Cryopreserved allograft tissues are now standard materials for the reconstructive cardiac surgeon. Since publication of the first edition ("Cardiac Reconstructions with Allograft Valves") in 1989, the field has progressed dramatically with increased clinical use of cardiovascular allograft tissues, with the development of new surgical techniques, and with advances in the understanding of the fundamentals of valve transplantation biology and cryopreservation. As a result, over two-thirds of the present volume represents new material. Fifty-six authors bring their expertise to thirteen comprehensive, lavishly illustrated sections which discuss the principles of the use of homograft valves, major clinical series of homograft valves for both left and right ventricular outflow tracts, cryopreserved allograft tissue for cardiac reconstruction, cell biology of heart valve leaflets, cryobiology of heart valve preservation, morphological, biochemical, and explant pathology studies of allograft heart valves, allograft valve banking, as well as detailed explanation of surgical techniques for valve and root methods for left and right ventricular outflow tract reconstructions, the Ross operation and variants, and complex reconstructions. A final section presents potential future directions for the field. Over 400 illustrations, created expressly for this book, depict the surgical techniques from the perspective of the surgeon standing at the operating table. All surgeons performing pediatric and/or adult valve replacements and reconstructive cardiac surgeries will benefit from the described methods. Cardiothoracic residents and cardiologists will also find the text useful. It will provide the surgeon with an enhanced understanding of the biological and material properties of allografts and increased familiarity with the range of surgical techniques applicable for the use of these valves, particularly in the successful management of challenging cardiac reconstructions.>
Make your workforce happier, healthier—and more productive—with strategies from a world-leader in company culture and health In A Cure for the Common Company: A Well-Being Prescription for a Happier, Healthier, and More Resilient Organization, health and well-being expert, Richard Safeer, M.D. delivers a step-by-step roadmap to creating a culture of health on your team and in your company that keeps your people happier and more engaged. In the book, you’ll discover the importance of shaping your well-being culture, challenging yourself, your team, and your workforce to live better lives by offering them new tools and methods to do just that. This book discusses: Bulletproof strategies to help leaders build a sound cultural foundation that supports their efforts at change A path forward that allows organizational leaders to step up and help their employees be the best versions of themselves Techniques to build a supportive culture that overcomes common obstacles to change, including positive social climates, norms, and peer supports A can't-miss resource for business and human resource leaders at medium- to large-sized organizations, A Cure for the Common Company also belongs on the bookshelves of every professional interested in supporting employee health and well-being.
Thoroughly updated for its Fifth Edition, Dr. Light's classic text provides a focused, single-authored perspective on the pathophysiology, clinical manifestations, diagnosis, and management of pleural diseases. This edition has three new chapters on physiological effects of a pneumothorax or pleural effusion, animal models in pleural investigation, and cytokines and the pleura. Other chapters present significant updates on use of thoracoscopy in diagnosis of pleural effusions and on new diagnostic tests for mesothelioma, parapneumonic effusion, and effusions due to congestive heart failure. Also included are discussions of recent advances in the therapy of malignant pleural effusions, mesothelioma, and parapneumonic effusions.
The first detailed introduction to the entirety of Seamus Heaneys workThis study will enable readers to gain clearer understanding of the life and major works of Seamus Heaney. It considers literary influences on Heaney, ranging from English poets such as Wordsworth, Hughes, and Auden to Irish poets such as Kavanagh and Yeats to world poets such as Virgil and Dante. It shows how Heaney was closely attuned to poetry's impact on daily life and current events even as he articulated a convincing apologia for poetry's own life and integrity. Discussing Heaney's deep immersion in Irish Catholicism, this book demonstrates how faith influenced his belief system, poetry and politics. Finally, it also considers how deeply Heaney's artistic endeavours were intertwined with politics in Northern Ireland, especially through his embrace of constitutional nationalism but rejection of physical force republicanism.Key FeaturesIncludes sections on biography, historical, cultural and political contexts, poetry and other genres, as well as a concluding section on primary works and secondary criticismPays special attention to the marriage of form and content in the poetry and how they work together to express subtle shades of meaningOffers close readings of Heaney's canonical poems throughout his career, including the early seminal poems such as Digging, the abog poems, and his many elegies, such as Casualty, Station Island, and ClearancesDraws on drafts of the poems and prose at the Heaney archives at Emory University and the National Library of Ireland
Dazzling...a cerebral thriller that's both intellectually engaging and emotionally compelling, a lively tour de force."—Michiko Kakutani, The New York Times After four novels and several years living abroad, the fictional protagonist of Galatea 2.2—Richard Powers—returns to the United States as Humanist-in-Residence at the enormous Center for the Study of Advanced Sciences. There he runs afoul of Philip Lentz, an outspoken cognitive neurologist intent upon modeling the human brain by means of computer-based neural networks. Lentz involves Powers in an outlandish and irresistible project: to train a neural net on a canonical list of Great Books. Through repeated tutorials, the device grows gradually more worldly, until it demands to know its own name, sex, race, and reason for existing.
The final of four volumes in the 'California History Sesquicentennial Series', this text compiles original essays which treat the consequential role of post-Gold Rush California government, politics and law in the building of a dynamic state with lasting impact to the present day.
A major need of all cardiologists and surgeons involved with the application of allograft tissue to cardiac surgical reconstructions is met by this unique atlas. Step by step, it carefully describes the procedures involved in acquiring, sterilizing, and cryo-preserving allograft valves as well as the surgical technique used in left and right ventricular outflow tract reconstructions. All of the information needed to perform the reconstructions is given, including relevant references and applicable variations in method. Excellent illustrations accompany the description of surgical technique. All of the techniques are based on classic approaches, but assimilate the authors' modifications arrived at through vast experience. The wealth of references, illustrations and expertise in this volume make it a valuable asset for all cardiac surgeons.
Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.
Dominating the Windy City for decades, the Chicago Democratic Machine has become a fixture in American political history. Under Mayor Richard J. Daley, it acquired almost mythical (perhaps notorious) status. Yet its origins have remained murky--some say is began as a shady enterprise during the ethnic upheaval of the late 1920s. Based upon new research, this book offers a fresh perspective. Formed through factional warfare and consolidated with methods borrowed from the business world, the Machine grew out of the unfettered capitalism of the late 19th century. Its principal founder and first "boss," Roger C. Sullivan, represented a generation of businessmen-politicians who emerged in the 1880s. Sullivan and his allies created an informal public power structure that, while serving their own interests, also made government more functional. The Machine is a product of America's Gilded Age and the Progressive Era and offers a lesson in the advantages and limitations of representative government.
Scientific research is the search for truth and this is a noble pursuit. Yet the scientists who power this endeavor are all-too human; they are driven by desire for fame, for power, for money and in many cases they will not be denied. For a few, the path leads to uncollegiality, deceit and even crime. Results may be manipulated, competitors may be obstructed even destroyed.You will meet some of these villains in this group of short stories, which are based upon real-life occurrences which came to the ears of the author during his many years in the trenches of Science and through his work as an ombudsman. Read with care! Not all of the people whom you will meet will be White Knights!
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