The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development.Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.
This award–winning “powerful narrative history” presents a vividly detailed chronicle of grueling combat operations in Fallujah during the Iraq War (Midwest Book Review). Few places are as closely associated with blood, sacrifice, and valor as the ancient city Fallujah, forty miles west of Baghdad. This sprawling concrete jungle was the scene of two major U.S. combat operations in 2004. The first, Operation Vigilant Resolve, was an aborted effort by U.S. Marines to punish the city’s insurgents. The second, Operation Phantom Fury, was launched seven months later. Also known as the Second Battle for Fallujah, Operation Phantom Fury was a protracted house-to-house and street-to-street conflict that began on November 7th and continued unabated for seven bloody weeks. It was the largest fight of Operation Iraqi Freedom and the heaviest urban combat since the Battle of Hue City, Vietnam in 1968. By the time the fighting ended, more than 1,400 insurgents were dead, along with ninety-five Americans (and another 1,000 wounded). In New Dawn, military historian Richard Lowry draws on archival research, as well as the personal recollections of nearly 200 soldiers and Marines who participated in the battles for Fallujah, from the commanding generals who planned the operations to the privates who kicked in the doors. The result is a gripping narrative of individual sacrifice and valor that also documents the battles for future military historians. Winner of the Military Writers Society of America Gold Medal for History
City-country consolidation builds upon the Progressive tradition of favoring structural reform of local governments. This volume looks at some important issues confronting contemporary efforts to consolidate governments and develops a theoretical approach to understanding both the motivations for pursuing consolidation and the way the rules guiding the process shape the outcome. Individual chapters consider the push for city-county consolidation and the current context in which such decisions are debated, along with several alternatives to city-county consolidation. The transaction costs of city-county consolidation are compared against the costs of municipal annexation, inter-local agreements, and the use of special district governments to achieve the desired consolidation of services. The final chapters compare competing perspectives for and against consolidation and put together some of the pieces of an explanatory theory of local government consolidation.
The Gerontological Prism" promotes disciplinary cooperation in aging research and practice. To some extent, each chapter explores a unified objective, that of generating a disciplinary-blind gerontology. The fundamental assumption throughout this book is that the aging individual and society can be enhanced by an understanding of the correlates of basic social, behavioral, demographic, economic, political, ethical, and biomedical processes involving aging. Each author touches on issues that have both social psychological, and practical policy significance. They aim toward sensitizing the reader to the possibilities of a properly informed interdisciplinary approach to gerontology.
This two-volume reference examines the translational research field of oxidative stress and ageing. It focuses on understanding the molecular basis of oxidative stress and its associated age-related diseases, with the goal of developing new methods for treating the human ageing processes.
These stories of military heroism, focusing on members of the Legion of Valor, offer a sweeping study of courage in service to America. Published in conjunction with the Legion of Valor of the United States of America, Courage in Combat shares the stories of military heroes from the Civil War onward. They are recipients of the Medal of Honor, the Distinguished Service Cross, the Navy Cross, and the Air Force Cross. Their awards are our nation’s highest military decorations, given only to one in twenty thousand combatants. Among them are sergeants and generals, as well as corpsmen, civilians, engineers, “grunts,” and paratroopers. There are men and women, a mess attendant, aviators, spies and POWs, a cavalry scout, candidates for sainthood, and a president of the United States. The stories of these brave individuals relate personal accounts of heroism, as well as reflections on combat and war. This book also includes a short history of the Legion of Valor, America’s oldest military service organization, and an extensive list of its members, past and present. Courage in Combat explores the concept of courage through the lives, thoughts, and actions of this elite group—most of whom would say, “I was just doing my job.”
Demonstrating the quantum leap genomics represents in technology, this book documents the initial research strategies, the development of genomic tools and resources, and the legume-community consensus on the research objectives that will guide the genomic characterization of major legume crops. The book presents this technical theme in a manner that helps readers answer the question, "What is genomics?" And finally, this book helps readers formulate an opinion on the question, "Why is genomic research needed?" The application of this technology in legume crop enhancement will ensure that U.S. agriculture remains competitive in domestic and global markets for legumes and legume crop products.
This unique single-source reference-the first book of its kind to address systematically the problems involved in the field-offers comprehensive coverage of hydraulic system troubleshooting and encourages change in the trial-and-error methods common in rectifying problems and restoring system downtime, furnishing a new paradigm for troubleshooting
Medical Genetics is the application of genetics to medicine. Medical genetics is broad and varied and encompasses many different individual fields, including clinical genetics, biochemical genetics, cytogenetics, molecular genetics, the genetics of common diseases (such as neural tube defects), and genetic counselling. Each of the individual fields within medical genetics is a hybrid. Clinical genetics is a hybrid of clinical medicine with genetics. Biochemical genetics is a hybrid of biochemistry, mainly the biochemistry of amino acids and proteins, with genetics. Molecular genetics is a hybrid of the biochemistry of DNA and RNA with genetics. Cytogenetics is a hybrid of cytology and genetics; it involves the study of chromosomes under the microscope. And genetic counselling is a hybrid of genetics with non-directional counselling. This book presents leading-edge research on medical genetics as well as on Down's syndrome.
