Thrombotic disorders of the circulatory system represent the leading cause of morbidity, motality, and health care expenditure in the United States. Fibrinolytic and Antithrombotic Therapy provides a practical, evidence-based approach to the management of thrombotic disorders for all clinicians involved in the care of patients with these disorders. It provides not only vital conceptual information on fibrinolytic and antithrombotic therapy, but also the means to apply it to everyday decision making and patient care. Focusing on managment guidelines and critical pathways, the text stresses practicality and usability. It will be a valuable resource for the wide range of clinicians involved in the care of patients with these disorders, including cardiologists, emergency physicians, primary care physicians, hematologists, neurologists, intensivists, pharmacists, and nurse practitioners. The origins of mammalian blood coagulation can be traced back over 400 million years. Despite its long history, it is only within the past century that this complex and pivotal teleologic system has begun to be understood. Most recently, the intricacies of hemostasis and pahtologic thrombosis have come to light, leading the way toward new, more effective, and safer treatment modalities. The Second Edition of Fibrinolytic and Antithrombotic Therapy, even more concise and clinically relevant than the First, provides vital, evidence-based information on management of patients with arterial and venous thrombotic disorders. Since the First Edition, the text has been expanded to cover the evolving topics of atherothrombosis, thrombocardiology, hematologic/thrombophilic conditions, and vascular medicine. It includes up-to-date guidelines for antithrombotic and fibrinolytic therapy, and offers concise summaries of current "standards of care." Chapters are dedicated to discussions of patient-specific therapeutics and to the importance of genomics, proteomics, and metabolomics in defining genotype-phenotype relationships, while throughout the book coagulation, inflammation, and vascular medicine are newly examined as elements in an intricatley-linked triad of biochemical and cellular based phenomenology.
Stroke is the most common cause of adult mortality in the United States. Antithrombotic agents form the mainstay of stroke prevention. Aspirin produces a modest reduction in the risk of second stroke and transient ischemic attack (TIA, mini-stroke) and is widely recommended for initial therapy. The thienopyridines (Ticlid) and clopodogrel (Plavix) are alternatives for secondary prevention in patients who do not respond to or cannot take aspirin. They are no more effective than aspirin and have been associated with thrombotic thrombocytopenic purpura. The combination of aspirin and extended-release dipyridamole (Aggrenox) has several mechanisms of action and an additive effect on reducing stroke risk compared with either agent alone. A 2-fold increase in risk reduction and favorable safety profile suggest that the combination can serve as first-line prophylaxis against a second stroke. This volume, as part of the Oxford American Pocket Note series, provides the clinician wtih up-to-date information on the guidelines, and therapeutic options in recurrent stroke/TIA prevention. Useful features include treatment algorithms, illustrations, medication tables, charts and figures to enable both the specialist and the primary provider to ensure the best options to their patients in order to prevent the reocurrence of stroke/TIA.
Thrombotic disorders of the circulatory system represent the leading cause of morbidity, motality, and health care expenditure in the United States. Fibrinolytic and Antithrombotic Therapy provides a practical, evidence-based approach to the management of thrombotic disorders for all clinicians involved in the care of patients with these disorders. It provides not only vital conceptual information on fibrinolytic and antithrombotic therapy, but also the means to apply it to everyday decision making and patient care. Focusing on managment guidelines and critical pathways, the text stresses practicality and usability. It will be a valuable resource for the wide range of clinicians involved in the care of patients with these disorders, including cardiologists, emergency physicians, primary care physicians, hematologists, neurologists, intensivists, pharmacists, and nurse practitioners. The origins of mammalian blood coagulation can be traced back over 400 million years. Despite its long history, it is only within the past century that this complex and pivotal teleologic system has begun to be understood. Most recently, the intricacies of hemostasis and pahtologic thrombosis have come to light, leading the way toward new, more effective, and safer treatment modalities. The Second Edition of Fibrinolytic and Antithrombotic Therapy, even more concise and clinically relevant than the First, provides vital, evidence-based information on management of patients with arterial and venous thrombotic disorders. Since the First Edition, the text has been expanded to cover the evolving topics of atherothrombosis, thrombocardiology, hematologic/thrombophilic conditions, and vascular medicine. It includes up-to-date guidelines for antithrombotic and fibrinolytic therapy, and offers concise summaries of current "standards of care." Chapters are dedicated to discussions of patient-specific therapeutics and to the importance of genomics, proteomics, and metabolomics in defining genotype-phenotype relationships, while throughout the book coagulation, inflammation, and vascular medicine are newly examined as elements in an intricatley-linked triad of biochemical and cellular based phenomenology.
Clinical application of antithrombotic therapy in both arterial disease (acute coronary syndromes, acute MI, peripheral arterial disease, valvular heart disease, atrial fibrillation) and venous disease, (venous thromboembolic disease and pulmonary embolism). Results of major clinical trials and their implications for clinical practice.
