Expertly bridging the gap between basic science and clinical information, Williams Textbook of Endocrinology, 14th Edition, brings together an outstanding collection of world-renowned authors to provide authoritative discussions of the full spectrum of adult and pediatric endocrine system disorders. New chapters and significant revisions throughout keep you up to date with recent advances in medications, therapies, clinical trials, and more. This essential reference is a must-have resource for endocrinologists, endocrine surgeons, gynecologists, internists, pediatricians, and other clinicians who need current, comprehensive coverage of this multifaceted field. Up to date with recent advances in medications, therapies, and clinical trials. Provides state-of-the-art coverage of diabetes, metabolic syndrome, metabolic bones disorders, obesity, thyroid disease, testicular disorders, newly defined adrenal disorders and much more - all designed to help you provide optimal care to every patient. Contains new chapters on Global Burden of Endocrine Disease, Navigation of Endocrine Guidelines, and Transgender Endocrinology. Includes significant updates to the Diabetes section, including a new chapter on Physiology of Insulin Secretion and greater coverage of Type 2 Diabetes. Presents current information in a highly illustrated, user-friendly format for quick reference.
Steroid 17-hydroxylase 17,20-lyase (cytochrome P450c17, CYP17A1) occupies a critical position in the pathways of human steroidogenesis, regulating the classes of steroid hormones produced by cells of the adrenal glands and gonads. CYP17A1 catalyzes two major reactions: the 17-hydroxylase and 17,20-lyase reactions. Mutations that compromise all CYP17A1 activities cause combined 17-hydroxylase/17,20-lyase deficiency, which presents as hypertension, hypokalemia, and sexual infantilism. A few mutations selectively impair 17,20-lyase activity, and some mutations in cofactor proteins cytochrome P450-oxidoreductase and cytochrome b5 also selectively disrupt 17,20-lyase activity. This chapter reviews the genetics, clinical presentation, management, and history of these disorders.
Expertly bridging the gap between basic science and clinical information, Williams Textbook of Endocrinology, 14th Edition, brings together an outstanding collection of world-renowned authors to provide authoritative discussions of the full spectrum of adult and pediatric endocrine system disorders. New chapters and significant revisions throughout keep you up to date with recent advances in medications, therapies, clinical trials, and more. This essential reference is a must-have resource for endocrinologists, endocrine surgeons, gynecologists, internists, pediatricians, and other clinicians who need current, comprehensive coverage of this multifaceted field. Up to date with recent advances in medications, therapies, and clinical trials. Provides state-of-the-art coverage of diabetes, metabolic syndrome, metabolic bones disorders, obesity, thyroid disease, testicular disorders, newly defined adrenal disorders and much more - all designed to help you provide optimal care to every patient. Contains new chapters on Global Burden of Endocrine Disease, Navigation of Endocrine Guidelines, and Transgender Endocrinology. Includes significant updates to the Diabetes section, including a new chapter on Physiology of Insulin Secretion and greater coverage of Type 2 Diabetes. Presents current information in a highly illustrated, user-friendly format for quick reference.
It started as a single idea, under the working title of Siegfried's Death, and ended as an epic four-opera cycle, "Der Ring des Nibelungen." Inspired by the great Nordic and Germanic sagas, Richard Wagner created a unique statement of the interplay between love and power — a struggle he movingly expressed through recurrent motifs of yearning and loss. Die Walküre, the second opera in the series, remains the most popular and frequently performed of the mighty Ring Cycle works. From its gripping opening — in which the hero finds himself weaponless in the house of his enemy — to its heartrending finale — a father' s final farewell to his favorite daughter — generations of listeners have thrilled and swooned to this story and its magical music. First performed as part of the complete Ring Cycle in 1876, at the grand opening of the Bayreuth Festival Theatre, Die Walküre boasts one of opera's best-known passages, the exhilarating "Ride of the Walküre." This vocal score of the complete opera, with lyrics in both German and English, features a piano reduction of the orchestral part and is ideal for study, rehearsal, and concert performances.
A must-have resource for any emergency or urgent care setting, Fleisher & Ludwig’s 5-Minute Pediatric Emergency Medicine Consult, 3rd Edition, provides clear, succinct guidance on hundreds of diseases and common pediatric conditions. Editors-in-Chief Drs. Robert J. Hoffman and Vincent J. Wang lead an editorial and author team who put evidence-based answers at your fingertips—essential information on clinical orientation, differential diagnosis, medications, management, discharge criteria, and more.
