Internet Infrastructure: Networking, Web Services, and Cloud Computing provides a comprehensive introduction to networks and the Internet from several perspectives: the underlying media, the protocols, the hardware, the servers, and their uses. The material in the text is divided into concept chapters that are followed up with case study chapters that examine how to install, configure, and secure a server that offers the given service discussed. The book covers in detail the Bind DNS name server, the Apache web server, and the Squid proxy server. It also provides background on those servers by discussing DNS, DHCP, HTTP, HTTPS, digital certificates and encryption, web caches, and the variety of protocols that support web caching. Introductory networking content, as well as advanced Internet content, is also included in chapters on networks, LANs and WANs, TCP/IP, TCP/IP tools, cloud computing, and an examination of the Amazon Cloud Service. Online resources include supplementary content that is available via the textbook’s companion website, as well useful resources for faculty and students alike, including: a complete lab manual; power point notes, for installing, configuring, securing and experimenting with many of the servers discussed in the text; power point notes; animation tutorials to illustrate some of the concepts; two appendices; and complete input/output listings for the example Amazon cloud operations covered in the book.
A True Textbook for an Introductory Course, System Administration Course, or a Combination Course Linux with Operating System Concepts, Second Edition merges conceptual operating system (OS) and Unix/Linux topics into one cohesive textbook for undergraduate students. The book can be used for a one- or two-semester course on Linux or Unix. It is complete with review sections, problems, definitions, concepts and relevant introductory material, such as binary and Boolean logic, OS kernels and the role of the CPU and memory hierarchy. Details for Introductory and Advanced Users The book covers Linux from both the user and system administrator positions. From a user perspective, it emphasizes command-line interaction. From a system administrator perspective, the text reinforces shell scripting with examples of administration scripts that support the automation of administrator tasks. Thorough Coverage of Concepts and Linux Commands The author incorporates OS concepts not found in most Linux/Unix textbooks, including kernels, file systems, storage devices, virtual memory and process management. He also introduces computer science topics, such as computer networks and TCP/IP, interpreters versus compilers, file compression, file system integrity through backups, RAID and encryption technologies, booting and the GNUs C compiler. New in this Edition The book has been updated to systemd Linux and the newer services like Cockpit, NetworkManager, firewalld and journald. This edition explores Linux beyond CentOS/Red Hat by adding detail on Debian distributions. Content across most topics has been updated and improved.
The piecemeal developments in product liability reform in Europe have their origins in the tragic association of phocomelia in children with thalidomide in 1962. In many ways these events have continued to generate pressure for reform of product liability, especially for the victims of drug-induced injury. This monograph attempts to address the major problems that typify claims for drug-induced injury, as well as highlighting the complex interrelationship between liability exposure and drug regulation. While medicinal products are subject to strict liability under the product liability directive, the claimant may have considerable difficulty in establishing that the relevant product is defective and that it caused the damage. It may also be necessary to overcome the development risk defence where this is pleaded. The monograph addresses these problems on a comparative jurisprudential basis, and seeks to determine whether medicinal products should be treated as a special case in the field of product liability. It examines the role of epidemiological evidence in assessing causation in product liability cases concerning medicinal products in the light of recent developments in the UK Supreme Court, the United States, Canada and France. In particular, it addresses the difficulties in reconciling the standards of proof in law and science, including the theory that causation can be proved on the balance of probabilities by reference to the doubling of risk of injury. An important case study compares and contrasts the approaches of the UK and the US to the measles, mumps, rubella Litigation. The book also examines the question as to whether compliance with regulatory standards should protect pharmaceutical manufacturers from product liability suits. It seeks to support a via media whereby the victims of drug induced injury can receive justice, while at the same time encouraging drug safety and innovation in drug development.
