Medical innovation as it stands today is fundamentally unsustainable. There is a widening gap between what biomedical research promises and the impact that it is currently achieving, in terms of patient benefit and health system improvement. This book highlights the global problem of the ineffective translation of bioscience innovation into health system improvements and its consequences, analyses the underlying causative factors and provides powerful prescriptions for change to close the gap. It contrasts the progress in biomedicine with other areas of scientific and technological endeavour, such as information technology, in which there are faster and more reliable returns for society. The author's career has spanned pharmaceuticals, diagnostics and health informatics and he draws lessons from a host of case examples in which bottlenecks have prevented progress, such as in dementia and antibiotic-resistant infections, and from many in which these barriers have been overcome, such as HIV therapy and targeted cancer treatment. The new era of precision medicine holds the greatest promise of closing this 'innovation gap'. Along with techniques such as open innovation and adaptive development, powerful new genomics and digital health tools are poised to transform the productivity of life sciences. Bioscience-Lost in Translation? lays out a fresh and provocative strategy for advancing the innovation process, shaping the right policy environment and building an ecosystem to deliver the 21st century cures that are urgently needed.
The inside scoop on a leading-edge data storage technology The rapid growth of e-commerce and the need to have all kinds of applications operating at top speed at the same time, all on a 24/7 basis while connected to the Internet, is overwhelming traditional data storage methods. The solution? Storage Area Networks (SANs)--the data communications technology that's expected to revolutionize distributed computing. Written by top technology experts at VERITAS Software Global Corporation, this book takes readers through all facets of storage networking, explaining how a SAN can help consolidate conventional server storage onto networks, how it makes applications highly available no matter how much data is being stored, and how this in turn makes data access and management faster and easier. System and network managers considering storage networking for their enterprises, as well as application developers and IT staff, will find invaluable advice on the design and deployment of the technology and how it works. Detailed, up-to-date coverage includes: The evolution of the technology and what is expected from SANs Killer applications for SANs Full coverage of storage networking and what it means for the enterprise's information processing architecture Individual chapters devoted to the storage, network, and software components of storage networking Issues for implementation and adoption
Examines the human consequences (individual, social, cultural, and economic) of civil war and political repression in Castilleja del Campo, a town in southern Spain with barely more than 600 inhabitants. This title presents the events from the proclamation of the Second Spanish Republic in April 1931 onward from multiple points of view.
Ronnie Barker was one of our most respected and best-loved comedy actors and here, in this fascinating biography, Richard Webber delves deep in to the heart of Barker's life and career, peppering his narrative with original and incisive memories from some of Barker's closest contemporaries, including Ronnie Corbett, Michael Palin and Barry Cryer. Star of the much-adored comedy classics Porridge, The Two Ronnies - one of the most successful and long-running television comedy shows ever on British television - and Open All Hours, Ronnie Barker was universally admired by the public and industry insiders alike. From his early days writing for and performing skits on The Frost Report right up to his retirement in 1988, he lit up television screens across the country with his wonderful gift for comedy and his remarkable skill for character acting. Beyond his performances on the stage and screen, Barker was also an accomplished comedy writer, providing many of the sketches and songs for The Two Ronnies and contributing material to a number of other television and radio shows. And despite his retirement he retained pole position in the public's affection, returning to the screen in 1999 to team up with his erstwhile comedy partner and great friend Ronnie Corbett for a Two Ronnies night on BBC1, followed by a BAFTA tribute in 2004 and a final appearance on television in 2005 on The Two Ronnies Christmas Sketchbook. Effortlessly funny, universally adored and an actor and writer responsible for some of Britain's best-loved and most-respected comedy, Ronnie Barker was a true comedy legend. Here he's brought to the page in winning style as he's remembered by those who best loved and knew him.
An introduction to the fundamentals of accounting and how it is used that will help students apply accounting as a usable, everyday business tool. It adopts an intuitive, informal approach to describe basic principles - what they are, why they exist and how they are used - to help students see the connections between different parts of accounting and the rest of the business world. Written by an award-winning teacher and former management accountant, it encourages students to engage with the material by using questions and worked examples to test knowledge and understanding as they read. It includes a glossary of financial terms that is a useful guide to the language of business. Part of the Cambridge Short Introductions series of concise, authoritative guides to core subjects in business and management.