The ancient walled town of Butrint sits at the crossroads of the Mediterranean. In its heyday it could command sea-routes up the Adriatic Sea to the north, across the Mediterranean to the west, and south through the Ionian islands. It also controlled a land-route into the mountainous Balkan interior. For much of its long history it occupied a hill on a bend in the Vivari Channel, which connects the Straits to the large inland lagoon of Lake Butrint. Designated a UNESCO World Heritage site in 1992, Butrint covers an area of around 16 ha, but geophysical survey has shown that at times it was almost twice this size. The site itself is made up of two parts: the acropolis and the lower city. The acropolis is a long narrow hill, whose sides are accentuated by a circuit of walls that separate it from the natural and artificial terraces gathered around the flanks of the hill. The lower city occupies the lower-lying contours down to the edge of the Vivari Channel. This book brings to life this extraordinary Byzantine town, with chapters on the historical sources, various aspects of the archaeological excavation and survey, finds of pottery and environmental remains.
Beautifully written, brilliantly insightful' Owen Jones Tony Blair and Noel Gallagher shaking hands at No. 10. Saatchi’s YBAs setting the international art world aflame. Geri Halliwell in a Union Jack dress. A time of vibrancy and optimism: when the country was united by the hope of a better and brighter future. So why, twenty years on, did that future never happen? Richard Power Sayeed takes a provocative look at this epochal year, arguing that the dark undercurrents of that time had a much more enduring legacy than the marketing gimmick of ‘Cool Britannia’. He reveals how the handling of the Stephen Lawrence inquiry ushered in a new type of racism. How the feminism-lite of 'Girl Power' made sexism stronger. And how the promises of New Labour left the country more fractured than ever. This lively, rich and evocative book explores why 1997 was a turning point for British culture and society - away from a fairer, brighter future and on the path to our current malaise.
Offering a unique, multidisciplinary approach to the complexities of CPB, the 4th Edition of Cardiopulmonary Bypass and Mechanical Support: Principles & Practice remains the gold standard in the field. This edition brings you fully up to date with every aspect of cardiopulmonary bypass, including new information on management of pediatric patients, CPB’s role with minimally invasive and robotic cardiac surgery, mechanical circulatory support, miniaturized circuits and CPB, sickle cell disease and CPB management, and much more. A newly expanded title reflects the rapidly evolving nature of extracorporeal technology, encompassing both short-term and long-term forms of cardiac and pulmonary support.
Trusted by physicians and advanced practice providers through ten standard-setting editions, Fanaroff and Martin's Neonatal-Perinatal Medicine, 11th Edition, remains the reference of choice for expert, multidisciplinary guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. An expanded team of international authors, led by Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh of Rainbow Babies and Children's Hospital, brings you up to date with advances in the control of nosocomial infections in preterm infants, genetic disorders and birth defects, the fetal origins of adult disease, the late preterm infants, and much more – all designed to help you improve the quality of life and long-term outcomes of your patients. - Helps you make informed clinical choices for each patient – from diagnosis and treatment selection through post-treatment strategies and management of complications – with a dual focus on neonatology and perinatology. - Includes a new chapter on Social and Economic Contributors to Neonatal Outcome. - Features extensive updates and reorganization throughout, with new Key Points at the end of each chapter - Provides up-to-date, evidence-based content, with more information on precision medicine and genetics. - Uses detailed, full-color illustrations that depict disorders in the clinical setting and explain complex information. - Remains the most comprehensive, multidisciplinary text in the field – an excellent source of information for every stage of your practice.
The #1 choice for more than 35 years for those involved in the care of adolescents and young adults, Neinstein’s Adolescent and Young Adult Health: A Practical Guide, 7th Edition is your go-to resource for practical, authoritative guidance. The fully updated seventh edition, edited by Drs. Debra K. Katzman, Catherine M. Gordon, S. Todd Callahan, Richard J. Chung, Alain Joffe, Susan L. Rosenthal, and Maria E. Trent, offers a comprehensive view of the interdisciplinary nature of the field and is inclusive of the wide variety of health professionals who care for adolescents and young adults. This award-winning text features a full-color design, several new chapters, numerous algorithms, bulleted text throughout for quick reference at the point of care, and fresh perspectives from new editors—making it ideal for daily practice or certification examination preparation.
