The complex dynamic behavior exhibited by many nonlinear systems - chaos, episodic volatility bursts, stochastic regimes switching - has attracted a good deal of attention in recent years. A Nonlinear Time Series Workshop provides the reader with both the statistical background and the software tools necessary for detecting nonlinear behavior in time series data. The most useful existing detection techniques are described, including Engle's LaGrange Multiplier test for conditional hetero-skedasticity and tests based on the correlation dimension and on the estimated bispectrum. These techniques are illustrated using actual data from fields such as economics, finance, engineering, and geophysics.
This book presents the foundations of key problems in computational molecular biology and bioinformatics. It focuses on computational and statistical principles applied to genomes, and introduces the mathematics and statistics that are crucial for understanding these applications. The book features a free download of the R software statistics package and the text provides great crossover material that is interesting and accessible to students in biology, mathematics, statistics and computer science. More than 100 illustrations and diagrams reinforce concepts and present key results from the primary literature. Exercises are given at the end of chapters.
Multistate Models for the Analysis of Life History Data provides the first comprehensive treatment of multistate modeling and analysis, including parametric, nonparametric and semiparametric methods applicable to many types of life history data. Special models such as illness-death, competing risks and progressive processes are considered, as well as more complex models. The book provides both theoretical development and illustrations of analysis based on data from randomized trials and observational cohort studies in health research. It features: Discusses a wide range of applications of multistate models, Presents methods for both continuously and intermittently observed life history processes, Gives a thorough discussion of conditionally independent censoring and observation processes, Discusses models with random effects and joint models for two or more multistate processes, Discusses and illustrates software for multistate analysis that is available in R, Target audience includes those engaged in research and applications involving multistate models.
Supporting People with Dementia at Home details a groundbreaking study of an intensive care management scheme designed for older people with dementia that are at risk of entry into residential care. The authors use a quasi-experimental approach to compare how the individuals on the mental health team in one community were matched to a similar community without the service. They analyze the evidence focusing on the eventual placement of the individual suffering, the quality of care they receive, and also the needs of their carers. This book offers valuable evidence about the factors which can maximize the independence and well being of older people with dementia, from the perspective of older people and their carers. For those who commission services, it is highly relevant to service models for the National Dementia Strategy in England.
Now in its fourth edition, this textbook remains the indispensable text to guide readers through automotive or mechanical engineering, both at university and beyond. Thoroughly updated, clear, comprehensive and well-illustrated, with a wealth of worked examples and problems, its combination of theory and applied practice aids in the understanding of internal combustion engines, from thermodynamics and combustion to fluid mechanics and materials science. This textbook is aimed at third year undergraduate or postgraduate students on mechanical or automotive engineering degrees. New to this Edition: - Fully updated for changes in technology in this fast-moving area - New material on direct injection spark engines, supercharging and renewable fuels - Solutions manual online for lecturers
In the midst of an addiction epidemic, this newly updated edition of The American Society of Addiction Medicine Principles of Addiction Medicine, 5th edition is the sought-after text every addiction researcher and care provider needs. This comprehensive reference text dedicates itself to both the science and treatment of addiction. You’ll receive a thorough grounding in both the scientific principles behind the causes of addiction and the practical aspects of clinical care. Chapters are written by recognized experts, covering areas such as the basic science of addiction medicine; diagnosis, assessment and early intervention; pharmacologic and behavioral interventions; mutual help and twelve-step; and co-occurring addiction, medical and psychiatric disorders—backed by the latest research data and successful treatment methods. Features: Numerous figures, tables and diagrams elucidate the text Chapters include case examples List of data research reports provided at end of each chapter NEW material on Prescription Drug Abuse, Club Drugs, Nursing Roles in Addressing Addiction, Conceptual and Treatment Issues in Behavioral Addictions, Rehabilitation Approaches to Pain Management, Comorbid Pain and Addiction, Pharmacotherapy for Adolescents with Substance Use Disorders, Preventing and Treating Substance Use Disorders in Military Personnel, and more.
