Progress in Drug Research is a prestigious book series which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmacological research. It serves as an important source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines.
Three pipe bombs exploded in Salt Lake County in 1985, killing two people. Behind the murders lay a vast forgery scheme aimed at dozens of other victims, most prominently the Church of Jesus Christ of Latter-day Saints. Mark Hofmann, a master forger, went to prison for the murders. He had bilked the church, document dealers, and collectors of hundreds of thousands of dollars over several years while attempting to alter Mormon history. Other false documents of Americana still circulate. The crimes garnered intense media interest, spawning books, TV and radio programs, and myriad newspaper and magazine articles. Victims is a thoughtful corrective to the more sensationalized accounts. More important, Richard Turley adds substantially to the record with previously unavailable church documentation and exclusive interviews with church officials, giving this book greater depth and resonance. He also goes beyond the Hofmann case, illustrating how forgeries have hampered the church's efforts to document its history. Victims includes a complete appendix of every known document the church acquired from Hofmann, reviews of trial transcripts and police reports, as well as dozens of photographs, some never before published. Turley, who gave up the practice of law to become a historian, has managed the delicate task of exposing the myths and complexities of this case with skill and objectivity. His unique access to church documents and personnel, together with his understanding of the legal system and Mormon history, afforded him an unparalleled view of how the case affected the church as well as the many others who were involved. Victims will fascinate anyone who does archival work, who cares aboutthe historical record, or who likes to read compelling mystery.
Our big brains, our language ability, and our intelligence make us uniquely human. But barely 10,000 years ago (a mere blip in evolutionary time) human-like creatures called "Boskops" flourished in South Africa. They possessed extraordinary features: forebrains roughly 50% larger than ours, and estimated IQs to match--far surpassing our own. Many of these huge fossil skulls have been discovered over the last century, but most of us have never heard of this scientific marvel. Prominent neuroscientists Gary Lynch and Richard Granger compare the contents of the Boskop brain and our own brains today, and arrive at startling conclusions about our intelligence and creativity. Connecting cutting-edge theories of genetics, evolution, language, memory, learning, and intelligence, Lynch and Granger show the implications of large brains for a broad array of fields, from the current state of the art in Alzheimer's and other brain disorders, to new advances in brain-based robots that see and converse with us, and the means by which neural prosthetics-- replacement parts for the brain--are being designed and tested. The authors demystify the complexities of our brains in this fascinating and accessible book, and give us tantalizing insights into our humanity--its past, and its future.
TCP/IP Illustrated, Volume 1, Second Edition, is a detailed and visual guide to today?s TCP/IP protocol suite. Fully updated for the newest innovations, it demonstrates each protocol in action through realistic examples from modern Linux, Windows, and Mac OS environments. There?s no better way to discover why TCP/IP works as it does, how it reacts to common conditions, and how to apply it in your own applications and networks. Building on the late W. Richard Stevens? classic first edition, author Kevin R. Fall adds his cutting-edge experience as a leader in TCP/IP protocol research, updating the book to fully reflect the latest protocols and best practices. He first introduces TCP/IP?s core goals and architectural concepts, showing how they can robustly connect diverse networks and support multiple services running concurrently.
It's only natural to want to avoid making mistakes, but imperfection is a part of being human. And while perfectionists are often praised for their abilities, being constantly anxious about details can hold you back and keep you from reaching your full potential. In this fully revised and updated second edition of When Perfect Isn't Good Enough, you'll discover the root cause of your perfectionism, explore the impact of perfectionism on your life, and find new, proven-effective coping skills to help you overcome your anxiety about making mistakes. This guide also includes tips for dealing with other perfectionists and discussions about how perfectionism is linked to worry, depression, anger, social anxiety, and body image. As you complete the exercises in this book, you'll find it easier and easier to keep worries at bay and enjoy life — imperfections and all. This book has been awarded The Association for Behavioral and Cognitive Therapies Self-Help Seal of Merit — an award bestowed on outstanding self-help books that are consistent with cognitive behavioral therapy (CBT) principles and that incorporate scientifically tested strategies for overcoming mental health difficulties. Used alone or in conjunction with therapy, our books offer powerful tools readers can use to jump-start changes in their lives.