Special Education in Contemporary Society: An Introduction to Exceptionality offers a comprehensive, engaging, and readable introduction to the dynamic field of special education. Grounded in research and updated to reflect the most current thinking and standards of the field, this book provides students with the knowledge, skills, attitudes, and beliefs that are crucial to constructing learning environments that allow all students to reach their full potential. Authors Richard M. Gargiulo and Emily C. Bouck encourage a deep awareness and understanding of the "human" side of special education, providing students with a look into the lives of exceptional students and their families, as well as the teachers that work with exceptional persons throughout their lives. The Seventh Edition maintains the broad context and research focus for which the book is known while expanding on current trends and contemporary issues to better serve both pre-service and in-service teachers of exceptional individuals. This title is accompanied by a complete teaching and learning package.
Widely regarded as the definitive reference in the field, Youmans and Winn Neurological Surgery offers unparalleled, multimedia coverage of the entirety of this complex specialty. Fully updated to reflect recent advances in the basic and clinical neurosciences, the 8th Edition covers everything you need to know about functional and restorative neurosurgery, deep brain stimulation, stem cell biology, radiological and nuclear imaging, and neuro-oncology, as well as minimally invasive surgeries in spine and peripheral nerve surgery, and endoscopic and other approaches for cranial procedures and cerebrovascular diseases. In four comprehensive volumes, Dr. H. Richard Winn and his expert team of editors and authors provide updated content, a significantly expanded video library, and hundreds of new video lectures that help you master new procedures, new technologies, and essential anatomic knowledge in neurosurgery. - Discusses current topics such as diffusion tensor imaging, brain and spine robotic surgery, augmented reality as an aid in neurosurgery, AI and big data in neurosurgery, and neuroimaging in stereotactic functional neurosurgery. - 55 new chapters provide cutting-edge information on Surgical Anatomy of the Spine, Precision Medicine in Neurosurgery, The Geriatric Patient, Neuroanesthesia During Pregnancy, Laser Interstitial Thermal Therapy for Epilepsy, Fetal Surgery for Myelomeningocele, Rehabilitation of Acute Spinal Cord Injury, Surgical Considerations for Patients with Polytrauma, Endovascular Approaches to Intracranial Aneurysms, and much more. - Hundreds of all-new video lectures clarify key concepts in techniques, cases, and surgical management and evaluation. Notable lecture videos include multiple videos on Thalamotomy for Focal Hand Dystonia and a video to accompany a new chapter on the Basic Science of Brain Metastases. - An extensive video library contains stunning anatomy videos and videos demonstrating intraoperative procedures with more than 800 videos in all. - Each clinical section contains chapters on technology specific to a clinical area. - Each section contains a chapter providing an overview from experienced Section Editors, including a report on ongoing controversies within that subspecialty. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
In this now classic textbook, Richard Kearney surveys the work of nineteen of this century’s most influential European thinkers. The second edition has a new chapter devoted to Julia Kristeva, whose work in the fields of semiotics and psychoanalytic theory has made a significant contribution to recent continental thought.
In this book, Philip Rosenbaum and Richard Webb consider the complexities of working as counselors and psychotherapists for college students, and offer a broad and detailed account of the developmental issues essential to understanding adolescent experience. Drawing on existentialism, cultural psychology and relational and object relations theories in psychoanalysis, this book offers a perspective that is sensitive to both clinical concerns and the broader context of college counseling and working with adolescents. Particular attention is paid to the emergence of adolescent identities through a relationship with "otherness," and several considerations are explored as a result. These include the emergence and reconciliation of destructive feelings, suicidal phenomenology and the effects of trauma. By taking a fresh look at clinical developmental theories as they affect adolescents and young adults, Rosenbaum and Webb provide a view of college-student development that is theoretically rich and clinically applicable in a way that warrants renewed appreciation and practice among counselors, psychotherapists and psychoanalysts working with college-age clients.
The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style
Over the past 40 years, ERCP has become an effective therapeutic modality with diagnostic purposes that are continually improved.. The 3rd Edition of this practical reference helps you make the most of today's endoscopic retrograde cholangiopancreatography in your practice. You'll find authoritative, highly illustrated guidance on every aspect of ERCP, including coverage of the latest techniques. - Clearly depicts each step of ERCP procedures in dozens of step-by-step videos, including Needle Knife Sphincterotomy, Biliary Sphincterotomy, Cannulation, and Fistulotomy. - Provides clear guidelines on when and when not to perform ERCP. - Features superb, full-color images, and a wealth of illustrative diagrams. - Includes new chapters that cover duodenoscope reprocessing; endomicrocopy; EUS-guided endotherapy related to pancreatobiliary disorders; and CT and MRCP related to pancreatobiliary disorders. - Contains updated information on radiofrequency ablation for cancer, percutaneous vs. endoscopic drainage, scope cleaning practices, and pancreatic necrosis. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Food and the Literary Imagination explores ways in which the food chain and anxieties about its corruption and disruption are represented in poetry, theatre and the novel. The book relates its findings to contemporary concerns about food security.
