This book is a must read for anyone in close proximity to middle schoolers. Using actual events from the lives of real teenagers, the authors (a middle school principal and a child neuropsychologist) combine perspectives to provide an engaging, light-hearted journey into the adventures and misadventures of newly-minted teens. First, the authors put to rest some long-standing misconceptions about teenage behavior. However bizarre they appear to adults, teenagers' emotional reactions and their behaviors can no longer be explained solely by raging hormones. Using the stories as a backdrop, the authors provide emerging findings from developmental psychology and the neurosciences to explain why young teens do the things they do. The developing brain of a young teenager produces thoughts and feelings that are vastly different from an adult. Knowing this helps us to appreciate and accept the unique challenges they face.
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. - Updates to all chapters, including new examples and references - Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book - Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry - Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant - Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis - Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: - for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib - for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid - for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin - Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples - Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites - Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
This textbook considers the properties and applications of dental materials and includes all the necessary basic science and clinical applications. Virtually all procedures in restorative dentistry make use of a dental material. Among these materials are metals, ceramics, polymers and composites, and their uses include filling of cavities and root canals and the making of impressions or replicas of teeth and tissues prior to the construction of crowns, bridges and dentures. All dental students need to acquire a working knowledge of both the properties and applications of the materials which they will use. - Written in an accessible friendly style which provides core information only – perfect for the busy dental student! - Rich with pull-out boxes, tables, line artworks and photographs - Describes the structure of materials with chapters on atomic bonding, metals, ceramics and polymers - Explores the use of clinical dental materials including resin bonding to enamel and dentine and impression materials - Describes the use of laboratory and related dental materials used in the construction of fixed and removable prostheses - Contains everything that students need for BDS and equivalent exams! - Accompanied by an ALL NEW ON-LINE SELF-ASSESSMENT MODULE to provide essential exam practice for all BDS candidates and those taking equivalent exams - Includes updated coverage of recent developments in dental biomaterials, including endodontic materials, digital impressions and a useful new chapter on nanotechnology in dentistry - Reflects the growing need to be aware of the safety aspects of dental materials and the care that has to be taken when sourcing materials from across the world - Fully updated and now published in full colour throughout!
Toward the end of the twentieth century, the solution to mental illness seemed to be found. It lay in biological solutions, focusing on mental illness as a problem of the brain, to be managed or improved through drugs. We entered the "Prozac Age" and believed we had moved far beyond the time of frontal lobotomies to an age of good and successful mental healthcare. Biological psychiatry had triumphed. Except maybe it hadn’t. Starting with surprising evidence from the World Health Organization that suggests that people recover better from mental illness in a developing country than in the first world, Doctoring the Mind asks the question: how good are our mental healthcare services, really? Richard P. Bentall picks apart the science that underlies our current psychiatric practice. He puts the patient back at the heart of treatment for mental illness, making the case that a good relationship between patients and their doctors is the most important indicator of whether someone will recover. Arguing passionately for a future of mental health treatment that focuses as much on patients as individuals as on the brain itself, this is a book set to redefine our understanding of the treatment of madness in the twenty-first century.
The author of Ephesians shows an interest in the Isaianic new exodus (INE) in facilitating his focus on the present triumph of the people of God. The recipients required both insight and confidence, especially in regard to the certainty of their salvation, its mysterious nature, Jewish-Gentile relations, and their former manner of life. In the face of these challenges the author maintains that victory is secured through God's choice of them and the working of his redemptive program--which inevitably leads to triumphal blessings. As with the exodus-era Hebrews, the readers participate in paschal redemption, now embodied in Christ, along with his resurrection and ascension as the triumphant new exodus warrior over principalities and powers. In addition, and as predicted by OT writers, Gentile proselytes share the blessings of the new exodus, but now on equal footing and access as Jewish Christians--creating a new eschatological temple. Triumphant Christ distributes gifts, facilitates Spirit-endowed living, and enables Christian warfare that mirrors Yahweh and his servant. The recipients of the epistle appear to be called to view INE triumph as above, below, now and not yet, while not discarding current applications on earth.
The life of John Marshall, Founding Father and America's premier chief justice. In 1801, a genial and brilliant Revolutionary War veteran and politician became the fourth chief justice of the United States. He would hold the post for 34 years (still a record), expounding the Constitution he loved. Before he joined the Supreme Court, it was the weakling of the federal government, lacking in dignity and clout. After he died, it could never be ignored again. Through three decades of dramatic cases involving businessmen, scoundrels, Native Americans, and slaves, Marshall defended the federal government against unruly states, established the Supreme Court's right to rebuke Congress or the president, and unleashed the power of American commerce. For better and for worse, he made the Supreme Court a pillar of American life. In John Marshall, award-winning biographer Richard Brookhiser vividly chronicles America's greatest judge and the world he made.