There’s nothing wrong with being shy. But if shyness or social anxiety keeps you from building meaningful relationships with others, advancing in your education or career, or simply living your best life, The Shyness and Social Anxiety Workbook offers a comprehensive program to help you confront your fears and become actively involved in the world. If you are shy or socially anxious, you may dread going to parties, speaking in front of crowds or people you don’t know, going to job interviews, and other critical life situations. You aren’t alone. In fact, studies show that millions of people suffer from a social anxiety disorder. Unfortunately, you can’t hide from some social situations—no matter how much you wish you could. But you don’t have to go on suffering silently. The good news is there are proven-effective techniques you can start using right away to help ease your anxiety or shyness and start living the life you were meant to live: a life where fear doesn’t get in the way of reaching your goals. This fully revised and updated third edition incorporates breakthrough new research and techniques for overcoming social phobia, including a new chapter on mindfulness-based treatments, updated information on medications, and an overview of treatment-enhancing technological advances. As you complete the activities in this workbook, you'll learn to find your strengths and weaknesses using self-evaluation, explore and examine your fears, create a personalized plan for change, and put your plan into action through gentle and gradual exposure to the very social situations that cause you to feel uneasy. After completing this program, you'll be well-equipped to make connections with the people around you. Soon, you'll be on your way to enjoying all the benefits of being actively involved in the social world. If you’re ready to confront your fears to live an enjoyable, satisfying life, this new edition of The Shyness and Social Anxiety Workbook offers a comprehensive program to help you get started. What are you waiting for?
Richard Schonberger, in his fourth and most important book yet, introduces a powerful new concept: that the many links between and within the four main business functions -- design, operations, accounting, and marketing -- form a continuous "chain of customers" that extends to those who buy the product or service. Everyone has a customer -- the next department, office, shop, or person -- at the hundreds of pioneering companies Schonberger has studied throughout the world. Schonberger demonstrates the universality of customer wants: Both the next and final customers want ever better quality, quicker response, greater flexibility, and lower cost. This condition provides a common strategy and calls for common methods to be used across the organization. Every employee is a data gatherer and analyst, unearthing more and better ways to provide for these customers' wants -- before the competition does so. As the new thinking and methods permeate every comer of the firm, they topple departmental walls and adjust gang-like mind-sets and "them-versus-us" attitudes. Performance is no longer measured by internal costs but by improvement as seen by the next customer; direct control of causes generally replaces after-the-fact control of costs. Design is brought out of isolation. Finally, with the rest of the firm reoriented toward customer service, marketing escapes from a "negative" mode -- covering up for failures -- to a positive one -- crowing about the firm's competence and ability to improve. With the close attention to detail for which he has become famous, Schonberger constructs a blueprint for unifying corporate functions, brilliantly describing the new microcosms that will make up the company of the 1990s -- focused teams of multi-skilled, involved employees arranged according to the way the work flows or the service is provided -- that compose the chain of customers. Aetna, for example, is organizing customer-focused teams that cut across underwriting and the administrative functions. At Hewlett-Packard, teams of marketing, manufacturing, and R&D people have already gone through several iterations of "activity-based costing", which provides product designers with previously unavailable data for shaving costs throughout product life cycles. And at Du Pont, even production people on the factory floor are involved in assessing competitors' product quality and probable costs and methods. Through these and hundreds of other real company examples, Schonberger shows how the customer-driven chain of action leads directly to the kinds of bottom-line performance that have been so elusive to executives who manage at a distance "by the numbers" -- namely, higher profits, greater security, and gains in market share at the expense of the laggard competion.
