If you have ever attended a funeral or stood beside the bed of a sick loved one, you can't help but ask, "Is this it? Is there life after death?" In this compelling true story of two brothers' journey, you will see the supernatural and natural worlds collide as they fight together for healing and life. This riveting experience will take you beyond this life to see what is to come. You will get a vivid glimpse of heaven and its glorious details. In contrast, you will also walk through the journey of hell and the bone-chilling sights and creatures. You will be inspired to see how people, prayer, and providence can affect everyday outcomes. This beautiful account is a testimony that when we are weak and unable to help ourselves, both God and others can be the strength to bring hope and restoration. You are sure to be comforted, strengthened, and shaken in your faith and future as you read this story. It is guaranteed you will never look at life here or beyond the same.
The new edition of this extremely well-received political biography of Vladimir Putin builds on the strengths of the first edition to provide the most detailed and nuanced account of the man, his politics and his profound influence on Russian politics, foreign policy and society. New to this edition: analysis of Putin's second term as President more biographical information in the light of recent research detailed discussion of changes to the policy process and the élites around Putin developments in state-society relations including the conflicts with oligarchs such as Khodorkovsky review of changes affecting the party system and electoral legislation, including the development of federalism in Russia details on economic performance under Putin, including more discussion of the energy sector and pipeline politics Russia’s relationship with NATO after the ‘big bang’ enlargement, EU-Russian relations after enlargement, and Russia’s relations with other post-Soviet states the conclusion brings us up-to-date with debates over the question of democracy in Russia today and the nature of Putin’s leadership and his place in the world. Putin is essential reading for all scholars and students of Russian politics.
This textbook explores the fundamental principles of marketing applied to tourism and hospitality businesses, placing special emphasis on SMEs in the international tourism industry. It includes examples from a wide range of destinations, from emerging markets to high-income countries. Taking a comprehensive approach, the book covers the whole spectrum of tourism and hospitality marketing including destination marketing, marketing research, consumer behaviour, and digital and social media marketing. Practical in focus, it gives students the tools, techniques, and underlying theory required to design and implement successful tourism marketing plans. Chapters contain in-depth case studies, including companies like Marine Dynamics Shark Tours (South Africa), Reality Tours & Travel (Mumbai, India), and Makeover Tours (Turkey). Thematic case studies include ‘Halal Tourism in Southeast Asia’, and ‘Marketing and Branding Rwanda’. These illustrate key concepts and theory, with definitions, key summaries, and discussion questions providing further insights. This textbook is ideal for undergraduate and postgraduate students looking for a comprehensive text with a practical orientation.
It has been ten years since the publication of the third edition of this seminal text on plant virology, during which there has been an explosion of conceptual and factual advances. The fourth edition updates and revises many details of the previous editon, while retaining the important older results that constitute the field's conceptual foundation. Key features of the fourth edition include: * Thumbnail sketches of each genera and family groups * Genome maps of all genera for which they are known * Genetic engineered resistance strategies for virus disease control * Latest understanding of virus interactions with plants, including gene silencing * Interactions between viruses and insect, fungal, and nematode vectors * New plate section containing over 50 full-color illustrations.
Published and updated annually, Russia and Eurasia deals with the twelve independent republics that became members of the Commonwealth of Independent States following the collapse of the Soviet Union in December 1992. The text focuses strongly on recent economic and political developments with shorter sections dealing with foreign policy, the military, religion, education, and specific cultural elements that help to define each republic and differentiate one from the other. Approximately one-third of the book is devoted to Russia, but also includes sections on Ukraine, Belarus, Moldova, Armenia, Azerbaijan, Georgia, Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. How the Commonwealth of Independent States came into being and how it has evolved since 1992 is also discussed. The combination of factual accuracy and up-to-date detail along with its informed projections make this an outstanding resource for researchers, practitioners in international development, media professionals, government officials, potential investors and students.
This impressive compilation offers a nearly complete listing of sound recordings made by American minority artists prior to mid-1942. Organized by national group or language, the seven-volume set cites primary and secondary titles, composers, participating artists, instrumentation, date and place of recording, master and release numbers, and reissues in all formats. Because of its clear arrangements and indexes, it will be a unique and valuable tool for music and ethnic historians, folklorists, and others.
