Robert A. Copeland's Books

Enzymes

A Practical Introduction to Structure, Mechanism, and Data Analysis

By: Robert A. Copeland

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Enzymes

A Practical Introduction to Structure, Mechanism, and Data Analysis

By: Robert A. Copeland

ENZYMES A complete and approachable introduction to the study of enzymes, from theory to practice Enzymes catalyze the bulk of important biological processes, both metabolic and biochemical. They are specialized proteins whose function is determined by their structure, understanding which is therefore a key focus of biological, pharmacological, and agrarian research, among many others. A thorough knowledge of enzyme structure, pathways, and mechanisms is a fundamental building block of the life sciences and all others connected to them. Enzymes offers a detailed introduction to this critical subject. It analyzes enzyme proteins at the structural level and details the mechanisms by which they perform their catalyzing functions. The book’s in-depth engagement with primary literature and up-to-date research allows it to continuously deploy illustrative examples and connect readers with further research on key subjects. Fully updated after decades as the standard text, this book unlocks a thriving field of biological and biochemical research. Readers of the third edition of Enzymes will also find: Expanded chapters on steady-state and transient-state enzyme kinetics, structural components of enzymes, and more New chapters on enzyme regulation, enzyme-macromolecule interactions, enzyme evolution, and enzymes in human health Key Learning Points at the beginning of each chapter to assist students and instructors Enzymes promises to continue as the standard reference on this subject for practitioners of the life sciences and related fields in both academia and industry.

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Page Count

581

Publisher

John Wiley & Sons

Published Date

ISBN 10

1119793254

ISBN 13

9781119793250

Evaluation of Enzyme Inhibitors in Drug Discovery

A Guide for Medicinal Chemists and Pharmacologists

By: Robert A. Copeland

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Evaluation of Enzyme Inhibitors in Drug Discovery

A Guide for Medicinal Chemists and Pharmacologists

By: Robert A. Copeland

Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields— from pharmacology to medicinal chemistry to biophysics to clinical medicine.

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Page Count

588

Publisher

John Wiley & Sons

Published Date

ISBN 10

111854028X

ISBN 13

9781118540282

The Bakers Creek Air Crash

America’S Worst Aviation Disaster

By: Robert S. Cutler

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The Bakers Creek Air Crash

America’S Worst Aviation Disaster

By: Robert S. Cutler

The unique feature of this book, and the tragic accident it documents, is not simply the number of deaths but, rather, the extraordinary loss that occurred to so many American families simultaneously and how important it is that people in Australia and America have ensured that this historic incident is long remembered.

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Page Count

279

Publisher

Xlibris Corporation

Published Date

ISBN 10

1514489597

ISBN 13

9781514489598

The Raid on Harpers Ferry, October 16, 1859

A Brutal Skirmish Widens the Rift Between North and South

By: Robert N. Webb

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The Raid on Harpers Ferry, October 16, 1859

A Brutal Skirmish Widens the Rift Between North and South

By: Robert N. Webb

Describes the causes, events, and aftermath of the raid led by John Brown on the United States arsenal at Harpers Ferry.

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Publisher

Franklin Watts

Published Date

ISBN 10

0531010201

ISBN 13

9780531010204

Book's by Robert A. Copeland

Enzymes

Enzymes

Evaluation of Enzyme Inhibitors in Drug Discovery

Evaluation of Enzyme Inhibitors in Drug Discovery

The Bakers Creek Air Crash

The Bakers Creek Air Crash

The Raid on Harpers Ferry, October 16, 1859

The Raid on Harpers Ferry, October 16, 1859

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