If China's space ambitions continue unchallenged, America will be seriously economically and militarily disadvantaged. This book provides a comprehensive strategy to secure U.S. primacy in the space domain. From Moon landings to plans for asteroid mining, China is beginning to exploit space to achieve its great power ambitions. Its strategy could, over time, severely and adversely impact U.S. economic and military security. The United States needs to structure its approach to space to ensure that it can meet or surpass PRC timelines. Authors Richard M. Harrison and Peter A. Garretson, both from the American Foreign Policy Council, review the literature on Chinese space ambitions and assess U.S. space-related initiatives across the government, military, and private sector to understand the maturity of technology available to support space initiatives. Their first-hand research and findings are supplemented by interviews with industry experts, corporate space leaders, and government and military officials. The Next Space Race describes and seeks to influence the development of American space policy to ensure the U.S. industrial base is ready to meet or surpass PRC milestones, empower and clarify the mission of the newly minted Space Force, provide guidance to NASA and other federal agencies, and incentivize private sector companies to contribute to ensuring American space primacy.
Just as an archeologist can reassemble pot shards and draw inferences about the civilization that produced it, I've examined a mass of verbal chunks left by Lincoln and people around him. I've sorted jumbled piles of fragments, restored them, and pieced them together in a way that reveals the speakers' world. --Richard Lawrence Miller, from the preface Quoting from eyewitness accounts, Richard Lawrence Miller allows Lincoln and his contemporaries to tell the story of this monumental American and bring a fascinating era of American history to life. The book covers Lincoln's birth through his first election to the Illinois legislature in 1834. Subsequent volumes will deal with Lincoln's life up to the White House years.
From the contents: · C. Brater and M. D. Murray: The effects of NSAIDs on the kidney · G. Edwards and A. H. Weston: Latest developments in potassium channel modulator drugs · M.R. Juchau and Y. Huang: Chemical teratogenesis in humans: Biochemical and molecular mechanisms · S.P. Gupta: Studies on cardiovascular drugs · G. Polak: Antifungal chemotherapy: An everlasting battle · O. Valdenaire: New insights into the bioamine receptor family.
For many years, physicians and the public assumed that the discovery of new antimicrobial agents would outpace the ability of bacteria to mutate and develop drug resistance. Yet the development of new antibiotics has not kept up with bacterial evolution, especially since the late 1990’s. At that time a multitude of pharmaceutical companies abandoned antibiotic research because of strong economic disincentives. For example, it is challenging for these companies to recuperate the investment (typically in the hundreds of millions of dollars) made in developing a new antibiotic, which is typically prescribed for a few days, compared to drugs that treat chronic conditions like heart disease or mental illness. This situation has led the U.S. federal government to take a more active lead in addressing antibiotic resistance. Recently, the White House announced an action plan that includes improving surveillance, developing better diagnostic tools, accelerating drug development, and improving global coordination of antibiotic resistance issues. Equally important is the $1.2 billion dollars that has been pledged to fund these efforts. While we await the implementation of new policies, this issue of Infectious Disease Clinics of North America brings together leading authorities in the field of antibiotic resistance who discuss current issues including antibiotic stewardship, the changing role of the microbiology laboratory in determining antibiotic resistance in gram-negative pathogens, the continuing spread of metallo-ß-lactamases, ESBLs and KPCs, antibiotic options for treating resistant gram-negative infections such as colistin and tigecycline, resistance mechanisms and new treatment options for Mycobacterium tuberculosis, emerging resistance mechanisms in aminoglycosides, issues with antibiotic resistance in immunocompromised patients, new ß-lactamase inhibitors in the clinic, and resistance in VRE and Staphylococcus aureus. Additionally, combination therapy for resistant gram-negative infections has been advocated by some authorities and the advantages and disadvantages of this strategy will be reviewed.
