Richard D. Shih's Books

Handbook of Poisonous and Injurious Plants

By: Lewis S. Nelson,Richard D. Shih,Michael J. Balick

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Handbook of Poisonous and Injurious Plants

By: Lewis S. Nelson,Richard D. Shih,Michael J. Balick

The second edition of this book is created to assist the clinician in the initial response to the needs of a child or adult exposed to a poisonous or injurious plant. It lists common plants that might lead to the development of the symptom complex and describes the mechanisms of action of the implicated toxin, additional clinical manifestations, and specific therapeutics for each presentation. It has methodically enhanced the previous edition’s botanical rigor with insights from both pharmacognosy and clinical medicine to make it a truly comprehensive source for anyone who has an interest in plants.

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Page Count

348

Publisher

Springer Science & Business Media

Published Date

ISBN 10

0387338179

ISBN 13

9780387338170

Irwin and Rippe's Intensive Care Medicine

By: Richard S. Irwin

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Irwin and Rippe's Intensive Care Medicine

By: Richard S. Irwin

With a focus on evidence-based, state-of-the-art information throughout, the eighth edition of Irwin and Rippe’s Intensive Care Medicine offers authoritative guidance to the wide variety of specialty physicians and non-physicians practicing in the adult intensive care environment. This comprehensive textbook covers both the theoretical and practical aspects of the field, and has been completely updated to provide encyclopedic, interprofessional coverage to support practitioners in every area of this complex field.

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Page Count

5735

Publisher

Lippincott Williams & Wilkins

Published Date

ISBN 10

1975102223

ISBN 13

9781975102227

Irwin and Rippe's Intensive Care Medicine

By: Craig M. Lilly,Richard S. Irwin,Walter A. Boyle,William F. Kelly

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Irwin and Rippe's Intensive Care Medicine

By: Craig M. Lilly,Richard S. Irwin,Walter A. Boyle,William F. Kelly

Covering both the theoretical and practical aspects of critical care,Irwin & Rippe’s Intensive Care Medicine, Ninth Edition, provides state-of-the-art, evidence-based knowledge for specialty physicians and non-physicians practicing in the adult intensive care environment. Drs. Craig M. Lilly, Walter A. Boyle, and Richard S. Irwin, along with a team of expert contributing authors and education expert, William F. Kelly, offer authoritative, comprehensive guidance from an interprofessional, collaborative, educational, and scholarly perspective, encompassing all adult critical care specialties.

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Page Count

7955

Publisher

Lippincott Williams & Wilkins

Published Date

ISBN 10

1975181468

ISBN 13

9781975181468

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition-

By: Richard B. Silverman

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Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition-

By: Richard B. Silverman

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style

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Page Count

737

Publisher

Academic Press

Published Date

ISBN 10

0126437319

ISBN 13

9780126437317

The Organic Chemistry of Drug Design and Drug Action

By: Richard B. Silverman,Mark W. Holladay

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The Organic Chemistry of Drug Design and Drug Action

By: Richard B. Silverman,Mark W. Holladay

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. - Updates to all chapters, including new examples and references - Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book - Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry - Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant - Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis - Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: - for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib - for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid - for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin - Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples - Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites - Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates

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Page Count

537

Publisher

Academic Press

Published Date

ISBN 10

0123820316

ISBN 13

9780123820310

Preparation of Compounds Labeled with Tritium and Carbon-14

By: Rolf Voges,J. Richard Heys,Thomas Moenius

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Preparation of Compounds Labeled with Tritium and Carbon-14

By: Rolf Voges,J. Richard Heys,Thomas Moenius

Compounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals. Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustrating the range of possibilities for embedding isotopic labels in selected moieties of complex structures. Topics include: Formulation of synthetic strategies for preparing labeled compounds Isotope exchange methods and synthetic alternatives for preparing tritiated compounds In-depth discussion of carbon-14 building blocks and their utility in synthesis Preparation of enantiomerically pure isotopically labeled compounds Applications of biotransformations Preparation of Compounds Labeled with Tritium and Carbon-14 is an essential guide to the specialist strategies and tactics used by chemists to prepare compounds tagged with theradioactive atoms carbon-14 and tritium.

