Incorporating the most important advances in the fast-growing field of cancer biology, the text maintains all of its hallmark features. It is admired by students, instructors, researchers, and clinicians around the world for its clear writing, extensive full-color art program, and numerous pedagogical features.
The new second edition has been comprehensively revised and updated to include major advances in cancer biology over the past six years. Updates include current information on: The tumor microenvironment, Metastatic dissemination, Tumor immunology, Cancer stem cells, The epithelial-mesenchymal transition, Multi-step tumorigenesis, Invasion and metastasis, Mutation of cancer cell genomes, Greatly expanded treatment of traditional therapy, Epigenetic contributions, MicroRNA involvement, The Warburg effect.
Cancer research has reached a major turning point, and no one is better qualified to explain the past two deacades' dramatic leaps forward in understanding this disease than world-renowned molecular biologist Robert Weinberg, director of the Oncology Research Laboratory at the Whitehead Institute in Cambridge, Massachusetts. In One Renegade Cell, Weinberg presents a state-of-the-art account of how cancer begins and how, one day, it will be cured.
Cancer research has reached a major turning point. The quality and quantity of information gathered about this disease in the past twenty years has revolutionized our understanding of its origins and behavior. No one is better qualified to comment on these dramatic leaps forward than molecular biologist Robert A. Weinberg, director of one of the leading cancer research centers in the world. In One Renegade Cell , Weinberg presents an accessible and state-of-the-art account of how the disease begins and how, one day, it will be cured.Weinberg tells how the roots of cancer were uncovered in 1909 and when the first cancer-causing virus was discovered. He then moves forward to the discovery of the role of chemical carcinogens and radiation in triggering cancer, and relates the remarkable story of the discoveries of oncogenes and tumor suppressor genes, the master controllers of normal and malignant cell proliferation.This book, which presumes little prior knowledge of biology, describes the revolution in biomedical research that has finally uncovered the forces driving malignant growth. Drawing on insights that simply were not available until recently, the discoveries presented in One Renegade Cell have already begun to profoundly alter the way that we diagnose and treat human cancers.
The true story behind the film AMERICAN HUSTLE The Sting Man is the amazing inside story of Mel Weinberg, one of the most fascinating fast-buck operators to ever live, and the incredible scandals he masterminded. Hustling his way from the streets of the Bronx to hawking bogus businesses around the world, Weinberg netted millions and famously dreamed up Abscam—the infamous FBI-run sting operation of the late 1970’s that would bag seven congressmen and one U.S. senator.
Analysis of Genetic Association Studies is both a graduate level textbook in statistical genetics and genetic epidemiology, and a reference book for the analysis of genetic association studies. Students, researchers, and professionals will find the topics introduced in Analysis of Genetic Association Studies particularly relevant. The book is applicable to the study of statistics, biostatistics, genetics and genetic epidemiology. In addition to providing derivations, the book uses real examples and simulations to illustrate step-by-step applications. Introductory chapters on probability and genetic epidemiology terminology provide the reader with necessary background knowledge. The organization of this work allows for both casual reference and close study.
Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free. Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers. Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.
Apocalyptic AI, the hope that we might one day upload our minds into machines or cyberspace and live forever, is a surprisingly wide-spread and influential idea, affecting everything from the world view of online gamers to government research funding and philosophical thought. In Apocalyptic AI, Robert Geraci offers the first serious account of this "cyber-theology" and the people who promote it. Drawing on interviews with roboticists and AI researchers and with devotees of the online game Second Life, among others, Geraci illuminates the ideas of such advocates of Apocalyptic AI as Hans Moravec and Ray Kurzweil. He reveals that the rhetoric of Apocalyptic AI is strikingly similar to that of the apocalyptic traditions of Judaism and Christianity. In both systems, the believer is trapped in a dualistic universe and expects a resolution in which he or she will be translated to a transcendent new world and live forever in a glorified new body. Equally important, Geraci shows how this worldview shapes our culture. Apocalyptic AI has become a powerful force in modern culture. In this superb volume, he shines a light on this belief system, revealing what it is and how it is changing society.