This book is a welcome introduction and reference for users and innovators in geochronology. It provides modern perspectives on the current state-of-the art in most of the principal areas of geochronology and thermochronology, while recognizing that they are changing at a fast pace. It emphasizes fundamentals and systematics, historical perspective, analytical methods, data interpretation, and some applications chosen from the literature. This book complements existing coverage by expanding on those parts of isotope geochemistry that are concerned with dates and rates and insights into Earth and planetary science that come from temporal perspectives. Geochronology and Thermochronology offers chapters covering: Foundations of Radioisotopic Dating; Analytical Methods; Interpretational Approaches: Making Sense of Data; Diffusion and Thermochronologic Interpretations; Rb-Sr, Sm-Nd, Lu-Hf; Re-Os and Pt-Os; U-Th-Pb Geochronology and Thermochronology; The K-Ar and 40Ar/39Ar Systems; Radiation-damage Methods of Geo- and Thermochronology; The (U-Th)/He System; Uranium-series Geochronology; Cosmogenic Nuclides; and Extinct Radionuclide Chronology. Offers a foundation for understanding each of the methods and for illuminating directions that will be important in the near future Presents the fundamentals, perspectives, and opportunities in modern geochronology in a way that inspires further innovation, creative technique development, and applications Provides references to rapidly evolving topics that will enable readers to pursue future developments Geochronology and Thermochronology is designed for graduate and upper-level undergraduate students with a solid background in mathematics, geochemistry, and geology. "Geochronology and Thermochronology is an excellent textbook that delivers on the difficult balance between having an appropriate level of detail to be useful for an upper undergraduate to graduate-level class or research reference text without being too esoteric for a more general audience, with content and descriptions that are understandable and enlightening to the non-specialist. I would recommend this textbook for anyone interested in the history, principles, and mechanics of geochronology and thermochronology." --American Mineralogist, 2021 Read an interview with the editors to find out more: https://eos.org/editors-vox/the-science-of-dates-and-rates
One of the most striking trends in economic development since the 1970s has been the rising importance of the small firm. Focusing on the issues of enterprise development and the regional dimensions of small-firm growth, this book explores the literature of this area. Moving from an analysis of measures of growth to the effects of both internal and external variables - arguing that the owner-manager has a key role in the growth performance of the firm - the authors explore regional disparities in, and constraints on, growth, and make significant advances in the policy debate on understanding how faster growth can be achieved.
This fascinating new volume provides a comprehensive yet concise overview of the chemical aspects of some of the major innovations and changes that occurred during the 20th century, relating chemical structures and properties to real-life applications. Developed for a course taught by the author for several years at UVA, the author covers the important and consequential developments in chemistry and explains their everyday, real-life applications. These include such topics as consumer products, fossil fuel use, polymers, agriculture, food production, nutrition, explosives, and drugs. The section Molecular Biology and Its Applications includes examples of the application of biotechnology and genetic engineering.
Cold atmospheric plasma (CAP) is a promising and rapidly emerging technology for a wide range of applications, from daily life to industry. CAP’s key advantage is its unique ability to effectively deliver reactive species to subjects including biological materials, liquid media, aerosols, and manufactured surfaces. This book assesses the state-of-art in CAP research and implementation for applications including agriculture, medicine, environment, materials, catalysis, and energy. The mechanisms of generation and transport of the key reactive species in the plasma are introduced and examined in the context of their applications. Opportunities and challenges for novel technologies, fresh ideas/concepts, expanded multidisciplinary study, and new applications are discussed. The authors’ vision for the converging trends across diverse disciplines is proposed to stimulate critical discussions, research directions, and collaborations.
A book of great importance; it surpasses all others in breadth and depth."--Commentary If the past century will be remembered for its tragic pairing of civilized achievement and organized destruction, at the heart of darkness may be found Hitler, Stalin, and the systems of domination they forged. Their lethal regimes murdered millions and fought a massive, deadly war. Yet their dictatorships took shape within formal constitutional structures and drew the support of the German and Russian people. In the first major historical work to analyze the two dictatorships together in depth, Richard Overy gives us an absorbing study of Hitler and Stalin, ranging from their private and public selves, their ascents to power and consolidation of absolute rule, to their waging of massive war and creation of far-flung empires of camps and prisons. The Nazi extermination camps and the vast Soviet Gulag represent the two dictatorships in their most inhuman form. Overy shows us the human and historical roots of these evils.