This book dissects the effects of ethanol on the major neurotransmitter systems affected by ethanol and correlates these actions with the behavioral consequences. The subject is approached first from the perspective of the neurochemical system and the behaviors resulting from ethanol's effects on that system. The behaviors themselves are discussed in later chapters. Some older theories of the effects of ethanol such as the membrane fluidization hypothesis are evaluated in light of new and updated information. Fetal Alcohol Syndrome (FAS) as well as the structural damage in the brain by long term ethanol exposure are also discussed.
This volume describes concurrent engineering developments that affect or are expected to influence future development of digital diagnostic imaging. It also covers current developments in Picture Archiving and Communications System (PACS) technology, with particular emphasis on integration of emerging imaging technologies into the hospital environment.
The definitive core text in its field, Stroke Recovery and Rehabilitation is a comprehensive reference covering all aspects of stroke rehabilitation ó from neurophysiology of stroke through the latest treatments and interventions for functional recovery and restoration of mobility. This second edition is completely updated to reflect recent advances in scientific understanding of neural recovery and growing evidence for new clinical therapies. The second edition ó which includes free e-book access with every print purchase ó continues to provide in-depth information on the assessment and management of all acute and long-term stroke-related impairments and complications including cognitive dysfunctions, musculoskeletal pain, and psychological issues. It examines risk factors, epidemiology, prevention, and neurophysiology as well as complementary and alternative therapies, functional assessments, care systems, ethical issues, and community and psychosocial reintegration. With contributions from over 100 acknowledged leaders from every branch of the stroke recovery field, this edition features expanded coverage of key issues such as the role of robotics and virtual reality in rehabilitation. New chapters have been incorporated to cover fields of recent exploration including transcranial magnetic stimulation, biomarkers, and genetics of recovery as well as essentials like the use of medication and the survivorís perspective. The up-to-date presentation of scientific underpinnings and multi-specialty clinical perspectives from physical medicine and rehabilitation, neurology, physical therapy, occupational therapy, speech and language pathology, and nursing ensures that Stroke Recovery and Rehabilitation will continue to serve as an invaluable reference for every health care professional working to restore function and help stroke survivors achieve their maximum potential. New to Stroke Recovery and Rehabilitation, Second Edition All chapters are thoroughly revised and updated to reflect advances in scientific understanding of neural recovery and clinical progress Five completely new chapters and expanded coverage of key issues that drive the field forward New contributions from leading stroke specialists from all involved disciplines Includes access to the fully-searchable downloadable ebook
Pharmacists who refuse to fill prescriptions for contraceptives. Surgeons who pray in the OR. Pro-life clinics and end-of-life interventions, intelligent-design activists and stem-cell-research opponents. Is this the state of modern medicine in America? In Blind Faith, Dr. Richard P. Sloan examines the fragile balance and dangerous alliance between religion and medicine—two practices that have grown disconcertingly close during the twenty-first century. While Sloan does not dispute the fact that religion can bring a sense of comfort in times of difficulty, he nevertheless believes, and in fact proves, that there is no compelling evidence that faith provides an actual cure for any ailment. By exposing the flawed research, Sloan gives readers the tools to understand when good medical science is subverted and, at the same time, provides a thought-provoking examination into the origins and varieties of faith, and human nature itself.
Principles of Addiction Medicine, 7th ed is a fully reimagined resource, integrating the latest advancements and research in addiction treatment. Prepared for physicians in internal medicine, psychiatry, and nearly every medical specialty, the 7th edition is the most comprehensive publication in addiction medicine. It offers detailed information to help physicians navigate addiction treatment for all patients, not just those seeking treatment for SUDs. Published by the American Society of Addiction Medicine and edited by Shannon C. Miller, MD, Richard N. Rosenthal, MD, Sharon Levy, MD, Andrew J. Saxon, MD, Jeanette M. Tetrault, MD, and Sarah E. Wakeman, MD, this edition is a testament to the collective experience and wisdom of 350 medical, research, and public health experts in the field. The exhaustive content, now in vibrant full color, bridges science and medicine and offers new insights and advancements for evidence-based treatment of SUDs. This foundational textbook for medical students, residents, and addiction medicine/addiction psychiatry fellows, medical libraires and institution, also serves as a comprehensive reference for everyday clinical practice and policymaking. Physicians, mental health practitioners, NP, PAs, or public officials who need reference material to recognize and treat substance use disorders will find this an invaluable addition to their professional libraries.
This softcover manual covers all procedures and techniques necessary for certification in critical care from the internal medicine, anesthesiology, and surgical critical care certification exam. Each procedure or monitoring technique discusses indications/contraindications, equipment, anatomy, techniques, postprocedure care, and complications. Specific nursing indications are indicated where appropriate.
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