Mathematical models are increasingly being used to examine questions in infectious disease control. Applications include predicting the impact of vaccination strategies against common infections and determining optimal control strategies against HIV and pandemic influenza. This book introduces individuals interested in infectious diseases to this exciting and expanding area. The mathematical level of the book is kept as simple as possible, which makes the book accessible to those who have not studied mathematics to university level. Understanding is further enhanced by models that can be accessed online, which will allow readers to explore the impact of different factors and control strategies, and further adapt and develop the models themselves. The book is based on successful courses developed by the authors at the London School of Hygiene and Tropical Medicine. It will be of interest to epidemiologists, public health researchers, policy makers, veterinary scientists, medical statisticians and infectious disease researchers.
Cluster Randomised Trials, Second Edition discusses the design, conduct, and analysis of trials that randomise groups of individuals to different treatments. It explores the advantages of cluster randomisation, with special attention given to evaluating the effects of interventions against infectious diseases. Avoiding unnecessary mathematical detail, the book covers basic concepts underlying the use of cluster randomisation, such as direct, indirect, and total effects. In the time since the publication of the first edition, the use of cluster randomised trials (CRTs) has increased substantially, which is reflected in the updates to this edition. There are greatly expanded sections on randomisation, sample size estimation, and alternative designs, including new material on stepped wedge designs. There is a new section on handling ordinal outcome data, and an appendix with descriptions and/or generating code of the example data sets. Although the book mainly focuses on medical and public health applications, it shows that the rigorous evidence of intervention effects provided by CRTs has the potential to inform public policy in a wide range of other areas. The book encourages readers to apply the methods to their own trials, reproduce the analyses presented, and explore alternative approaches.
Micro-Facts has proved to be a useful ready reference for practising food microbiologists and others concerned with ensuring the microbiological safety of foods. For the new fifth edition, key sections of the text have been updated and focussed directly on the assurance of safety in the food supply. The information presented remains topical and takes into account the wealth of recent research into food-poisoning organisms and their current relevance to food safety. This fifth edition also gives a more international view of foodborne disease. As in previous editions, the emphasis of this book is on microbiological safety. Foodborne bacterial pathogens - source, incidences of food poisoning, growth/survival characteristics and control - are discussed in detail. Foodborne viruses and protozoa are also examined. The section on spoilage organisms (produced as a supplement to the fourth edition) has been expanded to include a new section on the acetic acid bacteria. The book concludes with brief coverage of HACCP, EC Food Hygiene Legislation, and equipment suppliers. Micro-Facts 5th Edition is an invaluable tool for food microbiologists everywhere, as a source book of information relevant to the prevention of food-poisoning hazards worldwide.
This book has two purposes: first to argue that there is a greater need now than ever before for liberal adult education for the working class. Such provision would both help to ameliorate the gross inequalities of our society and provide some counter-balance to the increasingly utilitarian and vocational orientation of post-school education. Secondly, the book aims to describe and analyse in some detail the community-based programme for various ‘disadvantaged’ working class groups that has been developed by a British Pioneer Work team concerned with adult continuing education. The methods, objectives and overall practice described in this case study are of relevance to those working in all sectors of adult and community education. This book is edited by two members of staff concerned with Pioneer Work development from the outset, and the contributors include other members of the Pioneer Work team of lecturers and researchers.
This book provides engineers and scientists with a single source introduction to the concepts, models, and case studies for making credible reliability assessments. It satisfies the need for thorough discussions of several fundamental subjects. Section I contains a comprehensive overview of assessing and assuring reliability that is followed by discussions of: • Concept of randomness and its relationship to chaos • Uses and limitations of the binomial and Poisson distributions • Relationship of the chi-square method and Poisson curves • Derivations and applications of the exponential, Weibull, and lognormal models • Examination of the human mortality bathtub curve as a template for components Section II introduces the case study modeling of failure data and is followed by analyses of: • 5 sets of ideal Weibull, lognormal, and normal failure data • 83 sets of actual (real) failure data The intent of the modeling was to find the best descriptions of the failures using statistical life models, principally the Weibull, lognormal, and normal models, for characterizing the failure probability distributions of the times-, cycles-, and miles-to-failure during laboratory or field testing. The statistical model providing the preferred characterization was determined empirically by choosing the two-parameter model that gave the best straight-line fit in the failure probability plots using a combination of visual inspection and three statistical goodness-of-fit (GoF) tests. This book offers practical insight in dealing with single item reliability and illustrates the use of reliability methods to solve industry problems.
