John Grote struggled to construct an intelligible account of philosophy at a time when radical change and sectarian conflict made understanding and clarity a rarity. This book answers three questions: * How did John Grote develop and contribute to modern Cambridge and British philosophy? * What is the significance of these contributions to modern philosophy in general and British Idealism and language philosophy in particular? * How were his ideas and his idealism incorporated into the modern philosophical tradition? Grote influenced his contemporaries, such as his students Henry Sidgwick and John Venn, in both style and content; he forged a brilliantly original philosophy of knowledge, ethics, politics and language, from a synthesis of the major British and European philosophies of his day; his social and political theory provide the origins of the 'new liberal' ideas later to reach their zenith in the writings of Green, Sidgwick, and Collingwood; he founded the 'Cambridge style' associated with Moore, Russell, Broad, McTaggart and Wittgenstein; and he was also a major influence on Oakeshott.
Braden and his coauthors give a comprehensive overview of the use of polymers and polymer composites as dental materials. These comprise polyelectrolyte based materials, elastomers, glassy and crystalline polymers and fibres. Such materials are used in dentistry as restorative materials, hard and soft prostheses, and impression materials. The chemistry of materials is reviewed, together with mechanical, thermal, visco-elastic and water solution properties. These properties are related to clinical performance, with emphasis on some of the difficulties inherent in developing materials for oral use. Indications are given of possible future developments.
Implementing the Mediterranean Diet Implementing the Mediterranean Diet: Nutrition in Practice and Public Health situates this ‘gold standard’ of diets within the wider food environment by bridging the gap between the evidence-based health benefits of the Mediterranean diet and its implementation. The text explores the many approaches that can be used by health professionals to help consumers adopt this healthy eating pattern, as well as the barriers encountered with implementing this diet at home and in the wider environment. It also considers sustainable food and farming practices, and national food strategies. A one-stop resource for food and health professionals, this seminal text demonstrates the full range of benefits that the Mediterranean diet can bring to society. This ground-breaking book: Gives an in-depth review of the effectiveness of the Mediterranean diet in disease prevention and the management of chronic diseases Contextualises the diet within the food environment, showing why the whole dietary pattern and minimizing the consumption of highly processed foods are both so important Shows how to implement the Mediterranean diet, motivating and guiding consumers to make the transition Addresses the practical and behavioural barriers to food choice in terms of taste, cost, variety, convenience and animal welfare concerns Implementing the Mediterranean Diet is a must-have resource for advanced undergraduate and postgraduate students in the food sciences, and for healthcare professionals such as dietitians, nutritionists, GPs, and health workers, especially those working in non-Mediterranean, high-income countries.
Widely regarded as the definitive reference in the field, Youmans and Winn Neurological Surgery offers unparalleled, multimedia coverage of the entirety of this complex specialty. Fully updated to reflect recent advances in the basic and clinical neurosciences, the 8th Edition covers everything you need to know about functional and restorative neurosurgery, deep brain stimulation, stem cell biology, radiological and nuclear imaging, and neuro-oncology, as well as minimally invasive surgeries in spine and peripheral nerve surgery, and endoscopic and other approaches for cranial procedures and cerebrovascular diseases. In four comprehensive volumes, Dr. H. Richard Winn and his expert team of editors and authors provide updated content, a significantly expanded video library, and hundreds of new video lectures that help you master new procedures, new technologies, and essential anatomic knowledge in neurosurgery. - Discusses current topics such as diffusion tensor imaging, brain and spine robotic surgery, augmented reality as an aid in neurosurgery, AI and big data in neurosurgery, and neuroimaging in stereotactic functional neurosurgery. - 55 new chapters provide cutting-edge information on Surgical Anatomy of the Spine, Precision Medicine in Neurosurgery, The Geriatric Patient, Neuroanesthesia During Pregnancy, Laser Interstitial Thermal Therapy for Epilepsy, Fetal Surgery for Myelomeningocele, Rehabilitation of Acute Spinal Cord Injury, Surgical Considerations for Patients with Polytrauma, Endovascular Approaches to Intracranial Aneurysms, and much more. - Hundreds of all-new video lectures clarify key concepts in techniques, cases, and surgical management and evaluation. Notable lecture videos include multiple videos on Thalamotomy for Focal Hand Dystonia and a video to accompany a new chapter on the Basic Science of Brain Metastases. - An extensive video library contains stunning anatomy videos and videos demonstrating intraoperative procedures with more than 800 videos in all. - Each clinical section contains chapters on technology specific to a clinical area. - Each section contains a chapter providing an overview from experienced Section Editors, including a report on ongoing controversies within that subspecialty. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Stress has been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli also appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood. Stress and Mental Disorders: Insights from Animal Models begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioral alterations as a newer approach to understanding why some animals are susceptible to stress and others are resilient, even though they are essentially genetically identical. The final chapter discusses how these basic laboratory studies are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders.