This volume is a sequel to the landmark work that established an exciting new field of study, Stress, Appraisal and Coping (Lazarus and Folkman, 1984). The author now explores the newest trends in research and theory, focusing on the rationale for a cognitive-mediational approach to stress and emotions. He makes clear distinctions between social stress, physiological stress, and psychological stress. By integrating both stress and emotion into one theoretical framework, with appraisal and coping as its basis, this book takes a narrative approach to both theory and research. Lazarus concludes with a look at stress and health, with a specific focus on new developments in infectious diseases, the role of the nervous system, and his view of recent changes in psychotherapy. For all upper division psychology majors, graduate students, academics, and professionals in related fields
Effectively perform today’s most state-of-the-art neurosurgical procedures with Youmans Neurological Surgery, 6th Edition, edited by H. Richard Winn, MD. Still the cornerstone of unquestioned guidance on surgery of the nervous system, the new edition updates you on the most exciting developments in this ever-changing field. In print and online, it provides all the cutting-edge details you need to know about functional and restorative neurosurgery (FRN)/deep brain stimulation (DBS), stem cell biology, radiological and nuclear imaging, neuro-oncology, and much more. And with nearly 100 intraoperative videos online at www.expertconsult.com, as well as thousands of full-color illustrations, this comprehensive, multimedia, 4-volume set remains the clinical neurosurgery reference you need to manage and avoid complications, overcome challenges, and maximize patient outcomes. Overcome any clinical challenge with this comprehensive and up-to-date neurosurgical reference, and ensure the best outcomes for your patients. Rely on this single source for convenient access to the definitive answers you need in your practice. Successfully perform functional and restorative neurosurgery (FRN) with expert guidance on the diagnostic aspects, medical therapy, and cutting-edge approaches shown effective in the treatment of tremor, Parkinson’s disease, dystonia, and psychiatric disorders. Sharpen your neurosurgical expertise with updated and enhanced coverage of complication avoidance and intracranial pressure monitoring, epilepsy, neuro-oncology, pain, peripheral nerve surgery, radiosurgery/radiation therapy, and much more. Master new techniques with nearly 100 surgical videos online of intraoperative procedures including endoscopic techniques for spine and peripheral nerve surgery, the surgical resection for spinal cord hemangiomas, the resection of a giant AVM; and the radiosurgical and interventional therapy for vascular lesions and tumors. Confidently perform surgical techniques with access to full-color anatomic and surgical line drawings in this totally revised illustration program. Get fresh perspectives from new section editors and authors who are all respected international authorities in their respective neurosurgery specialties. Conveniently search the complete text online, view all of the videos, follow links to PubMed, and download all images at www.expertconsult.com.
Rothman-Simeone The Spine helps you achieve optimal outcomes in the clinical practice of spine surgery in adults and children. Drs. Harry N. Herkowitz, Steven R. Garfin, Frank J. Eismont, Gordon R. Bell, Richard Balderston, and an internationally diverse group of authorities help you keep up with the fast-paced field and get the best results from state-of-the-art treatments and surgical techniques, such as spinal arthroplasty and the latest spinal implants and equipment. An all-new full-color design and surgical videos online at www.expertconsult.com make this classic text more invaluable than ever before. Get the best results from the full range of both surgical and non-surgical treatment approaches with guidance from the world’s most trusted authorities in orthopaedic spine surgery. Find important information quickly through pearls, pitfalls, and key points that highlight critical points. Watch experts perform key techniques in real time with videos, on DVD and online, demonstrating minimally invasive surgery: SED procedure; thorascopic techniques; lumbar discectomy; pedicle subtraction osteotomy (PSO); C1, C2 fusion; intradural tumor; cervical laminoforaminoty; and much more. Apply the newest developments in the field thanks to expert advice on minimally invasive surgery, spinal arthroplasty and the latest spinal implants and equipments. See procedures clearly through an all new full-color design with 2300 color photographs and illustrations placed in context. Access the fully searchable contents of text online at www.expertconsult.com.
Fetal and Neonatal Physiology, edited by Drs. Polin, Fox, and Abman, focuses on physiologic developments of the fetus and newborn and their impact on the clinical practice of neonatology. A must for practice, this 4th edition brings you the latest information on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Gain a comprehensive, state-of-the-art understanding of normal and abnormal physiology, and its relationship to disease in the fetus and newborn premature infant, from Dr. Richard Polin and other acknowledged worldwide leaders in the field. Understand the implications of fetal and neonatal physiology through chapters devoted to clinical correlation. Apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Effectively manage the consequences of intrauterine infections with three new chapters covering intrauterine infection and preterm birth, intrauterine infection and brain injury, and intrauterine infection and chronic lung disease.