Offering a rich introduction to how scholars analyze crime, this Fifth Edition of the authors’ clear, accessible text moves readers beyond often-mistaken common sense knowledge of crime to a deeper understanding of the importance of theory in shaping crime control policies. This thoroughly revised edition covers traditional and contemporary theory within a larger sociological and historical context and now includes new sources that assess the empirical status of the major theories, as well as updated coverage of crime control policies and their connection to criminological theory.
Proceedings of the 1996 AMS-IMS-SIAM Joint Summer Research Conference, Discrete and Computational Geometry--Ten Years Later, July 14-18, 1996, Mount Holyoke College
Proceedings of the 1996 AMS-IMS-SIAM Joint Summer Research Conference, Discrete and Computational Geometry--Ten Years Later, July 14-18, 1996, Mount Holyoke College
This volume is a collection of refereed expository and research articles in discrete and computational geometry written by leaders in the field. Articles are based on invited talks presented at the AMS-IMS-SIAM Summer Research Conference, "Discrete and Computational Geometry: Ten Years Later", held in 1996 at Mt. Holyoke College (So.Hadley, MA). Topics addressed range from tilings, polyhedra, and arrangements to computational topology and visibility problems. Included are papers on the interaction between real algebraic geometry and discrete and computational geometry, as well as on linear programming and geometric discrepancy theory.
This book is open access under a CC BY-NC 4.0 license. The third edition of this indispensable book in radio interferometry provides extensive updates to the second edition, including results and technical advances from the past decade; discussion of arrays that now span the full range of the radio part of the electromagnetic spectrum observable from the ground, 10 MHz to 1 THz; an analysis of factors that affect array speed; and an expanded discussion of digital signal-processing techniques and of scintillation phenomena and the effects of atmospheric water vapor on image distortion, among many other topics. With its comprehensiveness and detailed exposition of all aspects of the theory and practice of radio interferometry and synthesis imaging, this book has established itself as a standard reference in the field. It begins with an overview of the basic principles of radio astronomy, a short history of the development of radio interferometry, and an elementary discussion of the operation of an interferometer. From this foundation, it delves into the underlying relationships of interferometry, sets forth the coordinate systems and parameters to describe synthesis imaging, and examines configurations of antennas for multielement synthesis arrays. Various aspects of the design and response of receiving systems are discussed, as well as the special requirements of very-long-baseline interferometry (VLBI), image reconstruction, and recent developments in image enhancement techniques and astrometric observations. Also discussed are propagation effects in the media between the source and the observer, and radio interference, factors that limit performance. Related techniques are introduced, including intensity interferometry, optical interferometry, lunar occultations, tracking of satellites in Earth orbit, interferometry for remote Earth sensing, and holographic measurements of antenna surfaces. This book will benefit anyone who is interested in radio interferometry techniques for astronomy, astrometry, geodesy, or electrical engineering.
Textbook of Gastrointestinal Radiology remains your indispensable source for definitive, state-of-the-art guidance on all the latest and emerging GI and abdominal imaging technologies. Drs. Richard M. Gore and Marc S. Levine lead a team of world-renowned experts to provide unparalleled comprehensive coverage of all major abdominal disorders as well as the complete scope of abdominal imaging modalities, including the latest in MDCT, MRI, diffusion weighted and perfusion imaging, ultrasound, PET/CT, PET/MR, plain radiographs, MRCP, angiography, and barium studies. This edition is the perfect "go-to" reference for today’s radiologist. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Characterize abdominal masses and adenopathy with the aid of diffusion-weighted MR imaging. See how gastrointestinal conditions present with more than 2,500 multi-modality, high-quality digital images that mirror the findings you're likely to encounter in practice. Make optimal use of the latest abdominal and gastrointestinal imaging techniques with new chapters on diffusion weighted MRI, perfusion MDCT and MRI, CT colonography, CT enterography and MR enterography—sophisticated cross-sectional imaging techniques that have dramatically improved the utility of CT and MR for detecting a host of pathologic conditions in the gastrointestinal tract. Expert guidance is right at your fingertips. Now optimized for use on mobile devices, this edition is perfect as an on-the-go resource for all abdominal imaging needs. Effectively apply MR and CT perfusion, diffusion weighted imaging, PET/CT and PET/MR in evaluating tumor response to therapy.
Comprehensive, readable, and clinically oriented, Stoelting’s Pharmacology & Physiology in Anesthetic Practice, Sixth Edition, covers all aspects of pharmacology and physiology that are relevant either directly or indirectly to the anesthetic practice—a challenging topic that is foundational to the practice of anesthesia and essential to master. This systems-based, bestselling text has been thoroughly updated by experts in the field, giving you the detailed information needed to make the most informed clinical decisions about the care of your patients.
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