An inside look at how patients living with terminal illness created one of the country’s first medical marijuana collectives Marijuana as medicine has been a politically charged topic in this country for more than three decades. Despite overwhelming public support and growing scientific evidence of its therapeutic effects (relief of the nausea caused by chemotherapy for cancer and AIDS, control over seizures or spasticity caused by epilepsy or MS, and relief from chronic and acute pain, to name a few), the drug remains illegal under federal law. In Dying to Get High, noted sociologist Wendy Chapkis and Richard J. Webb investigate one community of seriously-ill patients fighting the federal government for the right to use physician-recommended marijuana. Based in Santa Cruz, California, the Wo/Men’s Alliance for Medical Marijuana (WAMM) is a unique patient-caregiver cooperative providing marijuana free of charge to mostly terminally ill members. For a brief period in 2004, it even operated the only legal non-governmental medical marijuana garden in the country, protected by the federal courts against the DEA. Using as their stage this fascinating profile of one remarkable organization, Chapkis and Webb tackle the broader, complex history of medical marijuana in America. Through compelling interviews with patients, public officials, law enforcement officers and physicians, Chapkis and Webb ask what distinguishes a legitimate patient from an illegitimate pothead, good drugs from bad, medicinal effects from just getting high. Dying to Get High combines abstract argument and the messier terrain of how people actually live, suffer and die, and offers a moving account of what is at stake in ongoing debates over the legalization of medical marijuana.
Thirty-five years ago, the four authors of this book addressed the problems of validity in social science research. They were interested in new and unused methods for obtaining information. The original edition and an expanded version have often been cited as justification for using novel means to supplement, if not replace, conventional techniques, especially survey and archival research. Illustrations abound in this book. While the novelty of the illustrations will keep many a graduate student amused, the more serious purpose is to authorize and motivate ingenuity in obtaining information. Even more fundamental is the strategy of combining very different methods so that research results can, by triangulation, withstand "threats to validity" that so frequently invalidate single-measure, conventional research.
Since the discovery of the circulating ?fibrocyte? in 1994 as a collagen-producing cell of the peripheral blood, the physiologic and pathologic role of this unique cell populaton has grown steadily. This pioneering new book provides the first comprehensive review of the role of fibrocytes in wound repair, granuloma formation, antigen presentation, scar formation, and various fibrosing disorders such as interstitial lung disease and nephrogenic systemic fibrosis. It also includes discussions of the recent studies on the molecular signals that influence fibrocyte migration, proliferation, and function in the context of normal physiology and pathology. The chapters are contributed by the leading researchers in the field.
This book examines the impact that nostalgia has had on the Labour Party’s political development since 1951. It argues that nostalgia has defined Labour’s identity and determined the party’s trajectory. Nostalgia has hindered policy discussion, determined the form and parameters of party modernisation, shaped internal conflict and cohesion and made it difficult for the party to adjust to socioeconomic changes. It has frequently left the party out of touch with the modern world. In this way, this study offers an assessment of Labour’s failures to adapt to the changing nature of post-war Britain and will be of interest to both students and academics and to those with a more general interest in Labour’s history and politics.
This volume offers an overview of the philosophy of cognitive science that balances breadth and depth, with chapters covering every aspect of the psychology and cognitive anthropology.
Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.
Examining portraits of black people over the past two centuries, Cutting a Figure argues that these images should be viewed as a distinct category of portraiture that differs significantly from depictions of people with other racial and ethnic backgrounds. The difference, Richard Powell contends, lies in the social capital that stems directly from the black subject’s power to subvert dominant racist representations by evincing such traits as self-composure, self-adornment, and self-imagining. Powell forcefully supports this argument with evidence drawn from a survey of nineteenth-century portraits, in-depth case studies of the postwar fashion model Donyale Luna and the contemporary portraitist Barkley L. Hendricks, and insightful analyses of images created since the late 1970s. Along the way, he discusses major artists—such as Frédéric Bazille, John Singer Sargent, James Van Der Zee, and David Hammons—alongside such overlooked producers of black visual culture as the Tonka and Nike corporations. Combining previously unpublished images with scrupulous archival research, Cutting a Figure illuminates the ideological nature of the genre and the centrality of race and cultural identity in understanding modern and contemporary portraiture.