The Psychotic Wavelength provides a psychoanalytical framework for clinicians to use in everyday general psychiatric practice and discusses how psychoanalytic ideas can be of great value when used in the treatment of seriously disturbed and disturbing psychiatric patients with psychoses, including both schizophrenia and the affective disorders. In this book Richard Lucas suggests that when clinicians are faced with psychotic patients, the primary concern should be to make sense of what is happening during their breakdown. He refers to this as tuning into the psychotic wavelength, a process that allows clinicians to distinguish between, and appropriately address, the psychotic and non-psychotic parts of the personality. He argues that if clinicians can find and identify the psychotic wavelength, they can more effectively help the patient to come to terms with the realities of living with a psychotic disorder. Divided into five parts and illustrated throughout with illuminating clinical vignettes, case examples and theoretical and clinical discussions, this book covers: the case for a psychoanalytical perspective on psychosis a historical overview of psychoanalytical theories for psychosis clinical evidence supporting the concept of a psychotic wavelength the psychotic wavelength in affective disorders implications for management and education. The Psychotic Wavelength is an essential resource for anyone working with disturbed psychiatric patients. It will be of particular interest to junior psychiatrists and nursing staff and will be invaluable in helping to maintain treatment aims and staff morale. It will also be useful for more experienced psychiatrists and psychoanalysts.
An understanding of the immune system is central to the understanding of how the body interacts with its surroundings. Presenting an insight into this biological system, this book leads students through both innate and adaptive immunity, how infection is detected and how the cells of the immune system interact to generate a response.
Written by two preeminent authors in the field, this book provides an accessible global narrative of the nuclear arms race since 1945 that focuses on the roles of key scientists, military chiefs, and political leaders. The first book of its kind to provide a global perspective of the arms race, this two-volume work connects episodes worldwide involving nuclear weapons in a comprehensive, narrative fashion. Beginning with a discussion of the scientific research of the 1930s and 1940s and the Hiroshima decision, the authors focus on five basic themes: political dimensions, technological developments, military and diplomatic strategies, and impact. The history of the international nuclear arms race is examined within the context of four historical eras: America's nuclear monopoly, America's nuclear superiority, superpower parity, and the post-Cold War era. Information about the historical development of the independent deterrence of Britain, France, and China, as well as the piecemeal deterrence of newcomers Israel, India, Pakistan, and North Korea is also included, as is coverage of the efforts aimed at the international control of nuclear weapons and the diplomatic architecture that underpins the global nuclear non-proliferation regime.
With a focus on evidence-based, state-of-the-art information throughout, the eighth edition of Irwin and Rippe’s Intensive Care Medicine offers authoritative guidance to the wide variety of specialty physicians and non-physicians practicing in the adult intensive care environment. This comprehensive textbook covers both the theoretical and practical aspects of the field, and has been completely updated to provide encyclopedic, interprofessional coverage to support practitioners in every area of this complex field.
Cirrhosis: a practical guide to management providesgastroenterologists and hepatologists with an up-to-date clinicalguide presenting the very best evidence-based practice in thediagnosis, treatment and management of liver cirrhosis and its manycomplications. Designed to offer practical guidance at alltimes, it provides doctors with an extremely useful tool in theclinical setting, with each chapter featuring diagnostic/managementalgorithms, key points and other pedagogic features. Divided into 2 parts, a diagnosis and pathophysiology section and amanagement of complications section, key topics include: - Diagnostic laboratory tests - Diagnostic imaging modalities - Acute-on chronic liver failure - Agents and drugs to avoid - End stage liver failure: liver transplant evaluation - Hepatocellular carcinoma Aimed at the specialist, as well as the practicing trainee at thetop-end of specialty training, the emphasis throughout is onproviding optimum clinical management guidance most relevant topracticing hepatologists and gastroenterologists, and is aninvaluable guide to this increasingly common condition.
