Organic Chemistry, Volume 18: The Chemistry of Indoles discusses the chemistry of indole derivatives. This book explores the potent biological activity of several indole derivatives and explains the structure of indole alkaloids. Organized into 10 chapters, this monograph starts with an overview of the most important types of reactions of the indole ring on a mechanical basis. This text then proceeds to review the methods of synthesizing indoles and describes the oxidations and rearrangements of indole derivatives. Other chapters explore the special features of the synthesis and reactivity of hydroxyindoles, acylindoles, and aminoindoles. This book discusses as well the properties of carboxyl groups, which is substituted on the benzenoid ring of the indole nucleus that is typical of aromatic carboxylic acids. The final chapter deals with the certain classes of indoles that are found in nature. Chemists, researchers, and readers interested in the chemistry of indoles will find this book extremely useful.
Cryopreserved allograft tissues are now standard materials for the reconstructive cardiac surgeon. Since publication of the first edition ("Cardiac Reconstructions with Allograft Valves") in 1989, the field has progressed dramatically with increased clinical use of cardiovascular allograft tissues, with the development of new surgical techniques, and with advances in the understanding of the fundamentals of valve transplantation biology and cryopreservation. As a result, over two-thirds of the present volume represents new material. Fifty-six authors bring their expertise to thirteen comprehensive, lavishly illustrated sections which discuss the principles of the use of homograft valves, major clinical series of homograft valves for both left and right ventricular outflow tracts, cryopreserved allograft tissue for cardiac reconstruction, cell biology of heart valve leaflets, cryobiology of heart valve preservation, morphological, biochemical, and explant pathology studies of allograft heart valves, allograft valve banking, as well as detailed explanation of surgical techniques for valve and root methods for left and right ventricular outflow tract reconstructions, the Ross operation and variants, and complex reconstructions. A final section presents potential future directions for the field. Over 400 illustrations, created expressly for this book, depict the surgical techniques from the perspective of the surgeon standing at the operating table. All surgeons performing pediatric and/or adult valve replacements and reconstructive cardiac surgeries will benefit from the described methods. Cardiothoracic residents and cardiologists will also find the text useful. It will provide the surgeon with an enhanced understanding of the biological and material properties of allografts and increased familiarity with the range of surgical techniques applicable for the use of these valves, particularly in the successful management of challenging cardiac reconstructions.>
Forensic psychology is a thriving subject with a dedicated focus beginning to emerge on the issue of crime from the discipline of psychology. Applied Criminal Psychology provides the reader with a comprehensive and practical guide to psychological research and techniques. Major topics include: (1) mental disorders and criminal behavior, antisocial behavior and personality disorders, the role of the forensic psychologist, risk and assessment; (2) the detection of deceit, eyewitness testimony, cognitive interviewing, forensic hypnosis, false confessions; and (3) criminal profiling, psychological.
Little is known about the specific disinfection by-products (DBPs) in drinking water that may cause cancer in humans. In fact, toxicological research in the past decade has cast significant doubt on the risk associated with the THMs and HAAs that are subject to regulation. This research identifies from among hundreds of disinfection by-products formed by the chlorination of drinking water those DBPs that are most likely to cause human cancer. Identification of potential cancer-causing DBPs will help researchers prioritize further research.
Highly Commended, BMA Medical Book Awards 2015Since the first edition of this book was published in 2004, the management of congenital heart disease has continued to evolve at a rapid pace. Not only have new operations been developed and expanded, such as the intra/extracardiac conduit Fontan and the double root translocation for corrected transpos
The management of congenital heart disease has changed dramatically over the last 15 years and continues to evolve at a rapid pace. More than ever before contemporary practice requires a collaborative effort by a large healthcare team comprised not only of congenital cardiac surgeons but also pediatric cardiac nurses, pediatric cardiologists, perfu
A unique offering in this field from a sterling author team, Health Law and Bioethics: Cases in Context presents the stories and context of landmark cases in the field. By conveying back story and creating context, this brief text hooks students’ interest and deepens their understanding of the law and policy implications of each case.
Integrating the study of individual European nation-states within the framework of the European Union, this unique new text is essentially two books in one: a book on the EU and a comparative introduction to European politics. This text provides more value to students by combining two texts in one, but engages student interest and facilitates learning through a variety of useful features. Role-playing exercises encourage participation and test students' critical thinking skills, while an emphasis on the people behind the politics "humanizes" material and provides lively insights into contemporary European politics and society. To ensure student understanding, there is extensive material comparing and contrasting EU states to one another and to the United States, a thorough glossary at the end of the book, and an abundance of examples, tables, charts, and graphs to illustrate and extend the discussions.
Compounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals. Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustrating the range of possibilities for embedding isotopic labels in selected moieties of complex structures. Topics include: Formulation of synthetic strategies for preparing labeled compounds Isotope exchange methods and synthetic alternatives for preparing tritiated compounds In-depth discussion of carbon-14 building blocks and their utility in synthesis Preparation of enantiomerically pure isotopically labeled compounds Applications of biotransformations Preparation of Compounds Labeled with Tritium and Carbon-14 is an essential guide to the specialist strategies and tactics used by chemists to prepare compounds tagged with theradioactive atoms carbon-14 and tritium.
A Manual of Paper Chromatography and Paper Electrophoresis provides a comprehensive discussion of the techniques of paper chromatography and paper electrophoresis. The book is organized into two parts. Part I on paper chromatography provides a readily accessible source for some of the many uses and adaptations of paper chromatography. An effort has been made to write a practical manual in which tried and proved procedures, employing relatively simple equipment and available reagents, are summarized. Part II on paper electrophoresis discusses basic principles and methodology. The emphasis throughout has been on the separation of protein mixtures, particularly blood serum. This reflects the fact that it is in this particular application that paper electrophoresis has thus far not been challenged by paper chromatography, whereas many of the smaller molecules can be resolved equally well or better by the thus far more widely employed chromatographic procedures.
Man Discovers the Galaxies describes the development of galactic theories and models of the stellar system from 1900 to 1940. It is written in an interesting and lucid style, lavishly illustrated with photographs & diagrams.
Thoroughly updated for its Second Edition, this volume is the most comprehensive, current reference on perioperative transfusion medicine and coagulation. It provides complete information on all current blood products and transfusion risks, transfusion and coagulation issues during the preoperative, intraoperative, and postoperative periods, and specific concerns in each surgical subspecialty. Eighteen new chapters in this edition cover blood shortages, economic concerns, emergency needs, virus transmission, parasitic and septic risks, immunosuppression risks, non-infectious risks, production and storage issues, hemoglobin-based oxygen-carrying solutions, perfluorocarbon-based oxygen-carrying solutions, preoperative plateletphoresis, volume resuscitation, antifibrinolytics, aprotinin, DDAVP, platelet inhibitors, burn patients, and post-surgical stress response.
The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.
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