Dr Warmington's examination of the impact of the Civil War in Gloucestershire begins with the descent into war between 1640 and 1642, showing how the two sides formed and why the Parliamentarians had the more durable war machine. He then goes on to consider the anarchic situation between 1645 and 1649, and the series of new experiments in government which followed until 1660. The book demonstrates how the war created an almost entirely new governing group of minor gentlemen, based on military service to the regime and religious affiliations, looks at the vexed question of the cultural dimensions of popular allegiance in the period, and examines popular activity (or lack of it) in Gloucestershire's distinct regions of Vale, Wold and Forest during the Civil War. The attempted rebellion of 1659 is examined in detail.
A must-have resource for any emergency or urgent care setting, Fleisher & Ludwig’s 5-Minute Pediatric Emergency Medicine Consult, 3rd Edition, provides clear, succinct guidance on hundreds of diseases and common pediatric conditions. Editors-in-Chief Drs. Robert J. Hoffman and Vincent J. Wang lead an editorial and author team who put evidence-based answers at your fingertips—essential information on clinical orientation, differential diagnosis, medications, management, discharge criteria, and more.
Superconductivity, Third Edition is an encyclopedic treatment of all aspects of the subject, from classic materials to fullerenes. Emphasis is on balanced coverage, with a comprehensive reference list and significant graphics from all areas of the published literature. Widely used theoretical approaches are explained in detail. Topics of special interest include high temperature superconductors, spectroscopy, critical states, transport properties, and tunneling. This book covers the whole field of superconductivity from both the theoretical and the experimental point of view. This third edition features extensive revisions throughout, and new chapters on second critical field and iron based superconductors. - Comprehensive coverage of the field of superconductivity - New content on magnetic properties, fluxons, anisotropies, and more - Over 2500 references to the literature - Enhanced data tables
As our understanding of what constitutes ‘good health’ grows, so does our need to understand the psychological aspects of medicine and health, as well as the psychological interventions available in healthcare. This new edition of this bestselling textbook provides a comprehensive overview of the research, theory, application and current practices in the field, covering topics from epigenetics to social determinants of health and transdiagnostic approaches to mental health and everything in between. An essential read for all medicine and healthcare students, this text is now accompanied by a suite of online resources for all your learning needs.
This book compares models of low-rent and high-rent development to explain the divergent growth of regions and to query the continued prioritization of industrialization over agriculture and export services as the engine of economic prosperity.
In 1934 Wilder Penfield's vision of an establishment dedicated to the relief of sickness and pain and the study of neurology led to the creation of the Montreal Neurological Institute. Setting the standard for neurological research and care for patients disabled by neurological illnesses, Penfield's institute became a beacon of light in a largely unexplored field of medicine. The Wounded Brain Healed describes the pioneering research that took place during the MNI's first fifty years. During the institute's golden age, Penfield and his colleagues designed the EEG test for the study of epileptic patients, discovered some of the causes of epilepsy, and developed new treatments that have since been adopted worldwide. Additionally, they delineated the sensory and motor representation in the cerebral cortex and localized the major areas of the brain related to speech. The institute also boasts the discoveries of two types of memory - one serving immediate recall, the other long term - as well as the discovery of the localization of short-term memory to the inner structures of the temporal lobe. Physicians and scientists who trained at the MNI went on to establish renowned neurology and neurosurgery departments throughout Canada, the United States, Europe, Asia, and Latin America. Recounting the story of one of Canada’s greatest contributions to international medical science through archival research, personal interviews, photographs, illustrations, and paintings, The Wounded Brain Healed provides fascinating insight into the institution that had a global and lasting impact.