Apocalyptic AI, the hope that we might one day upload our minds into machines and live forever in cyberspace, is a surprisingly wide-spread and influential idea. Robert Geraci points out that the rhetoric of 'Apocalyptic AI' is strikingly similar to that of the apocalyptic traditions of Judaism and Christianity.
In this wide-ranging philosophical work, Koons takes on two powerful dogmas--anti-realism and materialism. In doing so, Koons develops an elegant metaphysical system that accounts for such phenomena as information, mental representation, our knowledge of logic, mathematics and science, the structure of spacetime, the identity of physical objects, and the objectivity of values and moral norms.
The best music of the 20th century "developed our capacity for feeling, deepened our compassion, and furthered our quest for and understanding of what Aristotle called 'the perfect end of life' ". — from the Foreword by NPR music critic Ted Libbey The single greatest crisis of the 20th century was the loss of faith. Noise—and its acceptance as music—was the product of the resulting spiritual confusion and, in its turn, became the further cause of its spread. Likewise, the recovery of modern music, the theme to which this book is dedicated, stems from a spiritual recovery. This is made explicitly clear by the composers whose interviews with the author are collected in this book. Robert Reilly spells out the nature of the crisis and its solution in sections that serve as bookends to the chapters on individual composers. He does not contend that all of these composers underwent and recovered from the central crisis he describes, but they all lived and worked within its broader context, and soldiered on, writing beautiful music. For this, they suffered ridicule and neglect, and he believes their rehabilitation will change the reputation of modern music. It is the spirit of music that this book is most about, and in his efforts to discern it, Reilly has discovered many treasures. The purpose of this book is to share them, to entice you to listen—because beauty is contagious. English conductor John Eliot Gardiner writes that experiencing Bach's masterpieces "is a way of fully realizing the scale and scope of what it is to be human". The reader may be surprised by how many works of the 20th and 21st centuries of which this is also true.
Through six editions, Thompson & Thompson's Genetics in Medicine has been a well-established favorite textbook on this fascinating and rapidly evolving field, integrating the classic principles of human genetics with modern molecular genetics to help you understand a wide range of genetic disorders. The 7th edition incorporates the latest advances in molecular diagnostics, the Human Genome Project, and much more. More than 240 dynamic illustrations and high-quality photos help you grasp complex concepts more easily. This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included. Acquire the state-of-the-art knowledge you need on the latest advances in molecular diagnostics, the Human Genome Project, pharmacogenetics, and bio-informatics. Better understand the relationship between basic genetics and clinical medicine with a variety of clinical case studies. Recognize a wide range of genetic disorders with visual guidance from more than 240 dynamic illustrations and high-quality photos. This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included.
Provides a choice of 46 laboratory topics and more than 200 experiments. Includes a diversity of instructional approaches, including simple guided inquiries, more complex experimental designs, and original student investigations.
Dr. Weinberg turns the abstract concept of mental toughness into an achievable reality. The book is a terrific read for anyone striving for excellence in business or sports. It is a clear guide through the processes and outcomes associated with attaining mental toughness.
Fundamentals of Weed Science, Fifth Edition, provides the latest information on this constantly advancing area of study. Placing weed management in the largest context of weed research and science, the book presents the latest advances in the role, control and potential uses of weed plants. From the emergence and genetic foundation of weeds, to the latest means of control and environmental impact, the book uses an ecological framework to explore the role of responsible and effective weed control in agriculture. In addition, users will find discussions of related areas where research is needed for additional understanding. Explored topics include the roles of culture, economics and politics in weed management, all areas that enable scientists and students to further understand the larger effects on society. - Winner of a 2019 The William Holmes McGuffey Longevity Award (College) (Texty) from the Textbook Association of America - Completely revised with 35% new content - Contains expanded coverage of ethnobotany, the specific identity and role of invasive weed species, organic agriculture, and herbicide resistance in GM crops - Includes an emphasis on herbicide resistance and molecular biology, both of which have come to dominate weed science research - Covers all traditional aspects of weed science as well as current research - Provides broad coverage, including relevant related subjects like weed ecology and weed population genetics
This book offers a comprehensive overview of fundamental concepts of animal behavior as they relate to insects. Considerably updated and expanded, this new edition includes 26 case studies, as well as 45 new color plates and 173 figures (over 40% of them new) with detailed legends that add richness to the well-written, accessible text.