Principles of Addiction Medicine, 7th ed is a fully reimagined resource, integrating the latest advancements and research in addiction treatment. Prepared for physicians in internal medicine, psychiatry, and nearly every medical specialty, the 7th edition is the most comprehensive publication in addiction medicine. It offers detailed information to help physicians navigate addiction treatment for all patients, not just those seeking treatment for SUDs. Published by the American Society of Addiction Medicine and edited by Shannon C. Miller, MD, Richard N. Rosenthal, MD, Sharon Levy, MD, Andrew J. Saxon, MD, Jeanette M. Tetrault, MD, and Sarah E. Wakeman, MD, this edition is a testament to the collective experience and wisdom of 350 medical, research, and public health experts in the field. The exhaustive content, now in vibrant full color, bridges science and medicine and offers new insights and advancements for evidence-based treatment of SUDs. This foundational textbook for medical students, residents, and addiction medicine/addiction psychiatry fellows, medical libraires and institution, also serves as a comprehensive reference for everyday clinical practice and policymaking. Physicians, mental health practitioners, NP, PAs, or public officials who need reference material to recognize and treat substance use disorders will find this an invaluable addition to their professional libraries.
Covering both the theoretical and practical aspects of critical care,Irwin & Rippe’s Intensive Care Medicine, Ninth Edition, provides state-of-the-art, evidence-based knowledge for specialty physicians and non-physicians practicing in the adult intensive care environment. Drs. Craig M. Lilly, Walter A. Boyle, and Richard S. Irwin, along with a team of expert contributing authors and education expert, William F. Kelly, offer authoritative, comprehensive guidance from an interprofessional, collaborative, educational, and scholarly perspective, encompassing all adult critical care specialties.
Comprehensive, readable, and clinically oriented, Stoelting’s Pharmacology & Physiology in Anesthetic Practice, Sixth Edition, covers all aspects of pharmacology and physiology that are relevant either directly or indirectly to the anesthetic practice—a challenging topic that is foundational to the practice of anesthesia and essential to master. This systems-based, bestselling text has been thoroughly updated by experts in the field, giving you the detailed information needed to make the most informed clinical decisions about the care of your patients.
This authoritative guide to the southwest corner of Wales by three local experts encompasses a wide sweep of history, from the rugged prehistoric remains that stud the distinctive windswept landscape overlooking the Atlantic to distinguished recent buildings that respond imaginatively to their natural setting. The comprehensive gazetteer encompasses the great cathedral of St David's and its Bishop's Palace, the numerous churches, and the magnificent Norman castles that reflect the turbulent medieval past. It gives attention also to the lesser-known delights of Welsh chapels--both simple rural and sophisticated Victorian examples--in all their wayward variety and provides detailed accounts of a rewarding range of towns, including the county town, Haverfordwest, the attractively unspoilt Regency resort of Tenby, and Milford Haven and Pembroke Dock, with their important naval history. An introduction with valuable specialist contributions sets the buildings in context.
Richard Ned Lebow spells out the implications of historical experience for American perceptions of the place of crisis management in superpower strategic relations. identifying and discussing three reasons for the outbreak of World War I—preemption, loss of control, and miscalculated escalation—he argues that all three are equally serious threats to peace and survival. He documents how psychological stress in past crises has induced erratic, dysfunctional behavior from national leaders, even paralysis. A nuclear crisis, he argues, would generate even more acute stress because of the unprecedented destructiveness of nuclear weapons and the extreme time pressure that leaders are likely to face.
Drawing from the challenges the author has seen in supervising dissertation students, the book breaks down the dissertation chapter into smaller pieces, providing specific and detailed advice on how to frame the chapter, identify a research setting, work with data sources, develop data collection instruments, articulate a data analysis procedure, and adopt a reflexive stance on research roles.
Tap into the gold standard on central nervous system infections: Infections of the Central Nervous System, 4e is now fully revised and updated to accommodate the wealth of new CNS information discovered over the past decade. More than 90 leading experts contribute chapters, providing comprehensive, up-to-date information. With a broad scope and thorough detail, the text addresses pathogenesis, clinical manifestations, diagnosis, and therapy of various CNS infections and related conditions. Features: Every chapter has been extensively revised and updated, nearly half with new author teams NEW chapter on acute encephalitis NEW clinical information on treatment of tuberculosis, non-tubercular mycobacterial infections, brain abscess, and Lyme disease NEW color design and color images Numerous diagrams, figures, tables, illustrations and photographs demonstrate the content Evidence-based references
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