“March of the Mountain Sun…an epic adventure! A tale of three brothers, the women they love, and a legacy of blood, honor, deceit and betrayal. A must read!” -The Home Review When a mystery as ancient as time itself resurfaces, and threatens life and loved ones, brothers Mike, Tyler and Ben find Themselves embroiled in an unbelievable adventure. A beautiful but elusive woman is at once a solution and a problem. As they track fragments of legends through majestic and remote mountain regions of the world, they begin to piece together a mystery as haunting as it is ancient. “Clean and compelling…An adventure the whole family will love!” -A.E. Bell author of The Discoveries of the Sisterhood Harris richardcharringtonauthor.blogspot.com
For many of us, thinking about the future conjures up images of Cormac McCarthy’s The Road: a post-apocalyptic dystopia stripped of nature. Richard Louv, author of the landmark bestseller Last Child in the Woods, urges us to change our vision of the future, suggesting that if we reconceive environmentalism and sustainability, they will evolve into a larger movement that will touch every part of society. This New Nature Movement taps into the restorative powers of the natural world to boost mental acuity and creativity; promote health and wellness; build smarter and more sustainable businesses, communities, and economies; and ultimately strengthen human bonds. Supported by groundbreaking research, anecdotal evidence, and compelling personal stories, Louv offers renewed optimism while challenging us to rethink the way we live.
The story of Allied merchant ships and crews who braved the frigid far north to extend a lifeline to Russia, filled with “sheer heroism and brazen drama” (Literary Review). During the last four years of the Second World War, the Western Allies secured Russian defenses against Germany by supplying vital food and arms. The plight of those in Murmansk and Archangel who benefited is now well known, but few are aware of the courage, determination, and sacrifice of Allied merchant ships, which withstood unremitting U-boat attacks and aerial bombardment to maintain the lifeline to Russia. In the storms, fog, and numbing cold of the Arctic, where the sinking of a ten thousand–ton freighter was equal to a land battle in terms of destruction, the losses sustained were huge. Told from the perspective of their crews, this is the inspiring story of the long-suffering merchant ships without which Russia would almost certainly have fallen to Nazi Germany.
In 1925 Adolfo ‘Babe’ Romo, a Mexican American rancher in Tempe, Arizona, filed suit against his school district on behalf of his four young children, who were forced to attend a markedly low-quality segregated school, and won. But Romo v. Laird was just the beginning. Some sources rank Mexican Americans as one of the most poorly educated ethnic groups in the United States. Chicano Students and the Courts is a comprehensive look at this community’s long-standing legal struggle for better schools and educational equality. Through the lens of critical race theory, Valencia details why and how Mexican American parents and their children have been forced to resort to legal action. Chicano Students and the Courts engages the many areas that have spurred Mexican Americans to legal battle, including school segregation, financing, special education, bilingual education, school closures, undocumented students, higher education financing, and high-stakes testing, ultimately situating these legal efforts in the broader scope of the Mexican American community’s overall struggle for the right to an equal education. Extensively researched, and written by an author with firsthand experience in the courtroom as an expert witness in Mexican American education cases, this volume is the first to provide an in-depth understanding of the intersection of litigation and education vis-à-vis Mexican Americans.
This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature.
To effectively exploit novel pharmacologic targets in oncology, drug leads must be translated through an intense, iterative process involving progressive improvement in multiple qualities, ultimately yielding registered pharmaceutical agents. The challenges of juggling multiple, sometimes mutually antagonistic qualities can be difficult, but in this chapter is illustrated by approaches that have proven effective historically. Ideal or highly optimized pharmacokinetics, pharmacodynamics and safety are properties essential to the success of a new therapy within a specific indication. The goal of general pharmacokinetic investigation in drug discovery is to identify a drug candidate with properties that allow delivery and exposure to the target molecule for a sufficient duration of time so as to confer the desired pharmacologic activity. The adequate exposure of the candidate to the target or target occupancy must be defined in efficacy studies and is frequently characterized by concentration and duration, such as area under the concentration versus time curve (AUC) or time above a defined concentration (i.e., time above IC50). The ability of a candidate to achieve adequate exposure is dependent upon its pharmacokinetic properties, which include absorption (including exclusion by enteric or brain transporters and innate permeability), distribution (including target receptor occupancy, concentration in certain tissues), metabolism (liver, kidney, intestine and other tissues), and excretion, collectively referred to as the ADME properties of a drug candidate. The candidate must also have an acceptable safety profile relative to the potential benefit of treatment. Safety concerns for oncologic agents are frequently related to the mechanism of activity, so unfortunately they often track with efficacy, but they can also be related to off-target effects, such as nonselectivity or metabolite activity. Engineering a qualified drug candidate with the appropriate and balanced pharmacokinetic, pharmacodynamic, and safety properties rarely occurs by happenstance, although one must be able to recognize and exploit serendipitous success in this field. For small molecule drug candidates, these qualities are engineered by way of optimization and multiple structure-activity and structure-liability response iterations, involving the integrated activities of pharmaceutical medicinal chemists, pharmacokineticists and toxicologists.
