This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered! n Emphasizes the use of the principles of physical organic chemistry as a basis for drug design n Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes n Uses figures and literature references extensively throughout n This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style
The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style
Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization
This CD-ROM edition of Silverman's Organic Chemisry of Drug Design and Drug Action, Second Edition reflects the significant changes in the drug industry in recent years, using an accessible interactive approach. This CD-ROM integrates the author's own PowerPoint slides, indexed and linked to the book pages in PDF format. The three-part structure includes an all-electronic text with full-text search capabilites and nearly 800 powerpoint slides. This is a unique and powerful combination of electronic study guide and full book pages. Users can hyperlink seamlessly from the main text to key points and figures on the outline and back again. It serves as a wonderful supplement for instructors as well as a fully integrated text and study aid for students. * Three-part package includes 1) powerpoint, 2) integrated powerpoint and pdf-based text, and 3) fully searchable PDF-based text with index * Includes new full-color illustrations, structures, schemes, and figures as well as extensive chapter problems and exercises * User-friendly buttons transition from overview (study-guide) format to corresponding book page and back with the click of a mouse * Full-text search capabality an incomparable tool for researchers seeking specific references and/or unindexed phrases
The eighth volume in this series concentrates on developments of enormous importance to all of social science. Through such techniques as meta-analysis, the findings of very different studies can be given different mathematical weights and combined. Thus literature review becomes a way of consolidating past work in order to build upon it genuinely. In this volume, methodological questions are dealt with and a range of examples of reviews of research in education, mental health and medicine are presented.
An all-inclusive overview of cardiology in a trusted landmark reference A Doody's Core Title ESSENTIAL PURCHASE! 5 STAR DOODY'S REVIEW! "This well-organized textbook begins with a thoughtful discussion of cardiology's past and future. It presents readers with the foundations of cardiovascular medicine and the basics of cardiovascular evaluation. These initial chapters provide an excellent overview of topics in general cardiology from guidelines to newer diagnostic modalities such as MRI, CT, and PET. Subsequently, the book is organized to provide readers with a focused approach to other areas of cardiology from heart failure to electrophysiology and interventional cardiology." This is a very useful reference that compiles a vast amount of information on the diagnosis and management of cardiovascular diseases in one book. It continues to be one of best overall references in this field. -- Doody's Review Service Developed by a team of internationally renowned editors and authors, Hurst's The Heart is synonymous with the most comprehensive and current perspectives on treating the full range of heart problems. Inside, you'll get an incisive look at all the global advances in the diagnosis and management of cardiovascular disease, including the translation of basic science research into clinical applications. And integrated throughout are the latest treatment protocols, ACC/AHA and ESC treatment guidelines, as well as quick-reference tables and algorithms. NEW to this Edition: Stunning full-color illustrations Information from the COURAGE trial, covering the use and misuse of drug eluting stents Vital coverage of advances in the treatment of pulmonary hypertension and new information on hypertrophic cardiomyopathy Expert-authored chapters on coronary blood flow, stunning, and hibernation; race and ethnicity in cardiovascular disease; and cardiovascular physiology Up-to-date information on the diagnosis and management of heart failure Latest guidelines for the management of atrial fibrillation New advances in curative catheter ablation of arrhythmias Increased number of international contributors Expanded chapters on epidemiology, diagnosis, and treatment of hypertension
The perfect “bridge” book between physical exam textbooks and clinical reference books Covers the essentials of the diagnostic exam procedure and the preparation of the patient record Includes overviews of each organ/region/system, followed by the definition of key presenting signs and their possible causes Unrivaled in its comprehensive coverage of differential diagnosis, organized by systems, signs, and syndromes
For more than forty years, the single-best guide for learning how to become a master clinical diagnostician Much more than a text describing how to perform a history and physical examination, DeGowin's Diagnostic Examination is unmatched in its ability to help you logically assess symptoms and physical signs to facilitate development of reasonable, testable diagnostic hypotheses. Part physical examination primer, part differential diagnosis guide, DeGowin's: Describes how to obtain a complete history and perform a thorough physical examination Links symptoms and signs with the pathophysiology of disease Presents a symptom, sign, anatomy, and physiology-based approach to differential diagnosis Facilitates efficient cost-effective diagnostic testing using focused differential diagnoses Organized as a practical bedside guide to assist diagnosis, DeGowin's is valuable as a quick reference at the point-of-care or as a text to study the principles and practice of history taking and physical examination.
For more than forty years, the single-best guide for learning how to become a master clinical diagnostician Much more than a text describing how to perform a history and physical examination, DeGowin's Diagnostic Examination is unmatched in its ability to help you logically assess symptoms and physical signs to facilitate development of reasonable, testable diagnostic hypotheses. Part physical examination primer, part differential diagnosis guide, DeGowin's: Describes how to obtain a complete history and perform a thorough physical examination Links symptoms and signs with the pathophysiology of disease Presents a symptom, sign, anatomy, and physiology-based approach to differential diagnosis Facilitates efficient cost-effective diagnostic testing using focused differential diagnoses Organized as a practical bedside guide to assist diagnosis, DeGowin's is valuable as a quick reference at the point-of-care or as a text to study the principles and practice of history taking and physical examination.
The classic internal medicine manual for students and residents! This handy guide addresses physical examination techniques and procedures while providing a catalog of clinical findings resulting from the physical examination. Thoroughly reorganized, the Eighth Edition of DeGowin’s Diagnostic Examination features a more user-friendly, easy-access format than previous editions.
This book details the engineering principles underlying mobile computing, serving as a basic reference as text for graduate and advanced undergraduates. It is the first systematic explanation of mobile communications as a discipline in itself, containing Exercises, projects, and solutions.
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.