In 1865, Wild Bill Hickok killed Dave Tutt in a Missouri public square in the West’s first notable "walkdown." One hundred and twenty-nine years later, Bernard Goetz shot four threatening young men in a New York subway car. Apart from gunfire, what do the two events have in common? Goetz, writes Richard Maxwell Brown, was acquitted of wrongdoing in the spirit of a uniquely American view of self-defense, a view forged in frontier gunfights like Hickok’s. When faced with a deadly threat, we have the right to stand our ground and fight. We have no duty to retreat.
To preserve the environment with the lowest possible cost to the social sector means that private costs should be aligned with social costs. Many governments in the Latin American and Caribbean Region are doing this now using market-based instruments (MBIs). This publication investigates the use of MBIs in the Latin America and the Caribbean (LAC) context. The investigation covers a sample of eleven countries in the region and a cross-section of environmental issues in an urban setting.
This book surveys the models for the origin of life and presents a new model starting with shaped droplets and ending with life as polygonal Archaea; it collects the most published micrographs of Archaea (discovered only in 1977), which support this conclusion, and thus provides the first visual survey of Archaea. Origin of Life via Archaea’s purpose is to add a new hypothesis on what are called “shaped droplets”, as the starting point, for flat, polygonal Archaea, supporting the Vesicles First hypothesis. The book contains over 6000 distinct references and micrographs of 440 extant species of Archaea, 41% of which exhibit polygonal phenotypes. It surveys the intellectual battleground of the many ideas of the origin of life on earth, chemical equilibrium, autocatalysis, and biotic polymers. This book contains 17 chapters, some coauthored, on a wide range of topics on the origin of life, including Archaea’s origin, patterns, and species. It shows how various aspects of the origin of life may have occurred at chemical equilibrium, not requiring an energy source, contrary to the general assumption. For the reader’s value, its compendium of Archaea micrographs might also serve many other interesting questions about Archaea. One chapter presents a theory for the shape of flat, polygonal Archaea in terms of the energetics at the surface, edges and corners of the S-layer. Another shows how membrane peptides may have originated. The book also includes a large table of most extant Archaea, that is searchable in the electronic version. It ends with a chapter on problems needing further research. Audience This book will be used by astrobiologists, origin of life biologists, physicists of small systems, geologists, biochemists, theoretical and vesicle chemists.
After more than a decade of democratic regression, three major crises have acted to reshape global politics in recent years: climate change, the Covid-19 pandemic and its economic legacy, and geopolitical conflict. In Democratic Crossroads, Richard Youngs argues these crises are altering the balance between democratic and authoritarian dynamics around the world. Yet while they add to the strains on democracy, they are also awakening a momentum of democratic resilience and renewal. He argues that to deal with the era's momentous challenges, democratic politics need a major boost and reboot. Without stronger commitments to uphold and improve democratic norms and practices, democracy may not weather these challenges. As Youngs shows, far-reaching democratic innovation that gives citizens effective influence over epoch-defining matters will help ensure that democratic values are more vigorously defended. In a moment of pivotal change, this book explains how democracies can retain their resiliency and highlights the key factors that will determine democracy's fortunes in the future.
Little now remains of the vast network of passenger and freight railroad lines that once crisscrossed much of eastern and midwestern America, but in 1946, the steam locomotive was king. This is a record of a time when traveling out of town meant, for most Americans, taking the train.
Recognized as the definitive book in laboratory medicine since 1908, Henry’s Clinical Diagnosis and Management by Laboratory Methods, edited by Richard A. McPherson, MD and Matthew R. Pincus, MD, PhD, is a comprehensive, multidisciplinary pathology reference that gives you state-of-the-art guidance on lab test selection and interpretation of results. Revisions throughout keep you current on the latest topics in the field, such as biochemical markers of bone metabolism, clinical enzymology, pharmacogenomics, and more! A user-friendly full-color layout puts all the latest, most essential knowledge at your fingertips. Update your understanding of the scientific foundation and clinical application of today's complete range of laboratory tests. Get optimal test results with guidance on error detection, correction, and prevention as well as cost-effective test selection. Reference the information you need quickly and easily thanks to a full-color layout, many new color illustrations and visual aids, and an organization by organ system. Master all the latest approaches in clinical laboratory medicine with new and updated coverage of: the chemical basis for analyte assays and common interferences; lipids and dyslipoproteinemia; markers in the blood for cardiac injury evaluation and related stroke disorders; coagulation testing for antiplatelet drugs such as aspirin and clopidogrel; biochemical markers of bone metabolism; clinical enzymology; hematology and transfusion medicine; medical microbiology; body fluid analysis; and many other rapidly evolving frontiers in the field. Effectively monitor the pace of drug clearing in patients undergoing pharmacogenomic treatments with a new chapter on this groundbreaking new area. Apply the latest best practices in clinical laboratory management with special chapters on organization, work flow, quality control, interpretation of results, informatics, financial management, and establishing a molecular diagnostics laboratory. Confidently prepare for the upcoming recertification exams for clinical pathologists set to begin in 2016.