Since its original appearance in 1977, Advanced Organic Chemistry has found wide use as a text providing broad coverage of the structure, reactivity and synthesis of organic compounds. The Fourth Edition provides updated material but continues the essential elements of the previous edition. The material in Part A is organized on the basis of fundamental structural topics such as structure, stereochemistry, conformation and aromaticity and basic mechanistic types, including nucleophilic substitution, addition reactions, carbonyl chemistry, aromatic substitution and free radical reactions. The material in Part B is organized on the basis of reaction type with emphasis on reactions of importance in laboratory synthesis. As in the earlier editions, the text contains extensive references to both the primary and review literature and provides examples of data and reactions that illustrate and document the generalizations. While the text assumes completion of an introductory course in organic chemistry, it reviews the fundamental concepts for each topic that is discussed. The Fourth Edition updates certain topics that have advanced rapidly in the decade since the Third Edition was published, including computational chemistry, structural manifestations of aromaticity, enantioselective reactions and lanthanide catalysis. The two parts stand alone, although there is considerable cross-referencing. Part A emphasizes quantitative and qualitative description of structural effects on reactivity and mechanism. Part B emphasizes the most general and useful synthetic reactions. The focus is on the core of organic chemistry, but the information provided forms the foundation for future study and research in medicinal and pharmaceutical chemistry, biological chemistry and physical properties of organic compounds. The New Revised 5th Edition will be available shortly. For details, click on the link in the right-hand column.
Previously known as the Textbook of Uroradiology, the newly retitled Genitourinary Radiology continues to bring you top-flight expertise in interpreting imaging studies of the genitourinary tract. A team of leading authorities walks you through the full range of relevant modalities and findings for each anatomical region, providing a multitude of high-quality representative images that capture the characteristic appearance of the conditions you’re likely to encounter. The result remains an indispensable resource for diagnosing genitourinary diseases and disorders.
This popular reference is the definitive guide on exam techniques for neurology residents, fellows, and practitioners, integrating details of neuroanatomy and diagnosis in an easy-to-read, easy-to-follow format. A new clinical focus, new videos online, and new illustrations makeDeJong’s The Neurologic Examination, 8th Edition,even more useful for mastery of this complex area. Anatomical and exam illustrations ensure proper technique, and illustrative case studies and tables summarize differentials and clinical findings.
Nelson Textbook of Pediatrics has been the world’s most trusted pediatrics resource for nearly 75 years. Drs. Robert Kliegman, Bonita Stanton, Richard Behrman, and two new editors—Drs. Joseph St. Geme and Nina Schor—continue to provide the most authoritative coverage of the best approaches to care. This streamlined new edition covers the latest on genetics, neurology, infectious disease, melamine poisoning, sexual identity and adolescent homosexuality, psychosis associated with epilepsy, and more. Understand the principles of therapy and which drugs and dosages to prescribe for every disease. Locate key content easily and identify clinical conditions quickly thanks to a full-color design and full-color photographs. Stay current on recent developments and hot topics such as melamine poisoning, long-term mechanical ventilation in the acutely ill child, sexual identity and adolescent homosexuality, age-specific behavior disturbances, and psychosis associated with epilepsy. Tap into substantially enhanced content with world-leading clinical and research expertise from two new editors—Joseph St. Geme, III, MD and Nina Schor, MD—who contribute on the key subspecialties, including pediatric infectious disease and pediatric neurology. Manage the transition to adult healthcare for children with chronic diseases through discussions of the overall health needs of patients with congenital heart defects, diabetes, and cystic fibrosis. Recognize, diagnose, and manage genetic conditions more effectively using an expanded section that covers these diseases, disorders, and syndromes extensively. Find information on chronic and common dermatologic problems more easily with a more intuitive reorganization of the section.
Long considered the gold standard comprehensive reference for diagnosing and managing emergent health issues in children, Fleisher & Ludwig’s Textbook of Pediatric Emergency Medicine is an essential resource for clinicians at all levels of training and experience. The revised eighth edition has been updated from cover to cover, providing practical, evidence-based content to help you meet any clinical challenge in the emergency care of pediatric patients.