Human values change over time. Unfortunately, this change is not always in the best interests of humankind. Moral decay, for instance, is currently taking a huge toll on the well-being and happiness of the individual. Why do human values evolve? Why does this evolution almost always go in a negative direction? Is there anything that humans can do to control this downward spiral? "Steering Evolution" proposes a theory that answers these questions. There are certain parallels between the evolution of genetic information and the evolution of manmade information, but these two forms of evolution are diametrically opposed in the way that they create and affect human values. Fortunately, there is a way for us to free ourselves from the tyranny of evolution, and put the destiny of humankind into the hands of humankind.
The latest in bridge design and analysis—revised to reflect the eighth edition of the AASHTO LRFD specifications Design of Highway Bridges: An LRFD Approach, 4th Edition, offers up-to-date coverage of engineering fundamentals for the design of short- and medium-span bridges. Fully updated to incorporate the 8th Edition of the AASHTO Load and Resistance Factor Design Specifications, this invaluable resource offers civil engineering students and practitioners a a comprehensive introduction to the latest construction methods and materials in bridge design, including Accelerated Bridge Construction (ABC), ultra high-performance concrete (UHPC), and Practical 3D Rigorous Analysis. This updated Fourth Edition offers: Dozens of end-of-chapter worked problems and design examples based on the latest AASHTO LRFD Specifications. Access to a Solutions Manual and multiple bridge plans including cast-in-place, precast concrete, and steel multi-span available on the Instructor’s companion website From gaining base knowledge of the AASHTO LRFD specifications to detailed guidance on highway bridge design, Design of Highway Bridges is the one-stop reference for civil engineering students and a key study resource for those seeking engineering licensure through the Principles and Practice of Engineering (PE) exam.
This text is written to provide a mathematically sound but accessible and engaging introduction to Bayesian inference specifically for environmental scientists, ecologists and wildlife biologists. It emphasizes the power and usefulness of Bayesian methods in an ecological context. The advent of fast personal computers and easily available software has simplified the use of Bayesian and hierarchical models . One obstacle remains for ecologists and wildlife biologists, namely the near absence of Bayesian texts written specifically for them. The book includes many relevant examples, is supported by software and examples on a companion website and will become an essential grounding in this approach for students and research ecologists. Engagingly written text specifically designed to demystify a complex subject Examples drawn from ecology and wildlife research An essential grounding for graduate and research ecologists in the increasingly prevalent Bayesian approach to inference Companion website with analytical software and examples Leading authors with world-class reputations in ecology and biostatistics
Over the last couple of years, the credit crunch has driven a near-collapse of the world's financial systems. With the benefit of hindsight, many say this could have been predicted and avoided. Over the next 10-20 years, healthcare is headed for its own meltdown: an inability to fund the growth in demand and the appearance of costly new medical technology within the current healthcare systems framework. This 'meltdown' will not be as sudden as that in the world of finance: it will occur over the next 20 years, but the failure of the current sources of healthcare funding to meet our expectations of care quantity and quality will have consequences every bit as serious as the banking crisis. The warning signs are there, the crisis is already being predicted - but is it inevitable, or can it be avoided? This book offers a penetrating analysis of the underlying problems, and offers some simple, but far-reaching solutions to bring supply and demand back into balance and avoid the meltdown. It is not a contribution to the current political debate but a primer for the changes to the underlying fabric of healthcare if reforms such as Obamacare have any chance of sustainable success. In the course of the book, we confront many topical challenges: How can people be persuaded to manage their own health better?; Can we afford to spend more of today's money on disease prevention and detection, to save future costs?; Will 'personalised medicine' be cheaper, or more expensive?; Are healthcare IT systems a key part of the solution or doomed to be expensive white elephants?; and most importantly: What will the future of healthcare look like, for us and for our children and grandchildren? To bring the answers to this final question alive, the book uses a fictitious family, the Carters, to illustrate the changes we will see, the dilemmas we will face and the solutions we must strive for. Interspersed between the text are the vignettes of members of the family, their diseases and treatments and how change has affected each of their lives.
This text is about the methods used to value companies. It contains both analytical reviews of valuation models and evaluation of the data available for use in valuation models.
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