The third edition of this monograph continues to have the goal of providing an overview of current thought about the spinal cord mechanisms that are responsible for sensory processing. We hope that the book is of value to both basic and clinical neuroscientists. Several changes have been made in the presentation, as well as additions because of the research advances that have been made during the past decade. Chapters 3 and 4 in the previous edition have been subdivided, and now the morphology of primary afferent neu rons of the dorsal root ganglia is described in Chapter 3 and the chemical neuroanatomy 4. The description of the dorsal hom in the previous Chapter 4 of these neurons in Chapter is now included in Chapter 5, and the chemical neuroanatomy of the dorsal hom in Chapter 6. Furthermore, discussions of the descending control systems have now been of Chapter 12. consolidated at the end The authors would like to express their appreciation for the help provided by several individuals. R.E.C. wishes to acknowledge the many things he learned about primary afferent neurons from conversations with Dr S. N. Lawson. He also thanks Lyn Shilling for her assistance with the typing. WDW thanks Dr Nada Lawand for her critical reading of parts of the manuscript, Rosaline Leigh for help with the manuscript, and Griselda Gonzales for preparing the illustrations.
Chemoattractant Ligands and Their Receptors succinctly summarizes cutting-edge research in the important area of chemoattraction in immunology. It explains how chemoattractant molecules mobilize immune cells to ward off attack by invading pathogens, both at a molecular and at a cellular level. Written by acknowledged experts in the field, it contains detailed molecular and structural information on each of the major chemoattractants and their receptors. Its unique multidisciplinary approach encompasses biology, immunology, protein chemistry, and molecular biology. A time-saving reference for both researchers and students.
This CD-ROM edition of Silverman's Organic Chemisry of Drug Design and Drug Action, Second Edition reflects the significant changes in the drug industry in recent years, using an accessible interactive approach. This CD-ROM integrates the author's own PowerPoint slides, indexed and linked to the book pages in PDF format. The three-part structure includes an all-electronic text with full-text search capabilites and nearly 800 powerpoint slides. This is a unique and powerful combination of electronic study guide and full book pages. Users can hyperlink seamlessly from the main text to key points and figures on the outline and back again. It serves as a wonderful supplement for instructors as well as a fully integrated text and study aid for students. * Three-part package includes 1) powerpoint, 2) integrated powerpoint and pdf-based text, and 3) fully searchable PDF-based text with index * Includes new full-color illustrations, structures, schemes, and figures as well as extensive chapter problems and exercises * User-friendly buttons transition from overview (study-guide) format to corresponding book page and back with the click of a mouse * Full-text search capabality an incomparable tool for researchers seeking specific references and/or unindexed phrases
With a focus on evidence-based, state-of-the-art information throughout, the eighth edition of Irwin and Rippe’s Intensive Care Medicine offers authoritative guidance to the wide variety of specialty physicians and non-physicians practicing in the adult intensive care environment. This comprehensive textbook covers both the theoretical and practical aspects of the field, and has been completely updated to provide encyclopedic, interprofessional coverage to support practitioners in every area of this complex field.
Sited at the furthest limits of the Neolithic revolution and standing at the confluence of the two great sea routes of prehistory, Britain and Ireland are distinct from continental Europe for much of the prehistoric sequence. In this landmark study, Richard Bradley offers an interpretation of the unique archaeological record of these islands. Highlighting the achievements of its inhabitants, Bradley surveys the entire archaeological sequence over a 5,000 year period, from the last hunter-gatherers and the adoption of agriculture in the Neolithic period, to the discovery of Britain and Ireland by travellers from the Mediterranean during the later pre-Roman Iron Age. His study places special emphasis on landscapes, settlements, monuments, and ritual practices. This edition has been thoroughly revised and updated. The text takes account of recent developments in archaeological science, such as isotopic analyses of human and animal bone, recovery of ancient DNA, and more subtle and precise methods of radiocarbon dating.
*** Winner of the PROSE Award (2019) for Classics *** This major new work on Roman London brings together the many new discoveries of the last generation and provides a detailed overview of the city from before its foundation in the first century to the fifth century AD. Richard Hingley explores the archaeological and historical evidence for London under the Romans, assessing the city in the context of its province and the wider empire. He explores the multiple functions of Londinium over time, considering economy, industry, trade, status and urban infrastructure, but also looking at how power, status, gender and identity are reflected through the materiality of the terrain and waterscape of the evolving city. A particular focus of the book is the ritual and religious context in which these activities occurred. Hingley looks at how places within the developing urban landscape were inherited and considers how the history and meanings of Londinium built upon earlier associations from its recent and ancient past. As well as drawing together a much-needed synthesis of recent scholarship and material evidence, Hingley offers new perspectives that will inspire future debate and research for years to come. This volume not only provides an accessible introduction for undergraduate students and anyone interested in the ancient city of London, but also an essential account for more advanced students and scholars.
