A complete and comprehensive theory of failure is developed for homogeneous and isotropic materials. The full range of materials types are covered from very ductile metals to extremely brittle glasses and minerals. Two failure properties suffice to predict the general failure conditions under all states of stress. With this foundation to build upon, many other aspects of failure are also treated, such as extensions to anisotropic fiber composites, cumulative damage, creep and fatigue, and microscale and nanoscale approaches to failure.
A comprehensive account of the basic theory of the mechanical behavior of heterogeneous media, this volume assembles, interprets, and interrelates contributions to the field of composite materials from theoretical research, laboratory developments, and product applications. The text focuses on the continuum mechanics aspects of behavior; specifically, it invokes idealized geometric models of the heterogeneous system to obtain theoretical predictions of macroscopic properties in terms of the properties of individual constituent materials. The wide range of subjects encompasses macroscopic stiffness properties, failure characterization, and wave propagation. Much of the book presumes a familiarity with the theory of linear elasticity; but it also takes into consideration behavior characterized by viscoelasticity and inviscid plasticity theories and problems involving nonlinear kinematics. Because of the close relationship between mechanical and thermal effects, the text also examines macroscopic, thermal properties of heterogeneous media. Although the primary emphasis centers on the development of theory, this volume also pays critical attention to the practical assessment of results and applications. Comparisons between different approaches and with reliable experimental data appear at main junctures. Suitable as a graduate-level text, Mechanics of Composite Materials is also a valuable reference for professionals.
The concept of this project is based on the premise that neurosurgeons are vital agents in the application of the American health care apparatus. They remain the true advocates for patients undergoing surgery for a neurological condition. Yet, the tenets of health care economics, health care policy, and the business of medicine remain largely debated within the context of politicians, policy experts, and administrators. This textbook will ease that gap. It will bring material generally absent from medical curricula into discussion. It will make potent features of health care economics, policy, and the business of practice digestible to clinical neurosurgeons in order to help them better treat their patients. The information provided in this text will also provide an excellent foundation for understanding the mechanics of running a neurosurgical practice. It simultaneously addresses career progression and opportunity evaluation.
Stress has been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli also appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood. Stress and Mental Disorders: Insights from Animal Models begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioral alterations as a newer approach to understanding why some animals are susceptible to stress and others are resilient, even though they are essentially genetically identical. The final chapter discusses how these basic laboratory studies are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders.
Foundations of Wildlife Diseases is a comprehensive overview of the basic principles that govern the study of wildlife diseases. The authors integrate theoretical foundations with a thorough examination of the factors that can affect the health and fitness of animals. They include specific information on a wide array of infectious agents such as bacteria, viruses, arthropods, fungi, protista, and helminths, as well as immunity to these agents. Also provided is a foundation for the study of noninfectious diseases, cancers, and prion diseases that affect wildlife. Supporting students, faculty, and researchers in areas related to wildlife management, biology, and veterinary sciences, this volume fills an important gap in wildlife disease resources, focusing on mammalian and avian wildlife while also considering reptiles and amphibians. Foundations of Wildlife Diseases provides students with a structure for thinking about and understanding infective agents and their interactions with wildlife. Each chapter includes an outline, select definitions and concepts, an overview and summary, and literature cited. Ê
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. - Updates to all chapters, including new examples and references - Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book - Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry - Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant - Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis - Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: - for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib - for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid - for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin - Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples - Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites - Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
Integration of numerous theoretical developments offers a complete, consistent description of the linear theory of the viscoelastic behavior of materials. Relevant theoretical formulations are derived from a continuum mechanics viewpoint, followed by discussions of problem-solving techniques. "A welcome addition to the literature." — American Scientist. 29 figures. 1982 edition.
If you are not already in a management position, chances are you soon will be. According to the Bureau of Statistics, the fastest growing areas of employment for engineers are in engineering/science management. With over 200 contributing authors, The Technology Management Handbook informs and assists the more than 1.5 million engineering managers in the practice of technical management. Written from the technical manager's perspective and written for technologists who are managers, The Technology Management Handbook presents in-depth information on the science and practice of management. Its comprehensive coverage encompasses the field of technology management, offering information on: Entrepreneurship Innovations Economics Marketing Product Development Manufacturing Finance Accounting Project Management Human Resources International Business
This volume covers binary alloys and intermetallic compounds of uranium with transition metals of the Cu, Zn, Sc (including the lanthanides), and Ti groups as well as ternary alloys containing another transition metal as a third component. The compounds UCu5, UAu2, U14Au51, U2Zn17, UZn12, and UCd11 have been shown to be heavy-fermion materials exhibiting unusual behavior as far as the heat capacity and the magnetic and electrical properties at low temperatures are concerned. The alloys of uranium with titanium and zirconium and related ternary alloys are of technological interest. Thus emphasis in this volume is placed on recent scientific as well as technological work.
