This book presents the foundations of key problems in computational molecular biology and bioinformatics. It focuses on computational and statistical principles applied to genomes, and introduces the mathematics and statistics that are crucial for understanding these applications. The book features a free download of the R software statistics package and the text provides great crossover material that is interesting and accessible to students in biology, mathematics, statistics and computer science. More than 100 illustrations and diagrams reinforce concepts and present key results from the primary literature. Exercises are given at the end of chapters.
At last, here is a baseline book for anyone who is confused by cryptic computer programs, algorithms and formulae, but wants to learn about applied bioinformatics. Now, anyone who can operate a PC, standard software and the internet can also learn to understand the biological basis of bioinformatics, of the existence as well as the source and availability of bioinformatics software, and how to apply these tools and interpret results with confidence. This process is aided by chapters that introduce important aspects of bioinformatics, detailed bioinformatics exercises (including solutions), and to cap it all, a glossary of definitions and terminology relating to bioinformatics.
As communities continue to undergo rapid demographic shifts that modify their composition, culture, and collective values, police departments serving those communities must evolve accordingly in order to remain effective. The Future of Policing: A Practical Guide for Police Managers and Leaders provides concrete instruction to agencies on how to pr
Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. The right amount of basic science and practical clinical guidance assists in making efficient and informed decisions. Extensive updates on key topics keep you at the forefront of the field. New chapters on glomerulonephritis associated with complement disorders, interventional treatments for hypertension, renal disease and cancer, and epidemiology and prognostic impact of acute kidney injury. Over 1,500 color illustrations highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management. Hundreds of color coded algorithms promote quick reference and to help you retain concepts. Over 400 NEW self-assessment questions available at Expert Consult.
Therapy in Sleep Medicine, by Drs. Teri J. Barkoukis, Jean K. Matheson, Richard Ferber, and Karl Doghrami, provides the clinically focused coverage you need for rapid diagnosis and effective treatment of sleep disorders. A multidisciplinary team of leading authorities presents the latest on sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy in a highly illustrated, easy-to-follow format. Diagnose and treat patients effectively with complete coverage of the full range of sleep disorders. Find diagnostic and treatment information quickly and easily thanks to a highly illustrated, easy-to-read format that highlights key details. Stay current on discussions of hot topics, including sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy. Tap into the expertise of a multidisciplinary team of leading authorities for well-rounded, trusted guidance.
A napping volcano blinked awake in March 1980. Two months later, when that mountain roared, Jim Scymanky was about twelve miles northwest, logging a north slope above Hoffstadt Creek. “Rocks zinged through the woods, bouncing off trees, then the tops of trees snapped off... Suddenly I could see nothing...it got hot right away, then scorching hot and impossible to breathe. The air had no oxygen, like being trapped underwater...I was being cremated, the pain unbearable.” Steve Malone, at the University of Washington Seismology Laboratory, was inconsolable. “We’d failed. For two months we’d counted and located thousands of earthquakes, looked for changes to anticipate an eruption. Then it just happened. It killed many people. It killed David Johnston. We could hardly work.” Author Richard Waitt was part of a U.S. Geological Survey team doing volcano research in the Cascades, and was one of the first to arrive following the mountain’s early rumblings. His journey collecting eyewitness accounts began with a conversation in a bar the third week after Mount St. Helens erupted. The couple he met barely outraced a searing ash cloud, and Waitt realized their experiences could inform geologic studies. He eventually conducted hundreds of interviews--sometimes two and three decades later--often making multiple visits to gather additional details, correct errors, and resolve discrepancies. A meticulous scientist with intimate knowledge of Mount St. Helens, Waitt delivers a detailed and accurate chronicle of events. He tapped numerous primary sources--interviews, legal depositions, personal diaries, geologists’ field notes, radio logs, and police records. Newspaper stories and even sun shadows on photographs revealed additional intricacies. In the Path of Destruction’s eruption story unfolds through unforgettable, riveting narratives--the heart of a masterful chronology that also delivers engrossing science, history, and journalism.
The increasing integration between gene manipulation and genomics is embraced in this new book, Principles of Gene Manipulation and Genomics, which brings together for the first time the subjects covered by the best-selling books Principles of Gene Manipulation and Principles of Genome Analysis & Genomics. Comprehensively revised, updated and rewritten to encompass within one volume, basic and advanced gene manipulation techniques, genome analysis, genomics, transcriptomics, proteomics and metabolomics Includes two new chapters on the applications of genomics An accompanying website - www.blackwellpublishing.com/primrose - provides instructional materials for both student and lecturer use, including multiple choice questions, related websites, and all the artwork in a downloadable format. An essential reference for upper level undergraduate and graduate students of genetics, genomics, molecular biology and recombinant DNA technology.
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