For the first time ever, Richard B Jones' novels of vampires and family drama have been combined into one book. In Vampyre, discover what happens when two worlds collide between a human and a vampire. Experience hope, loss and faith as these two lovers battle a sinister vampire and demons from the past to prove that true love can endure any obstacle and conquer all. Night and Day lets the reader experience the weddings, deaths, romances, betrayals, murders, secrets and births that have shaped the lives of so many in the town of Eastlake. Cry at the deaths of loved ones, hold onto your seat during the many action adventures and gasp at the sudden plot twists. Come get lost in the many great romances that blossomed and the weddings that were memorable."--Back cover
An entirely new text for students of political geography following in the footsteps of the author's highly successful Modern Political Geography. Unlike other texts in this field it takes a broad and inclusive view of its subject matter, a pluralist and humanistic approach, and combines coverage of theory and empirical developments drawn from a wide range of countries throughout.
A uniquely rich portrayal of Tennesseans who fought and lost their lives in the Civil War is presented in this collection of stories and portraits that are joined with personal remembrances from recovered letters and diaries and detailed historical background.
In The History of Music Production, Richard James Burgess draws on his experience as a producer, musician, and author. Beginning in 1860 with the first known recording of an acoustic sound and moving forward chronologically, Burgess charts the highs and lows of the industry throughout the decades and concludes with a discussion on the present state of music production. Throughout, he tells the story of the music producer as both artist and professional, including biographical sketches of key figures in the history of the industry, including Fred Gaisberg, Phil Spector, and Dr. Dre. Burgess argues that while technology has defined the nature of music production, the drive toward greater control over the process, end result, and overall artistry come from producers. The result is a deeply knowledgeable book that sketches a critical path in the evolution of the field, and analyzes the impact that recording and disseminative technologies have had on music production. A key and handy reference book for students and scholars alike, it stands as an ideal companion to Burgess's noted, multi-edition book The Art of Music Production.
Handbook of Plant Virus Diseases presents basic information about viral-caused and viral-like diseases in many cultivated crops. It provides authoritative descriptive symptomatic signatures of virus diseases to aid in the diagnosis and possible control of viruses. It organizes cultivated plants into groups according to their final destinations and uses after harvest - a useful grouping system that indicates that some diseases, their resultant epidemiology, and control measures are characteristic within different groups. It summarizes current knowledge about various virus-induced diseases in many economically important cultivated crops and addresses the need for an improved acronym system by presenting a new system that provides
Richard John Kosciejew explores the goals of any scientific enterprise and analyzes the strategies employed in reaching those goals in this well-researched book. The philosophy of science offers a perspective from which we can examine and potentially evaluate the endeavors of cognitive science. Philosophy of mind offers substantive theses about the nature of the mind and of mental activity. While these theses have not resulted from empirical investigation, they have been applied to empirical investigations in cognitive science and its predecessors. However, the roles philosophy plays in cognitive science are quite different and must be examined independently. Some philosophical views about science presented in this book are no longer widely accepted by philosophers of science, but that doesnt change the fact that they have been, and in some cases remain, influential outside of philosophy. Some of these older ideas have also provided starting points for current philosophical thinking. Join the author as he examines the connections between philosophy and science and the ideas of Newton, Einstein, Copernicus, Galileo, and other great thinkers in The Pursuing Presence of Facts.
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. - Updates to all chapters, including new examples and references - Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book - Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry - Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant - Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis - Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: - for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib - for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid - for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin - Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples - Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites - Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
As television grew more enticing for both viewers and filmmakers in the 1950s, several independent film producers with knowledge of making low-cost films and radio shows transferred their skills to producing shows for the small screen. Rather than funding live programs that were popular at the time, these producers saw the value in pre-taped shows, which created large financial returns through episode reruns. This low-cost, high-yield production model resulted in what are known and beloved as "B" television shows. Part historical account and part filmography, this book documents the careers of over a dozen "B" television producers. It chronicles the rise of situation comedies and crime dramas and explores the minds behind popular shows like My Little Margie, The Lone Ranger, Lassie, Highway Patrol and Sea Hunt. Divided into 14 chapters of producer profiles, this work is rich in both trivia and critical assessments of the first years of television. A chapter detailing the work of early female television producers rounds out the text.
