Beginning with Jackson networks and ending with spatial queuing systems, this book describes several basic stochastic network processes, with the focus on network processes that have tractable expressions for the equilibrium probability distribution of the numbers of units at the stations. Intended for graduate students and researchers in engineering, science and mathematics interested in the basics of stochastic networks that have been developed over the last twenty years, the text assumes a graduate course in stochastic processes without measure theory, emphasising multi-dimensional Markov processes. Alongside self-contained material on point processes involving real analysis, the book also contains complete introductions to reversible Markov processes, Palm probabilities for stationary systems, Little laws for queuing systems and space-time Poisson processes.
Stochastic processes are mathematical models of random phenomena that evolve according to prescribed dynamics. Processes commonly used in applications are Markov chains in discrete and continuous time, renewal and regenerative processes, Poisson processes, and Brownian motion. This volume gives an in-depth description of the structure and basic properties of these stochastic processes. A main focus is on equilibrium distributions, strong laws of large numbers, and ordinary and functional central limit theorems for cost and performance parameters. Although these results differ for various processes, they have a common trait of being limit theorems for processes with regenerative increments. Extensive examples and exercises show how to formulate stochastic models of systems as functions of a system’s data and dynamics, and how to represent and analyze cost and performance measures. Topics include stochastic networks, spatial and space-time Poisson processes, queueing, reversible processes, simulation, Brownian approximations, and varied Markovian models. The technical level of the volume is between that of introductory texts that focus on highlights of applied stochastic processes, and advanced texts that focus on theoretical aspects of processes.
Recognizing the urgent need for an up-to-date review of new and innovative research on growth hormone (GH) secretagogues, this exclusive work furnishes the state of the art on the mechanisms of action, design, synthesis, evaluation, and clinical applications of GH secretagogues, including orally active and xenobiotic GH-releasing compounds. Beg
Food for Thought: Nutrition and the Aging Brain" presents and analyzes the research on nutrition’s impacts on the aging brain, on possibly-declining cognitive abilities, and on changing emotional dispositions. With 40 pages of references, the depth of coverage of the underlying science makes the book appropriate for scientists in fields such as nutrition, geriatrics, and psychology. However, the book was also designed to be understandable for lay readers wanting a deeper understanding than can be found in typical books on food-brain relationships. To make this book useful for non-scientists and for students, the first three chapters provide background. They sketch relevant brain structure and neurochemistry, and then discuss in only slightly more detail how aging and stress affect neurochemistry, brain structure, cognitive capacities, and resilience. The third chapter introduces basic nutrition research issues, and the extensive Glossary provides additional explanations of scientific concepts. The subsequent 14 chapters consolidate modern research on impacts of nutrition on brain and cognitive capacities. The research shows how much various nutrients can affect cognition in aging people, and then how those impacts are achieved—that is, how genes are affected that in turn have impacts on neural structures and neurochemistry. That series of 14 chapters begins with analyses of general diets such as the Mediterranean and the MIND, but subsequent chapters examine impacts of specific classes of nutrients. Chapter 18 describes nutrition that affects resilience, interpreted as stress tolerance, and resistance to both anxiety and depression. Chapter 19 describes how other types of activities that affect brain and cognition, such as programs of physical exercise and cognitive stimulation, can interact with nutrition to build brain and sharpen cognition. The final chapter summarizes the information on nutrition impacts on brain and cognition, and extends the discussion of interactions of nutrition with other brain-enhancing activities.
This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.
The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. - Illustrates the organic mechanism associated with each enzyme-catalyzed reaction - Makes the connection between organic reaction mechanisms and enzyme mechanisms - Compiles the latest information about molecular mechanisms of enzyme reactions - Accompanied by clearly drawn structures, schemes, and figures - Includes an extensive bibliography on enzyme mechanisms covering the last 30 years - Explains how enzymes can accelerate the rates of chemical reactions with high specificity - Provides approaches to the design of inhibitors of enzyme-catalyzed reactions - Categorizes the cofactors that are appropriate for catalyzing different classes of reactions - Shows how chemical enzyme models are used for mechanistic studies - Describes catalytic antibody design and mechanism - Includes problem sets and solutions for each chapter - Written in an informal and didactic style
Designed for parents who want to help their children succeed in school, this educator-approved program fosters a collaboration between parent and teacher by providing home-based activities that support a child's classroom education. Features a pull-out assessment test. Line illustrations. booklet.
Beginning with Jackson networks and ending with spatial queuing systems, this book describes several basic stochastic network processes, with the focus on network processes that have tractable expressions for the equilibrium probability distribution of the numbers of units at the stations. Intended for graduate students and researchers in engineering, science and mathematics interested in the basics of stochastic networks that have been developed over the last twenty years, the text assumes a graduate course in stochastic processes without measure theory, emphasising multi-dimensional Markov processes. Alongside self-contained material on point processes involving real analysis, the book also contains complete introductions to reversible Markov processes, Palm probabilities for stationary systems, Little laws for queuing systems and space-time Poisson processes.
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