This book presents models and statistical methods for the analysis of recurrent event data. The authors provide broad, detailed coverage of the major approaches to analysis, while emphasizing the modeling assumptions that they are based on. More general intensity-based models are also considered, as well as simpler models that focus on rate or mean functions. Parametric, nonparametric and semiparametric methodologies are all covered, with procedures for estimation, testing and model checking.
Multistate Models for the Analysis of Life History Data provides the first comprehensive treatment of multistate modeling and analysis, including parametric, nonparametric and semiparametric methods applicable to many types of life history data. Special models such as illness-death, competing risks and progressive processes are considered, as well as more complex models. The book provides both theoretical development and illustrations of analysis based on data from randomized trials and observational cohort studies in health research. It features: Discusses a wide range of applications of multistate models, Presents methods for both continuously and intermittently observed life history processes, Gives a thorough discussion of conditionally independent censoring and observation processes, Discusses models with random effects and joint models for two or more multistate processes, Discusses and illustrates software for multistate analysis that is available in R, Target audience includes those engaged in research and applications involving multistate models.
A well-researched biography about the public and private life of J. Edgar Hoover—former FBI director and America’s most controversial law enforcer—that draws on previously unknown personal documents, a study of FBI files, and the presidential papers of nine administrations. Secrecy and Power is a full biography of former FBI director, covering all aspects of Hoover’s controversial career from the Red Scare following World War I to the 1960s and his personal vendettas against Martin Luther King and the civil rights and antiwar movements.
This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered!n Emphasizes the use of the principles of physical organic chemistry as a basis for drug designn Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemesn Uses figures and literature references extensively throughoutn This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications
Nelson Textbook of Pediatrics has been the world’s most trusted pediatrics resource for nearly 75 years. Drs. Robert Kliegman, Bonita Stanton, Richard Behrman, and two new editors—Drs. Joseph St. Geme and Nina Schor—continue to provide the most authoritative coverage of the best approaches to care. This streamlined new edition covers the latest on genetics, neurology, infectious disease, melamine poisoning, sexual identity and adolescent homosexuality, psychosis associated with epilepsy, and more. Understand the principles of therapy and which drugs and dosages to prescribe for every disease. Locate key content easily and identify clinical conditions quickly thanks to a full-color design and full-color photographs. Access the fully searchable text online at www.expertconsult.com, along with abundant case studies, new references and journal articles, Clinics articles, and exclusive web-only content. Stay current on recent developments and hot topics such as melamine poisoning, long-term mechanical ventilation in the acutely ill child, sexual identity and adolescent homosexuality, age-specific behavior disturbances, and psychosis associated with epilepsy. Tap into substantially enhanced content with world-leading clinical and research expertise from two new editors—Joseph St. Geme, III, MD and Nina Schor, MD—who contribute on the key subspecialties, including pediatric infectious disease and pediatric neurology. Manage the transition to adult healthcare for children with chronic diseases through discussions of the overall health needs of patients with congenital heart defects, diabetes, and cystic fibrosis. Recognize, diagnose, and manage genetic conditions more effectively using an expanded section that covers these diseases, disorders, and syndromes extensively. Find information on chronic and common dermatologic problems more easily with a more intuitive reorganization of the section.
Comprehensive and up to date, the Second Edition of Diagnostic Pathology: Infectious Disease, by Dr. Richard Kradin, is an invaluable tool for the accurate diagnosis of any infectious disease―from the common to the most challenging. The organ-based format makes it an especially useful tool for surgical pathologists' daily diagnostic and management issues. High-quality, full-color illustrations and differential diagnosis tables accompany each lesion, clearly depicting how to recognize the morphology of organisms and the spectrum of histological responses that they may cause. - Addresses the most difficult diagnostic issues that practicing or trainee surgical pathologists face when handling infectious disease tissue specimens. - Highlights morphological characteristics and landmarks of tissue samples for easy access to information necessary for signing out a specimen. - Emphasizes the host responses critical in differential diagnosis to serve as a second opinion when non-infectious diagnoses mimic and confound the diagnosis of infection. - Completely revised with the latest diagnostic support and hot topics in the field: - A new chapter on novel techniques in microbiology - A new chapter on eye infections - New coverage of immunohistochemical staining and other molecular diagnostic techniques - New discussions of human papillomavirus, a critical tool in predictive cancer screening - New information on infections in the immunocompromised host and related special considerations - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.