The outlook for philosophy in our society is buoyant. But philosophy is like music in that, although it has many practical use+s, its supreme value lies not in any of them but in what it is in itself. It may be that from within the confines of our human imitations we will never be able to find the answers to some of our most fundamental questions. But, as this book has tried to show, we can make such worthwhile progress in our understanding of the human situation that even if we never reach any ultimate goal in that respect that we will find that the journey is a hugely enriching experience that is worth undertaking for its own sake. There may be no final answers, but there is a wonderful lot to learn.
The European Mosaic is an up-to-date introduction to all aspects of the politics, economics, culture and recent history of the European Union in particular and Europe in general. The European Mosaic effectively familiarizes students with EU issues that are currently in the news and likely to remain so for the foreseeable future. It is a clear and accessible introduction to the European polity. Its strongly interdisciplinary focus provides a multidimensional understanding of contemporary Europe, of the process of European integration, and of the dynamics of the European Union. Suitable for undergrduate courses in European politics.
Compounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals. Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustrating the range of possibilities for embedding isotopic labels in selected moieties of complex structures. Topics include: Formulation of synthetic strategies for preparing labeled compounds Isotope exchange methods and synthetic alternatives for preparing tritiated compounds In-depth discussion of carbon-14 building blocks and their utility in synthesis Preparation of enantiomerically pure isotopically labeled compounds Applications of biotransformations Preparation of Compounds Labeled with Tritium and Carbon-14 is an essential guide to the specialist strategies and tactics used by chemists to prepare compounds tagged with theradioactive atoms carbon-14 and tritium.
This CD-ROM edition of Silverman's Organic Chemisry of Drug Design and Drug Action, Second Edition reflects the significant changes in the drug industry in recent years, using an accessible interactive approach. This CD-ROM integrates the author's own PowerPoint slides, indexed and linked to the book pages in PDF format. The three-part structure includes an all-electronic text with full-text search capabilites and nearly 800 powerpoint slides. This is a unique and powerful combination of electronic study guide and full book pages. Users can hyperlink seamlessly from the main text to key points and figures on the outline and back again. It serves as a wonderful supplement for instructors as well as a fully integrated text and study aid for students. * Three-part package includes 1) powerpoint, 2) integrated powerpoint and pdf-based text, and 3) fully searchable PDF-based text with index * Includes new full-color illustrations, structures, schemes, and figures as well as extensive chapter problems and exercises * User-friendly buttons transition from overview (study-guide) format to corresponding book page and back with the click of a mouse * Full-text search capabality an incomparable tool for researchers seeking specific references and/or unindexed phrases
A COMPLETE review package for the Emergency Medicine qualifying exam -- based on the popular Manhattan Review Course Based on the acclaimed Manhattan Review Course and drawing on valuable insights from top New York City emergency departments, this review has everything you need to pass the Emergency Medicine written boards on your very first try. Here, you'll, get a concise walk-through of key emergency medicine topics, board-format Q&A, and a full-color image review with cases on CD -- all designed to give you a solid idea of what to expect on exam day. Intensive Review for the Emergency Medicine Qualifying Examination features a succinct outline format, yet it leaves nothing out, covering the full range of emergency medicine specialties. It all adds up to the ultimate board study companion -- one that can help you recall information pertinent to the practice of emergency medicine and approach the exam with confidence. FEATURES: Concise yet comprehensive outline-format review of all areas in the American Board of Emergency Medicine core curriculum, packed with insights emergency physicians and residents must know to succeed on the boards CD-ROM containing more than 250 board-style questions, answers, and rationales to simulate the actual exame 250+ board-style questions and answers More than 250 high-yield clinical images, including a section in full color Practical approach to emergency medicine exam preparation that refreshes your knowledge, instead of re-teaching what you already know Based on the respected Manhattan Review Course, and written by experts from New York City emergency departments
The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style
There are plenty of books on specialized risk topics but few that deal with the broad diversity and daily applicability of this subject. Risk applications require a robust knowledge of many attributes of this seemingly simple subject. This book teaches the reader through examples and case studies the fundamental (and subtle) aspects of risk - regardless of the specific situation. The text allows the reader to understand the concept of risk analysis while not getting too involved in the mathematics; in this method the reader can apply these techniques across a wide range of situations. The second edition includes new examples from NASA and several other industries as well as new case studies from legal databases. The many real-life discussion topics enable the reader to form an understanding of the concepts of risk and risk management and apply them to day-to-day issues.