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
Product Liability is a recognised authority in the field and covers the product liability laws through which manufacturers, retailers, and others may be held liable to compensate persons who are injured, or who incur financial loss, when the products which they manufacture or sell are defective or not fit for their purpose. Product defects may originate in the production process, be one of design, or be grounded in a failure to issue an adequate warning or directions for safe use and practitioners advising business clients or claimants will find this book provides all the necessary information for practitioners to manage a product liability claim. This new edition has been fully updated to take account of 10 years of development in case law and regulation, and the increasing impact of cross-border and transnational sale of goods. The Court of Justice of the European Union handed down major rulings concerning the Product Liability Directive which affect the application of the Directive and national arrangements and Fairgrieve and Goldberg examines this in detail. For any legal practitioner operating in areas which require knowledge of European product liability law, an understanding of the impact of recent developments is essential and this work is an essential resource for practitioners working on product liability, sale of goods, personal injury and negligence. The work provides comprehensive coverage of the law of negligence as it applies to product liability, of the strict liability provisions of the Consumer Protection Act 1987, and of the EU's Product Liability Directive on which the Act is based. Although the majority of cases involve pharmaceuticals and medical devices, in recent English cases the allegedly defective products have been as diverse as a child's buggy, an All Terrain Vehicle, and even a coffee cup. Many cases are brought as group actions, and the book examines the rights of those who are injured by defective products. As well as considering the perspective of the law as it has developed in the UK, this edition contains detailed discussion of case law from other jurisdictions including the USA, Australia, New Zealand, Canada, France and Germany. The coverage in the work is complemented by a full analysis of issues which arise in transnational litigation involving problems of jurisdiction and the choice of laws.
Sorting out the scientific facts from the unsupported hype about emotional intelligence. Emotional intelligence (or EI)—the ability to perceive, regulate, and communicate emotions, to understand emotions in ourselves and others—has been the subject of best-selling books, magazine cover stories, and countless media mentions. It has been touted as a solution for problems ranging from relationship issues to the inadequacies of local schools. But the media hype has far outpaced the scientific research on emotional intelligence. In What We Know about Emotional Intelligence, three experts who are actively involved in research into EI offer a state-of-the-art account of EI in theory and practice. They tell us what we know about EI based not on anecdote or wishful thinking but on science. What We Know about Emotional Intelligence looks at current knowledge about EI with the goal of translating it into practical recommendations in work, school, social, and psychological contexts.
Offering rich insights into what Asperger's is like for the child, this compassionate book will empower parents and teachers, enabling them to nurture the child's strengths and work towards a happy and promising future. The book is packed with strategies, insights, and points to remember in order to address common areas of difficulty.
Practical and Theoretical Geoarchaeology, Second Edition, provides an invaluable and vastly updated overview of geoarchaeology and how it can be used effectively in the study of archaeological sites and contexts. Taking a pragmatic and functional approach, this book presents: a fundamental, broad-based perspective of the essentials of modern geoarchaeology in order to demonstrate the breadth of the approaches and the depth of the problems that it can tackle. the rapid advances made in the area in recent years, but also gives the reader a firm grasp of conventional approaches. covers traditional topics with the emphasis on landscapes, as well as anthropogenic deposits and site formation processes and their investigation. provides guidelines for the presentation of field and laboratory methods and the reporting of geoarchaeological results. essential reading for archaeology undergraduate and graduate students, practicing archaeologists and geoscientists who need to understand and apply geoarchaeological methodologies, and help foster the dialog among diverse researchers investigating archaeological sites. Practical and Theoretical Geoarchaeology, Second Edition, is an ideal resource for undergraduate and graduate students in archaeology, and a great practical reference for practicing archaeologists and geoscientists who need to understand and apply geoarchaeological methodologies internationally.
Trusted by physicians and advanced practice providers through ten standard-setting editions, Fanaroff and Martin's Neonatal-Perinatal Medicine, 11th Edition, remains the reference of choice for expert, multidisciplinary guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. An expanded team of international authors, led by Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh of Rainbow Babies and Children's Hospital, brings you up to date with advances in the control of nosocomial infections in preterm infants, genetic disorders and birth defects, the fetal origins of adult disease, the late preterm infants, and much more – all designed to help you improve the quality of life and long-term outcomes of your patients. Helps you make informed clinical choices for each patient – from diagnosis and treatment selection through post-treatment strategies and management of complications – with a dual focus on neonatology and perinatology. Includes a new chapter on Social and Economic Contributors to Neonatal Outcome. Features extensive updates and reorganization throughout, with new Key Points at the end of each chapter Provides up-to-date, evidence-based content, with more information on precision medicine and genetics. Uses detailed, full-color illustrations that depict disorders in the clinical setting and explain complex information. Remains the most comprehensive, multidisciplinary text in the field – an excellent source of information for every stage of your practice.