The latest edition of a popular introductory linguistics text, now including a section on computational linguistics, new non-English examples, quizzes for each chapter, and additional special topics. This popular introductory linguistics text is unique for its integration of themes. Rather than treat morphology, phonetics, phonology, syntax, and semantics as completely separate fields, the book shows how they interact. The authors provide a sound introduction to linguistic methodology, focusing on a set of linguistic concepts that are among the most fundamental within the field. By studying the topics in detail, students can get a feeling for how work in different areas of linguistics is done. As in the last edition, part I covers the structural and interpretive parts of language—morphology, phonetics, phonology, syntax, semantics, variation, and change. Part II covers use and context of language and includes chapters on pragmatics, psychology of language, language acquisition, and language and the brain. This seventh edition has been extensively revised and updated; new material includes a chapter on computational linguistics (available in digital form and updated regularly to reflect the latest research in a rapidly developing field), more non-English examples, and a wide range of exercises, quizzes, and special topics. The seventh edition of Linguistics includes access to a new, web-based eCourse and enhanced eTextbook. The content from the former print supplement A Linguistics Workbook is now available in this online eCourse as interactive exercises. The eCourse is available via the Rent eTextbook link at http://mitpress.mit.edu/linguistics7, and may be used on its own for self-study or integrated with instructor-led learning management systems. The eCourse is a comprehensive, web-based eLearning solution. There is nothing to download or install; it is accessible through any modern web browser and most mobile devices. It features a singular new tool for building syntax trees, an IPA keyboard, a combination of auto-graded and essay questions, and classroom management tools. The enhanced eTextbook includes videos and flashcards and allows bookmarking, note-taking, highlighting, and annotation sharing. Access to the eCourse is free with the purchase of a new textbook or e-book. New print copies of this book include a card affixed to the inside back cover with a unique access code for the eTextbook. If you purchased an e-book, you may obtain a unique access code by emailing digitalproducts-cs@mit.edu or calling 617-253-2889 or 800-207-8354 (toll-free in the U.S. and Canada). If you have a used copy of this book, you may purchase a digitally delivered access code separately via the Rent eTextbook link at http://mitpress.mit.edu/linguistics7.
Portable and high yield, Pediatric Secrets is perfect for use in clinical rotations, exam prep, or as a handy clinical reference. Drs. Richard A. Polin and Mark F. Ditmar present the essential questions and answers to help you better meet the challenges you face every day, while updated chapters highlight the latest standards in pediatric care. A bestselling volume in the Secret Series®, its Q&A format, helpful lists and tables, mnemonics, and informal tone combine to make reference fast, easy, and enjoyable. "Key Points" boxes and a highly detailed index allow you to find information quickly and easily. Unique Q&A format expedites learning and retention. Top 100 Secrets section combines the top 100, high-yield facts into one chapter, providing a concise overview of the latest issues in pediatrics. High-yield content is ideal for exam preparation. Useful 2-color design highlights key headings and all questions. Portable size is designed to fit perfectly into a lab coat pocket. Provides the current standards of care for pediatric students and practitioners. Updated chapters reflect the latest advances in pediatrics. Expert Consult eBook version included with purchase. This enhanced eBook experience gives access to the text, figures, references, and additional content on a variety of devices.
Expertly bridging the gap between basic science and clinical information, Williams Textbook of Endocrinology, 14th Edition, brings together an outstanding collection of world-renowned authors to provide authoritative discussions of the full spectrum of adult and pediatric endocrine system disorders. New chapters and significant revisions throughout keep you up to date with recent advances in medications, therapies, clinical trials, and more. This essential reference is a must-have resource for endocrinologists, endocrine surgeons, gynecologists, internists, pediatricians, and other clinicians who need current, comprehensive coverage of this multifaceted field. - Up to date with recent advances in medications, therapies, and clinical trials. - Provides state-of-the-art coverage of diabetes, metabolic syndrome, metabolic bones disorders, obesity, thyroid disease, testicular disorders, newly defined adrenal disorders and much more - all designed to help you provide optimal care to every patient. - Contains new chapters on Global Burden of Endocrine Disease, Navigation of Endocrine Guidelines, and Transgender Endocrinology. - Includes significant updates to the Diabetes section, including a new chapter on Physiology of Insulin Secretion and greater coverage of Type 2 Diabetes. - Presents current information in a highly illustrated, user-friendly format for quick reference. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Scale Models in Engineering: Fundamentals and Applications provides a simple and fundamental method of designing scale model experiments. This book is divided into two parts. Part I explores the background of scale modeling and explains the design procedure of scale models and experiments. The relaxation method commonly applied to conflicting requirements in model design is also analyzed. Part II is devoted to case studies selected from modern fields of model application. These studies have been interpreted uniformly. This publication is designed not only as a college textbook for senior and graduate levels but also as a working reference for practicing engineers.
As our understanding of what constitutes ‘good health’ grows, so does our need to understand the psychological aspects of medicine and health, as well as the psychological interventions available in healthcare. This new edition of this bestselling textbook provides a comprehensive overview of the research, theory, application and current practices in the field, covering topics from epigenetics to social determinants of health and transdiagnostic approaches to mental health and everything in between. An essential read for all medicine and healthcare students, this text is now accompanied by a suite of online resources for all your learning needs.