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Page Count

682

Publisher

John Wiley & Sons

Published Date

ISBN 10

0470743433

ISBN 13

9780470743430

Veterinary Ocular Pathology

A Comparative Review

By: Richard R. Dubielzig,Kerry L. Ketring,Gillian J McLellan,Daniel M. Albert

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Veterinary Ocular Pathology

A Comparative Review

By: Richard R. Dubielzig,Kerry L. Ketring,Gillian J McLellan,Daniel M. Albert

Veterinary Ocular Pathology: A Comparative Review links the clinical features of ocular disease with gross and microscopic pathology to demonstrate the essential features observable during diagnosis. It is designed to be kept next to the microscope as an invaluable guide to accurate diagnosis in ocular pathology. The book presents a wide range of images of the highest quality. A unique and distinctive feature is the juxtaposition of clinical and pathological images while offering detailed enumeration of the diagnostic features. Expert comparative comments by Dr Daniel Albert and contextual information on relative incidence are provided throughout. The authors address spontaneous disease of the eye in all animal species, with a particular emphasis on companion species. In addition, specific, common or interesting conditions of exotic species are included. - The first text devoted to the pathology of spontaneous diseases of the eyes and periocular tissues of domestic animal species - Exceptionally high quality illustrations are presented throughout, demonstrating clinical features, gross pathology and histopathology - Written by pathologists and clinicians - Includes a chapter devoted to the pathology of conditions associated with glaucoma in domestic animals A convenient, comprehensive and easy-to-use reference for veterinary pathologists, veterinary ophthalmologists, students and comparative vision scientists. - The first text devoted to the pathology of spontaneous diseases of the eyes and periocular tissues of domestic animal species - Exceptionally high quality illustrations are presented throughout, demonstrating clinical features, gross pathology and histopathology - Written by pathologists and clinicians - Includes a chapter devoted to the pathology of conditions associated with glaucoma in domestic animals

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Page Count

467

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0702044423

ISBN 13

9780702044427

Chinese Dialect Classification

A comparative approach to Harngjou, Old Jintarn, and Common Northern Wu

By: Richard VanNess Simmons

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Chinese Dialect Classification

A comparative approach to Harngjou, Old Jintarn, and Common Northern Wu

By: Richard VanNess Simmons

This volume is an investigation and classification of dialects along the Wu and Jiang-Hwai Mandarin border in China's eastern Yangtze Valley. It is the first monograph-length study to critically question the traditional single criterion of initial voicing for the classification of Wu dialects and propose a comprehensive comparative framework as a more successful alternative. Arguing that dialect affiliation is best determined through analysis of dialect correspondence to common phonological systems, the author develops a taxonomic analysis that definitively distinguishes Common Northern Wu and Mandarin dialects. By clarifying dialect affiliation in the Wu and Mandarin border region, this volume makes significant contributions to our understanding of the true nature of the region's dialects and their history. Using primarily data drawn from the author's own fieldwork, the volume contains copious comparative examples and an extensive lexicon of the Old Jintarn dialect.

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Page Count

337

Publisher

John Benjamins Publishing

Published Date

ISBN 10

9027284334

ISBN 13

9789027284334

The Prostate as an Endocrine Gland

By: Richard J. Ablin,Wells E. Farnsworth

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The Prostate as an Endocrine Gland

By: Richard J. Ablin,Wells E. Farnsworth

This unique publication illustrates that the prostate elaborates an array of local hormones or "autocoids" and how these influence prostatic growth, function and oncogenesis. It describes how familiarity with these participants and how they effect the character and direction of prostatic function may suggest diagnostic markers of malfunction and new sites and modes of therapeutic intervention. The catholic scope and authorship of the work seeks to integrate the views of those urologists, reproductive physiologists and endocrinologists who presently work with the prostate. It attempts to show all other biologists the full range of the gland's activities and participating molecules. Included are: oncogenes, mitogens, polyamines, prostaglandins, growth factors, antigens, and the familiar steroid, peptide and protein hormones. This volume is unique in its point of view and in the new concepts it presents. Addressed are actions of spermine-binding protein and osteoblastic mitogens, consequences of inhibin/thyrotropin-releasing hormone balance, and urokinase effects. Covered also are androgen modulation of vasoactive intestinal polypeptides, evidence of a prostatolymphoreticular system, secretion of dihydrotestosterone, and a model of the inter-dependence of prostatic epithelium and stroma. This unique new volume is of great value to those in urology, internal medicine, physiology, endocrinology and pharmacology.

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Page Count

240

Publisher

CRC Press

Published Date

ISBN 10

0849353645

ISBN 13

9780849353642

Environmental Chemistry of Selenium

By: William T. Frankenberger,Richard A. Engberg

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Environmental Chemistry of Selenium

By: William T. Frankenberger,Richard A. Engberg

Written as a complement to the definitive work selenium in the Environment (Marcel Dekker, Inc.). Presents basic and the most recent applied research developments in selenium remediation-emphasizing field investigations as well as covering topics from analytical methods and modeling to regulatory aspects from federal and state perspectives.

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Page Count

746

Publisher

CRC Press

Published Date

ISBN 10

0824701364

ISBN 13

9780824701369

Book's by Richard D. Shih

Handbook of Poisonous and Injurious Plants

Handbook of Poisonous and Injurious Plants

Irwin and Rippe's Intensive Care Medicine

Irwin and Rippe's Intensive Care Medicine

Irwin and Rippe's Intensive Care Medicine

Irwin and Rippe's Intensive Care Medicine

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition-

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition-

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action

Preparation of Compounds Labeled with Tritium and Carbon-14

Preparation of Compounds Labeled with Tritium and Carbon-14

Veterinary Ocular Pathology

Veterinary Ocular Pathology

Chinese Dialect Classification

Chinese Dialect Classification

The Prostate as an Endocrine Gland

The Prostate as an Endocrine Gland

Environmental Chemistry of Selenium

Environmental Chemistry of Selenium

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