The Clerical Guide, Or Ecclesiastical Directory: Containing a Complete Register of the Dignities and Benefices of the Church of England, with the names of their present possessors,patrons &c. and an alphabetical list of the dignitaries and benefits clergy.
The peace of Santo Christo, a sleepy New Mexican town, was shattered by the brutal murder of Charlie Harrington. Young, wealthy, a genius with computers, Charlie had hurt a lot of people and made a lot of enemies. In fact, Lt. Johnny Oritz has a big problem: too many suspects.
On the afternoon of June 25, 1867, an overwhelming force of Sioux and Cheyenne Indians quickly mounted a savage onslaught against General George Armstrong Custer’s battalion, driving the doomed troopers of the U.S. Seventh Cavalry to a small hill overlooking the Little Bighorn River, where Custer and his men bravely erected their heroic last stand. So goes the myth of the Battle of the Little Bighorn, a myth perpetuated and reinforced for over 100 years. In truth, however, "Custer’s Last Stand" was neither the last of the fighting nor a stand. Using innovative and standard archaeological techniques, combined with historical documents and Indian eyewitness accounts, Richard Allan Fox, Jr. vividly replays this battle in astonishing detail. Through bullets, spent cartridges, and other material data, Fox identifies combat positions and tracks soldiers and Indians across the Battlefield. Guided by the history beneath our feet, and listening to the previously ignored Indian testimonies, Fox reveals scenes of panic and collapse and, ultimately, a story of the Custer battle quite different from the fatalistic versions of history. According to the author, the five companies of the Seventh Cavalry entered the fray in good order, following planned strategies and displaying tactical stability. It was the sudden disintegration of this cohesion that caused the troopers’ defeat. The end came quickly, unexpectedly, and largely amid terror and disarray. Archaeological evidences show that there was no determined fighting and little firearm resistance. The last soldiers to be killed had rushed from Custer Hill.
This book explores a widely lived yet little remembered facet of America's cultural and political history: the Cold War as experienced at the grassroots level. Here, Fried traces the cresting of modern patriotic observance during World War II and then shows how patriotic and civic activists afterwards labored to recreate a remembered unity and commitment in the tension-filled Cold War era. A variety of national and local entities mounted campaigns "to sell America to the Americans" through "rededication" celebrations like Know Your America Week and Freedom Week. The American Heritage Foundation wheeled out the Freedom Train, which carried seminal documents of the nation's past to railroad depots across the US. Fried revisits the 1950 "Communist invasion" of Mosinee, Wisconsin, when ersatz Stalinists harassed and bullied citizens and the town's eateries served only potato soup and black bread. He also depicts the creation and inauguration of new patriotic events like Loyalty Day and Armed Forces Day. Meticulously researched, this book recreates a colorful, sometimes comical, and always revealing dimension of our history.
Debates about the future of fatherhood have been central to a range of conversations about changing family forms, parenting and society. Law has served an important, yet often neglected, role in these discussions, serving as an important focal point for broader political frustrations, playing a central role in mediating disputes, and operating as a significant, symbolic, state-sanctioned account of the scope of paternal rights and responsibilities. Fragmenting Fatherhood provides the first sustained engagement with the way that fatherhood has been understood, constructed and regulated within English law. Drawing on a range of disparate legal provisions and material from diverse disciplines, it sketches the major contours of the figure of the father as drawn in law and social policy, tracing shifts in legal and broader understandings of what it means to be a 'father'and what rights and obligations should accrue to that status. In thematically linked chapters cutting across substantive areas of law, the book locates fatherhood as a key site of contestation within broader political debates regarding the family and gender equality. Multiple visions of fatherhood, evolving unevenly over time across diverse areas of law, emerge from this analysis. Fatherhood is revealed as an essentially fragmented status and one which is intertwined in complex ways with the legal, cultural and political contexts in which discourses of parenthood are produced. Fragmenting Fatherhood provides an important and unique resource, speaking to debates about fatherhood across a range of fields including law and legal theory, sociology, gender studies, social policy, marriage and the family, women's studies and gender studies.
This three-volume text provides a comprehensive review and reference source for those with a teaching, research, or practical involvement in alcohol metabolism in humans. Written by 70 contributing authors from 12 countries, this publication covers a wide range of material, from medicolegal aspects of alcohol metabolism to the structure of enzymes involved in metabolizing alcohol. Although primarily concerned with human alcohol metabolism, information from animal experiments is included where it clarifies results of human studies, or where information for human subjects is not available.
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