Fetal and Neonatal Physiology, edited by Drs. Polin, Fox, and Abman, focuses on physiologic developments of the fetus and newborn and their impact on the clinical practice of neonatology. A must for practice, this 4th edition brings you the latest information on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. You'll also have easy access to the complete contents and illustrations online at expertconsult.com. Gain a comprehensive, state-of-the-art understanding of normal and abnormal physiology, and its relationship to disease in the fetus and newborn premature infant, from Dr. Richard Polin and other acknowledged worldwide leaders in the field. Understand the implications of fetal and neonatal physiology through chapters devoted to clinical correlation. Apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Effectively manage the consequences of intrauterine infections with three new chapters covering intrauterine infection and preterm birth, intrauterine infection and brain injury, and intrauterine infection and chronic lung disease. Access the complete contents and illustrations online at expertconsult.com - fully searchable! Get the latest developments and a full understanding of the distinct physiology of the fetus and newborn so you can treat and manage sick newborns and preemies.
Having been fully revised and updated to reflect the considerable changes in Russia over the last decade, the fourth edition of this classic text builds on the strengths of the previous editions to provide a comprehensive and sophisticated analysis on Russian politics and society. New to this edition: extended coverage of electoral laws, party development and regional politics new chapter on the ‘phoney democracy’ period, 1991-93 historical evaluation of Yeltsin’s leadership full coverage of Putin’s presidency discussion of the development of civil society and the problems of democratic consolidation latest developments in the Chechnya conflict more on foreign policy issues the re-introduction of the Russian Constitution as an appendix an updated Select Bibliography more focus on the challenges facing Russia in the twenty-first century. Written in an accessible and lively style, this book is packed with detailed information on the central debates and issues in Russia’s difficult transformation. This makes it the best available textbook on the subject and is essential reading for all those concerned with the fate of Russia, and with the future of international society.
Mechanisms and Manifestations of Obesity in Lung Disease is a complete resource on the epidemiology and molecular mechanisms related to obesity and lung disease. Obesity has not simply changed the epidemiology of pulmonary disease, it has had a profound impact on the pathophysiology of common pulmonary diseases. As the obesity epidemic has taken hold throughout the developed world, scientists and clinicians are now challenged with identifying the mechanisms by which obesity alters lung health and the pathogenesis of lung diseases. This book is an important new resource for both clinicians and scientists dealing with these new health problems in pulmonary medicine. Presents an all-in-one resource that describes the impact of obesity on the development and severity of lung disease Details the molecular and immunologic mechanisms by which obesity impacts the pathogenesis and outcomes of lung disease Includes contributions from authors who are internationally recognized as leaders in the area of obesity and lung disease
Syracuse possesses a unique place in the history of the ancient Mediterranean because of its contribution to Greek culture and political thought and practice. Even in the first century BC Cicero could still declare ’You have often heard that of all the Greek cities Syracuse is the greatest and most beautiful.’ Sicily’s strategic location in the Mediterranean brought the city prosperity and power, placing it in the first rank of states in the ancient world. The history and governance of the city were recorded from the fifth century BC and the volume of literary sources comes close to matching the records of Athens or Rome. Combining literary and material evidence this monograph traces the history of Syracuse, offering new arguments about the date of the city’s foundation, and continues through the fifth century when, as a democracy, Syracuse’s military strength grew to equal that of Athens or Sparta, surpassing them in the early fourth century under the tyrant Dionysius I. From ca. 350 BC, however, the city’s fortunes declined as the state was wracked with civil strife as the tyranny lost control. The result was a collapse so serious that the city faced complete and imminent destruction.
England has had a predominantly conservative political culture for some centuries. Yet there is a persistent, minority strand of radicalism that has challenged the practices, beliefs and structures of power of the established order. This book explores this ‘radical tradition’ as articulated in the twentieth century. The main currents of English radicalism range from liberal reformers, through socialist parliamentarians, to social movement activists in the peace, women’s and labour movements. Despite their differing agendas, all have held their moral and political commitments to achieving a free, democratic, equal and just society in common. Moreover, all have believed, whatever their other differences, in the importance of extra-parliamentary social movements. What is it that has constituted this ‘radical tradition’? Is it a coherent, distinctive and important political force in the twentieth century? And how do these ideas and practices relate to radical politics in England in the early twenty-first century? This book offers an analysis of the historical and ideological development of English radicalism from the English Civil War onwards. Richard Taylor examines how the problems of achieving radical change in England in the twentieth century were approached by the ten key figures from a range of ideological positions within the tradition: Bertrand Russell, Sylvia Pankhurst, Ellen Wilkinson, George Orwell, E.P. Thompson, Michael Foot, Joan Maynard, Stuart Hall, Tony Benn and Nicolas Walter.