Drawing on a wide range of major literary voices, including Richard Wright, Ralph Ellison, and Toni Morrison, as well as lesser-known writers such as William Attaway (Blood on the Forge) and Dorothy West (The Living Is Easy), Rodgers conducts a kind of literary archaeology of the Great Migration. He mines the writers' biographical connections to migration and teases apart the ways in which individual novels relate to one another, to the historical situation of black America, and to African-American literature as a whole. In reading migration novels in relation to African-American literary texts such as slave narratives, folk tales, and urban fiction, Rodgers affirms the southern folk roots of African-American culture and argues for a need to stem the erosion of southern memory.
PULITZER PRIZE WINNER • No book before this one has rendered the story of cigarettes—mankind's most common self-destructive instrument and its most profitable consumer product—with such sweep and enlivening detail. "A great battleship of a book—formidable, majestic.”—The New York Times Book Review Here for the first time, in a story full of the complexities and contradictions of human nature, all the strands of the historical process—financial, social, psychological, medical, political, and legal—are woven together in a riveting narrative. The key characters are the top corporate executives, public health investigators, and antismoking activists who have clashed ever more stridently as Americans debate whether smoking should be closely regulated as a major health menace. We see tobacco spread rapidly from its aboriginal sources in the New World 500 years ago, as it becomes increasingly viewed by some as sinful and some as alluring, and by government as a windfall source of tax revenue. With the arrival of the cigarette in the late-nineteenth century, smoking changes from a luxury and occasional pastime to an everyday—to some, indispensable—habit, aided markedly by the exuberance of the tobacco huskers. This free-enterprise success saga grows shadowed, from the middle of this century, as science begins to understand the cigarette's toxicity. Ironically the more detailed and persuasive the findings by medical investigators, the more cigarette makers prosper by seeming to modify their product with filters and reduced dosages of tar and nicotine. We see the tobacco manufacturers come under intensifying assault as a rogue industry for knowingly and callously plying their hazardous wares while insisting that the health charges against them (a) remain unproven, and (b) are universally understood, so smokers indulge at their own risk. Among the eye-opening disclosures here: outrageous pseudo-scientific claims made for cigarettes throughout the '30s and '40s, and the story of how the tobacco industry and the National Cancer Institute spent millions to develop a "safer" cigarette that was never brought to market. Dealing with an emotional subject that has generated more heat than light, this book is a dispassionate tour de force that examines the nature of the companies' culpability, the complicity of society as a whole, and the shaky moral ground claimed by smokers who are now demanding recompense.
Cirrhosis: a practical guide to management provides gastroenterologists and hepatologists with an up-to-date clinical guide presenting the very best evidence-based practice in the diagnosis, treatment and management of liver cirrhosis and its many complications. Designed to offer practical guidance at all times, it provides doctors with an extremely useful tool in the clinical setting, with each chapter featuring diagnostic/management algorithms, key points and other pedagogic features. Divided into 2 parts, a diagnosis and pathophysiology section and a management of complications section, key topics include: - Diagnostic laboratory tests - Diagnostic imaging modalities - Acute-on chronic liver failure - Agents and drugs to avoid - End stage liver failure: liver transplant evaluation - Hepatocellular carcinoma Aimed at the specialist, as well as the practicing trainee at the top-end of specialty training, the emphasis throughout is on providing optimum clinical management guidance most relevant to practicing hepatologists and gastroenterologists, and is an invaluable guide to this increasingly common condition.
Challenging traditional scholarship on the New Deal, the book reinterprets the history of rural electrification. It tells the previously unacknowledged story of how private power companies, with allies in land-grant universities, engendered social and technical innovations in the 1920s and early 1930s that enabled growing numbers of farmers to obtain electrical service, well before the creation of Depression-era government programs"--
In the 1990s Richard B. Alley and his colleagues made headlines with the discovery that the last ice age came to an abrupt end over a period of only three years. In The Two-Mile Time Machine, Alley tells the fascinating history of global climate changes as revealed by reading the annual rings of ice from cores drilled in Greenland. He explains that humans have experienced an unusually temperate climate compared to the wild fluctuations that characterized most of prehistory. He warns that our comfortable environment could come to an end in a matter of years and tells us what we need to know in order to understand and perhaps overcome climate changes in the future. In a new preface, the author weighs in on whether our understanding of global climate change has altered in the years since the book was first published, what the latest research tells us, and what he is working on next.