This best-selling emergency department reference is now in its thoroughly updated Fifth Edition. The foremost authorities provide practical information on over 600 clinical problems in a fast-access two-page outline format that's perfect for on-the-spot consultation during care in the emergency department. Coverage of each disorder includes clinical presentation, pre-hospital, diagnosis, treatment, disposition, and ICD-9 coding. Icons enable practitioners to quickly spot the information they need. This edition provides up-to-date information on topics such as emerging infections, new protocols, and new treatments.
This volume collects together core papers by Richard K. Larson developing what has since come to be known as the "VP Shell" or "Split VP" analysis of sentential structure. The volume includes five previously published papers together with two major unpublished works from the same period: "Light Predicate Raising" (1989), which explores the interesting consequences of a leftward raising analysis of "NP Shift" phenomena, and "The Projection of DP (and DegP)" (1991), which extends the shell approach to the projection of nominal and adjectival structure, showing how projection can be handled in a uniform way. In addition to published, unpublished and limited distribution work, the volume includes extensive new introductory material. The general introduction traces the conceptual roots of VP Shells and its problems in the face of subsequent developments in theory, and offers an updated form compatible with modern Minimalist syntactic analysis. The section introductions to the material on datives, complex predicates and nominals show how the updated form of shell theory applies in the empirical domains where it was originally developed.
Written and edited by world leaders in nephrology, Comprehensive Clinical Nephrology, 6th Edition, by Drs. John Feehally, Jurgen Floege, Richard J. Johnson, and Marcello Tonelli, provides current information on clinical procedures and conditions as well as the scientific facts and pathophysiology that are foundational to nephrology practice. Ideal for practicing nephrologists, fellows, residents, and internists, it thoroughly covers fluids and electrolytes, hypertension, diabetes, dialysis, and transplantation, and more – all in a single convenient volume. A "just right" amount of basic science and practical clinical guidance helps you make efficient and informed decisions. More than 1,500 full-color illustrations highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management. New quick-reference boxes with links to clinical guidelines in all relevant chapters. New chapters on common issues regarding prescribing in kidney disease, palliative nephrology, endemic nephropathies, pathophysiology of chronic kidney disease, and outcomes of dialysis.
Examine the changing structure of the family as America’s population ages! As the United States’ economy evolves and manufacturing jobs disappear, the prospect of each generation experiencing a standard of living that exceeds that of their parents’ generation also disappears. Challenges of Aging on U.S. Families: Policy and Practice Implications explores this trend, presenting the latest original research on the changing roles of caregivers along with the economic and emotional effects on the family unit. Respected authorities discuss in detail long-term care and the standard of living of families, with a focus on the effects of changing family structures on families themselves and society at large. The coming boom in the population of the aging will impact families at several levels. Challenges of Aging on U.S. Families thoroughly examines the economic demands of aging on families, then focuses on different roles elderly family members are likely to play over the next several decades. Some of the issues explored include “skipped generation parenting” where children are raised in grandparent homes where neither parent is present, the impending economic impact of caregiving on families, the stress on families with fewer siblings to share the caregiving tasks, and the tendency for family members to live in different parts of the country and subsequently become unable to offer caregiver support. Detailed tables provide clarity of thought while comprehensive bibliographies offer further opportunity for study. Challenges of Aging on U.S. Families discusses: the economics of aging the implications of aging economics and emotional stress on the future of families the coming labor shortage of caregivers family-based intervention in residential long-term care shifting relationships between parents and their children caregivers self-esteem issues involving daughter caregivers paying family caregivers—as public policy a proposed policy of requiring adult children to care for their aging parents inheritance and intergenerational transmission of parental care the inherent psychological stress within skipped generation families Challenges of Aging on U.S. Families: Policy and Practice Implications is an eye-opening text for researchers, health professionals, social workers, counselors, caregivers, educators, and students.