Here is the first biography of Mario Savio, the brilliant leader of Berkeley's Free Speech Movement, the largest and most disruptive student rebellion in American history. Savio risked his life to register black voters in Mississippi in the Freedom Summer of 1964 and did more than anyone to bring daring forms of non-violent protest from the civil rights movement to the struggle for free speech and academic freedom on American campuses. Drawing upon previously unavailable Savio papers, as well as oral histories from friends and fellow movement leaders, Freedom's Orator illuminates Mario's egalitarian leadership style, his remarkable eloquence, and the many ways he embodied the youthful idealism of the 1960s. The book also narrates, for the first time, his second phase of activism against "Reaganite Imperialism" in Central America and the corporatization of higher education. Including a generous selection of Savio's speeches, Freedom's Orator speaks with special relevance to a new generation of activists and to all who cherish the '60s and democratic ideals for which Savio fought so selflessly.
The Second Creation is a dramatic--and human--chronicle of scientific investigators at the last frontier of knowledge. Robert Crease and Charles Mann take the reader on a fascinating journey in search of "unification" with brilliant scientists such as Niels Bohr, Max Planck, Albert Einstein, Erwin Schrödinger, Richard Feynman, Murray Gell-Mann, Sheldon Glashow, Steven Weinberg, and many others. They provide the definitive and highly entertaining story of the development of modern physics, and the human story of the physicists who set out to find the "theory of everything.
Updated to reflect the newest changes in genetics, Thompson & Thompson's Genetics in Medicine returns as one of the most favored texts in this fascinating and rapidly evolving field. By integrating the classic principles of human genetics with modern molecular genetics, this medical reference book utilizes a variety of learning tools to help you understand a wide range of genetic disorders. Acquire the state-of-the-art knowledge you need on the latest advances in molecular diagnostics, the Human Genome Project, pharmacogenetics, and bio-informatics. Better understand the relationship between basic genetics and clinical medicine with a variety of clinical case studies. Recognize a wide range of genetic disorders with visual guidance from more than 240 dynamic illustrations and high-quality photos. Immerse yourself in updated graphics, full-color text, illustrations, line diagrams, and clinical photos of genetic diseases. Explore the latest genetic content available in order to remain up to date on the most current trends in the field. Take advantage of a double-page clinical case study section that demonstrates and reinforces general principles of disease inheritance, pathogenesis, diagnosis, management, and counseling. Enhance your critical thinking skills and better retain information. Each chapter ends with up to 5 quick genetic "problems" related to what has just been reviewed, with answers provided in the back of the book. Student Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. You'll also access USMLE-style and multiple choice questions.
Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.
In 1989 a political fire storm erupted after the United States Supreme Court declared that dissidents had the constitutional right under the First Amendment to burn the flag. To some, including President George Bush and many members of Congress, the flag was a sacred symbol of American freedoms. They believed its physical destruction posed a serious threat to the country and demanded a constitutional amendment to reverse the Court's decision. For those who defended the Court's ruling, flag desecration was a form of constitutionally protected free speech, and any attempt to forbid such conduct was seen as creating a dangerous precedent. Burning the Flag brings together the disciplines of law, journalism, political science, and history to explain and place the development of the controversy in its full context. It is based on extensive research in legal, congressional, and journalistic sources and on exclusive interviews with nearly 100 of the key players in the dispute, among them flag burners, judges, lawyers and lobbyists on both sides, members of Congress, congressional aides, and journalists. A timely addendum chronicles the late 1995 attempts once again to pass a constitutional amendment on flag desecration, adding to the significance of this readable account. Burning the Flag will be of value to both an academic and a general audience, particularly to civil libertarians, flag buffs, and those interested in popular media, American politics, modern American history, and constitutional law.
