Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. - New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations - Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years - Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization
Mutual distrust defines the relationship between those who are the sources of hazardous wastes and those who oversee their activities. A lack of credibility, argue the authors, is a formidable, if not the biggest, obstacle to properly managing hazardous waste in the United States. Nowhere is the credibility gap wider than where there are hazardous waste management facilities or where sites have been proposed. The purpose of this book is to provide comprehensive perspectives on hazardous waste sites in the United States. The sources of hazardous waste are described along with the scientific and legal climates that allowed wastes to be discarded with little attention to impacts. Evidence is weighed for and against public health, as well as environmental, economic, and social damages at abandoned sites. Political processes and analytical techniques are suggested and illustrated for those who are involved in the siting of new facilities. A strategy for hazardous waste management is offered, together with approaches to substantially reduce the difficulties faced by local planners and site managers who face a hostile public. A historical legacy of mismanagement, fueled by exaggeration of impacts and by a lack of information, characterizes hazardous waste management in the United States. This book will be important to planners, environmental scientists, and public health officials. In order to assure accessibility for the casual reader, the authors keep the explanation of mathematical methods and technologies in this area to a minimum.
Founder of Wallaces' Farmer, adviser to Theodore Roosevelt, and consultant to Iowa State College, Uncle Henry Wallace - perhaps more than any writer since Jefferson - spoke of rural society in terms of its significant role in the success of the American democratic vision. This book fills a gap in the history of Midwestern agriculture and the influence of the farm press.
[A] penetrating biography…Munson makes vivid the genius’s eventful life." —Barbara Kiser, Nature Nikola Tesla invented radio, robots, and remote control. His electric induction motors run our appliances and factories. In the early 1900s, he designed plans for cell phones, the Internet, death-ray weapons, and interstellar communication. His ideas have lived on to shape the modern economy, yet he has been largely overlooked by history. In Tesla, Richard Munson presents a comprehensive portrait of this farsighted and underappreciated mastermind. Drawing on letters, technological notebooks, and other primary sources, Munson pieces together the magnificently bizarre personal life and mental habits of the enigmatic inventor whose most famous inventions were the product of a mind fueled by both the humanities and sciences—Tesla conceived the induction motor while walking through a park and reciting Goethe’s Faust. Clear, authoritative, and highly readable, Tesla takes into account all the phases of Tesla’s remarkable life and career.
This comprehensive atlas presents the clinical practice of neonatal EEG through text, references, and detailed figures demonstrating normal and abnormal features of the neonatal EEG from the most premature infant to one month post-term. Each chapter contains dozens of full-page EEG images, along with detailed legends that place them in context, to emphasize specific components of the neonatal EEG as a benchmark for recognizing signature characteristics and interpreting clinical data. For the new Fourth Edition, Eli Mizrahi and Richard Hrachovy, established authorities in neonatal neurophysiology, have distilled the advances of the last ten years and provided the latest and best references for each chapter, updating their indispensable atlas to reflect current research and practice throughout. Atlas of Neonatal Electroencephalographyis a singular atlas, unrivaled in the breadth of its coverage and level of detail in presenting examples of normal and abnormal recordings of neonatal EEG patterns at varying young ages. This edition includes many new digital figures which emphasize findings in the premature infant, artifacts, and abnormal features, and expanded discussions of age-dependent features of sleep and bedside monitoring. Designed to appeal to practicing neurologists, neurophysiologists, epileptologists, and electroneurodiagnostic technologists, this book is a must-have for anyone involved in recording and interpreting neonatal EEG readouts. Trainees will also find this atlas to be an approachable and an essential guide to the development of the infant brain. Key Features: Contains more than 250 EEG figures, including more than 60 new to this edition Presents comprehensive full-page examples of neonatal EEG from prematurity to term Includes chapters on approach to visual analysis and interpretation, technical aspects of recording, artifacts, normal neonatal EEG of premature and term infants, patterns of uncertain diagnostic significance, abnormal neonatal EEG of premature and term infants, and neonatal seizures Updated to reflect current references and clinical practice guidelines Comprehensive review and synthesis of historical and current medical literature relating to neonatal EEG
A favorite classroom prep tool of successful students that is often recommended by professors, the Examples & Explanations (E&E) series provides an alternative perspective to help you understand your casebook and in-class lectures. Each E&E offers hypothetical questions complemented by detailed explanations that allow you to test your knowledge of the topics in your courses and compare your own analysis. Here’s why you need an E&E to help you study throughout the semester: Clear explanations of each class topic, in a conversational, funny style. Features hypotheticals similar to those presented in class, with corresponding analysis so you can use them during the semester to test your understanding, and again at exam time to help you review. It offers coverage that works with ALL the major casebooks, and suits any class on a given topic. The Examples & Explanations series has been ranked the most popular study aid among law students because it is equally as helpful from the first day of class through the final exam.