Highly accessible, authoritative, and intellectually provocative, a startlingly original theory of how Homo sapiens came to be: Richard Wrangham forcefully argues that, a quarter of a million years ago, rising intelligence among our ancestors led to a unique new ability with unexpected consequences: our ancestors invented socially sanctioned capital punishment, facilitating domestication, increased cooperation, the accumulation of culture, and ultimately the rise of civilization itself. Throughout history even as quotidian life has exhibited calm and tolerance[,] war has never been far away, and even within societies violence can be a threat. The Goodness Paradox gives a new and powerful argument for how and why this uncanny combination of peacefulness and violence crystallized after our ancestors acquired language in Africa a quarter of a million years ago. Words allowed the sharing of intentions that enabled men effectively to coordinate their actions. Verbal conspiracies paved the way for planned conflicts and, most importantly, for the uniquely human act of capital punishment. The victims of capital punishment tended to be aggressive men, and as their genes waned, our ancestors became tamer. This ancient form of systemic violence was critical, not only encouraging cooperation in peace and war and in culture, but also for making us who we are: Homo sapiens"--
This book builds on the strengths of the previous volumes by the same author to provide the most detailed and nuanced account of the man, his politics and his profound influence on Russian politics, foreign policy and society. However, this is not a new edition of the earlier books but is an entirely new work. The focus now is on the dilemmas of power since 2008. There is a brief biographical sketch of Vladimir Putin and much analysis of his ideas and policies, but the book now focuses on the systemic contradictions that have created a blockage on modernisation and a stalemate in politics, Putin's role as Prime Minister since 2008 and his political successes and failures, analysis of the implications of Putin's third term as President and the 2011-12 electoral cycle and the ensuing crisis which led to thousands protesting on the streets This work assesses the achievements and failing of Putin’s rule, but above all tries to make sense of contemporary developments. This is the definitive account of Putin and is essential reading for all scholars and students of Russian politics.
Generalized Anxiety Disorder occurs in approximately 4% of the population and is characterized by excessive uncontrollable worry about everyday things. The constant worry can be extremely impairing if left untreated, even to the point of causing physical symptoms. Written by the developers of an empirically supported and effective cognitive-behavioral therapy program for treating GAD, this second edition therapist guide includes all the information and materials necessary to implement a successful treatment protocol. The therapeutic technique described in this book is research-based with a proven success rate when used in both individual and group formats, as well as with clients currently taking medication. Designed to be used in conjunction with its corresponding workbook, this therapist guide outlines a 10-session program comprised of four primary treatment modules including, cognitive restructuring, progressive muscle relaxation, worry exposures, and in vivo exposure exercises. New features to this edition include expanded chapters that provide detailed instructions for conducting each session, session outlines, and recommended homework assignments. This user-friendly guide is a dependable resource that no clinician can do without! TreatmentsThatWorkTM represents the gold standard of behavioral healthcare interventions! · All programs have been rigorously tested in clinical trials and are backed by years of research · A prestigious scientific advisory board, led by series Editor-In-Chief David H. Barlow, reviews and evaluates each intervention to ensure that it meets the highest standard of evidence so you can be confident that you are using the most effective treatment available to date · Our books are reliable and effective and make it easy for you to provide your clients with the best care available · Our corresponding workbooks contain psychoeducational information, forms and worksheets, and homework assignments to keep clients engaged and motivated · A companion website (www.oup.com/us/ttw) offers downloadable clinical tools and helpful resources · Continuing Education (CE) Credits are now available on select titles in collaboration with PsychoEducational Resources, Inc. (PER)
The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development.Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.
