Richard B. Cook's Books

That's What I'm Talking about

By: Richard B. Cook

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Collection of Previously Published Articles and Reviews. The selections are tied together by the theme: the nature of belief, its expression and appliction in different contexts, both historical and literary. There is an emphasis upon the missionary career of St Paul both as an organizer of newly converted Gentile believers and as a former persecutor of believers, who denounced him to his converts.

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Page Count

224

Publisher

RICHARD BALDWIN COOK

Published Date

ISBN 10

0979125707

ISBN 13

9780979125706

The Organic Chemistry of Drug Design and Drug Action

By: Richard B. Silverman,Mark W. Holladay

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The Organic Chemistry of Drug Design and Drug Action

By: Richard B. Silverman,Mark W. Holladay

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. - Updates to all chapters, including new examples and references - Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book - Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry - Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant - Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis - Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: - for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib - for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid - for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin - Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples - Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites - Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates

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Page Count

537

Publisher

Academic Press

Published Date

ISBN 10

0123820316

ISBN 13

9780123820310

Organometallic Chemistry Research Perspectives

By: Richard P. Irwin

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Organometallic Chemistry Research Perspectives

By: Richard P. Irwin

Organometallic chemistry is based on the reactions and use of a class of compounds (R-M) that contain a covalent bond between carbon and metal. They are prepared either by direct reaction of the metal with an organic compound or by replacement of a metal from another organometallic substance. This book presents research in this field.

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324

Publisher

Nova Publishers

Published Date

ISBN 10

160021780X

ISBN 13

9781600217807

Who Killed Jane Stanford?: A Gilded Age Tale of Murder, Deceit, Spirits and the Birth of a University

By: Richard White

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Who Killed Jane Stanford?: A Gilded Age Tale of Murder, Deceit, Spirits and the Birth of a University

By: Richard White

Named One of the Best Nonfiction Books of 2022 by the Los Angeles Times A premier historian penetrates the fog of corruption and cover-up still surrounding the murder of a Stanford University founder to establish who did it, how, and why. In 1885 Jane and Leland Stanford cofounded a university to honor their recently deceased young son. After her husband’s death in 1893, Jane Stanford, a devoted spiritualist who expected the university to inculcate her values, steered Stanford into eccentricity and public controversy for more than a decade. In 1905 she was murdered in Hawaii, a victim, according to the Honolulu coroner’s jury, of strychnine poisoning. With her vast fortune the university’s lifeline, the Stanford president and his allies quickly sought to foreclose challenges to her bequests by constructing a story of death by natural causes. The cover-up gained traction in the murky labyrinths of power, wealth, and corruption of Gilded Age San Francisco. The murderer walked. Deftly sifting the scattered evidence and conflicting stories of suspects and witnesses, Richard White gives us the first full account of Jane Stanford’s murder and its cover-up. Against a backdrop of the city’s machine politics, rogue policing, tong wars, and heated newspaper rivalries, White’s search for the murderer draws us into Jane Stanford’s imperious household and the academic enmities of the university. Although Stanford officials claimed that no one could have wanted to murder Jane, we meet several people who had the motives and the opportunity to do so. One of these, we discover, also had the means.

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Page Count

394

Publisher

W. W. Norton & Company

Published Date

ISBN 10

1324004347

ISBN 13

9781324004349

The Grand Old Man

in large print

By: Richard B. Cook

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The Grand Old Man

in large print

By: Richard B. Cook

Reproduction of the original. The publishing house Megali specialises in reproducing historical works in large print to make reading easier for people with impaired vision.

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Page Count

458

Publisher

BoD – Books on Demand

Published Date

ISBN 10

3387333374

ISBN 13

9783387333374

Veterinary Ocular Pathology

A Comparative Review

By: Richard R. Dubielzig,Kerry L. Ketring,Gillian J McLellan,Daniel M. Albert

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Veterinary Ocular Pathology

A Comparative Review

By: Richard R. Dubielzig,Kerry L. Ketring,Gillian J McLellan,Daniel M. Albert

Veterinary Ocular Pathology: A Comparative Review links the clinical features of ocular disease with gross and microscopic pathology to demonstrate the essential features observable during diagnosis. It is designed to be kept next to the microscope as an invaluable guide to accurate diagnosis in ocular pathology. The book presents a wide range of images of the highest quality. A unique and distinctive feature is the juxtaposition of clinical and pathological images while offering detailed enumeration of the diagnostic features. Expert comparative comments by Dr Daniel Albert and contextual information on relative incidence are provided throughout. The authors address spontaneous disease of the eye in all animal species, with a particular emphasis on companion species. In addition, specific, common or interesting conditions of exotic species are included. - The first text devoted to the pathology of spontaneous diseases of the eyes and periocular tissues of domestic animal species - Exceptionally high quality illustrations are presented throughout, demonstrating clinical features, gross pathology and histopathology - Written by pathologists and clinicians - Includes a chapter devoted to the pathology of conditions associated with glaucoma in domestic animals A convenient, comprehensive and easy-to-use reference for veterinary pathologists, veterinary ophthalmologists, students and comparative vision scientists. - The first text devoted to the pathology of spontaneous diseases of the eyes and periocular tissues of domestic animal species - Exceptionally high quality illustrations are presented throughout, demonstrating clinical features, gross pathology and histopathology - Written by pathologists and clinicians - Includes a chapter devoted to the pathology of conditions associated with glaucoma in domestic animals

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Page Count

467

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0702044423

ISBN 13

9780702044427

Racing Stripes

By: Richard G. Smith

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Racing Stripes

By: Richard G. Smith

K-8 reading program.

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Page Count

552

Published Date

ISBN 10

0673114139

ISBN 13

9780673114136

Book's by Richard B. Cook

That's What I'm Talking about

That's What I'm Talking about

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action

Organometallic Chemistry Research Perspectives

Organometallic Chemistry Research Perspectives

Who Killed Jane Stanford?: A Gilded Age Tale of Murder, Deceit, Spirits and the Birth of a University

Who Killed Jane Stanford?: A Gilded Age Tale of Murder, Deceit, Spirits and the Birth of a University

The Grand Old Man

The Grand Old Man

Veterinary Ocular Pathology

Veterinary Ocular Pathology

Racing Stripes

Racing Stripes

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