This book explores the journey of young people through a Secure Training Centre and, more generally, the criminal justice system in the UK. It examines the extent to which young people have been failed by the system at every stage of their lives, with incarceration used as a means of removing ‘the problem’ from society. To explore this process, the authors utilise an integrated theoretical framework to develop a new rehabilitative approach focused on developing positive outcomes for young people. The book deploys a social impact measurement methodology to evaluate the experience and outcomes of youth justice interventions at a Secure Training Centre. Such an approach provides a fresh perspective on the youth justice debate which has traditionally utilised outcome data to measure immediate impact relating to recidivism and is therefore not focused on the young person holistically. Using a social impact framework to evaluate youth justice, underpinned by an integrated theoretical framework, allows for assessment to be made which place the young person at the centre of evaluation.
Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.
Immunology: A Short Course provides an overview of the physiology of the immune system and the pathophysiology of a broad range of immune-mediated diseases, offering accessible and comprehensive guidance to the basic concepts and clinical approaches in the discipline. Now in its eighth edition, this bestselling textbook has been fully updated to reflect our expanded knowledge of how the immune system develops and functions, and the ways in which these physiological phenomena can fail or be compromised. New chapters examine cells and organs of the immune system, organization and expression of lymphocyte antigen receptor genes, experimental systems and methods, and B- and T-cell development activation. Helping students gain an integrated understanding of immunology, this textbook: Offers substantial new and revised material, expanded clinical coverage, enhanced pedagogical features, and updated figures, tables, and references Features recent research advances and therapeutic successes in the field of immunology Includes a companion website containing multiple choice questions, electronic flashcards, downloadable figures, PowerPoint slides, and sample cases Can be supplemented with the Clinical Cases in Immunology companion book The eighth edition of Immunology: A Short Course is an ideal resource for life and health science students, dental and nursing students seeking a short course text, and basic scientists and clinical researchers looking to refresh their knowledge in the subject.
Chronic joint pain is often associated with rheumatic diseases, but rheumatic diseases can also cause damage to vital organs including the heart. This articles in this issue will cover cardiac involvement in a variety of rheumatic diseases with discussions abotu clinical presentations and mechanistic aspects.
These ten papers from two Theoretical Roman Archaeology Conference (2007) sessions bring together a growing body of new archaeological evidence in an attempt to reconsider the way in which the Roman army was provisioned. Clearly, the adequate supply of food was essential to the success of the Roman military. But what was the nature of those supply networks? Did the army rely on imperial supply lines from the continent, as certainly appears to be the case for some commodities, or were provisions requisitioned from local agricultural communities? If the latter was the case, was unsustainable pressure placed on such resources and how did local communities respond? Alternatively, did the early stages of conquest include not only the development of a military infrastructure, but also an effective supply-chain network based on contracts? Beyond the initial stages of conquest, how were provisioning arrangements maintained in the longer term, did supply chains remain static or did they change over time and, if so, what precipitated those changes? Addressing such questions is critical if we are to understand the nature of Roman conquest and the extent of interaction between indigenous communities and the Roman army. Case studies come from Roman Britain (Alchester, Cheshire, Dorset), France, the Netherlands and the Rhine Delta, looking at evidence from animal products, military settlements, the size of cattle, horses, pottery and salt. The editors also provide a review of current research and suggest a future agenda for economic and environmental research.
First Published in 1988, Richard Dien Winfield's The Just Economy investigates what the economy should be, undertaking a normative inquiry ignored by contemporary economists. Drawing upon Hegel's Philosophy of Right, Winfield's book shows how justice lies in self-determination, how the economy can realize social freedom, and how economic relations must be regulated to uphold family welfare, equal economic opportunity, and political autonomy. Exposing the pitfalls in past attempts to conceive economic justice, including those of ancient Greek philosophers, social contract thinkers, the classical political economists, and Marx, The Just Economy settles the controversy between capitalism, socialism, and communism. It is crucial reading for thinkers and citizens the world over.
In the midst of an addiction epidemic, this newly updated edition of The American Society of Addiction Medicine Principles of Addiction Medicine, 5th edition is the sought-after text every addiction researcher and care provider needs. This comprehensive reference text dedicates itself to both the science and treatment of addiction. You’ll receive a thorough grounding in both the scientific principles behind the causes of addiction and the practical aspects of clinical care. Chapters are written by recognized experts, covering areas such as the basic science of addiction medicine; diagnosis, assessment and early intervention; pharmacologic and behavioral interventions; mutual help and twelve-step; and co-occurring addiction, medical and psychiatric disorders—backed by the latest research data and successful treatment methods. Features: Numerous figures, tables and diagrams elucidate the text Chapters include case examples List of data research reports provided at end of each chapter NEW material on Prescription Drug Abuse, Club Drugs, Nursing Roles in Addressing Addiction, Conceptual and Treatment Issues in Behavioral Addictions, Rehabilitation Approaches to Pain Management, Comorbid Pain and Addiction, Pharmacotherapy for Adolescents with Substance Use Disorders, Preventing and Treating Substance Use Disorders in Military Personnel, and more.