Over the past few decades numerous scientists have called for a unification of the fields of embryo development, genetics, and evolution. Each field has glaring holes in its ability to explain the fundamental phenomena of life. In this book, the author shows how the phenomenon of cell differentiation, considered in its temporal and spatial aspects during embryogenesis, provides a starting point for a unified theory of multicellular organisms (plants, fungi and animals), including their evolution and genetics. This unification is based on the recent discovery of differentiation waves by the author and his colleagues, described in the appendices, and illustrated by a flip movie prepared by a medical artist. To help the reader through the many fields covered, a glossary is included.This book will be of great value to the researcher and practicing doctors/scientists alike. The research students will receive an in-depth tutorial on the topics covered. The seasoned researcher will appreciate the applications and the gold mine of other possibilities for novel research topics.
The Later Prehistory of North-West Europe provides a unique, up-to-date, and easily accessible synthesis of the later prehistoric archaeology of north-west Europe, transcending political and language barriers that can hinder understanding. By surveying changes in social forms, landscape organization, monument types, and ritual practices over six millennia, the volume reassesses the prehistory of north-west Europe from the late Mesolithic to the end of the pre-Roman Iron Age. It explores how far common patterns of social development are apparent across north-west Europe, and whether there were periods when local differences were emphasized instead. In relation to this, it also examines changes through time in the main axes of contact between the various regions of continental Europe, Britain, and Ireland. Key to the volume's broad scope is its focus on the vast mass of new evidence provided by recent development-led excavations. The authors collate data that has been gathered on thousands of sites across Britain, Ireland, northern France, the Low Countries, western Germany, and Denmark, using sources including unpublished 'grey literature' reports. The results challenge many aspects of previous narratives of later prehistory, allowing the volume to present a distinctively fresh perspective.
Debates the fundamental question of how far effective human resource management policies can enable schools and colleges to transcend the paradoxes of the global reform agenda. This title analyzes the relationship between leadership, the classroom and results.
The care of children with acute medical problems is evolving as knowledge of new conditions develops. In addition, technology also changes to provide solutions to optimize care. This issue of PCNA highlights the important populations, disease states, and technological advancements in pediatric emergency medicine. Although concussion and head injury are common occurrences for the practicing pediatrician, we now better understand how to evaluate and manage these children and to use CT scans appropriately. Pediatric offices need to be incorporated in any emergency plan for both acute emergencies and common injuries. Analgesia and sedation must always be considered to provide comfort for children. Technologically assisted children and children with acute psychiatric and behavioral problems are now more commonplace in the Emergency Department as well as the office setting, and the practicing pediatrician needs to have a clear plan in understanding these medical conditions and appropriate management and referral. New drugs of abuse and foreign body ingestions are prevalent and have unique diagnostic and treatment challenges. Skin infections and abscesses have always been common but our knowledge of resistance patterns and best practices for treatment is changing. Finally, whether it is the pediatric office practitioner or the Emergency medicine physician, we need to continue our important efforts in injury prevention for the future of our children.
Produced by the advisors to the Nobel Peace Prize and the 1984 Olympics, this book offers practical event management and marketing advice flavoured with various anecdotes in one easy-to-read format. It explains precisely how to build image or company recognition by sponsoring diverse sizes and types of events ranging from entertainment to sports. It also covers every stage of marketing, logistics, finance, concessions and public relations.
Obesity in children and adolescents is a serious issue with many health and social consequences that often continue into adulthood. Implementing prevention programs and getting a better understanding of treatment for youngsters is important to controlling the obesity epidemic. The term "childhood obesity" may refer to both children and adolescents. Between 5-25 percent of children and teenagers in the United States are obese. As with adults, the prevalence of obesity in the young varies by ethnic group. It is estimated that 5-7 percent of White and Black children are obese, while 12 percent of Hispanic boys and 19 percent of Hispanic girls are obese. Some data indicate that obesity among children is on the increase. The second National Children and Youth Fitness Study found 6-9 year olds to have thicker skinfolds than their counterparts in the 1960s. During the same period, others documented a 54 percent increase in the prevalence of obesity among 6-11 year olds. This book examines leading research in this area of great concern to society.
This softcover manual covers all procedures and techniques necessary for certification in critical care from the internal medicine, anesthesiology, and surgical critical care certification exam. Each procedure or monitoring technique discusses indications/contraindications, equipment, anatomy, techniques, postprocedure care, and complications. Specific nursing indications are indicated where appropriate.
Private-eye Fritz Malone becomes embroiled in a murder case when his client, Robin Burrell--a witness at the trial of TV celebrity Marshall Fox, accused of killing two women--turns up dead, killed in the same manner as the prior victims.