An indispensible collection of Office 2013 Bibles Eager to delve into the new suite of Office 2013 applications? Look no further than this spectacular collection of four invaluable resources that boast nearly 5,000 pages and cover the core Office programs: Excel, Access, PowerPoint, and Word. The world's leading experts of these applications provide you with an arsenal of information on the latest version of each program. Features four essential books on the most popular applications included in the Office 2013 suite: Excel, Access, PowerPoint, and Word Excel 2013 Bible - serves as an essential reference for Excel users, no matter your level of expertise, and updates you on the latest Excel tips, tricks, and techniques Access 2013 Bible - offers a detailed introduction to database fundamentals and terminology PowerPoint 2013 Bible - shows you how to use the newest features and make successful presentations Word 2013 Bible - begins with a detailed look at all the latest features and then cover more advanced, intricate topics Look no further than Office 2013 Library for the most thorough coverage on every aspect of the Office 2013 suite!
These stories of military heroism, focusing on members of the Legion of Valor, offer a sweeping study of courage in service to America. Published in conjunction with the Legion of Valor of the United States of America, Courage in Combat shares the stories of military heroes from the Civil War onward. They are recipients of the Medal of Honor, the Distinguished Service Cross, the Navy Cross, and the Air Force Cross. Their awards are our nation’s highest military decorations, given only to one in twenty thousand combatants. Among them are sergeants and generals, as well as corpsmen, civilians, engineers, “grunts,” and paratroopers. There are men and women, a mess attendant, aviators, spies and POWs, a cavalry scout, candidates for sainthood, and a president of the United States. The stories of these brave individuals relate personal accounts of heroism, as well as reflections on combat and war. This book also includes a short history of the Legion of Valor, America’s oldest military service organization, and an extensive list of its members, past and present. Courage in Combat explores the concept of courage through the lives, thoughts, and actions of this elite group—most of whom would say, “I was just doing my job.”
We all want to look and feel good. We also want to perform well whether it's in the weight room, in sports, or at work. Research has shown exercise, proper nutrition, and adequate recovery affect health and human performance. However, there's lot of conflicting and confusing information regarding exercise and nutrition. In Essentials of Exercise and Sport Nutrition, author Dr. Richard B. Kreider offers an up-to-date assessment of the science and practice of exercise and sport nutrition. Kreider, who has conducted extensive research on the subject and has consulted with numerous teams, coaches, and athletes for more than thirty years, brings a scientific and applied perspective to discussing the latest research and how it can be used to optimize performance. He also provides summary recommendations, training programs, and meal plans for beginners through athletes, as well as for individuals who want to lose and/or manage their weight.
Our aim in this volume, as in Volume I, HormonaI Correlates of Behavior: A Life Span View, has been to provide a critical assess ment of the state of behavioral endocrinology as weIl as the more usual summary of extant data. Each contributor was asked to probe the strengths and weaknesses of his area as candidly as possible. As aresult, we hope the reader will find this Volume useful as a reference source and as an honest evaluation of our present know ledge of the interaction between hormones and behavior. R. L. Sprott Bar Harbor, 1975 B. E. Eleftheriou v CONTRIBUTORS Robert Ader, Ph.D., Department of Psychiatry, University of Rochester Schoo1 of Medicine and Dentistry, Rochester, New York 14642. F. R. Brush, Ph.D., Experimental Psychology Laboratory, Syracuse University, Syracuse, New York 13210. Robert M. Benson, M.D., Pediatric Endocrine Clinic, Children's Medical and Surgical Center, The Johns Hopkins Hospital and University, Baltimore, Maryland 21205. John J. Christian, Sc.D., Department of Biological Sciences, Univer sity of New York at Binghamton, Binghamton, New York 13901. David A. Edwards, Ph.D., Department of Psychology, Emory University, Atlanta, Georgia 30304. Carl Eisdorfer, Ph.D., M.D., Department of Psychiatry and Behaviora1 Sciences, School of Medicine, University of Washington, Seattle, Washington 98101. Basil E. Eleftheriou, Ph.D., The Jackson Laboratory, Bar Harbor, Maine 04609. Merri11 F. Elias, Ph.D., Department of Psychology and All-University Gerontology Center, Syracuse University, Syracuse, New York 13210.
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