With this book, Richard A. Epstein provides a spirited and systematic defense of classical liberalism against the critiques mounted against it over the past thirty years. One of the most distinguished and provocative legal scholars writing today, Epstein here explains his controversial ideas in what will quickly come to be considered one of his cornerstone works. He begins by laying out his own vision of the key principles of classical liberalism: respect for the autonomy of the individual, a strong system of private property rights, the voluntary exchange of labor and possessions, and prohibitions against force or fraud. Nonetheless, he not only recognizes but insists that state coercion is crucial to safeguarding these principles of private ordering and supplying the social infrastructure on which they depend. Within this framework, Epstein then shows why limited government is much to be preferred over the modern interventionist welfare state. Many of the modern attacks on the classical liberal system seek to undermine the moral, conceptual, cognitive, and psychological foundations on which it rests. Epstein rises to this challenge by carefully rebutting each of these objections in turn. For instance, Epstein demonstrates how our inability to judge the preferences of others means we should respect their liberty of choice regarding their own lives. And he points out the flaws in behavioral economic arguments which, overlooking strong evolutionary pressures, claim that individual preferences are unstable and that people are unable to adopt rational means to achieve their own ends. Freedom, Epstein ultimately shows, depends upon a skepticism that rightly shuns making judgments about what is best for individuals, but that also avoids the relativistic trap that all judgments about our political institutions have equal worth. A brilliant defense of classical liberalism, Skepticism and Freedom will rightly be seen as an intellectual landmark.
This book prints for the first time two remarkable interlocking sequences of letters between Paris and the Netherlands: 40 letters from Gilles Ménage in Paris to Johann-Georg Grævius in Utrecht, and 30 from the printer Henrik Wetstein, in Amsterdam, to Ménage. Their principal focus is the publication of a considerable number of Ménage’s works outside France, above all his monumental edition of Diogenes Laertius’s Lives of the Philosophers. The letters give an engaging picture of mutual help within the community of scholars, Dutch, German, English, and French, including Huguenot exiles like Le Clerc and Bayle. Ménage’s are full of information from Paris; while Wetstein’s, forthright and humorous, concentrate on publishing details in a sometimes stormy relationship. The great Diogenes edition encountered an extraordinary range of problems: difficulties at every stage of publication, hazardous wartime communications, and, not least, a bizarrely eccentric collaborator in Marcus Meibomius. The two correspondences provide a fascinating case-study of the practical working of international scholarly publishing in time of war, and the European network of learned correspondence in the later seventeenth century. Each letter is printed in full, accompanied by a summary, detailed commentary, and extensive annotations.
Multimedia: A Critical Introduction is a comprehensive guide to the new media form which has resulted from the application of computer technology to existing techniques of broadcasting and telecommunications transmission. The rapid growth of multimedia technologies such as the internet, e-mail and digital television holds the promise of a new 'information age' in which individual tastes are catered for, citizens become better informed, and new wealth is created. But are new media technologies really designed to achieve these utopian aims? Multimedia: a critical introduction provides a historical, cultural and political context to the development of multimedia, as both a technology and a concept. Individual chapters address: * the origins of multimedia in the unlikely interaction between the military and 1960s counter-culture: how the phenomenal US budgets allocated to US military research resulted in the microchip, and why the efforts of counter-culture computer hobbyists evolved into a multi-billion dollar industry. *the wider democratic and cultural implications of multimedia in the wake of the deregulation of the media industries by 'new right' governments in the 1980s, which has led to the domination of the media by transnational conglomerates. * issues of privacy and censorship in relation to new media, including discussion of cryptography, electronic surveillance, and attempts to regulate material such as pornography on the internet. * the use of digital technology to create special effects in feature films.
Examines five central issues of second-language acquisition: transfer, staged development, cross-learner systematicity, incompleteness and variability.
For more than 30 years, the highly regarded Secrets Series® has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Written by Drs. Richard A. Polin and Mark F. Ditmar, Pediatric Secrets, 7th Edition, features the Secrets' popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style – making inquiry, reference, and review quick, easy, and enjoyable. - The proven Secrets Series® format gives you the most return for your time – succinct, easy to read, engaging, and highly effective. - Fully revised and updated throughout, including protocols and guidelines that are continuously evolving and that increasingly dictate best practices. - Practical, up-to-date coverage of the full range of essential topics in the practice of pediatrics. - Top 100 Secrets and Key Points boxes provide a fast overview of the secrets you must know for success in practice and on exams. - Features bulleted lists, mnemonics, practical tips from leaders in the field – all providing a concise overview of important board-relevant content. - Portable size makes it easy to carry with you for quick reference or review anywhere, anytime.
Portable and high yield, Pediatric Secrets is perfect for use in clinical rotations, exam prep, or as a handy clinical reference. Drs. Richard A. Polin and Mark F. Ditmar present the essential questions and answers to help you better meet the challenges you face every day, while updated chapters highlight the latest standards in pediatric care. A bestselling volume in the Secret Series®, its Q&A format, helpful lists and tables, mnemonics, and informal tone combine to make reference fast, easy, and enjoyable. - "Key Points" boxes and a highly detailed index allow you to find information quickly and easily. - Unique Q&A format expedites learning and retention. - Top 100 Secrets section combines the top 100, high-yield facts into one chapter, providing a concise overview of the latest issues in pediatrics. - High-yield content is ideal for exam preparation. - Provides the current standards of care for pediatric students and practitioners. - Updated chapters reflect the latest advances in pediatrics. - Expert Consult eBook version included with purchase. This enhanced eBook experience gives access to the text, figures, references, and additional content on a variety of devices.
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