. It gradually took shape in what may be termed "realist" and "nominalist" variants, the first represented by Luther Lee Bernard and the second by William F. Ogburn and F. Stuart Chapin. For Bernard, a scientific sociology was radical, prescribing absolute standards for social policy. For Ogburn and Chapin, it was essentially statistical and advisory in the sense that experts would concern themselves exclusively with means rather than ends. Although the objectivists differed among themselves, they together precipitated battles within the American Sociological Society during the 1930s that challenged the monopoly of the Chicago School, paving the way for the informal alliance of Parsonian theorists and a new generation of quantifiers that dominated the profession throughout the 1950s. By shedding new light on the careers of Ward and the other founders and by providing original accounts of the careers of the leading objectivists, Bannister presents a unique look at the course of sociology before and after World War I. He puts theory formation in an institutional, ideological, and biographical setting, and thus offers an unparalleled look at the formation of a modern academic profession.
An essential resource for both students and practitioners, this comprehensive text provides practical, up-to-date information about normal reproduction and reproductive disorders in horses, cattle, small ruminants, swine, llamas, and other livestock. Featuring contributions from experts in the field, each section is devoted to a different large animal species and begins with a review of the clinically relevant aspects of the reproductive anatomy and physiology of both males and females. Key topics include the evaluation of breeding soundness, pregnancy diagnosis, diagnosis and treatment of infertility, abortion, obstetrics, surgery of the reproductive tract, care of neonates, and the latest reproductive technology. Includes coverage of all large animal species. All sections provide a review of clinically pertinent reproductive physiology and anatomy of males and females of each species. Complete coverage of the most current reproductive technology, including embryo transfer, estrous synchronization, and artificial insemination. A new section on alternative farming that addresses reproduction in bison, elk, and deer. New to the equine section: stallion management, infertility, and breeding soundness evaluation. New to the bovine section: estrous cycle synchronization, reproductive biotechnology, ultrasonographic determination of fetal gender, heifer development, and diagnosis of abortion. New to the porcine section: artificial insemination, boar/stud management, diseases of postpartum period, and infectious disease control. New to the llama section: infectious disease and nutrition.
For many years, physicians and the public assumed that the discovery of new antimicrobial agents would outpace the ability of bacteria to mutate and develop drug resistance. Yet the development of new antibiotics has not kept up with bacterial evolution, especially since the late 1990’s. At that time a multitude of pharmaceutical companies abandoned antibiotic research because of strong economic disincentives. For example, it is challenging for these companies to recuperate the investment (typically in the hundreds of millions of dollars) made in developing a new antibiotic, which is typically prescribed for a few days, compared to drugs that treat chronic conditions like heart disease or mental illness. This situation has led the U.S. federal government to take a more active lead in addressing antibiotic resistance. Recently, the White House announced an action plan that includes improving surveillance, developing better diagnostic tools, accelerating drug development, and improving global coordination of antibiotic resistance issues. Equally important is the $1.2 billion dollars that has been pledged to fund these efforts. While we await the implementation of new policies, this issue of Infectious Disease Clinics of North America brings together leading authorities in the field of antibiotic resistance who discuss current issues including antibiotic stewardship, the changing role of the microbiology laboratory in determining antibiotic resistance in gram-negative pathogens, the continuing spread of metallo-β-lactamases, ESBLs and KPCs, antibiotic options for treating resistant gram-negative infections such as colistin and tigecycline, resistance mechanisms and new treatment options for Mycobacterium tuberculosis, emerging resistance mechanisms in aminoglycosides, issues with antibiotic resistance in immunocompromised patients, new β-lactamase inhibitors in the clinic, and resistance in VRE and Staphylococcus aureus. Additionally, combination therapy for resistant gram-negative infections has been advocated by some authorities and the advantages and disadvantages of this strategy will be reviewed.