Mixed-Mode Simulation and Analog Multilevel Simulation addresses the problems of simulating entire mixed analog/digital systems in the time-domain. A complete hierarchy of modeling and simulation methods for analog and digital circuits is described. Mixed-Mode Simulation and Analog Multilevel Simulation also provides a chronology of the research in the field of mixed-mode simulation and analog multilevel simulation over the last ten to fifteen years. In addition, it provides enough information to the reader so that a prototype mixed-mode simulator could be developed using the algorithms in this book. Mixed-Mode Simulation and Analog Multilevel Simulation can also be used as documentation for the SPLICE family of mixed-mode programs as they are based on the algorithms and techniques described in this book.
Here is the first published manual for cognitive-behavioral group therapy for social phobia (CBGT), an empirically supported treatment approach that has been applied in clinical and research settings for over 20 years. The authors demonstrate how to orient clients to the approach; implement in-session exposures, cognitive restructuring techniques, and homework assignments; and overcome stumbling blocks in treatment. Filled with helpful clinical pointers, case examples, and therapist -- client dialogues, the book also includes sample handouts and forms.
Mark A. Yarhouse, Richard E. Butman and Barrett W. McRay offer this revised companion volume to Modern Psychotherapies, addressing students and mental health professionals who want to sort through contemporary secular understandings of psychopathology in relationship to a Christian worldview.
Different animals have different visual systems and so presumably have different ways of seeing. How does the way in which we see depend on the optical, neural and motor components of our visual systems? Originally published in 1993, the mathematical tools needed to answer this question are introduced in this book. Elementary linear algebra is used to describe the transformations of the stimulus that occur in the formation of the optical, neural and motor images in the human visual system. The distinctive feature of the approach is that transformations are specified with enough rigour for readers to be able to set up their own models and generate predictions from them. Underlying the approach of this book is the goal of providing a self-contained source for the derivation of the basic equations of vision science. An introductory section on vector and matrix algebra covers the mathematical techniques which are applied to both sensory and motor aspects of the visual system, and the intervening steps in the mathematical arguments are given in full, in order to make the derivation of the equations easier to follow. A subsidiary goal of this book is to demonstrate the utility of current desktop computer packages which make the application of mathematics very easy. All the numerical results were produced using only a spreadsheet or mathematics package, and example calculations are included in the text.
These studies focus on personal eschatology in the Jewish and early Christian apocalypses. The apocalyptic tradition from its Jewish origins until the early middle ages is studied as a continuous literary tradition, in which both continuity of motifs and important changes in understanding of life after death can be charted. As well as better known apocalypses, major and often pioneering attention is given to those neglected apocalypses which portray human destiny after death in detail, such as the Apocalypse of Peter, the Apocalypse of the Seven Heavens, the later apocalypses of Ezra, and the four apocalypses of the Virgin Mary. Relationships with Greco-Roman eschatology are explored. Several chapters show how specific New Testament texts are illuminated by close knowledge of this tradition of ideas and images of the hereafter.
The third edition of Managing Social Anxiety: A Cognitive-Behavioral Therapy Approach, Therapist Guide is for individual or group cognitive-behavioral therapy for social anxiety with adults. This is an evidence-based approach backed by over three decades of research.
Covering both surgical and anesthetic considerations, Anesthesiologist’s Manual of Surgical Procedures, Sixth Edition, is an essential resource for formulation of an anesthetic plan and perioperative management of patients. All chapters are written by both surgeons and anesthesiologists, giving you a detailed, real-world perspective on the many variables that accompany today’s surgical procedures.
This book has two primary goals. On the level of theory development, the book clarifies the nature of an emerging "models and modeling perspective" about teaching, learning, and problem solving in mathematics and science education. On the level of emphasizing practical problems, it clarifies the nature of some of the most important elementary-but-powerful mathematical or scientific understandings and abilities that Americans are likely to need as foundations for success in the present and future technology-based information age. Beyond Constructivism: Models and Modeling Perspectives on Mathematics Problem Solving, Learning, and Teaching features an innovative Web site housing online appendices for each chapter, designed to supplement the print chapters with digital resources that include example problems, relevant research tools and video clips, as well as transcripts and other samples of students' work: http://tcct.soe.purdue.edu/booksULandULjournals/modelsULandUL modeling/ This is an essential volume for graduate-level courses in mathematics and science education, cognition and learning, and critical and creative thinking, as well as a valuable resource for researchers and practitioners in these areas.
