This two-volume conference proceedings summarizes the latest developments in the fields of neuroanatomy, physiology, neurochemistry, molecular biology, clinical medicine, and immunology as they impact on the understanding of stress. The paper are grouped by 11 topics: central monoamine and neuropeptide pathways and stress; peripheral monoamine and neuropeptide responses to stress; molecular genetics of stress hormones; molecular genetics of neurotransmitter enzymes; neuroendocrine responses to stress; sympathetic responses to stress; psychoneuroimmune responses to stress; adrenergic, peptidergic, and steroid receptors and stress; SART stress and neurotropin; clinical studies of stress; and (one paper) ethical issues of stress research with animals. Annotation copyrighted by Book News, Inc., Portland, OR
Stress has been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli also appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood. Stress and Mental Disorders: Insights from Animal Models begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioral alterations as a newer approach to understanding why some animals are susceptible to stress and others are resilient, even though they are essentially genetically identical. The final chapter discusses how these basic laboratory studies are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders.
Behavioral Treatment of Disease: A NATO Symposium on Behavioral Medicine was held on June 30th through July 3rd, 1981 at Porto Carras, Neo Marmaras, Greece. It was a multi disciplinary meeting which provided an opportunity for North American and European scientists from ten different NATO member countries to share the emerging principles and technology of behavioral treatment of disease. In addition, it served as a forum whereby continued high level research in the area was stimulated. Financial support for the symposium was initially provided by the Scientific Affairs Division or the North Atlantic Treaty Organization as part of their continuing seri.es of scientific symposia. Funds made available by a grant from the United States Office of Naval Reseach permitted widespread inter national participation in the symposium. We would like to thank each of these organizations for their support in making the symposium possible. In particular, we would like to thank Dr. B. A. Bayraktar of the Scientific Affairs Division of NATO and Dr. Donald Woodward of the U.S. Office of Naval Research. Though both of these men were unable to attend the meeting personally, they provided invaluable assistance in its planning.
Exposure to stressful life experiences can disrupt key regulatory systems in the body and contribute to a variety of negative health outcomes. This authoritative text takes a biopsychosocial approach to understanding the role of stress in alcohol use disorder, posttraumatic stress disorder, depression, cardiovascular disease, type 2 diabetes, cancer, and other chronic diseases. It presents cutting-edge knowledge about how stressors are conceptualized and measured; connections to disease processes; systemic racism as a significant, ongoing stressor for people of color; and factors that promote resilience. For each of the disorders discussed, proven and promising stress-targeted clinical interventions are reviewed. Student-friendly features include an end-of-book glossary and an extensive bibliography to facilitate in-depth study of selected topics of interest.
Prenatal Cocaine Exposures addresses the timely problem of maternal cocaine abuse and its effects on exposed infants, including growth retardation, learning, cardiovascular effects, and seizures. The impact of substance abuse on this and future generations presents an ongoing challenge to medical science. This comprehensive and authoritative volume reviews both animal and clinical studies to explain implications for treatment and long-term outcomes of early exposure. Prenatal Cocaine Exposures investigates the specific role of cocaine in altering fetal development. Discussions of current studies and state-of-the-art techniques provide a basis for informed clinical decisions. Pediatricians, medical specialists, basic scientists, educators, and policy makers will all benefit from the comprehensive research gathered in this volume.
Mechanisms and Manifestations of Obesity in Lung Disease is a complete resource on the epidemiology and molecular mechanisms related to obesity and lung disease. Obesity has not simply changed the epidemiology of pulmonary disease, it has had a profound impact on the pathophysiology of common pulmonary diseases. As the obesity epidemic has taken hold throughout the developed world, scientists and clinicians are now challenged with identifying the mechanisms by which obesity alters lung health and the pathogenesis of lung diseases. This book is an important new resource for both clinicians and scientists dealing with these new health problems in pulmonary medicine. Presents an all-in-one resource that describes the impact of obesity on the development and severity of lung disease Details the molecular and immunologic mechanisms by which obesity impacts the pathogenesis and outcomes of lung disease Includes contributions from authors who are internationally recognized as leaders in the area of obesity and lung disease
This edition of Health Psychology provides an even more effective introduction to the psychology behind why we get sick, how we stay well, how we react to illness, and how we relate to the health care system and health care providers.
This three-volume text provides a comprehensive review and reference source for those with a teaching, research, or practical involvement in alcohol metabolism in humans. Written by 70 contributing authors from 12 countries, this publication covers a wide range of material, from medicolegal aspects of alcohol metabolism to the structure of enzymes involved in metabolizing alcohol. Although primarily concerned with human alcohol metabolism, information from animal experiments is included where it clarifies results of human studies, or where information for human subjects is not available.
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