Written by clinicians, for clinicians, Cardiovascular Medicine and Surgery offers a comprehensive, authoritative, and multidisciplinary approach to this rapidly evolving field. Covering every area relevant to the daily practice of cardiovascular medicine, this new and innovative reference text, led by Drs. Debabrata Mukherjee and Richard A. Lange, brings together a stellar team of cardiovascular specialists from leading medical centers worldwide who focus on cutting-edge strategies for the clinical and surgical management of patients. Both medicine and surgery are highlighted in chapters along with follow-up care and changing technology to equip the clinician for optimal patient care. Highly structured and templated chapters cover pathogenesis, diagnosis, management, special considerations/limitations, follow-up care, and on-going and future research.
A group of science educators with experience of being involoved in curriculum development, and in conducting extensive research on many aspects of teaching and learning science, have combined their findings in this volume.; Each author has conducted research into his or her own area of science education and presents the implications of this research for a specific area of science teaching. The experiences of members of the Monash Children's Science Group; specifically three primary teachers and one biology teacher, have also been included so as to present the voices of teachers for whom writing a personal account of their teaching is often an unappealing task.
This best-selling emergency department reference is now in its thoroughly updated Fourth Edition. The foremost authorities provide practical information on over 600 clinical problems in a fast-access two-page outline format that's perfect for on-the-spot consultation during care in the emergency department. Coverage of each disorder includes clinical presentation, pre-hospital, diagnosis, treatment, disposition, and ICD-9 coding. Icons enable practitioners to quickly spot the information they need. This edition provides up-to-date information on topics such as emerging infections, new protocols, and new treatments.
This is the most authoritative archive of Barry Boehm's contributions to software engineering. Featuring 42 reprinted articles, along with an introduction and chapter summaries to provide context, it serves as a "how-to" reference manual for software engineering best practices. It provides convenient access to Boehm's landmark work on product development and management processes. The book concludes with an insightful look to the future by Dr. Boehm.
A new collection filled with winning ideas and strategies for improving¿ your sucess in the retail business... 2¿authoritative books, now in a convenient e-format, at a great price! Smart Retail, the world's #1 guide to retail success, complete with crucial, up-to-date insights--including new case studies, ideas, strategies, and tactics from today's best retailers, like TopShop, IKEA, and Best Buy. Covering everything from creating the ultimate retail experience to understanding the customer and the importance of motivated workers, this is the book that will equip managers, team-workers, retail entrepreneurs and indeed anybody who sells direct to customers, with practical winning ideas and strategies.¿ Competing in Tough Times brings together the powerful new strategies that world-class retailers, like Trader Joe’s, Costco, and Nordstrom, are using today to survive--and thrive--in a brutally unforgiving retail environment. Internationally respected retail management expert Barry Berman shows retailers and their suppliers exactly how to build effective strategies based on cost and differentiation, plan and implement those strategies, and measure the results.¿Berman offers detailed coverage of implementing strategies based on becoming the low-cost provider and minimizing product proliferation; enhancing the service experience; developing and maintaining a strong private label program; and more. From world-renowned experts Richard Hammond and Barry Berman.
A New Statesman best book of the year | New York Times Editors' Choice pick A Financial Times best economics book of 2019 An accessible, story-driven look at the future of the global economy, written by a leading expert To predict our future, we must look to the extremes. So argues the economist Richard Davies, who takes readers to the margins of the modern economy and beyond in his globe-trotting book. From a prison in rural Louisiana where inmates purchase drugs with prepaid cash cards to the poorest major city on earth, where residents buy clean water in plastic bags, from the world’s first digital state to a prefecture in Japan whose population is the oldest in the world, how these extreme economies function—most often well outside any official oversight—offers a glimpse of the forces that underlie human resilience, drive societies to failure, and will come to shape our collective future. While the people who inhabit these places have long been dismissed or ignored, Extreme Economies revives a foundational idea from medical science to turn the logic of modern economics on its head, arguing that the outlier economies are the place to learn about our own future. Whether following Punjabi migrants through the lawless Panamanian jungle or visiting a day-care for the elderly modeled after a casino, Davies brings a storyteller’s eye to places where the economy has been destroyed, distorted, and even turbocharged. In adapting to circumstances that would be unimaginable to most of us, the people he encounters along the way have helped to pioneer the economic infrastructure of the future. At once personal and keenly analytical, Extreme Economies is an epic travelogue for the age of global turbulence, shedding light on today’s most pressing economic questions.
