The Politics of Earthquake Prediction is a suspenseful account of what happens when scientists predict an enormous earthquake for a specific day--an earthquake that did not, in this instance, happen, but which, if it had, would have been one of the most destructive of our century. Working in a field where uncertainty abounds, Dr. Brian Brady of the U.S. Bureau of Mines and Dr. William Spence of the U.S. Geological Survey gradually came to the conclusion that a catastrophic quake would occur on June 28, 1981, off the coast of central Peru, near the great population center of Lima-Callao. Their research was based on a theory challenging scientific notions widely accepted in the seismological "establishment." This book is a fast-paced but thorough and sensitive description of how this scientific dispute became a political controversy. The work portrays in detail the struggles of scientists and government officials in both the United States and Peru attempting to "do the right thing" as the target date approached. The authors emphasize the political, economic, and moral dilemmas of earthquake prediction, the impact of the media, and the potentially drastic consequences of ignoring a valid prediction. Originally published in 1989. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Historians of science have long been intrigued by the impact of disparate cultural styles on the science of a given country and time period. Richard Olson's book is a case study in the interaction between philosophy and science as well as an examination of a particular scientific movement. The author investigates the methodological arguments of the Common Sense philosophers Thomas Reid, Dugald Stewart, Thomas Brown, and William Hamilton and the possible transmission of their ideas to scientists from John Playfair to James Clerk Maxwell. His findings point out the need for modifications to the Duhem-Poincaré interpretation of British scientific style and the reassessment of the extent of Kantian influence on British physics. Originally published in 1975. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
An estimated 30,000 children are born in the USA with congenital heart disease each year, two thirds of which will require corrective surgery. Medical advances have formed a trend of operating on newborns rather than waiting until the child is older. Ten years ago, the mortality for these operationswas 60% to 70%. That percentage has dropped to 2%. This specialized book explores the basic mechanisms of neurologic injury associated with congenital heart surgery while covering the emerging technologies for assessment of neurologic integrity and injury. The text also highlights the current and future techniques for reducing and preventing these injuries, and reviews the pertinent medicolegal issues.
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
A compilation of the author’s news articles recounting the history of the Nile Shrine Center in Seattle Washington with perspectives on the nation’s and world events occurring during those times. Includes insights and perspectives about the major events of the twentieth century.
Traces the history of the United States during the 1950s through such primary sources as memoirs, letters, contemporary journalism, and official documents.
This book analyzes the use of strategic embargoes and economic sanctions in the postwar period, tracing their changing applications in the context of developments in the global distribution of power. Dr. Ellings uses two approaches: a case study of the ongoing strategic Western embargo against selected communist countries and a comparative study of
Geared to a wide readership of practicing clinicians and trainees in primary care medicine and gastroenterology, this handbook offers practical information on Crohn's disease and ulcerative colitis. Coverage begins with the patient's first visit and proceeds through the diagnostic workup: endoscopy, radiologic testing, and instruments for rating and classifying inflammatory bowel disease. Discussions of therapy include conventional therapies, immunomodulators, biologic therapies, surgical approaches, and intestinal stomas. Chapters discuss extraintestinal manifestations of inflammatory bowel disease, inflammatory bowel disease and the liver, infections, and pouchitis. Additional chapters focus on nursing considerations, nutrition, women's health issues, and inflammatory bowel disease and the workplace.
I enjoyed reading this volume. It is rare to see such a comprehensive report on hard data published these days, especially one so insightfully contextualised by the editors' introductory and concluding chapters. These scholars and the others involved in the work really know their stuff, and it shows. The editors connect the preoccupations of Pacific archaeologists with those of their colleagues working in other island regions and on "big questions" of colonisation, migration, interaction and patterns and processes of cultural change in hitherto-uninhabited environments. These sorts of outward-looking, big-picture contextual studies are invaluable, but all too often are missing from locally- and regionally-oriented writing, very much to its detriment. In sum, the work strongly advances our understanding of the early prehistory of Fiji through its well-integrated combination of original research and the reinterpretation of existing knowledge in the context of wider theoretical and historical concerns. In doing so The Early Prehistory of Fiji makes a truly substantial contribution to Pacific and archaeological scholarship. Professor Ian Lilley, The University of Queensland
At long last in paperback, Richard Shenkman's bestselling sequel to Legends, Lies and Cherished Myths of American History. Provocative and amusingly heretical, "I Love Paul Revere, Whether He Rode or Not" (a quote attributed to Warren Harding) offers eye-opening revelations debunking long-held American legends. 12 drawings.
The greatest mystery of life is how a single fertilized egg develops into a fully functioning, sometimes conscious multicellular organism. Embryogenesis Explained offers a new theory of how embryos build themselves, and combines simple physics with the most recent biochemical and genetic breakthroughs, based on the authors' prediction and then discovery of differentiation waves. They explain their ideas in a form accessible to the lay person and a broad spectrum of scientists and engineers. The diverse subjects of development, genetics and evolution, and their physics, are brought together to explain this major, previously unanswered scientific question of our time.As a follow up on The Hierarchical Genome, this book is a shorter but conceptually expanded work for the reader who is interested in science. It is useful as a starting point for the curious layman or the scientist or professional encountering the problem of embryogenesis without the formal biology background. There is also material useful for the seasoned biologist caught up in the new rush of information about the role of mechanics in developmental biology and cellular level mechanics in medicine.
Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors. 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis. New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place. In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.
The largest collection of basic, clinical, and applied knowledge on the chemical senses ever compiled in one volume, the third edition of Handbook of Olfaction and Gustation encompass recent developments in all fields of chemosensory science, particularly the most recent advances in neurobiology, neuroscience, molecular biology, and modern functional imaging techniques. Divided into five main sections, the text covers the senses of smell and taste as well as sensory integration, industrial applications, and other chemosensory systems. This is essential reading for clinicians and academic researchers interested in basic and applied chemosensory perception.
A groundbreaking collection of essays by leading academics and intellectuals, this record examines the confiscation of Maori land in 19th-century New Zealand and the broader imperial context. Based on a 2008 conference entitled Coming to Terms? Raupatu/Confiscation and New Zealand History, this study examines topics associated with land confiscation, such as war, European settlements, colonialism, property rights, and politics. Contributors include Michael Allen, James Belich, Judith Binney, Alex Frame, Bryan Gilling, Mark Hickford, Vincent O'Malley, Dion Tuuta, Alan Ward, and John C. Weaver.
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