The increasing integration between gene manipulation and genomics is embraced in this new book, Principles of Gene Manipulation and Genomics, which brings together for the first time the subjects covered by the best-selling books Principles of Gene Manipulation and Principles of Genome Analysis & Genomics. Comprehensively revised, updated and rewritten to encompass within one volume, basic and advanced gene manipulation techniques, genome analysis, genomics, transcriptomics, proteomics and metabolomics Includes two new chapters on the applications of genomics An accompanying website - www.blackwellpublishing.com/primrose - provides instructional materials for both student and lecturer use, including multiple choice questions, related websites, and all the artwork in a downloadable format. An essential reference for upper level undergraduate and graduate students of genetics, genomics, molecular biology and recombinant DNA technology.
The author of Undoing Depression presents an effective guide to modern anxiety, and shows how you can recognize—and rescue yourself from—its effects. Twenty-first-century life evolves at a breakneck pace—and with it, stress seems to multiply by the day. We work long, harrowing hours. We fret over our families and finances. Our e-mail beeps and our cell phones ring. But our nervous systems were never meant to handle so many stressors. In this groundbreaking book, psychotherapist Richard O’Connor explains how a wide range of common problems—both emotional and physical—are actually side effects of modern life, and how you can undo their damage. Combining expertise with down-to-earth language, Undoing Perpetual Stress explains how you can: • Recognize the hidden effects of stress on your brain and body • Understand your inner sanity in conflict with a crazy world • Develop self-control over how you think, act and feel when stressed • Regain a sense of meaning and purpose in your life You already know how to “do” stress. With the help of this book, you can undo it, too.
A thoroughly revised edition of the go-to chemical engineering reference Fully updated for the latest advances, this must-have chemical engineering guide serves as a single source for up-to-date physical data, chemical data, and predictive and estimation methods. The Properties of Gases and Liquids, Sixth Edition provides the latest curated data on over 480 compounds and includes a special section devoted to the interpretation of uncertainty in physical property estimation. You will get new coverage of advanced EOSs, advanced computational methods, quantum density functional theory, and semi-empirical combinations. Clear explanations and sample calculations are provided throughout this all-inclusive resource. Coverage includes: Traditional and non-traditional estimation methods Uncertainty Critical properties and related constants Ideal gas properties Saturation properties and virial coefficients Equations of state for pure compounds Equations of state for mixture properties Vapor-liquid, liquid-liquid, and solid-liquid equilibria Infinite dilution activity coefficients Viscosity and thermal conductivity Diffusivity and surface tension
When we were first approached by the senior editors of this series to edit a book on interactions between the host and infectious agents, we accepted this offer as an exciting challenge. The only condition, readily agreed upon, was that such a book should focus on the immunology of infections in humans. Our reasons, if not biases, were severalfold. We sensed that the fields of microbiology and im munology, which had diverged as each was focusing on its individual search, were coming together. In agreement with the opinions expressed by Dr. Richard Krause in the Introduction, we strongly believed that the development of the immune system evolved in response to infectious agents and that the evolution of these agents was influenced in turn by the character of the host's responses. An inten sive examination of the multitude of primitive or more recently developed host defense mechanisms to determine their relative contribution to man's resistance to a given infectious agent appeared to us to be of crucial basic and practical interest. Many immune mechanisms studied in animals were being explored in humans and it appeared timely to focus particularly on what was known about man's resistance to infectious agents, correlating this information with lessons learned from relevant experiments in animal models.
The first—and only—source to integrate the multiple disciplines and professions exploring the many ways people interact with the natural and designed environments in which we live. Comprising more than 250 informative entries, The Encyclopedia of Human Ecology examines the interdisciplinary and complex topic of human ecology. Knowledge gathered from disciplines that study individuals and groups is blended with information about the environment from the fields of family science, geography, anthropology, urban planning, and environmental science. At the same time, professions intended to enhance individual and family life—marriage and family therapy, clinical psychology, social work, dietetic and other health professions—are represented alongside those concerned with the preservation, conservation, and management of the environment and its resources. How rampant are eating disorders among our youth? Are AIDS educational programs effective? What problems do adolescents transitioning into adulthood encounter? Here, four leading scholars in the field have assembled a team of top-tier psychologists, sociologists, anthropologists, and other experts to explore these and hundreds of other timely issues.