Dr. Rothstein has assembled top experts to present the current status of the role of endoscopy in managing the obese patient. Authors present current clinical information on the following topics: Small Bowel Target Devices and Techniques; Reimbursement Issues for Endoscopic Devices Used for Metabolic Endoscopy; the Physiologic Alteractions of Bariatric Surgery; Non-Balloon Gastric and Pyloric Therapies for Obesity; Aspiration Therapy for Obesity; Endoscopic Therapies after Surgery; Duodenal Mucosal Resurfacing: Role for Diabetes Treatment; Gastric Plication; and Gastric Balloons. Readers should come away with the information they need to utilize endoscopic techniques to improve outcomes in their patients.
This book looks systematically at the extent to which Jews, women, African Americans, Latinos, Asians and gay men and lesbians have entered the higher circles of power that constituted what sociologist C. Wright Mills called 'the power elite.' It examines why and how the power elite has diversified, the pathways taken by those who have entered the power elite, and the effect this diversification has had on the way power works in the United States.
Developed by the American Medical Association's Accelerating Change in Medical Education Consortium, Health Systems Science is the first text that focuses on providing a fundamental understanding of how health care is delivered, how health care professionals work together to deliver that care, and how the health system can improve patient care and health care delivery. Along with basic and clinical science, Health Systems Science (HSS) is rapidly becoming a crucial "third pillar" of medical science, requiring a practical, standardized curriculum with an emphasis on understanding the role of human factors, systems engineering, leadership, and patient improvement strategies that will help transform the future of health care and ensure greater patient safety. - Complete coverage of the evolving field of HSS includes patient safety, quality improvement, evidence-based medicine, value in health care, interprofessional teamwork, stewardship of health care resources, population management, clinical informatics, care coordination, leadership, and health care financing/reform. - Patient improvement strategies incorporates checklists, information technology, team training, and more. - A consistent chapter template provides clear coverage of each topic, including Learning Objectives, Chapter Outline, Core Chapter Content, Summary, Questions for Reflection, and Annotated Bibliography and References. - Highly relevant content applicable to today's evolving health care delivery written by experts in key, emerging areas of HSS. - Developed in partnership with the AMA's Accelerating Change in Medical Education Consortium, at the forefront of change and innovation in medical education.
Neuroscience Fundamentals for Communication Sciences and Disorders, Second Edition is a comprehensive textbook primarily designed for undergraduate neural bases or graduate neuroscience courses in communication sciences and disorders programs (CSD). The text can also be used as an accessible go-to reference for speech-language pathology and audiology clinical professionals practicing in medical and rehab settings. Written with an engaging and conversational style, the author uses humor and analogies to explain concepts that are often challenging for students. Complemented by more than 400 visually rich and beautifully drawn full-color illustrations, the book emphasizes brain and behavior relationships while also ensuring coverage of essential neuroanatomy and neurophysiology in an integrative fashion. With a comprehensive background in the principles, processes, and structures underlying the workings of the human nervous system, students and practitioners alike will be able to better understand and apply brain-behavior relationships to make appropriate clinical assessments and treatment decisions. Extending well beyond traditional neuroanatomy-based textbooks, this resource is designed to satisfy three major goals: Provide neuroanatomical and neurophysiological detail that meets the real-world needs of the contemporary CSD student as they move forward toward clinical practice and into the future where advancements in the field of health and brain sciences are accelerating and contributing more and more each day to all areas of rehabilitation. Provide clear, understandable explanations and intuitive material that explains how and why neuroanatomical systems, processes, and mechanisms of the nervous system operate as they do during human behavior. Provide a depth and scope of material that will allow the reader to better understand and appreciate a wide range of evidence-based literature related to behavior, cognition, emotion, language, and sensory perception—areas that all directly impact treatment decisions. New to the Second Edition: * 40 new full-color illustrations * Reorganization and division of content from Chapters 4, 5, and 6 of the previous edition, into six new and more digestible chapters * A new standalone chapter on the cranial nerves * Addition of a major section and discussion on the neural bases of swallowing * Addition of more summary tables and process flowcharts to simplify the text and provide ready-made study materials for students * Revisions to most figures to improve their clarity and coherence with the written material Disclaimer: Please note that ancillary content (such as documents, audio, and video, etc.) may not be included as published in the original print version of this book.
