Baseball is not the only sport to use "moneyball." American football fans, teams, and gamblers are increasingly using data to gain an edge against the competition. Professional and college teams use data to help select players and identify team needs. Fans use data to guide fantasy team picks and strategies. Sports bettors and fantasy football players are using data to help inform decision making. This concise book provides a clear introduction to using statistical models to analyze football data. Whether your goal is to produce a winning team, dominate your fantasy football league, qualify for an entry-level football analyst position, or simply learn R and Python using fun example cases, this book is your starting place. You'll learn how to: Apply basic statistical concepts to football datasets Describe football data with quantitative methods Create efficient workflows that offer reproducible results Use data science skills such as web scraping, manipulating data, and plotting data Implement statistical models for football data Link data summaries and model outputs to create reports or presentations using tools such as R Markdown and R Shiny And more
Kidnapped: The Disappearance of Christian McKinley is a captivating and horrifying kidnapping plot that twists and turns itself from the suburbs of Minneapolis to the Canadian border and beyond. On September 6, 2003, two men walked into the Hilton Hotel in downtown Minneapolis with an elaborate plan to kidnap a young teenager and hold him hostage for a seventeen-million-dollar payoff. The victimChristian McKinley. The fourteen-year-old is the adopted grandson of one of Minnesotas wealthiest bankers and business tycoons. The kidnapperstwo ex-cons, both products of neglectful and abusive childhoods, who turned to a life of crime early and havent looked back. Now they have only one thing on their drug-addled and psychologically damaged minds: scoring enough money for a luxurious retirement. But when jealousy and distrust invite themselves into the picture, plans begin to fall apart.
This CD-ROM edition of Silverman's Organic Chemisry of Drug Design and Drug Action, Second Edition reflects the significant changes in the drug industry in recent years, using an accessible interactive approach. This CD-ROM integrates the author's own PowerPoint slides, indexed and linked to the book pages in PDF format. The three-part structure includes an all-electronic text with full-text search capabilites and nearly 800 powerpoint slides. This is a unique and powerful combination of electronic study guide and full book pages. Users can hyperlink seamlessly from the main text to key points and figures on the outline and back again. It serves as a wonderful supplement for instructors as well as a fully integrated text and study aid for students. * Three-part package includes 1) powerpoint, 2) integrated powerpoint and pdf-based text, and 3) fully searchable PDF-based text with index * Includes new full-color illustrations, structures, schemes, and figures as well as extensive chapter problems and exercises * User-friendly buttons transition from overview (study-guide) format to corresponding book page and back with the click of a mouse * Full-text search capabality an incomparable tool for researchers seeking specific references and/or unindexed phrases
Almost all US cities are controlled by real estate and development interests, but Santa Cruz, California, is a deviant case. An unusual coalition of socialist-feminists, environmentalists, social-welfare liberals, and neighborhood activists has stopped every growth project proposed by landowners and developers since 1969, and controlled the city council since 1981. Even after a 1989 earthquake forced the city to rebuild its entire downtown, the progressive elected officials prevailed over developers and landowners. Drawing on hundreds of primary documents, as well as original, previously unpublished interviews, The Leftmost City utilizes an extended case study of Santa Cruz to critique three major theories of urban power: Marxism, public-choice theory, and regime theory. Santa Cruz is presented within the context of other progressive attempts to shape city government, and the authors' findings support growth-coalition theory, which stresses the conflict between real estate interests and neighborhoods as the fundamental axis of urban politics. The authors conclude their analysis by applying insights gleaned from Santa Cruz to progressive movements nationwide, offering a template for progressive coalitions to effectively organize to achieve political power.
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. - Updates to all chapters, including new examples and references - Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book - Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry - Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant - Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis - Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: - for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib - for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid - for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin - Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples - Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites - Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
The 21st century will witness the collision of two powerful forces - burgeoning population growth, together with a changing climate. With population growth, water scarcity will proliferate to new areas across the globe. And with climate change, rainfall will become more fickle, with longer and deeper periods of droughts and deluges. This report presents new evidence to advance understanding on how rainfall shocks coupled with water scarcity, impacts farms, firms, and families. On farms, the largest consumers of water in the world, impacts are channeled from declining yields to changing landscapes. In cities, water extremes especially when combined with unreliable infrastructure can stall firm production, sales, and revenue. At the center of this are families, who feel the impacts of this uncertainty on their incomes, jobs, and long-term health and welfare. Although a rainfall shock may be fleeting, its consequences can become permanent and shape the destiny of those who experience it. Pursuing business as usual will lead many countries down a 'parched path' where droughts shape destinies. Avoiding this misery in slow motion will call for fundamental changes to water policy around the globe. Building resilience to rainfall variability will require using different policy instruments to address the multifaceted nature of water. A key message of this report is that water has multiple economic attributes, each of which entail distinct policy responses. If water is not managed more prudently--from source, to tap, and back to source--the crises observed today will become the catastrophes of tomorrow.
Winner of the 1988 Clark Vincent Award for an "outstanding contribution to the profession through a literary work" and translated into four languages, the original edition of Therapeutic Metaphors for Children and the Child Within was considered a groundbreaking addition to the field of child and adolescent psychotherapy. The 1986 edition was the first—and to this day the only—book that solely intertwines the extraordinary foundational teachings and philosophies of Milton H. Erickson and creative healing approaches for children and adolescents. With resiliency at its core, this revision now brings forward important topics related to neurobiology and cultural value of metaphor and play, along with fresh case examples and creative activities to a new generation of mental health, education, and coaching professionals.
Molecular Biology of Assemblies and Machines provides a comprehensive narrative of the ways in which macromolecular structures assemble and how they interact with other complexes and organelles in the cell. Richly illustrated in full color, the text is written for advanced undergraduates, graduate students, and researchers in biochemistry, molecular biology, biophysics, cell biology, chemistry, structural biology, immunology, microbiology, and medicine.
Today, multidisciplinary approaches to treatment are at the heart of cancer care. They offer improved clinical outcomes, new possibilities in patient quality of life, and enable the development of true innovation in individualized treatment. To accurately reflect this modern day approach to cancer care, the content of the 6th edition of Principles and Practice of Gynecologic Oncology was written entirely by surgeons, medical oncologists, radiation oncologists, and pathologists. New to the editorial team, Dr. Andrew Berchuck has made significant contributions to the understanding of the molecular pathogenesis of ovarian and endometrial cancer in the book’s content. Every chapter of this book has been either completely rewritten or extensively updated to ensure that everyone involved in treating women with gynecologic cancer will have the most comprehensive and up-to-date information on the subject.
Organometallic chemistry is based on the reactions and use of a class of compounds (R-M) that contain a covalent bond between carbon and metal. They are prepared either by direct reaction of the metal with an organic compound or by replacement of a metal from another organometallic substance. This book presents research in this field.
ACCURATELY DIAGNOSE PEDIATRIC CONDITIONS BY VISIBLE SIGNS AND INTERNAL IMAGING WITH THIS FULL-COLOR ATLAS The Color Atlas of Pediatrics features more than 1,800 full-color photographs to help you visually diagnose a wide variety of common and uncommon conditions and disorders spanning the entire pediatric spectrum. This superb collection of clinical images is supported by concise, evidence-based treatment recommendations presented in easy-to-apply bulleted text. Each chapter begins with a patient story that ties the photographs to real-life patients. Coverage for conditions includes: Epidemiology Etiology and Pathophysiology Risk Factors Diagnosis Differential Diagnosis Management Prevention Patient Education Strength of recommendation ratings are cited throughout, skillfully blending the art and science of medicine for optimal patient care.
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