America’s emerging “fat war” threatens to pit a shrinking population of trim Americans against an expanding population of heavy Americans in raging policy debates over “fat taxes” and “fat bans.” These “fat policies” would be designed to constrain what people eat and drink – and theoretically crimp the growth in Americans’ waistlines and in the country’s healthcare costs. Richard McKenzie’s HEAVY! The Surprising Reasons America Is the Land of the Free—And the Home of the Fat offers new insight into the economic causes and consequences of America's dramatic weight gain over the past half century. It also uncovers the follies of seeking to remedy the country’s weight problems with government intrusions into people’s excess eating, arguing that controlling people’s eating habits is fundamentally different from controlling people’s smoking habits. McKenzie controversially links America’s weight gain to a variety of causes: the growth in world trade freedom, the downfall of communism, the spread of free-market economics, the rise of women's liberation, the long-term fall in real minimum wage, and the rise of competitive markets on a global scale. In no small way – no, in a very BIG way – America is the “home of the fat” because it has been for so long the “land of the free.” Americans’ economic, if not political, freedoms, however, will come under siege as well-meaning groups of “anti-fat warriors” seek to impose their dietary, health, and healthcare values on everyone else. HEAVY! details the unheralded consequences of the country's weight gain, which include greater fuel consumption and emissions of greenhouse gases, reduced fuel efficiency of cars and planes, growth in health insurance costs and fewer insured Americans, reductions in the wages of heavy people, and required reinforcement of rescue equipment and hospital operating tables. McKenzie advocates a strong free-market solution to how America's weight problems should and should not be solved. For Americans to retain their cherished economic freedoms of choice, heavy people must be held fully responsible for their weight-related costs and not be allowed to shift blame for their weight to their genes or environment. Allowing heavy Americans to shift responsibility for their weight gain can only exacerbate the country’s weight problems.
A personal and lyrical rediscovery of the history of England through archaeology and the imagination. History thrives on stories. TIME'S ANVIL explores archaeology's influence on what such stories say, how they are told, who tells them and how we listen. In a dazzlingly wide-ranging exploration, Richard Morris casts fresh light on three quarters of a million years of history in the place we now think of as England. Drawing upon genres that are usually pursued in isolation - like biography, poetry, or physics - he finds potent links between things we might imagine to be unrelated. His subjects range from humanity's roots to the destruction of the wildwood, from the first farmers to industrialization, and from Tudor drama to 20th-century conflict. Each topic sits at a different point along the continuum between epoch and the fleeting moment. In part, this is a history of archaeology; in part, too, it is a personal account of the author's history in archaeology. But mainly it is about how the past is read, and about what we bring to the reading as well as what we find. The result is a book that defies categorisation, but one which will by turns surprise, enthrall and provoke anyone who cares for England, who we are and where we have come from. TIME'S ANVIL was longlisted for the Samuel Johnson Prize for Non-Fiction 2013.
This accessible one-volume survey of the literature of Greece and Rome covers the period between Homer around 700 BC and Augustine around AD 410. Highlights what is important historically and of continuing interest and value in classical literature. An introduction by the editor presents essential information in a concise, accessible way. Each chapter focuses on a particular genre or area of literature. This structure allows readers to see continuities between different periods and to move easily between the Greek and Roman worlds. Includes extensive quotations in English. A timeline and an index of authors help to make the material as accessible as possible.
In these journals, Colonel Richard Irving Dodge, a well-known chronicler of western history and an authority on Plains Indians, provides an important account of conditions in Indian Territory from 1878 to 1880, a period of rapid transition. The Cheyenne-Arapaho reservation in present-day western Oklahoma was the center of Dodge’s activity. His writings offer a firsthand record of the 1878 retreat of the Northern Cheyenne, the conditions endured by Indians who remained on the reservation, and the jurisdictional conflicts between Army personnel and representatives of the Office of Indian Affairs. These journals also provide insight into Dodge’s character, with reports of his official duties as a military man and of several landmark events in his family life. Extensive commentaries and notes by Wayne R. Kime provide further detail, including a history of Cantonment North Fork Canadian River, a six-company post Dodge established and commanded in the region.