This highly illustrated student guide introduces the skills of interpreting a geological map and relating it to the morphology of the most important types of geological structure. Thoroughly revised, and with more international examples, it is ideal for use by students with a minimum of tutorial supervision.Photographs of structures are set alongside their representations on maps. The maps used in exercises have been chosen to provide all of the realism of a survey map without the huge amount of data often present, so that students can develop skills without becoming overwhelmed or confused. In particular, emphasis is placed throughout on developing the skill of three-dimensional visualization so important to the geologist.* Successful practical guide provides a solid introduction to the subject of geological maps* Fully revised edition includes more international examples to increase the breadth of your knowledge* Illustrations and end of chapter questions make this an ideal tool to aid self-guided study
Comprehensive and up to date, the Second Edition of Diagnostic Pathology: Infectious Disease, by Dr. Richard Kradin, is an invaluable tool for the accurate diagnosis of any infectious disease―from the common to the most challenging. The organ-based format makes it an especially useful tool for surgical pathologists' daily diagnostic and management issues. High-quality, full-color illustrations and differential diagnosis tables accompany each lesion, clearly depicting how to recognize the morphology of organisms and the spectrum of histological responses that they may cause. - Addresses the most difficult diagnostic issues that practicing or trainee surgical pathologists face when handling infectious disease tissue specimens. - Highlights morphological characteristics and landmarks of tissue samples for easy access to information necessary for signing out a specimen. - Emphasizes the host responses critical in differential diagnosis to serve as a second opinion when non-infectious diagnoses mimic and confound the diagnosis of infection. - Completely revised with the latest diagnostic support and hot topics in the field: - A new chapter on novel techniques in microbiology - A new chapter on eye infections - New coverage of immunohistochemical staining and other molecular diagnostic techniques - New discussions of human papillomavirus, a critical tool in predictive cancer screening - New information on infections in the immunocompromised host and related special considerations - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.
The second edition of this book is created to assist the clinician in the initial response to the needs of a child or adult exposed to a poisonous or injurious plant. It lists common plants that might lead to the development of the symptom complex and describes the mechanisms of action of the implicated toxin, additional clinical manifestations, and specific therapeutics for each presentation. It has methodically enhanced the previous edition’s botanical rigor with insights from both pharmacognosy and clinical medicine to make it a truly comprehensive source for anyone who has an interest in plants.
In a riveting narrative that includes information from newly declassified documents, acclaimed historian Richard B. Frank gives a scrupulously detailed explanation of the critical months leading up to the dropping of the atomic bomb. Frank explains how American leaders learned in the summer of 1945 that their alternate strategy to end the war by invasion had been shattered by the massive Japanese buildup on Kyushu, and that intercepted diplomatic documents also revealed the dismal prospects of negotiation. Here also, for the first time, is a comprehensive account of how Japan's leaders were willing to risk complete annihilation to preserve the nation's existing order. Frank's comprehensive account demolishes long-standing myths with the stark realities of this great historical controversy.
From the introduction: "Tradition has it that every American child receives, as part of his birthright, the freedom to mold his own life. . . . However inaccurate as a description of American society, the success myth reflects what millions believe that society is or ought to be. The degree to which opportunity has or has not been available in our society is a subject for empirical investigation. It rests within the realm of verifiable fact. The belief that opportunity exists for all is a subject for intellectual analysis and rests within the realm of ideology. This latter dimension of the success myth is the primary focus of this book.
Modern international law is widely understood as an autonomous system of binding legal rules. Nevertheless, this claim to autonomy is far from uncontroversial. International lawyers have faced recurrent scepticism as to both the reality and efficacy of the object of their study and practice. For the most part, this scepticism has focussed on international law's peculiar institutional structure, with the absence of centralised organs of legislation, adjudication and enforcement, leaving international legal rules seemingly indeterminate in the conduct of international politics. Perception of this 'institutional problem' has therefore given rise to a certain disciplinary angst or self-defensiveness, fuelling a need to seek out functional analogues or substitutes for the kind of institutional roles deemed intrinsic to a functioning legal system. The author of this book believes that this strategy of accommodation is, however, deeply problematic. It fails to fully grasp the importance of international law's decentralised institutional form in securing some measure of accountability in international relations. It thus misleads through functional analogy and, in doing so, potentially exacerbates legitimacy deficits. There are enough conceptual weaknesses and blindspots in the legal-theoretical models against which international law is so frequently challenged to show that the perceived problem arises more in theory, than in practice.
Provides comprehensive detail on the various aspects of particular molecules involved in the phases of injury and repair and the cellular movements and processes....This is an excellent reference book for libraries serving biology and health science clientele and for workers in this field of research.' -American Scientist, from a review of the First Edition All chapters of this second edition have been completely revised and expanded-especially the chapters on growth factors and extracellular matrix molecules. New chapters discuss provisional matrix proteins, extracellular matrix receptors, and scarring versus nonscarring wound healing.