The EuroQol Group first met in Rotterdam in May 1987 determined to develop a standardised non-disease-specific instrument for valuing health-related quality of life. The book traces the activities of the Group over the next 25 years. The instrument constructed, eventually named the EQ-5D, was translated into many languages and used in a wide range of countries and settings. The book describes how the instrument’s descriptive system was determined, how translation and language issues were handled, and how valuations were provided. Recent developments, in particular a 5-level version (EQ-5D-5L), and a youth version (EQ-5D-Y) are covered. The history of the institutional and administrative framework within which the Group operated is also treated.
Peripheral Neuropathy is a neurologic disorder characterized by damage to the peripheral nervous system, the part of the nervous system outside the central nervous system that connects it to all parts of the body. Over 100 forms of peripheral neuropathy have been identified. This issue of Neurologic Clinics features 12 articles about this disease that are of most interest to the clinician. Articles include: Diabetic Neuropathy; GBS and Variants; CIDP and Symmetrical Variants; Laboratory Evaluation of Peripheral Neuropathy; Treatment of Painful Peripheral Neuropathy;Cryptogenic Sensory Polyneuropathy; Vasculitic Neuropathy; Hereditary Neuropathy; Entrapment Neuropathy; Multifocal Motor Neuropathy and Multifocal Acquired Demyelinating Sensory and Motor Neuropathy; Nutritional Neuropathies.
The consumer packaged goods (CPG) industry is dominated by major Western brands. The dominance of such major brands extends to burgeoning Asian markets. These conglomerates often rely on packaging as a strategic tool to entice Asian consumers. This book illustrates how packaging as a marketing tool is more than simply changing the label or translating the brand into vernacular language. It examines how different packaging elements (e.g. information, imagery, packaging type) can help to communicate product values to Asian consumers. Drawing upon rich knowledge of the Asian CPG markets with extensive findings from fieldworks in the key Asian markets, this book explains how Western brands are localising their packaging design in Asian markets. It provides invaluable insight into how major Western CPG brands have relied heavily on their packaging strategies to compete not only against domestic brands but also against other foreign brands. The book includes in-depth interviews with brand managers of several major Western CPG brands and retailers, and sheds light on emerging trends of CPG packaging in Asia.
Comprehensive Clinical Nephrology provides you with all the tools you need to manage all forms of kidney disease. Drs. Jürgen Floege, Richard J. Johnson, John Feehally and a team of international experts have updated this fourth edition to include hot topics such as treatment of hypertensive emergencies, herbal and over-the-counter medicines and the kidney, neurologic complications of the kidney, and more. This essential resource gives you quick access to today’s best knowledge on every clinical condition in nephrology. Make efficient, informed decisions with just the right amount of basic science and practical clinical guidance for every disorder. Diagnose effectively and treat confidently thanks to more than 1100 illustrations, abundant algorithms, and tables that highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management. Get coverage of the latest developments in the field with 18 new chapters on the Management of the Diabetic Patient with Chronic Kidney Disease, Treatment of Hypertensive Emergencies, Principles of Drug Dosing and Prescribing of Chronic Kidney Disease, Herbal and Over-the-Counter Medicines and the Kidney, Neurologic Complications of the Kidney, and more. Tap into the experience and expertise of the world’s leading authorities in the field of nephrology. Floege, Johnson, and Feehally give you the information you need to make quick and correct clinical decisions
Written and edited by world leaders in nephrology, Comprehensive Clinical Nephrology, 6th Edition, by Drs. John Feehally, Jurgen Floege, Richard J. Johnson, and Marcello Tonelli, provides current information on clinical procedures and conditions as well as the scientific facts and pathophysiology that are foundational to nephrology practice. Ideal for practicing nephrologists, fellows, residents, and internists, it thoroughly covers fluids and electrolytes, hypertension, diabetes, dialysis, and transplantation, and more – all in a single convenient volume. - A "just right" amount of basic science and practical clinical guidance helps you make efficient and informed decisions. - More than 1,500 full-color illustrations highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management. - New quick-reference boxes with links to clinical guidelines in all relevant chapters. - New chapters on common issues regarding prescribing in kidney disease, palliative nephrology, endemic nephropathies, pathophysiology of chronic kidney disease, and outcomes of dialysis. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
The North Sea and Channel coasts form the geographic frontier of the Roman Empire with the sea – the edge of the then known world. This border represents a page in military maritime history, but its coasts, in Great Britain, the Netherlands, Belgium and France, contain archaeological sites of high heritage value that deserve a large audience.
This book explores the journey of young people through a Secure Training Centre and, more generally, the criminal justice system in the UK. It examines the extent to which young people have been failed by the system at every stage of their lives, with incarceration used as a means of removing ‘the problem’ from society. To explore this process, the authors utilise an integrated theoretical framework to develop a new rehabilitative approach focused on developing positive outcomes for young people. The book deploys a social impact measurement methodology to evaluate the experience and outcomes of youth justice interventions at a Secure Training Centre. Such an approach provides a fresh perspective on the youth justice debate which has traditionally utilised outcome data to measure immediate impact relating to recidivism and is therefore not focused on the young person holistically. Using a social impact framework to evaluate youth justice, underpinned by an integrated theoretical framework, allows for assessment to be made which place the young person at the centre of evaluation.
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