An indispensable tool for those working at the front lines of new drug development Written for busy professionals at the forefront of new drug development, Drug Delivery gets readers quickly up to speed on both the principles and latest applications in the increasingly important field of drug delivery. Recent developments in such areas as combinatorial chemistry, proteomics, and genomics have revolutionized researchers' ability to rapidly identify and synthesize new pharmacological compounds. However, delivery-related properties remain a significant reason for clinical trial failures. Bringing together contributions by leading international experts, Drug Delivery covers the entire field in a systematic but concise way. It begins with an in-depth review of key fundamentals, such as physiochemical and biological barriers; drug delivery pathways; metabolism; drug formulation; pharmacokinetic and pharmacodynamic issues; and more. The remainder of the book is devoted to the systematic examination-including overviews, timely examples, and extensive references-of a host of specific subjects, including: * Receptor-mediated drug delivery * Prodrug delivery approaches * Oral protein and peptide drug delivery * Gene therapy and gene delivery * Ultrasound-mediated drug delivery * Polycationic peptides and proteins in drug delivery * Pulmonary drug delivery * Antibody-directed drug delivery * Efflux transporters in drug excretion * Intellectual property issues in drug delivery
This volume makes JEC-commissioned expert studies of economic developments in East-Central Europe available to business people, educators and students. Coverage includes economic, political and social reform issues, regional relations, and the impact of Western assistance programmes.
This is a thoroughgoing revision of the first edition of this classic text and reference, published by Plenum in 1992. The authors convey the general principles that underlie this applied subdiscipline and demonstrate how the merging of demography and health care impacts on the planning processes of a range of health care organizations.
An entertaining and educated observer, Elliott provided readers back home with an account of the grueling march over the famous Santa Fe Trail, the triumphant entry of the army into Santa Fe, the U.S. occupation of New Mexico, and the volunteers' eventual return to St. Louis.
This volume describes concurrent engineering developments that affect or are expected to influence future development of digital diagnostic imaging. It also covers current developments in Picture Archiving and Communications System (PACS) technology, with particular emphasis on integration of emerging imaging technologies into the hospital environment.
We all want to look and feel good. We also want to perform well whether it's in the weight room, in sports, or at work. Research has shown exercise, proper nutrition, and adequate recovery affect health and human performance. However, there's lot of conflicting and confusing information regarding exercise and nutrition. In Essentials of Exercise and Sport Nutrition, author Dr. Richard B. Kreider offers an up-to-date assessment of the science and practice of exercise and sport nutrition. Kreider, who has conducted extensive research on the subject and has consulted with numerous teams, coaches, and athletes for more than thirty years, brings a scientific and applied perspective to discussing the latest research and how it can be used to optimize performance. He also provides summary recommendations, training programs, and meal plans for beginners through athletes, as well as for individuals who want to lose and/or manage their weight.
California is a region of rich geographic and human diversity. The Elusive Eden charts the historical development of California, beginning with landscape and climate and the development of Native cultures, and continues through the election of Governor Gavin Newsom. It portrays a land of remarkable richness and complexity, settled by waves of people with diverse cultures from around the world. Now in its fifth edition, this up-to-date text provides an authoritative, original, and balanced survey of California history incorporating the latest scholarship. Coverage includes new material on political upheavals, the global banking crisis, changes in education and the economy, and California's shifting demographic profile. This edition of The Elusive Eden features expanded coverage of gender, class, race, and ethnicity, giving voice to the diverse individuals and groups who have shaped California. With its continued emphasis on geography and environment, the text also gives attention to regional issues, moving from the metropolitan areas to the state's rural and desert areas. Lively and readable, The Elusive Eden is organized in ten parts. Each chronological section begins with an in-depth narrative chapter that spotlights an individual or group at a critical moment of historical change, bringing California history to life.
Thoroughly updated for its Fifth Edition, Dr. Light's classic text provides a focused, single-authored perspective on the pathophysiology, clinical manifestations, diagnosis, and management of pleural diseases. This edition has three new chapters on physiological effects of a pneumothorax or pleural effusion, animal models in pleural investigation, and cytokines and the pleura. Other chapters present significant updates on use of thoracoscopy in diagnosis of pleural effusions and on new diagnostic tests for mesothelioma, parapneumonic effusion, and effusions due to congestive heart failure. Also included are discussions of recent advances in the therapy of malignant pleural effusions, mesothelioma, and parapneumonic effusions.
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