Modern Labor Economics: Theory and Public Policy, now in its fourteenth edition, continues to be the leading text for one-semester courses in labor economics at the undergraduate and graduate levels. It offers a thorough overview of the modern theory of labor market behavior and reveals how this theory is used to analyze public policy. Designed for students who may not have extensive backgrounds in economics, the text balances theoretical coverage with examples of practical applications that allow students to see concepts in action. The authors believe that showing students the social implications of the concepts discussed in the course will enhance their motivation to learn. Consequently, this text presents numerous examples of policy decisions that have been affected by the ever-shifting labor market. This new edition continues to offer the following: a balance of relevant, contemporary examples coverage of the current economic climate an introduction to basic methodological techniques and problems tools for review and further study This fourteenth edition presents updated data throughout and a wealth of new examples, such as the impact of COVID-19 lockdowns, gig work, nudges, monopsony power in the technology industry, and the effect of machine learning on inequality. Supplementary materials for students and instructors are available on the book’s companion website.
Unparalleled in scope and content, Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas provides the most relevant and up-to-date clinical, etiologic, molecular, and therapeutic management information for surgical pathologists in training and in practice. The fully revised 4th Edition of this award-winning title offers a wealth of information in this fast-changing field, including recent advances in molecular biology and immunohistochemistry, in a clearly written, well-structured manner that is easy to read and navigate. This one-stop reference for the entire gastrointestinal system enables you to improve turnaround time when diagnosing a specimen and to clearly report on the prognosis and therapeutic management options to surgical and medical colleagues. Covers the latest developments in molecular technologies and immunohistochemical markers to provide useful diagnostic and prognostic information and inform therapeutic decisions. Provides all the necessary tools to make a comprehensive diagnostic workup, including data from ancillary techniques and molecular findings whenever appropriate. Incorporates more than 3000 high-quality color illustrations to help you recognize and diagnose any tissue sample under the microscope. Reviews next-generation sequencing (NGS) to help identify targetable mutations in gastrointestinal tract tumors and provide more accurate classification and precision therapies. Features extensive tables, graphs, and flowcharts to help you effectively grasp complex topics and streamline your decision-making. Helps you avoid diagnostic errors with practical advice on pitfalls in differential diagnosis. Incorporates the latest WHO guidelines throughout. Winner of the 2015 BMA Medical Book Awards First Prize Award in Pathology.
Global warming and climate change present complex interlocking issues of public policy, multilateral negotiation, and technological advancement. This book explores both the problems and the opportunities presented by international agreements, and examines the technological developments and policy goals that can be pursued to effect the changes necessary. Specific steps are proposed in the form of a list of priorities. This book represents a cooperative enterprise between two authors of different backgrounds - engineering and international relations - and is directed to an educated but non-professional lay audience without any formal training in either science or international relations. The points of view of negotiators from both developed and developing nations are presented and compared. Each topic is presented from both technical and policy perspectives as a means to evaluate the variety of proposals that have been offered as remedies to global warming. The text is supported by illustrations and tables where appropriate, including a list of References at the end of each chapter.
This comprehensive study of African American politics since the civil rights era concludes that the black movement has been co-opted, marginalized, and almost wholly incorporated into mainstream institutions.
Recent decades have seen substantial growth in the range of assistance programmes for SMEs and entrepreneurs across the world. Once regarded as peripheral to the economy and public policy, the role of small firms and of entrepreneurship is now recognized as of key importance in the economic growth and development strategies of many nations. The range of interventions and support focused on promoting SMEs and entrepreneurship is substantial and expanding, so Government, SMEs and Entrepreneurship Development asks ’what are some of the main policy instruments being used, and how effective are they?’ It considers policies in different countries, examines key interventions and tools used to promote entrepreneurship and SME development and concludes with contributions on how to best evaluate their effectiveness. The contributor chapters by academics and practitioners from businesses, enterprise development agencies and governments, are empirical or evidence-based and use both quantitative and qualitative approaches. Drawing on experience from a wide range of both developed and emerging countries and economies, the contributions focus on the broad strategies that different governments and communities have adopted to foster entrepreneurship and SMEs; the policy tools and instruments that can be used to promote small business and entrepreneurship; and on the outcomes of policy instruments and the methods used to evaluate interventions. Their findings will help researchers, policy-makers, economic development officers, civil servants, elected officials, and business associations to better understand the issues in this important field.
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