Trusted by physicians and advanced practice providers through ten standard-setting editions, Fanaroff and Martin's Neonatal-Perinatal Medicine, 11th Edition, remains the reference of choice for expert, multidisciplinary guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. An expanded team of international authors, led by Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh of Rainbow Babies and Children's Hospital, brings you up to date with advances in the control of nosocomial infections in preterm infants, genetic disorders and birth defects, the fetal origins of adult disease, the late preterm infants, and much more – all designed to help you improve the quality of life and long-term outcomes of your patients. - Helps you make informed clinical choices for each patient – from diagnosis and treatment selection through post-treatment strategies and management of complications – with a dual focus on neonatology and perinatology. - Includes a new chapter on Social and Economic Contributors to Neonatal Outcome. - Features extensive updates and reorganization throughout, with new Key Points at the end of each chapter - Provides up-to-date, evidence-based content, with more information on precision medicine and genetics. - Uses detailed, full-color illustrations that depict disorders in the clinical setting and explain complex information. - Remains the most comprehensive, multidisciplinary text in the field – an excellent source of information for every stage of your practice.
Fetal and Neonatal Physiology, edited by Drs. Polin, Fox, and Abman, focuses on physiologic developments of the fetus and newborn and their impact on the clinical practice of neonatology. A must for practice, this 4th edition brings you the latest information on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. You'll also have easy access to the complete contents and illustrations online at expertconsult.com. Gain a comprehensive, state-of-the-art understanding of normal and abnormal physiology, and its relationship to disease in the fetus and newborn premature infant, from Dr. Richard Polin and other acknowledged worldwide leaders in the field. Understand the implications of fetal and neonatal physiology through chapters devoted to clinical correlation. Apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Effectively manage the consequences of intrauterine infections with three new chapters covering intrauterine infection and preterm birth, intrauterine infection and brain injury, and intrauterine infection and chronic lung disease. Access the complete contents and illustrations online at expertconsult.com - fully searchable! Get the latest developments and a full understanding of the distinct physiology of the fetus and newborn so you can treat and manage sick newborns and preemies.
The #1 choice for more than 35 years for those involved in the care of adolescents and young adults, Neinstein’s Adolescent and Young Adult Health: A Practical Guide, 7th Edition is your go-to resource for practical, authoritative guidance. The fully updated seventh edition, edited by Drs. Debra K. Katzman, Catherine M. Gordon, S. Todd Callahan, Richard J. Chung, Alain Joffe, Susan L. Rosenthal, and Maria E. Trent, offers a comprehensive view of the interdisciplinary nature of the field and is inclusive of the wide variety of health professionals who care for adolescents and young adults. This award-winning text features a full-color design, several new chapters, numerous algorithms, bulleted text throughout for quick reference at the point of care, and fresh perspectives from new editors—making it ideal for daily practice or certification examination preparation.
Artificial intelligence (AI) has captured our imaginations—and become a distraction. Too many leaders embrace the oversized narratives of artificial minds outpacing human intelligence and lose sight of the original problems they were meant to solve. When businesses try to “do AI,” they place an abstract solution before problems and customers without fully considering whether it is wise, whether the hype is true, or how AI will impact their organization in the long term. Often absent is sound reasoning for why they should go down this path in the first place. Doing AI explores AI for what it actually is—and what it is not— and the problems it can truly solve. In these pages, author Richard Heimann unravels the tricky relationship between problems and high-tech solutions, exploring the pitfalls in solution-centric thinking and explaining how businesses should rethink AI in a way that aligns with their cultures, goals, and values. As the Chief AI Officer at Cybraics Inc., Richard Heimann knows from experience that AI-specific strategies are often bad for business. Doing AI is his comprehensive guide that will help readers understand AI, avoid common pitfalls, and identify beneficial applications for their companies. This book is a must-read for anyone looking for clarity and practical guidance for identifying problems and effectively solving them, rather than getting sidetracked by a shiny new “solution” that doesn’t solve anything.
The contributions of community colleges to society are well-documented. Yet, today’s community colleges are at a cross road. Decreases in funding support, a push for college completion, attention on developmental course work, and a host of other demands create a dynamic context for community college operations. Who leads these colleges matters as they face these demands and how they lead influences outcomes. Pending leadership retirements provide a prime opportunity for thinking about community college leadership in new ways. Entering this environment are prospective and aspiring leaders who are often not adequately prepared for the complexities of managing in a paradoxical organization. The era of accountability puts a fine point on the need for leaders to pay heed to the policy making process and to requirements dictated by state legislative bodies and accreditation bodies. Foundations and grant funders serve as instigators for changes in community colleges, as well and also support research into ways to link employer needs to college curricular changes. This book argues that neo-leaders are required to lead transformational change for today and tomorrow’s community colleges. No longer can we rely on single leaders atop a hierarchy. Talent throughout the institution must be tapped. The authors argue that networked leadership is needed. For networked leadership, we begin to advance thinking about the role of networks and connections among leaders throughout the college and beyond the college’s walls. This volume outlines underlying values critical for neo-leaders and offers questions leaders at various levels can use to jumpstart the type of courageous conversations needed on campus. The tools presented in this book provide current and aspiring leaders with resources to prepare for successfully leading the way and developing new leaders to shape the future. Our community colleges and their students require nothing less.
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