Why is there a need to ‘innovate healthcare’? The basic reason stems from the sheer scale of the challenges now facing healthcare provision in the UK and across many other countries. The aim of this book is to interrogate past and current attempts to innovate in this arena and to draw-out the key lessons. Innovating Healthcare: The Role of Political, Managerial and Clinical Leadership presents the latest state of knowledge based on original data from a series of NIHR-funded research projects set in the context of a review of extensive secondary research. The book draws upon first-person verbatim accounts of change attempts made by doctors and other clinicians as well as upon research findings about the roles played by policy-makers and managers. The analysis draws upon theory and practice in leadership, innovation and institution-building. The mutually-reinforcing contributions of political, managerial and clinical leadership are at the core of the investigative narrative. This book will be of interest to students and researchers, clinicians and managers in the health and care sectors as well as policy-makers. While the focus in on healthcare, the book has wider relevance for students of management, leadership, innovation and organizational studies. The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license
This is a history of the secret activities of the British government in response to threats to the nation's well-being and stability during the twentieth century. It is based on intensive and widespread research in private and public archives and on documents many of which have only recently come to light or been made available. The dangers perceived by the state have been manifold and various, coming from within and from abroad. Anarchists, fascists, socialists, communists, the IRA, trades-unionists and animal activists as well as spies, terrorists and saboteurs have been the subject of undercover investigation, along with almost every large-scale movement from suffragettes to campaigners for peace and nuclear disarmament. The author describes the methods and people employed, and the mixed nature of their results. The British state has always seen itself as civil and liberal, but as Dr Thurlow shows it has sometimes been far from open. The government has had many weapons at its disposal, from public order acts, censorship, internment and proscription on the one hand, to covert operations, infiltration and manipulation on the other. Yet when examined in the light of new evidence, the activities of the state are fully comprehensible only in terms of those who comprised it. The author shows the tensions among the departments (between MI5, MI6, SIS and the Special Branch, for example), and the crucial part played by individuals whose motives were often far from what the government supposed them to be. This is an at times disturbing, at others almost comical, but always fascinating account. It throws light on the inmost workings of the state, as well as on the movements and people subject to investigation and action.
Since 1975, Dr. Kenneth Swaiman's classic text has been the reference of choice for authoritative guidance in pediatric neurology, and the 6th Edition continues this tradition of excellence with thorough revisions that bring you fully up to date with all that's new in the field. Five new sections, 62 new chapters, 4 new editors, and a reconfigured format make this a comprehensive and clearly-written resource for the experienced clinician as well as the physician-in-training. - Nearly 3,000 line drawings, photographs, tables, and boxes highlight the text, clarify key concepts, and make it easy to find information quickly.
Deep-water (below wave base) processes, although generallyhidden from view, shape the sedimentary record of more than 65% ofthe Earth’s surface, including large parts of ancientmountain belts. This book aims to inform advanced-levelundergraduate and postgraduate students, and professional Earthscientists with interests in physical oceanography and hydrocarbonexploration and production, about many of the important physicalaspects of deep-water (mainly deep-marine) systems. The authorsconsider transport and deposition in the deep sea, trace-fossilassemblages, and facies stacking patterns as an archive of theunderlying controls on deposit architecture (e.g., seismicity,climate change, autocyclicity). Topics include modern and ancientdeep-water sedimentary environments, tectonic settings, and howbasinal and extra-basinal processes generate the typicalcharacteristics of basin slopes, submarine canyons, contouritemounds and drifts, submarine fans, basin floors and abyssalplains.
Eichner's classic A Guide to Post-Keynesian Economics (1978) is still seen as the definitive staging post for those wishing to familiarise themselves with the Post-Keynesian School. This book brings the story up-to-date. Of all the subgroups within heterodox economics, Post-Keynesianism has provided the most convincing alternative to mainstream theory. The main representatives of the Post-Keynesianism from both sides of the Atlantic are represented here, including Paul Davidson, Geoff Harcourt and Sheila Dow.
This text provides up-to-date, comprehensive, and accessible information about alcohol use in western society and other cultures. In 2009, President Barack Obama hosted a friendly "beer summit" on the White House lawn in an attempt to diffuse a racially charged incident between a Caucasian policeman and an African American professor. In the United States, beer and other alcoholic beverage companies are often the main advertisers during television sporting event coverage. A study has found that 44 percent of American college students participate in binge drinking, while the NHTSA reports that over 31 percent of traffic fatalities involve a driver with an illegal blood-alcohol content level. In our culture, consumption of alcohol is both widely accepted as a healthy social norm and condemned as a crime. Alcohol provides information about how alcohol acts upon the body, the social problems related to alcohol use, medical disorders connected to alcohol use, alcohol use throughout world cultures and the American population, and public policy issues. This book also contains sections on adolescent and college student alcohol use.
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