The concise, easy-to-understand Neurology for the Speech-Language Pathologist, 6th Edition provides students and clinicians with a practical guide for the study and understanding of neurology in speech-language pathology (SLP). Correlated with clinical syndromes and diseases seen in SLP, it gives you a solid understanding of the nervous system, including: development of the nervous system, organization of the brain, protective mechanisms, descending motor and ascending sensory pathways, and cranial nerves. New content, case studies, and a strong clinical focus make this new edition essential as you move into practice. - Case studies and clinical applications in clinically oriented chapters provide you with realistic clinical applications. - Presents complex information clearly in a concise, easy-to-understand manner. - Clinical emphasis throughout makes this text valuable as you move into clinical practice — and prepare for the Praxis exam. - Evolve companion website has vocabulary flashcards and study questions with answers so students can assess their knowledge. - Key terms in each chapter and an end-of-text glossary give you easy access to accurate, concise definitions. - NEW! Separate section on pediatric speech and language disorders, including a chapter on the developing brain. - EXPANDED! Updated sections on neurodiagnostic and neuroimaging procedures, as well as childhood apraxia of speech, fluency disorders, Autism, and TBI. - NEW! Updated discussion of the anatomy and function of the cerebellum gives you the most current information. - UPDATED! Covers the latest neuroimaging research on anatomy, physiology, and disorders of speech-language. - EXPANDED! Discusses the brain connectivity and the neural network underlying learning and language. - EXPANDED! Addresses motor control for speech production so you stay in the know.
For more than 100 years, Henry's Clinical Diagnosis and Management by Laboratory Methods has been recognized as the premier text in clinical laboratory medicine, widely used by both clinical pathologists and laboratory technicians. Leading experts in each testing discipline clearly explain procedures and how they are used both to formulate clinical diagnoses and to plan patient medical care and long-term management. Employing a multidisciplinary approach, it provides cutting-edge coverage of automation, informatics, molecular diagnostics, proteomics, laboratory management, and quality control, emphasizing new testing methodologies throughout. - Remains the most comprehensive and authoritative text on every aspect of the clinical laboratory and the scientific foundation and clinical application of today's complete range of laboratory tests. - Updates include current hot topics and advances in clinical laboratory practices, including new and extended applications to diagnosis and management. New content covers next generation mass spectroscopy (MS), coagulation testing, next generation sequencing (NGS), transfusion medicine, genetics and cell-free DNA, therapeutic antibodies targeted to tumors, and new regulations such as ICD-10 coding for billing and reimbursement. - Emphasizes the clinical interpretation of laboratory data to assist the clinician in patient management. - Organizes chapters by organ system for quick access, and highlights information with full-color illustrations, tables, and diagrams. - Provides guidance on error detection, correction, and prevention, as well as cost-effective test selection. - Includes a chapter on Toxicology and Therapeutic Drug Monitoring that discusses the necessity of testing for therapeutic drugs that are more frequently being abused by users. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
This work is concerned with Cystic Fibrosis (CF), the most common fatal genetic disease in the Caucasian population. The decade of the 1980s was one of spectacular progress in understanding the genetic and molecu lar basis of CF. The research breakthroughs of the decade began with the first fundamental insights, published in 1981-1983, into the basic cellular pathophysiology of CF with demonstrations of altered ion transport in spe cialized exocrine epithelial tissues (1-3). Research progress shifted into a triumph of "reverse genetics," using restriction-fragment-Iength polymor phism DNA technology (4), with the localization of the CF gene to a region of chromosome 7 (5-7). Understanding, accelerated by an explOSion of in vitro methodologies for epithelial cell culture and transformation, allowed and physiological studies (8-11); these focused, controlled biochemical with increasing precision, on the molecular pathology of distal steps in the regulatory pathways for epithelial ion transport (12-19). Finally, the "end of the beginning" occurred in late 1989 with one of the great achievements of molecular genetics, the isolation and cloning of the CF gene (20). As a result, we now have a CF gene product, the cystic fibrosis transmembrane regulator (CFfR), possessing predicted amino acid sequence, suggested tertiary structure, and possible transmembrane transport function (21). These amazing developments have set the stage for the next round of advances, which surely will include: 1.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.