In a report by the world's top environmental scientists, the only thing listed that mankind can do to have an impact on changing weather patterns is to reduce the excess CO2 levels from the air. Hemp for Victory: A Global Warming Solution is a key for reducing the effects of global warming using hemp. Why hemp? In this book you'll learn: hemp is a biomass champion, breathing in more carbon dioxide (the most abundant greenhouse gas) than any other plant. This carbon dioxide is turned into wood and fiber by photosynthesis. Hemp wood takes the pressure off our forests by making paper and building materials like pressboard. Hemp is the best plant at consuming the greenhouse gas CO2, a step the world leading scientists say is critical to at least slowing down the dramatic effects of global warming. Remove the cause, CO2 pollution, and the effect, global warming, can be reduced, if not healed. Hemp can do all the jobs fossil fuels do now. When used as a biofuel, hemp replaces toxic energy (i.e. fossil fuels, nuclear power) with clean sustainable energy. Hemp biofuel can be processed to run any engine, heat or cool any building, run any factory, and eliminate the greenhouse gases and pollution that come from modern energy sources. The Museum has thousands of hemp exhibits both on line and in the private wing, many included in this book. The Museum's founder and curator, Richard M. Davis, wrote this dynamic piece of literature that gives chapter and verse of how to best re-hemp the planet. This book is based on the museum's extensive research on hemp and the environment. The museum is also developing a Hemp for Victory plan to successfully use hemp to help solve the survival problem of global warming by coordinating famers with growing and market information. A 20% recreational hemp tax plan is in development to finance the program and help deal with the current impact of global warming, i.e. Hurricane Katrina."--Back cover.
Matthew's Jesus is typically described as the humble, compassionate messiah. This 2002 book argues that this is, however, only half the story. Matthew's theologically rich quotation of Isaiah 42.1–4, traditionally considered one of the four servant songs, underscores that manifest in Jesus' powerful message and deeds, particularly his healings and inclusion of the marginalized, is the justice that was thought to accompany the arrival of the kingdom of God. The study explores modifications to the text-form of the Isaianic citations, their relationship to the surrounding context, and the rhetorical force of the final form. It argues that the quotations are bi-referential, functioning on both a narrative and theological level, and also explores the issues surrounding the troublesome 'extraneous' content. It arrives at the conclusion that this citation was central to Matthew's understanding of Jesus' life and mission. All totalled, this study offers a refreshing exploration of Matthew's high, ethical Christology.
An aid to determine the possible cause of laboratory test abnormalities encountered in clinical practice. Sections include laboratory test index, disease keyword index, laboratory test listings, disease listings by ICD-9CM classification, and references.
How does the brain regulate sexual behavior, or control our body weight? How do we cope with stress? Addressing these questions and many more besides, this thoroughly revised new edition reflects the significant advances that have been made in the study of neuroendocrinology over the last twenty years. The text examines the importance of the hypothalamus in regulating hormone secretion from the endocrine glands, describing novel sites of hormone release including bone, heart, skeletal muscle and liver. The role of steroid hormone, neurotransmitter and peptide receptors, and the molecular responses of target tissues, is integrated into the discussion of the neuroendocrine brain, especially through changes in gene expression. Particular attention is attached to neuropeptides, including their profound influence on behavior. Complete with new full-color figures throughout, along with review and essay questions for each chapter, this is an ideal resource for undergraduate and graduate students of neuroscience, psychology, biology and physiology.