Obesity in children and adolescents is a serious issue with many health and social consequences that often continue into adulthood. Implementing prevention programs and getting a better understanding of treatment for youngsters is important to controlling the obesity epidemic. The term "childhood obesity" may refer to both children and adolescents. Between 5-25 percent of children and teenagers in the United States are obese. As with adults, the prevalence of obesity in the young varies by ethnic group. It is estimated that 5-7 percent of White and Black children are obese, while 12 percent of Hispanic boys and 19 percent of Hispanic girls are obese. Some data indicate that obesity among children is on the increase. The second National Children and Youth Fitness Study found 6-9 year olds to have thicker skinfolds than their counterparts in the 1960s. During the same period, others documented a 54 percent increase in the prevalence of obesity among 6-11 year olds. This book examines leading research in this area of great concern to society.
Using a proven, practical, algorithmic approach, Surgical Decision Making summarizes evidence-based guidelines and practice protocols in an easy-to-follow format. Designed to sharpen the decision-making skills of both trainees and practicing surgeons, the 6th Edition directs your focus to the critical decision points in a wide range of clinical scenarios, helping you determine optimal evaluation and management to secure the best possible patient outcomes. Algorithms are accompanied by annotations that explain all critical factors affecting decisions in a concise, readable manner. Reflects the scope of practice of today’s general surgeon, with fresh, expert perspectives from new editor Dr. Richard Schulick and numerous new contributors. Contains 58 new chapters and thoroughly revised content throughout. Includes new coverage of Preoperative Evaluation of the Geriatric Patient, Pancreatic Cystic Neoplasm, Familial Breast Cancer, Resuscitative Endovascular Balloon Occlusion of the Aorta, Blunt Cerebrovascular Injury, and much more. Uses an easy-to-follow, consistent format, with an algorithm on one page and short descriptions explaining the various steps in the decision-making process on the opposite page. Includes explanatory notes that summarize presenting signs and symptoms, laboratory investigation, diagnostic modalities, surgical therapies, and adjuvant therapies for each condition. Encompasses both general surgery and surgical subspecialties―helping you directly manage a broad range of problems. Emphasizes information that frequently appears on board exams.
The definitive core text in its field, Stroke Recovery and Rehabilitation is a comprehensive reference covering all aspects of stroke rehabilitation ó from neurophysiology of stroke through the latest treatments and interventions for functional recovery and restoration of mobility. This second edition is completely updated to reflect recent advances in scientific understanding of neural recovery and growing evidence for new clinical therapies. The second edition ó which includes free e-book access with every print purchase ó continues to provide in-depth information on the assessment and management of all acute and long-term stroke-related impairments and complications including cognitive dysfunctions, musculoskeletal pain, and psychological issues. It examines risk factors, epidemiology, prevention, and neurophysiology as well as complementary and alternative therapies, functional assessments, care systems, ethical issues, and community and psychosocial reintegration. With contributions from over 100 acknowledged leaders from every branch of the stroke recovery field, this edition features expanded coverage of key issues such as the role of robotics and virtual reality in rehabilitation. New chapters have been incorporated to cover fields of recent exploration including transcranial magnetic stimulation, biomarkers, and genetics of recovery as well as essentials like the use of medication and the survivorís perspective. The up-to-date presentation of scientific underpinnings and multi-specialty clinical perspectives from physical medicine and rehabilitation, neurology, physical therapy, occupational therapy, speech and language pathology, and nursing ensures that Stroke Recovery and Rehabilitation will continue to serve as an invaluable reference for every health care professional working to restore function and help stroke survivors achieve their maximum potential. New to Stroke Recovery and Rehabilitation, Second Edition All chapters are thoroughly revised and updated to reflect advances in scientific understanding of neural recovery and clinical progress Five completely new chapters and expanded coverage of key issues that drive the field forward New contributions from leading stroke specialists from all involved disciplines Includes access to the fully-searchable downloadable ebook
First published in 1991, this book covers three major areas essential to in vivo biochemical studies with PET and SPECT: synthesis of radiopharmaceuticals, biological modeling, and clinical applications. The book emphasizes advances in the synthesis of radiopharmaceuticals used in PET and SPECT studies of brain flow and oxidatative metabolism, in addition to biological modeling. The most widely used 2-deoxyglucose/2-fluorodeoxyglucose models are discussed, as well as models used in the quantitation of brain receptors. Other topics include a possible model for converting 6-[18F] fluorodopa images into the quantitative rate of dopamine synthesis, evaluations of technetium- and iodine-labeled blood flow tracers, and possibilities for using SPECT to measure other pathophysiological variables. This book will be a valuable reference source to students and specialists interested in these in vivo measurements.