Today, multidisciplinary approaches to treatment are at the heart of cancer care. They offer improved clinical outcomes, new possibilities in patient quality of life, and enable the development of true innovation in individualized treatment. To accurately reflect this modern day approach to cancer care, the content of the 6th edition of Principles and Practice of Gynecologic Oncology was written entirely by surgeons, medical oncologists, radiation oncologists, and pathologists. New to the editorial team, Dr. Andrew Berchuck has made significant contributions to the understanding of the molecular pathogenesis of ovarian and endometrial cancer in the book’s content. Every chapter of this book has been either completely rewritten or extensively updated to ensure that everyone involved in treating women with gynecologic cancer will have the most comprehensive and up-to-date information on the subject.
Written and edited by world leaders in nephrology, Comprehensive Clinical Nephrology, 6th Edition, by Drs. John Feehally, Jurgen Floege, Richard J. Johnson, and Marcello Tonelli, provides current information on clinical procedures and conditions as well as the scientific facts and pathophysiology that are foundational to nephrology practice. Ideal for practicing nephrologists, fellows, residents, and internists, it thoroughly covers fluids and electrolytes, hypertension, diabetes, dialysis, and transplantation, and more – all in a single convenient volume. - A "just right" amount of basic science and practical clinical guidance helps you make efficient and informed decisions. - More than 1,500 full-color illustrations highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management. - New quick-reference boxes with links to clinical guidelines in all relevant chapters. - New chapters on common issues regarding prescribing in kidney disease, palliative nephrology, endemic nephropathies, pathophysiology of chronic kidney disease, and outcomes of dialysis. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
A genealogy of Cecil Virgil Cook, Jr (1913-1970) and a history of the ancestry of Cecil Cook, extending backward some four hundred years, through various family lines and surnames. The principal surnames covered include (but are not limited to) COOK, FARMER, DORLAND, GOODE, FLOOD, BONDURANT, JONES, KEINADT (KAINADT, KOINER, KOYNER, COINERT AND COINER), DILLER, DORRIS, IRELAND, FELLOWS, SLAGLE, GRADELESS (GRAYLESS GRAYLEY), VAN ARSDALEN, MOORE, COTTON, CHENEY, CARMEAN (CREMEEN), CHEATHAM, HAWKINS, CROCKETT (CROSKETAGNE), DE SAIX, VAN METER (VAN METEREN), BODINE, DUBOIS, RENTFRO. The individuals represented by these surnames are placed in their context, with attention paid to events in which they played a part (the settlement of the earliest colonies, Indian Wars, the American Revolutionay War and Civil War, slavery and Reconstruction). Connections are also traced in Europe, primarily in England and France, in the 15th and 16th centuries.
Designed to serve as a basic text for an introductory course in Public Administration, this innovative work provides students with an understanding of the basic management functions that are covered in all standard textbooks with two important differences. First, it is written to address the needs of both the experienced practitioner and the entry-level public servant. Case examples bridge the content-rich environment of practitioners with the basic principles of public administration sought by pre-service students. Second, the discussion of basic management practices is grounded in the political and ethical tensions inherent in the American constitutional form of governance. This reflects the authors' belief that public administration operates as an integral part of the country's political traditions, and thereby helps define the political culture. The book provides a framework for understanding American political traditions and how they inform public administration as a political practice. Key Changes in the Second Edition include: A new introductory chapter that explains what the authors mean by a constitutional approach and why that is important. An expanded discussion of the role of civil society in promoting the common good. A new section in chapter 5 on New Public Governance. Updated exhibits that incorporate up-to-date census data and revenue figures (chapter 10). A new section in chapter 14 that recognises the importance of maintaining accountability in contract and networked systems of governance. Significantly rewritten chapters to add emphasis on the relevance of the chapter material to nonprofit organisations. A significantly revised bibliography which incorporates new bodies of research that have appeared since the first edition.