A favorite classroom prep tool of successful students that is often recommended by professors, the Examples & Explanations (E&E) series provides an alternative perspective to help you understand your casebook and in-class lectures. Each E&E offers hypothetical questions complemented by detailed explanations that allow you to test your knowledge of the topics in your courses and compare your own analysis. Here’s why you need an E&E to help you study throughout the semester: Clear explanations of each class topic, in a conversational, funny style. Features hypotheticals similar to those presented in class, with corresponding analysis so you can use them during the semester to test your understanding, and again at exam time to help you review. It offers coverage that works with ALL the major casebooks, and suits any class on a given topic. The Examples & Explanations series has been ranked the most popular study aid among law students because it is equally as helpful from the first day of class through the final exam.
In The Passions of the Soul Descartes proclaims his intention to explain the passions “only as a Physicist,” and titles Part I “About the passions in general, and incidentally about the whole nature of man”—not an incidental item. Two questions orient the present inquiry: What does Descartes mean by “the whole nature of man,” and how does a general theory of the human emotions based on his physics account for it? Not surprisingly, Descartes does not fulfill the letter of his intention; rather, he explains the passions “only [partly] as a Physicist.” The other part of his study—irreducible to any physics—consists in his own analysis of the life of the human being as union of soul and body. The resulting account is an unusual combination of scientific (hypothetico-deductive) psychophysics and prescientific insight into human experience. In it, a quasi-mechanical theory of the impact of imagination on passion and volition is combined with a distinctive emphasis on the human propensity to esteem what we imagine to be great. Human history and therewith “the whole [problematic] nature of man” is constituted in significant measure by the particular and variable objects of esteem. The correction and improvement of our nature is the aim of Descartes’s culminating doctrine of the one thing that is truly estimable: the firm and constant resolution to use well (autonomously) one’s own (individual) powers of cognition and volition. With the return of religious war The Passions of the Soul is newly relevant.
In the dramatic period leading to the American Revolution, no event did more to foment patriotic sentiment among colonists than the armed occupation of Boston by British soldiers. As If an Enemy's Country is Richard Archer's gripping narrative of those critical months between October 1, 1768 and the winter of 1770 when Boston was an occupied town. Bringing colonial Boston to life, Archer moves between the governor's mansion and cobble-stoned back-alleys as he traces the origins of the colonists' conflict with Britain. He reveals the maneuvering of colonial political leaders such as Governor Francis Bernard, Lieutenant Governor Thomas Hutchinson, and James Otis Jr. as they responded to London's new policies, and he evokes the outrage many Bostonians felt toward Parliament and its local representatives. Equally important, Archer captures the popular mobilization under the leadership of John Hancock and Samuel Adams that met the oppressive imperial measures--most notably the Sugar Act and the Stamp Act--with demonstrations, Liberty Trees, violence, and non-importation agreements. When the British government responded with the decision to garrison Boston with troops, it was a deeply felt affront to the local population. Almost immediately, tempers flared and violent conflicts broke out. Archer's tale culminates in the swirling tragedy of the Boston Massacre and its aftermath, including the trial of the British troops involved--and sets the stage for what was to follow.
Fetal and Neonatal Physiology, edited by Drs. Polin, Fox, and Abman, focuses on physiologic developments of the fetus and newborn and their impact on the clinical practice of neonatology. A must for practice, this 4th edition brings you the latest information on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Gain a comprehensive, state-of-the-art understanding of normal and abnormal physiology, and its relationship to disease in the fetus and newborn premature infant, from Dr. Richard Polin and other acknowledged worldwide leaders in the field. Understand the implications of fetal and neonatal physiology through chapters devoted to clinical correlation. Apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Effectively manage the consequences of intrauterine infections with three new chapters covering intrauterine infection and preterm birth, intrauterine infection and brain injury, and intrauterine infection and chronic lung disease.
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