Available for the first time in English, this is the definitive account of the practice of sexual slavery the Japanese military perpetrated during World War II by the researcher principally responsible for exposing the Japanese government's responsibility for these atrocities. The large scale imprisonment and rape of thousands of women, who were euphemistically called "comfort women" by the Japanese military, first seized public attention in 1991 when three Korean women filed suit in a Toyko District Court stating that they had been forced into sexual servitude and demanding compensation. Since then the comfort stations and their significance have been the subject of ongoing debate and intense activism in Japan, much if it inspired by Yoshimi's investigations. How large a role did the military, and by extension the government, play in setting up and administering these camps? What type of compensation, if any, are the victimized women due? These issues figure prominently in the current Japanese focus on public memory and arguments about the teaching and writing of history and are central to efforts to transform Japanese ways of remembering the war. Yoshimi Yoshiaki provides a wealth of documentation and testimony to prove the existence of some 2,000 centers where as many as 200,000 Korean, Filipina, Taiwanese, Indonesian, Burmese, Dutch, Australian, and some Japanese women were restrained for months and forced to engage in sexual activity with Japanese military personnel. Many of the women were teenagers, some as young as fourteen. To date, the Japanese government has neither admitted responsibility for creating the comfort station system nor given compensation directly to former comfort women. This English edition updates the Japanese edition originally published in 1995 and includes introductions by both the author and the translator placing the story in context for American readers.
Biology: How Life Works was written in response to recent and exciting changes in biology, education, and technology with the goal of helping students to think like biologists. The text, visual program, and assessments were developed together to provide students with the best resources to gain an understanding of modern biology. Content is selected carefully, is integrated to illustrate the connections between concepts, and follows six themes that are crucial to biology: the scientific method, chemical and physical processes, cells, evolution, ecological interactions, and human impact. The second edition continues this approach, but includes expanded coverage of ecology, new in-class activities to assist instructors in active teaching, new pedagogical support for visual synthesis maps, and expanded and improved assessment.
Cancer research has reached a major turning point. The amount of information gathered in the past twenty years about the origins of the disease is without equal in the history of biomedical research. In this book one of America's most eminent scientists explains to the general reader the step-by-step process by which cancers arise, and more importantly, how they spread.Robert Weinberg explains how normal genes control the conventional growth of the cell, how, in their mutated form, they enable cancers to arise, and why these genes have such life-and-death power over us. Drawing from information that simply was not available until recently, One Renegade Cell explains this insidious disease as no other book as ever been able to do.
With this extensive revision of their well-regarded casebook, authors O'Kelley and Thompson respond To The many changes in the world of business. Retaining its balance of legal theory, enlightening cases, and widely praised problems, CORPORATIONS AND OTHER BUSINESS ASSOCIATIONS, Third Edition, incorporates new material and analyzes important developments in the field. If you haven't already adopted this intelligent and straightforward casebook, you'll be pleased to discover its: real-life focus on: close corporations, mergers/changes in control, And The relationship between corporations and outsiders skillful blend of theory, cases, and problems carefully edited and thoughtfully selected classic and contemporary cases generous number of excellent problems ranked among the best for clarity and effectiveness sophisticated - but not intimidating-writing style flexible organization which makes it easily adaptable to various teaching methods New material in CORPORATIONS AND OTHER BUSINESS ASSOCIATIONS, Third Edition, includes: discussion and problems on the 'hot' new business entities: LLPs and LLCs expanded treatment of agency law new hyp othetical problems that develop and build within a chapter more emphasis on the applications of theory, presented in a more accessible style an updated Teacher's Manual If you want to expose your students To The realities of business today, this powerful set of teaching tools is an ideal choice. Check out authors' web site: www.vanderbilt.edu/Law/faculty/thompson/corpcasebook/
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