This book explores the journey of young people through a Secure Training Centre and, more generally, the criminal justice system in the UK. It examines the extent to which young people have been failed by the system at every stage of their lives, with incarceration used as a means of removing ‘the problem’ from society. To explore this process, the authors utilise an integrated theoretical framework to develop a new rehabilitative approach focused on developing positive outcomes for young people. The book deploys a social impact measurement methodology to evaluate the experience and outcomes of youth justice interventions at a Secure Training Centre. Such an approach provides a fresh perspective on the youth justice debate which has traditionally utilised outcome data to measure immediate impact relating to recidivism and is therefore not focused on the young person holistically. Using a social impact framework to evaluate youth justice, underpinned by an integrated theoretical framework, allows for assessment to be made which place the young person at the centre of evaluation.
A biography of Philip and a study of the emergence of the Burgundian state under his aegis in the years 1384-1404, paying particular attention to his crucial aquisition of Flanders. There is comprehensive analysis of how Philip'sgovernment worked. Boydell & Brewer does a major service by the simultaneous reissue of Richard Vaughan's studies of the Valois Dukes of Burgundy. Four distinguished scholars add extra value by contributing an introductory chapter for each ducal reign, surveying its historiography since the original publication... The story, which Vaughan tells with verve, has its full share of dramatic turns[: ] this is much more, though, than simply a narrative history; Vaughan's meticulousexplorations of the administrative and financial structures that underpinned ducal authority, and of the court and its culture, are integral to his exposition [...] His achievement remains monumental. There are no comparable, modern, in-depth studies of these four larger-than-life players on the late medieval European stage, in English or in any other language. They are, besides, eminently readable. Maurice Keen, TIMES LITERARY SUPPLEMENT Whenin 1363 the duke of Burgundy died without an heir, the duchy returned to the French crown. John II's decision to give it to his fourth son, Philip, had some logic behind it, given the independence of the inhabitants; but in so doing he created the basis for a power which was to threaten France's own existence in the following century, and which was to become one of the most influential and glittering courts of Europe. Much of this was due to the characterof Philip the Bold; by marrying the daughter of the count of Flanders, he inherited the wealth of the great Flemish towns in 1384, and the union of the two great fiefdoms to the north and east of France under one ruler meant thatthe resources of the duke of Burgundy were as great as those of the kingdom itself. From 1392 onwards, he was at loggerheads with the regent of France, his brother Louis, duke of Orleans, and this schism was to prove fatal to thekingdom, weakening the administration and leading to the French defeat by Henry V in 1415. Richard Vaughan describes the process by which Philip fashioned this new power, in particular his administrative techniques; but he also gives due weight to the splendours of the new court, in the sphere of the arts, and records the history of its one disastrous failure, the crusade of Nicopolis in 1396. He also offers a portrait of Philip himself, energetic, ambitious and shrewd, the driving force behind the new duchy and its rapid rise to an influential place among the courts of Europe.
Today, Scotland's history is frequently associated with the clarion call of political nationalism. However, in the nineteenth century the influence of history on Scottish national identity was far more ambiguous. How, then, did ideas about the past shape Scottish identity in a period when union with England was all but unquestioned? The activities of the antiquary Cosmo Innes (1798-1874) help us to address this question. Innes was a prolific editor of medieval and early modern documents relating to Scotland's parliament, legal system, burghs, universities, aristocratic families and pre-Reformation church. Yet unlike scholars today, he saw that editorial role in interventionist terms. His source editions were artificial constructs that powerfully articulated his worldview and agendas: emphasising Enlightenment-inspired narratives of social progress and institutional development. At the same time they used manuscript facsimiles and images of medieval architecture to foreground a romantic concern for the texture of past lives. Innes operated within an elite associational culture which gave him access to the leading intellectuals and politicians of the day. His representations of Scottish history therefore had significant influence and were put to work as commentaries on some of the major debates which exorcised Scotland's intelligentsia across the middle decades of the century. This analysis of Innes's work with sources, set within the intellectual context of the time and against the antiquarian activities of his contemporaries, provides a window onto the ways in which the 'national past' was perceived in Scotland during the nineteenth century. This allows us to explore how historical thinkers negotiated the apparent dichotomies between Enlightenment and Romanticism, whilst at the same time enabling a re-examination of prevailing assumptions about Scotland's supposed failure to maintain a viable national consciousness in the later 1800s.