Gene transfer to animal cells was first achieved more than thirty years ago. Since then, transformation technology has developed rapidly, resulting in a multitude of techniques for cell transformation and the creation of transgenic animals. As with any expanding technology, it becomes difficult to keep track of all the developments and to find a concise and comprehensive source of information that explains all the underlying principles. Gene Transfer to Animals Cells addresses this problem by describing the principles behind gene transfer technologies, how gene expression is controlled in animal cells and how advanced strategies can be used to add, exchange or delete sequences from animal genomes in a conditional manner. A final chapter provides an overview of all the applications of animal cell transformation in farming, medicine and research.
A thoroughly revised edition of the go-to chemical engineering reference Fully updated for the latest advances, this must-have chemical engineering guide serves as a single source for up-to-date physical data, chemical data, and predictive and estimation methods. The Properties of Gases and Liquids, Sixth Edition provides the latest curated data on over 480 compounds and includes a special section devoted to the interpretation of uncertainty in physical property estimation. You will get new coverage of advanced EOSs, advanced computational methods, quantum density functional theory, and semi-empirical combinations. Clear explanations and sample calculations are provided throughout this all-inclusive resource. Coverage includes: Traditional and non-traditional estimation methods Uncertainty Critical properties and related constants Ideal gas properties Saturation properties and virial coefficients Equations of state for pure compounds Equations of state for mixture properties Vapor-liquid, liquid-liquid, and solid-liquid equilibria Infinite dilution activity coefficients Viscosity and thermal conductivity Diffusivity and surface tension
Widely regarded as the definitive reference in the field, Youmans and Winn Neurological Surgery offers unparalleled, multimedia coverage of the entirety of this complex specialty. Fully updated to reflect recent advances in the basic and clinical neurosciences, the 8th Edition covers everything you need to know about functional and restorative neurosurgery, deep brain stimulation, stem cell biology, radiological and nuclear imaging, and neuro-oncology, as well as minimally invasive surgeries in spine and peripheral nerve surgery, and endoscopic and other approaches for cranial procedures and cerebrovascular diseases. In four comprehensive volumes, Dr. H. Richard Winn and his expert team of editors and authors provide updated content, a significantly expanded video library, and hundreds of new video lectures that help you master new procedures, new technologies, and essential anatomic knowledge in neurosurgery. - Discusses current topics such as diffusion tensor imaging, brain and spine robotic surgery, augmented reality as an aid in neurosurgery, AI and big data in neurosurgery, and neuroimaging in stereotactic functional neurosurgery. - 55 new chapters provide cutting-edge information on Surgical Anatomy of the Spine, Precision Medicine in Neurosurgery, The Geriatric Patient, Neuroanesthesia During Pregnancy, Laser Interstitial Thermal Therapy for Epilepsy, Fetal Surgery for Myelomeningocele, Rehabilitation of Acute Spinal Cord Injury, Surgical Considerations for Patients with Polytrauma, Endovascular Approaches to Intracranial Aneurysms, and much more. - Hundreds of all-new video lectures clarify key concepts in techniques, cases, and surgical management and evaluation. Notable lecture videos include multiple videos on Thalamotomy for Focal Hand Dystonia and a video to accompany a new chapter on the Basic Science of Brain Metastases. - An extensive video library contains stunning anatomy videos and videos demonstrating intraoperative procedures with more than 800 videos in all. - Each clinical section contains chapters on technology specific to a clinical area. - Each section contains a chapter providing an overview from experienced Section Editors, including a report on ongoing controversies within that subspecialty. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Tap into the gold standard on central nervous system infections: Infections of the Central Nervous System, 4e is now fully revised and updated to accommodate the wealth of new CNS information discovered over the past decade. More than 90 leading experts contribute chapters, providing comprehensive, up-to-date information. With a broad scope and thorough detail, the text addresses pathogenesis, clinical manifestations, diagnosis, and therapy of various CNS infections and related conditions. Features: Every chapter has been extensively revised and updated, nearly half with new author teams NEW chapter on acute encephalitis NEW clinical information on treatment of tuberculosis, non-tubercular mycobacterial infections, brain abscess, and Lyme disease NEW color design and color images Numerous diagrams, figures, tables, illustrations and photographs demonstrate the content Evidence-based references
Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors. 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis. New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place. In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.
Discusses brain asymmetry from four perspectives - function, evolution, development and causation - covering a wide range of species, including humans.
From the primates to the ancient world all the way to Hollywood, "You're Too Kind" presents a primer on flattery--where it originated, its development through the ages, and its myriad uses in contemporary culture.
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