Introduction to Digital Audio Coding and Standards provides a detailed introduction to the methods, implementations, and official standards of state-of-the-art audio coding technology. In the book, the theory and implementation of each of the basic coder building blocks is addressed. The building blocks are then fit together into a full coder and the reader is shown how to judge the performance of such a coder. Finally, the authors discuss the features, choices, and performance of the main state-of-the-art coders defined in the ISO/IEC MPEG and HDTV standards and in commercial use today. The ultimate goal of this book is to present the reader with a solid enough understanding of the major issues in the theory and implementation of perceptual audio coders that they are able to build their own simple audio codec. There is no other source available where a non-professional has access to the true secrets of audio coding.
The book is well provided with detailed references/bibliography for those who want to pursue the matter. . . The authors have effected a very thorough analysis of the moral issues and the book is strongly recommended for that reason. . . Brian Spear, World Patent Information This book should change the contours of the intellectual property debate. Spinello and Bottis fully appreciate what the standard instrumentalist accounts of intellectual property cannot even acknowledge that the lives and liberty of creators and artists are not the common property of society, and that it is intrinsically wrong to treat the efforts and projects of individuals as if they were unowned resources reaped as the fruit of the earth. Their work should help to reorient discussion of IP from an excessive concern with the economic and social consequences of competing policies back to the bedrock issues of basic respect for the integrity of our various particular lives and the labor that constitutes those lives. At the same time, they studiously avoid the unserious extremism that characterizes so much of the debate on every side, recognizing that respecting the lives and liberty of all sets real boundaries on the proper scope and stringency of IP claims, ruling out overzealous enforcement and radical repudiation alike. Richard Volkman, Southern Connecticut State University and Research Center on Computing and Society, US Since the rise of the Internet the question of intellectual property has been and still is one of the most controversial societal and ethical issues. The new global, interactive and bottom-up medium challenges moral, legal and economic structures not only in the music and film industry but also in the field of knowledge production, storage, distribution and access. The academic debate soon became and is still polarized between critics and defenders of IPR. The book by Richard A. Spinello and Maria Bottis A Defense of Intellectual Property Rights analyses in a critical and comprehensive manner some of the dogmas widely spread by the critics of IPR paying special attention to the differences between EU and European legal regimes. The authors explore the foundations of IP in Lockean philosophy, as a representative of a natural law approach, as well as in the theories of Fichte and Hegel based on deontological arguments. Both perspectives prevail in European law while American property law is widely based on utilitarian arguments. The authors argue in favor of Lockean and Hegelian foundations showing their relevance in the present debate as well as calling the attention to the link between these theories and the Catholic social doctrine. The book is an important contribution to this ongoing debate. Rafael Capurro, Stuttgart Media University, Germany Richard A. Spinello and Maria Bottis defend the thesis that intellectual property rights are justified on non-economic grounds. The rationale for this moral justification is primarily inspired by the theory of John Locke. In the process of defending Locke, the authors confront the deconstructionist critique of intellectual property rights and remove the major barriers interfering with a proper understanding of authorial entitlement. The book also familiarizes the reader with the rich historical and legal tradition behind intellectual property protection.
Will Automated Vehicles be Safer than Conventional Vehicles? One of the critically important questions that has emerged about advanced technologies in transportation is how to test the actual effects of these advanced systems on safety, particularly how to evaluate the safety of highly automated driving systems. Richard Young's Critical Analysis of Prototype Autonomous Vehicle Crash Rates does a deep dive into these questions by reviewing and then critically analyzing the first six scientific studies of AV crash rates.