The future of basic and translational research in health care depends on the ability of large, complex health science centers to educate, discover new answers to complex problems, and operate in the service of the public good. So what ingredients are required for successful research in academic health science centers (AHSCs)? This volume presents a number of compelling, international stories about personal and professional investments in research activities as well as the challenges, opportunities, and satisfactions. Each chapter explores concepts for successful research with a focus on the ways communities of practice form and sustain themselves in this complex environment. They explore questions such as creating and sustaining community, promoting innovation, transitions in leadership, and cross-generation collaboration from a personal perspective. They also present a series of portraits of scientists at work: building relationships, supporting one another, and contributing to their fields of study in unique ways. Enhancing the Professional Culture of Academic Health Science Centers offers enlightening reading for researchers, administrators, and policy makers interested in present and future research activities in AHSCs, who will be inspired by narratives of perseverance, passion, generosity, and generativity that fuel research in the centers.
Fetal and Neonatal Physiology, edited by Drs. Polin, Fox, and Abman, focuses on physiologic developments of the fetus and newborn and their impact on the clinical practice of neonatology. A must for practice, this 4th edition brings you the latest information on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Gain a comprehensive, state-of-the-art understanding of normal and abnormal physiology, and its relationship to disease in the fetus and newborn premature infant, from Dr. Richard Polin and other acknowledged worldwide leaders in the field. Understand the implications of fetal and neonatal physiology through chapters devoted to clinical correlation. Apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Effectively manage the consequences of intrauterine infections with three new chapters covering intrauterine infection and preterm birth, intrauterine infection and brain injury, and intrauterine infection and chronic lung disease.
“Unlike the standard nature guides that explain how to recognize common animals, Nature stresses the web of interrelationships that link the regional flora and fauna. This affectionate examination of some of North America’s most spectacular surviving old-growth forests will delight backpackers and armchair naturalists.” —Los Angeles Times Book Review Everything you ever wanted to know about the flora and fauna of Southeast Alaska is contained in the third edition of this lively field guide to the natural world, from bears to banana slugs, mountains to murrelets. The authors, who are both Alaskan residents and biologists, combine scientific research with personal experiences to make a definitive field guide for residents of or visitors to Southeast Alaska. The unique features of the book include: In-depth information about how wildlife coexists with the environment Detailed discussions of mammals, birds, fish, invertebrates, fungi, and plants Detailed map of wilderness areas in Southeast Alaska More than 200 black-and-white illustrations A bibliography, list of common and scientific names, and an index New to this edition: More than 100 new illustrations, many never before published, as well as new maps and photos Major expansion of sections on geology, old-growth forests, marine mammals, and amphibians Fifty-two new sidebars—written in the first person to give the text a more personal touch—that describe recent findings or experiences. Sweeping updates and elaborations to chapter narratives—often thanks to technology unknown in 1992. In-depth guide to Southeast Alaska’s flora and fauna; more than an identification manual, Nature explores how the species and habitats encountered in the woods and waters of Southeast Alaska fit into the bigger picture.
Colorectal Surgery equips you to overcome the clinical challenges you face in this area of surgery. Written for the general surgeon who is called upon to manage diseases and disorders of the large bowel, rectum, and anus, this reference provides advanced, expert guidance on how to avoid complications and achieve the most successful results. Visualize relevant anatomy and techniques more easily with high-quality, full-color line drawings and clinical photos throughout. Zero in on the information you need with key points boxes in every chapter that provide a quick overview of the topic at hand. Get practical, hands-on advice on managing the diseases and disorders you’re most likely to encounter. Learn from acknowledged leaders in the field who excel in both academic and clinical areas.
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