Are horrific experiences indelibly fixed in a victim’s memory? Or does the mind protect itself by banishing traumatic memories from consciousness? How victims remember trauma is the most controversial issue in psychology today, spilling out of consulting rooms and laboratories to capture headlines, rupture families, provoke legislative change, and influence criminal trials and civil suits. This book, by a clinician who is also a laboratory researcher, is the first comprehensive, balanced analysis of the clinical and scientific evidence bearing on this issue—and the first to provide definitive answers to the urgent questions at the heart of the controversy. Synthesizing clinical case reports and the vast research literature on the effects of stress, suggestion, and trauma on memory, Richard McNally arrives at significant conclusions, first and foremost that traumatic experiences are indeed unforgettable. Though people sometimes do not think about disturbing experiences for long periods of time, traumatic events rarely slip from awareness for very long; furthermore, McNally reminds us, failure to think about traumas—such as early sexual abuse—must not be confused with amnesia or an inability to remember them. In fact, the evidence for repressed memories of trauma—or even for repression at all—is surprisingly weak. A magisterial work of scholarship, panoramic in scope and nonpartisan throughout, this unfailingly lucid work will prove indispensable to anyone seeking to understand how people remember trauma.
We have defined out of the depressed category the positions that one takes to have major implications for who one treats and how, that data are going to be considered relevant, and how one organizes that data. Many of the differences in the theoretical positions taken to be discussed in this volume start with a fundamental difference in how depression is defined. We cannot pretend to resolve these controversies, but we can at least, identify them and note some of the definitions and distinctions that are being employed currently. Our purpose of this volume is to provide an overview of the phenomena of depression, as it should become apparent that there is a tremendous heterogeneity to what falls under the broad rubric of depression and it has an arbitrariness to any boundaries that are drawn on these phenomena, than others. Confronted with all of this ambiguity and confusion, one must be cautious and not seek more precision that the phenomena of depression afford, and one should probably be skeptical about any decisive statement about the nature of depression. It is also, intended to prepare the reader for the diversity of theoretical perspectives that will be presented in this volume. Contemplating the phenomena of depression, one can readily detect patterns and come to a conclusion that some aspects of depression are more central than others, some are primary and causal, and others are secondary. Cognizant of this, the observer might conclude that there is some sort of interpersonal process going on that is critical to any understanding of depression.
Stress has been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli also appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood. Stress and Mental Disorders: Insights from Animal Models begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioral alterations as a newer approach to understanding why some animals are susceptible to stress and others are resilient, even though they are essentially genetically identical. The final chapter discusses how these basic laboratory studies are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders.
Synthetic Biology -- A Primer (Revised Edition) presents an updated overview of the field of synthetic biology and the foundational concepts on which it is built. This revised edition includes new literature references, working and updated URL links, plus some new figures and text where progress in the field has been made.The book introduces readers to fundamental concepts in molecular biology and engineering and then explores the two major themes for synthetic biology, namely 'bottom-up' and 'top-down' engineering approaches. 'Top-down' engineering uses a conceptual framework of systematic design and engineering principles focused around the Design-Build-Test cycle and mathematical modelling. The 'bottom-up' approach involves the design and building of synthetic protocells using basic chemical and biochemical building blocks from scratch exploring the fundamental basis of living systems.Examples of cutting-edge applications designed using synthetic biology principles are presented, including: The book also describes the Internationally Genetically Engineered Machine (iGEM) competition, which brings together students and young researchers from around the world to carry out summer projects in synthetic biology. Finally, the primer includes a chapter on the ethical, legal and societal issues surrounding synthetic biology, illustrating the integration of social sciences into synthetic biology research.Final year undergraduates, postgraduates and established researchers interested in learning about the interdisciplinary field of synthetic biology will benefit from this up-to-date primer on synthetic biology.
The increasing integration between gene manipulation and genomics is embraced in this new book, Principles of Gene Manipulation and Genomics, which brings together for the first time the subjects covered by the best-selling books Principles of Gene Manipulation and Principles of Genome Analysis & Genomics. Comprehensively revised, updated and rewritten to encompass within one volume, basic and advanced gene manipulation techniques, genome analysis, genomics, transcriptomics, proteomics and metabolomics Includes two new chapters on the applications of genomics An accompanying website - www.blackwellpublishing.com/primrose - provides instructional materials for both student and lecturer use, including multiple choice questions, related websites, and all the artwork in a downloadable format. An essential reference for upper level undergraduate and graduate students of genetics, genomics, molecular biology and recombinant DNA technology.
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