In the classic edition of this outstanding book, originally published in 1998, Richard Frankel explores adolescence as a crucial, unique, and turbulent period of human development. He provides guidance for clinicians working with young people as they undergo significant transformations in the way they think, act, feel, and perceive the world. The book addresses how the disruptions manifest in adolescent behavior are upsetting and often incomprehensible to the adults surrounding them. It seeks to revision the traumas, extreme fantasies, testing of limits, etc., so endemic to this period of life through the lens of the urge toward self-realization. This allows for new and creative ways of working with the intensely confusing, and often extreme, countertransference feelings that arise in our encounter with adolescents. It offers ways of reflecting upon the vicissitudes of our own experience of being an adolescent that helps to unlock the typical impasses that occur in the stand-off between adult and adolescent ways of seeing the world. Through engagement with the work of Jung, Hillman, and Winnicott, Frankel offers a critique of the traditional psychoanalytic understanding of adolescence as a recapitulation of childhood, thus making a claim for adolescence as a discrete developmental period with its own originary dynamics. In this light, he explores such topics as individuation, persona, shadow, bodily, idealistic and ideational awakenings, as well as the effects of culture on development. Featuring numerous clinical case studies and clear theoretical formulations, this classic edition is important reading for psychotherapists, analysts, parents, educators, and anyone working with adolescents. This classic edition also includes also includes a new, extended introduction by the author that examines what effects the digital revolution is having on the contemporary experience of being an adolescent. Looking back on this work nearly 25 years since its publication, Frankel contends that the core themes of adolescence addressed in this book offer a compelling framework for comprehending both the positive and negative impacts of the digital on adolescent life.
The Spanish Craze is the compelling story of the centuries-long U.S. fascination with the history, literature, art, culture, and architecture of Spain. Richard L. Kagan offers a stunningly revisionist understanding of the origins of hispanidad in America, tracing its origins from the early republic to the New Deal. As Spanish power and influence waned in the Atlantic World by the eighteenth century, her rivals created the “Black Legend,” which promoted an image of Spain as a dead and lost civilization rife with innate cruelty and cultural and religious backwardness. The Black Legend and its ambivalences influenced Americans throughout the nineteenth century, reaching a high pitch in the Spanish-American War of 1898. However, the Black Legend retreated soon thereafter, and Spanish culture and heritage became attractive to Americans for its perceived authenticity and antimodernism. Although the Spanish craze infected regions where the Spanish New World presence was most felt—California, the American Southwest, Texas, and Florida—there were also early, quite serious flare-ups of the craze in Chicago, New York, and New England. Kagan revisits early interest in Hispanism among elites such as the Boston book dealer Obadiah Rich, a specialist in the early history of the Americas, and the writers Washington Irving and Henry Wadsworth Longfellow. He also considers later enthusiasts such as Angeleno Charles Lummis and the many writers, artists, and architects of the modern Spanish Colonial Revival in the United States in the late nineteenth and early twentieth centuries. Spain’s political and cultural elites understood that the promotion of Spanish culture in the United States and the Western Hemisphere in general would help overcome imperial defeats while uniting Spaniards and those of Spanish descent into a singular raza whose shared characteristics and interests transcended national boundaries. With elegant prose and verve, The Spanish Craze spans centuries and provides a captivating glimpse into distinct facets of Hispanism in monuments, buildings, and private homes; the visual, performing, and cinematic arts; and the literature, travel journals, and letters of its enthusiasts in the United States.
Evaluates the MacArthur Foundation's Window of Opportunity, a 20-year philanthropic initiative begun in 2000 that has allocated $187 million to preserve privately owned affordable rental housing.
Counselling for Alcohol Problems, third edition, is a practical and bestselling guide to working with people who have problems with their use of alcohol. It is the key book recommended by most alcohol counselling courses in the UK, including the Scottish national alcohol counsellors training scheme. The author provides clear guidance for counsellors and demonstrates the need to treat every client as an individual, attempting to understand and therefore enable the client to understand, what they are doing and why. This new edition includes: - New content on the current political, social and counselling context surrounding alcohol use - A wider range of case-studies - New ideas that help students and trainees develop the skills and strategies they need for working with their clients - Further guidance for generic or non-alcohol counsellors who face alcohol problems with their clients. This third edition is an invaluable resource for practitioners, both those specialising in work with alcohol misusers and those who encounter problem drinkers in the context of a more general counselling practice.
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