Surgical treatment of congenital adrenal hyperplasia has undergone dramatic evolution over the past 30 years. This chapter will explore current reconstructive techniques and historic as well as current surgical outcomes. A brief description of surgical technique and its evolution will be described, followed by an analysis of surgical outcomes. The chapter will conclude with a discussion regarding current controversies regarding timing and technique of surgical correction.
The first edition of this book was the first authoritative, systematic and comprehensive text to define the increasingly important and evolving specialty of paediatric palliative care. It explores both the clinical aspects and the multidimensional and holistic nature of care for the dying child, based on the knowledge that all human experience has a physical, emotional, psychological and spiritual impact. The book covers ways of providing support in all of these areas both for the child, families, and carers, recognising the importance of teamwork and taking an evidence-based approach. The Oxford Textbook of Palliative Care for Children is about the care of children for whom cure of their underlying disease is not possible. It encompasses the physical management of symptoms such as pain and nausea, as well as social issues such as accessing appropriate education, emotional issues such as techniques for communication, and spiritual issues such as feelings of guilt and isolation. The book suggests that if we are to maintain the quality of life for a child it is essential to recognise all these dimensions and try to address them. This can only be done by recognising the skills of a wide range of professionals and working together in ways that are not always intuitive to any one discipline. It explores the multidimensional and holistic nature of care for the dying child. Those working in paediatric palliative care recognise that all human experience has emotional, psychological and spiritual impact as well as physical, and this book offers the essential information needed for those involved in paediatric care to find ways of providing support in all of these areas. Comprehensive in scope, exhaustive in detail, and definitive in authority, this second edition has been thoroughly updated to cover new practices, current epidemiological data and the evolving models that support the delivery of palliative medicine to children. Paediatric palliative care is now developing in countries with differing health care systems, and being adapted to suit individual illnesses and the varying resources and geography in different parts of the world. This book is an essential resource for anyone who works with children worldwide.
Band 8 ist den Neuentwicklungen auf dem Gebiet der Herbizide gewidmet. Die Bedeutung der Herbizide ist von 1976 bis 1980 erneut gestiegen, und weltweit beträgt der Herbizid-Verkauf wertmäßig soviel, wie der Verkaufswert der Insekti zide und Fungizide zusammen! Langsam bedienen sich auch, bei intensiverem Anbau von Nahrungsmitteln und Nutzkulturen, "unterentwickelte" Länder aller Arten von Pestiziden und Herbiziden, und so ist mit einer weiteren Steigerung der Herbizid-Anwendung zu rechnen. Von 1976 bis 1980 wurden viele neue Versuchsprodukte, aber vergleichsweise wenig neuartige Handelsprodukte bekannt, denn der Herbizid-Standard ist schon sehr hoch, sodaß es immer schwieriger wird, Herbizide mit wesentlichen Vorteilen zu finden, zu entwickeln und zum Verkauf zu bringen. Die mengenmäßig hohe Produktion wichtiger Herbizide macht es zudem schwierig, preiswertere neue Produkte herzustellen und einzuführen. Die stark angestiegenen Forschungs-und Entwicklungskosten für ein neues Pflanzenschutzmittel - etwa 100 Mill. D- erschweren den Fortschritt außerordentlich. Wenngleich die meisten neuen Ver suchs- und Handelsprodukte Substanzgruppen entstammen, deren Bedeutung schon Ende 1976 erkannt worden war, und deren erste Versuchsprodukte bereits eine Weiterentwicklung anzeigten, so wurden doch auch spektakuläre Ent deckungen gemacht, von denen es wiederum erste Versuchsprodukte gibt. Herbi zide mit Aufwandmengen von etwa 20 g/ha, also mit extrem guter Wirksam keit zeigen, daß der Weg in unerwartetes Neuland noch lange kein Ende hat. Schon 1976 bekannte Verbindungsklassen, wie die der Diarylether-oxyalkan carbonsäuren, nicht nur von der Entdeckerfirma Hoechst AG intensiv bearbeitet, ergaben eine Fülle neuer Herbizide mit meist selektiver Gräserwirkung.
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