For 80 years, giant American amphibians have been spreading through tropical Australia, resulting in the death of millions of native animals. Rick Shine and his research team set out to understand that invasion and its impacts, and to develop new ways of protecting endangered wildlife from the tide of toads. In the process, Shine's work revealed that biological invasions can stimulate rapid evolutionary change, and that understanding your enemy is the essential first step in combatting its deadly effects"--Provided by publisher.
This book describes the complete iWarp system, from instruction-level parallelism to final parallel applications. The authors present a range of issues that must be considered to get a real system into practice. foreword by Gordon Bell and afterword by H.T. Kung Although researchers have proposed many mechanisms and theories for parallel systems, only a few have actually resulted in working computing platforms. The iWarp is an experimental parallel system that was designed and built jointly by Carnegie Mellon University and Intel Corporation. The system is based on the idea of integrating a VLIW processor and a sophisticated fine-grained communication system on a single chip. This book describes the complete iWarp system, from instruction-level parallelism to final parallel applications. The authors present a range of issues that must be considered to get a real system into practice. They also provide a start-to-finish history of the project, including what was done right and what was done wrong, that will be of interest to anyone who studies or builds computer systems.
The Handbook of Research on K-12 Online and Blended Learning is an edited collection of chapters that sets out to present the current state of research in K-12 online and blended learning. The beginning chapters lay the groundwork of the historical, international, and political landscape as well as present the scope of research methodologies used. Subsequent sections share a synthesis of theoretical and empirical work describing where we have been, what we currently know, and where we hope to go with research in the areas of learning and learners, content domains, teaching, the role of the other, and technological innovations."--Book home page.
Chemical and Biological Regulation of Aquatic Systems covers the fundamentals of chemical and microbial process that control the quality of surface water. Topics discussed include the nature and environmental role of surface, complexation and redox reactions; fluxes in the water column and at sediment-water interface; bioavailability; intra- and extra-cellular processes; interactions of microbes with their environment; and microbial ecology. Basic principles are clearly explained and important examples are described in each case. For each environmental process, the respective roles of chemistry and biology are explained. The book features 600 references, 140 figures, and 55 tables. It's an excellent text for students in environmental sciences, researchers involved in quality control, and government and industry professionals who need to learn the fundamentals of an integrated approach to aquatic systems.
This is the most authoritative archive of Barry Boehm's contributions to software engineering. Featuring 42 reprinted articles, along with an introduction and chapter summaries to provide context, it serves as a "how-to" reference manual for software engineering best practices. It provides convenient access to Boehm's landmark work on product development and management processes. The book concludes with an insightful look to the future by Dr. Boehm.
This book reflects a breakthrough in American music studies, an unrecognized field among traditional musicologists until the past few decades, during which enormous progress has been made in documenting three centuries of American musical activities and figures. Time and effort had to be expended exclusively on the development of basic historical studies. The time has come for a new phase, one that can take a creative, interpretive approach. Professor Crawford's study will introduce this higher level of scholarship into the field of American music studies."—Vivian Perlis, author of Charles Ives Remembered "A major statement by a senior scholar on what American musicology is all about. . . These themes are also topical; they come at a time when much more research is being done in American music, but little thought is being given to the big picture, the vision, the philosophy, and the implications of historical research. Now is the time for a synthesis, and there are few scholars better equipped to do that in American music than Richard Crawford."—Michael Broyles, author of Music of the Highest Class
Biblical scholars have often contrasted the exegesis of the early church fathers from the eastern region and school of Syrian Antioch against that of the school of Alexandria. The Antiochenes have often been described as strictly historical-literal exegetes in contrast to the allegorical exegesis of the Alexandrians. Patristic scholars now challenge those stereotypes, some even arguing that few differences existed between the two groups. This work agrees that both schools were concerned with a literal and spiritual reading. But, it also tries to show, through analysis of Theodore and Theodorets exegesis and use of the term theria, that how they integrated the literal-theological readings often remained quite distinct from the Alexandrians. For the Antiochenes, the term theria did not mean allegory, but instead stood for a range of perceptionsprophetic, christological, and contemporary. It is in these insights that we find the deep wisdom to help modern readers interpret Scripture theologically.
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