When we were first approached by the senior editors of this series to edit a book on interactions between the host and infectious agents, we acceptedthis offer as an exciting challenge. The only condition, readily agreed upon, was that such a book should focus on the immunology of infections in humans. Our reasons, if not biases, were severalfold. We sensed that the fields of microbiology and im munolgy, which had diverged as each was focusing on its individual search, were coming together. In agreement with the opinions expressed by Dr. Richard Krause in the Introduction, we strongly believed that the development of the immune system evolved in response to infectious agents and that the evolution of these agents was influenced in turn by the character of the host's responses. An inten sive examination of the multitude of primitive or more recently developed host defense mechanisms to determine their relative contribution to man's resistance to a given infectious agent appeared to us to be of crucial basic· and practical interest. Many immune mechanisms studied in animals were being explored in humans and it appeared timely to focus particularly on what was known about man's resistance to infectious agents, correlating this information with lessons learned from relevant experiments in animal models.
Using a highly effective, case-based approach, Workbook in Practical Neonatology puts neonatal evaluation, diagnosis, and treatment in a clinical context and tests your knowledge with questions and answers for each topic. You’ll find authoritative guidance on the problems you’re most likely to see in practice, including issues regarding resuscitation, mechanical ventilation, anemia, fluid therapy, and bronchopulmonary dysplasia. The 6th Edition has been extensively revised, with new authors, rewritten content, improved figures and tables, and many new cases throughout. Organizes chapters around case studies, followed by questions and answers that require you to make diagnostic decisions and help you understand how scientific concepts apply to each clinical problem. Guides you step-by-step through patient care with abundant diagnostic algorithms, illustrations, and decision trees. Features eleven chapters rewritten by new authors, new tables and algorithms, new cases, and updated discussions of existing cases. An excellent learning tool and everyday reference for practicing neonatologists, as well as students, trainees, nurses, and other clinicians.
Widely regarded as the definitive reference in the field, Youmans and Winn Neurological Surgery offers unparalleled, multimedia coverage of the entirety of this complex specialty. Fully updated to reflect recent advances in the basic and clinical neurosciences, the 8th Edition covers everything you need to know about functional and restorative neurosurgery, deep brain stimulation, stem cell biology, radiological and nuclear imaging, and neuro-oncology, as well as minimally invasive surgeries in spine and peripheral nerve surgery, and endoscopic and other approaches for cranial procedures and cerebrovascular diseases. In four comprehensive volumes, Dr. H. Richard Winn and his expert team of editors and authors provide updated content, a significantly expanded video library, and hundreds of new video lectures that help you master new procedures, new technologies, and essential anatomic knowledge in neurosurgery. Discusses current topics such as diffusion tensor imaging, brain and spine robotic surgery, augmented reality as an aid in neurosurgery, AI and big data in neurosurgery, and neuroimaging in stereotactic functional neurosurgery. 55 new chapters provide cutting-edge information on Surgical Anatomy of the Spine, Precision Medicine in Neurosurgery, The Geriatric Patient, Neuroanesthesia During Pregnancy, Laser Interstitial Thermal Therapy for Epilepsy, Fetal Surgery for Myelomeningocele, Rehabilitation of Acute Spinal Cord Injury, Surgical Considerations for Patients with Polytrauma, Endovascular Approaches to Intracranial Aneurysms, and much more. Hundreds of all-new video lectures clarify key concepts in techniques, cases, and surgical management and evaluation. Notable lecture videos include multiple videos on Thalamotomy for Focal Hand Dystonia and a video to accompany a new chapter on the Basic Science of Brain Metastases. An extensive video library contains stunning anatomy videos and videos demonstrating intraoperative procedures with more than 800 videos in all. Each clinical section contains chapters on technology specific to a clinical area. Each section contains a chapter providing an overview from experienced Section Editors, including a report on ongoing controversies within that subspecialty. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
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